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WO2016063265A3 - Formulação tópica para o tratamento de infeções na pele ou mucosas, método de preparação e seus usos - Google Patents

Formulação tópica para o tratamento de infeções na pele ou mucosas, método de preparação e seus usos Download PDF

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Publication number
WO2016063265A3
WO2016063265A3 PCT/IB2015/058245 IB2015058245W WO2016063265A3 WO 2016063265 A3 WO2016063265 A3 WO 2016063265A3 IB 2015058245 W IB2015058245 W IB 2015058245W WO 2016063265 A3 WO2016063265 A3 WO 2016063265A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
treating
infections
mucosae
bromelain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2015/058245
Other languages
English (en)
French (fr)
Other versions
WO2016063265A2 (pt
Inventor
Rita Manuela PALMEIRA DE OLIVEIRA
Ana Cristina PALMEIRA DE OLIVEIRA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP15805257.1A priority Critical patent/EP3210619A2/en
Priority to US15/521,403 priority patent/US20170304411A1/en
Publication of WO2016063265A2 publication Critical patent/WO2016063265A2/pt
Publication of WO2016063265A3 publication Critical patent/WO2016063265A3/pt
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22033—Fruit bromelain (3.4.22.33), i.e. juice bromelain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A presente divulgação insere-se no domínio da terapêutica de infeções na pele ou suas mucosas e diz respeito ao uso da bromelaína isolada ou com agentes antimicrobianos para inibir, reduzir ou tratar biofilmes em infeções derivadas da presença deste mecanismo de patogenicidade. Esta aplicação pretende usufruir da ação enzimática da bromelaína para destruir os biofilmes e permitir a penetração dos antifúngicos, potenciando, deste modo, a sua ação local no foco da infeção, tratando e reduzindo os sintomas. A presente divulgação pode ser utilizada na área farmacêutica para o tratamento de infeções, em cremes, loções, géis, ou ampolas para a aplicação local na pele ou mucosas. Foram desenvolvidas formulações com capacidade de manter a estabilidade da enzima e dos restantes componentes ativos com boas características para aplicação na pele ou mucosas, em particular a vagina, promovendo, deste modo, a eficácia e a aceitabilidade do produto final.
PCT/IB2015/058245 2014-10-24 2015-10-26 Formulação tópica para o tratamento de infeções na pele ou mucosas, método de preparação e seus usos Ceased WO2016063265A2 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP15805257.1A EP3210619A2 (en) 2014-10-24 2015-10-26 Topical formulation for treating skin or mucosal infections, preparation method and uses thereof
US15/521,403 US20170304411A1 (en) 2014-10-24 2015-10-26 Topical formulation for treating skin or mucosal infections, preparation method and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT108004 2014-10-24
PT10800414 2014-10-24

Publications (2)

Publication Number Publication Date
WO2016063265A2 WO2016063265A2 (pt) 2016-04-28
WO2016063265A3 true WO2016063265A3 (pt) 2016-06-16

Family

ID=54783955

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/058245 Ceased WO2016063265A2 (pt) 2014-10-24 2015-10-26 Formulação tópica para o tratamento de infeções na pele ou mucosas, método de preparação e seus usos

Country Status (3)

Country Link
US (1) US20170304411A1 (pt)
EP (1) EP3210619A2 (pt)
WO (1) WO2016063265A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3958869A4 (en) * 2019-05-10 2022-11-16 Locus IP Company, LLC COMPOSITIONS AND METHODS FOR TREATING BIOFILM-ASSOCIATED LUNG CONDITIONS
AU2023404684A1 (en) * 2022-12-02 2025-07-03 MUCPharm Pty Ltd Compositions and methods for treating fungal infections
JP7428842B1 (ja) * 2023-03-29 2024-02-06 ａｒｔｉｅｎｃｅ株式会社 活性エネルギー線硬化型インキ、その製造方法、および印刷物

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0358500A1 (en) * 1988-09-08 1990-03-14 The Public Health Laboratory Service Board Method and composition for the treatment and prevention of viral infections
WO1995023614A1 (en) * 1994-03-01 1995-09-08 E.R. Squibb & Sons, Inc. Enzymatic debridement compositions and methods
US5560910A (en) * 1994-08-26 1996-10-01 Crandall; Wilson T. Topical anti-inflammatory composition and method
US20040151716A1 (en) * 2003-02-03 2004-08-05 Hamer Richard A. Material and method for treating microbial mediated dermatological conditions
US20070275045A1 (en) * 2006-02-28 2007-11-29 Evans Robin D Composition for the treatment of warts and molluscum contagiosum
US20110182874A1 (en) * 2009-11-23 2011-07-28 Prothera, Inc. Compositions and methods comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions
US20110243918A1 (en) * 2009-08-25 2011-10-06 Thornton Joseph P Topical medication for the treatment of hemorrhoids and method of use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361551A (en) * 1979-11-05 1982-11-30 Riker Laboratories, Inc. Method of enzymatic debridement
US5939090A (en) * 1996-12-03 1999-08-17 3M Innovative Properties Company Gel formulations for topical drug delivery
US7241456B2 (en) * 2002-10-25 2007-07-10 Australian Importers Ltd. Formulations for topical delivery of bioactive substances and methods for their use
US20050281806A1 (en) * 2004-06-16 2005-12-22 Collegium Pharmaceutical, Inc., Delaware Compositions for topical enzymatic debridement
KR101757935B1 (ko) * 2008-10-30 2017-07-14 클린웰, 엘엘씨 항균성 발포 비누
US8557237B2 (en) * 2009-01-13 2013-10-15 Mindfulnessfyb, Inc. Crème comprising encapsulated bromelain for the skin, specifically for inhibiting ingrown hair
WO2012049544A1 (en) * 2010-10-15 2012-04-19 Sulur Subramaniam Vanangamudi A medicinal fusidic acid cream made using sodium fusidate and incorporating a biopolymer, a hydrocortisone acetate as a corticosteroid, and clotrimazole as an antifungal agent, and a process to make it
WO2013011514A1 (en) * 2011-07-20 2013-01-24 Mediwound Ltd. Proteolytic extract from bromelain for the treatment of connective tissue disorders

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0358500A1 (en) * 1988-09-08 1990-03-14 The Public Health Laboratory Service Board Method and composition for the treatment and prevention of viral infections
WO1995023614A1 (en) * 1994-03-01 1995-09-08 E.R. Squibb & Sons, Inc. Enzymatic debridement compositions and methods
US5560910A (en) * 1994-08-26 1996-10-01 Crandall; Wilson T. Topical anti-inflammatory composition and method
US20040151716A1 (en) * 2003-02-03 2004-08-05 Hamer Richard A. Material and method for treating microbial mediated dermatological conditions
US20070275045A1 (en) * 2006-02-28 2007-11-29 Evans Robin D Composition for the treatment of warts and molluscum contagiosum
US20110243918A1 (en) * 2009-08-25 2011-10-06 Thornton Joseph P Topical medication for the treatment of hemorrhoids and method of use
US20110182874A1 (en) * 2009-11-23 2011-07-28 Prothera, Inc. Compositions and methods comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NGUYEN UYEN T ET AL: "DNase I and proteinase K impair Listeria monocytogenes biofilm formation and induce dispersal of pre-existing biofilms", INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, ELSEVIER BV, NL, vol. 187, 4 July 2014 (2014-07-04), pages 26 - 32, XP029013073, ISSN: 0168-1605, DOI: 10.1016/J.IJFOODMICRO.2014.06.025 *
PAVAN RAJENDRA ET AL: "Properties and therapeutic application of bromelain: a review.", BIOTECHNOLOGY RESEARCH INTERNATIONAL 2012, vol. 2012, 976203, 2012, pages 1 - 6, XP002753417, ISSN: 2090-3146, DOI: 10.1155/2012/976203 *
SILVA JULIANA ET AL: "Antifungal activity of bromelain in Candida pre-formed biofilms", ANTIMICROBIAL RESEARCH - ICAR2012, LISBON (PORTUGAL) 21-23 NOVEMBER 2012, THE BOOK OF ABSTRACTS: PAGE 272, November 2012 (2012-11-01), pages 272, XP055244889 *

Also Published As

Publication number Publication date
EP3210619A2 (en) 2017-08-30
WO2016063265A2 (pt) 2016-04-28
US20170304411A1 (en) 2017-10-26

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