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WO2015027137A8 - Improved synthesis of capuramycin and its analogues - Google Patents

Improved synthesis of capuramycin and its analogues Download PDF

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Publication number
WO2015027137A8
WO2015027137A8 PCT/US2014/052246 US2014052246W WO2015027137A8 WO 2015027137 A8 WO2015027137 A8 WO 2015027137A8 US 2014052246 W US2014052246 W US 2014052246W WO 2015027137 A8 WO2015027137 A8 WO 2015027137A8
Authority
WO
WIPO (PCT)
Prior art keywords
capuramycin
formula
analogues
useful
improved synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2014/052246
Other languages
French (fr)
Other versions
WO2015027137A1 (en
Inventor
Michio Kurosu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tennessee Research Foundation
Original Assignee
University of Tennessee Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tennessee Research Foundation filed Critical University of Tennessee Research Foundation
Publication of WO2015027137A1 publication Critical patent/WO2015027137A1/en
Publication of WO2015027137A8 publication Critical patent/WO2015027137A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Provided herein are compounds of Formula I, Formula II, and Formula X, which are useful for the treatment of infectious diseases. Also provided herein are processes for preparing 1-[5-0-[4,6-Dideoxy-6-oxo-6-[[[(3S)-hexahydro-2-oxo-1H-azepine]-3-y1]amino]-Pβ-L-erythro-4- hexenopyranosyl]-3-0-methyl 6-deoxy-6-amino-α-L-talofuranuronosyl]-1,2,3,4-tetrahydro-2,4- dioxopyrimidine (capuramycin), analogues thereof, and intermediates useful therefore. Also provided herein are III, IIIa, and IX, which are useful in the process for preparing capuramycin and/or a certain compound of Formula I.
PCT/US2014/052246 2013-08-23 2014-08-22 Improved synthesis of capuramycin and its analogues Ceased WO2015027137A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361869390P 2013-08-23 2013-08-23
US61/869,390 2013-08-23

Publications (2)

Publication Number Publication Date
WO2015027137A1 WO2015027137A1 (en) 2015-02-26
WO2015027137A8 true WO2015027137A8 (en) 2015-12-23

Family

ID=52484186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/052246 Ceased WO2015027137A1 (en) 2013-08-23 2014-08-22 Improved synthesis of capuramycin and its analogues

Country Status (1)

Country Link
WO (1) WO2015027137A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201891620A1 (en) 2016-02-05 2019-02-28 Денали Терапьютикс Инк. INHIBITORS OF PROTEINKINASE 1, INTERACTIVATING WITH RECEPTOR
PL3552017T3 (en) 2016-12-09 2022-08-08 Denali Therapeutics Inc. Compounds useful as ripk1 inhibitors
CN111574444A (en) * 2020-07-07 2020-08-25 安徽贝克生物制药有限公司 Preparation method of bedaquiline
MX2024008648A (en) 2022-01-12 2024-09-23 Denali Therapeutics Inc Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3 -carboxamide.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI245047B (en) * 1999-08-20 2005-12-11 Sankyo Co Novel A-500359 derivatives
JP5022539B2 (en) * 2000-01-07 2012-09-12 セケラ インコーポレイテッド Antibacterial agent containing antibiotic A-500359 and derivative

Also Published As

Publication number Publication date
WO2015027137A1 (en) 2015-02-26

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