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WO2009112954A3 - Processes for the preparation of bosentan and related compounds - Google Patents

Processes for the preparation of bosentan and related compounds Download PDF

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Publication number
WO2009112954A3
WO2009112954A3 PCT/IB2009/005454 IB2009005454W WO2009112954A3 WO 2009112954 A3 WO2009112954 A3 WO 2009112954A3 IB 2009005454 W IB2009005454 W IB 2009005454W WO 2009112954 A3 WO2009112954 A3 WO 2009112954A3
Authority
WO
WIPO (PCT)
Prior art keywords
bosentan
preparation
processes
related compounds
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2009/005454
Other languages
French (fr)
Other versions
WO2009112954A2 (en
Inventor
Girish Dixit
Nandkumar Gaikwad
Hima Prasad Naidu
Nitin Sharadchandra Pradhan
Jon Valgeirsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actavis Group PTC ehf
Original Assignee
Actavis Group PTC ehf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actavis Group PTC ehf filed Critical Actavis Group PTC ehf
Priority to EP09718766A priority Critical patent/EP2268634A2/en
Publication of WO2009112954A2 publication Critical patent/WO2009112954A2/en
Publication of WO2009112954A3 publication Critical patent/WO2009112954A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of substantially pure ethylene glycol sulfonamide compounds such as bosentan.
PCT/IB2009/005454 2008-03-13 2009-03-12 Processes for the preparation of bosentan and related compounds using novel intermediates Ceased WO2009112954A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09718766A EP2268634A2 (en) 2008-03-13 2009-03-12 Processes for the preparation of bosentan and related compounds using novel intermediates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN628/CHE/2008 2008-03-13
IN628CH2008 2008-03-13

Publications (2)

Publication Number Publication Date
WO2009112954A2 WO2009112954A2 (en) 2009-09-17
WO2009112954A3 true WO2009112954A3 (en) 2009-11-05

Family

ID=40933188

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/005454 Ceased WO2009112954A2 (en) 2008-03-13 2009-03-12 Processes for the preparation of bosentan and related compounds using novel intermediates

Country Status (2)

Country Link
EP (1) EP2268634A2 (en)
WO (1) WO2009112954A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008272685B2 (en) 2007-06-29 2013-04-18 Generics [Uk] Limited Process for introduction of hydroxyethoxy side chain in bosentan
AU2008315757A1 (en) 2007-10-24 2009-04-30 Generics [Uk] Limited Novel crystalline forms
US8785461B2 (en) 2008-02-08 2014-07-22 Generics [Uk] Limited Process for preparing bosentan
WO2010015623A1 (en) * 2008-08-05 2010-02-11 Farmaprojects, S. A. Process for the preparation of endothelin receptor antagonists
EP2350028A1 (en) 2008-11-03 2011-08-03 Generics [UK] Limited Hplc method for the analysis of bosentan and related substances and use of these substances as reference standards and markers
WO2010118992A1 (en) 2009-04-13 2010-10-21 Sandoz Ag Process for preparation of endothelial receptor antagonist (bosentan)
US9139537B2 (en) 2010-08-11 2015-09-22 Megafine Pharma(P) Ltd. Process for preparation of bosentan
US20130245259A1 (en) 2012-03-16 2013-09-19 Natco Pharma Limited Process for the preparation of bosentan monohydrate
ES2608004T3 (en) * 2012-12-03 2017-04-05 WÖRWAG PHARMA GmbH & Co. KG Method by phase transfer catalysis

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0743307A1 (en) * 1995-05-16 1996-11-20 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
US6136971A (en) * 1998-07-17 2000-10-24 Roche Colorado Corporation Preparation of sulfonamides
WO2009004374A1 (en) * 2007-06-29 2009-01-08 Generics [Uk] Limited Process for introduction of hydroxyethoxy side chain in bosentan
EP2072503A2 (en) * 2007-12-18 2009-06-24 Dipharma Francis S.r.l. Process for the preparation of bosentan

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0743307A1 (en) * 1995-05-16 1996-11-20 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
US6136971A (en) * 1998-07-17 2000-10-24 Roche Colorado Corporation Preparation of sulfonamides
WO2009004374A1 (en) * 2007-06-29 2009-01-08 Generics [Uk] Limited Process for introduction of hydroxyethoxy side chain in bosentan
EP2072503A2 (en) * 2007-12-18 2009-06-24 Dipharma Francis S.r.l. Process for the preparation of bosentan

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HARRINGTON, PETER J. ET AL: "Research and Development of a Second-Generation Process for Bosentan, an Endothelin Receptor Antagonist", ORGANIC PROCESS RESEARCH & DEVELOPMENT , 6(2), 120-124 CODEN: OPRDFK; ISSN: 1083-6160, 2002, XP002495602 *
HOPFGARTNER, G. ET AL: "Fragmentation of Bosentan (Ro 47-0203) in ion-spray mass spectrometry after collision-induced dissociation at low energy: a case of radical fragmentation of an even-electron ion", JOURNAL OF MASS SPECTROMETRY , 31(1), 69-76 CODEN: JMSPFJ; ISSN: 1076-5174, 1996, XP002483149 *
YANG, NING ET AL: "Synthesis of bosentan as an endothelin receptor antagonist", ZHONGGUO YAOWU HUAXUE ZAZHI , 15(4), 230-233 CODEN: ZYHZEF; ISSN: 1005-0108, 2005, XP008096375 *

Also Published As

Publication number Publication date
EP2268634A2 (en) 2011-01-05
WO2009112954A2 (en) 2009-09-17

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