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WO2014168433A2 - Composition pour favoriser la croissance des cheveux, la régénération de la mélanine des cheveux gris et la régénération de la peau - Google Patents

Composition pour favoriser la croissance des cheveux, la régénération de la mélanine des cheveux gris et la régénération de la peau Download PDF

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Publication number
WO2014168433A2
WO2014168433A2 PCT/KR2014/003119 KR2014003119W WO2014168433A2 WO 2014168433 A2 WO2014168433 A2 WO 2014168433A2 KR 2014003119 W KR2014003119 W KR 2014003119W WO 2014168433 A2 WO2014168433 A2 WO 2014168433A2
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Prior art keywords
skin
extract
composition
hair
silt
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English (en)
Korean (ko)
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WO2014168433A3 (fr
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권성범
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

Definitions

  • the present invention relates to a substance composition, and more particularly, containing a natural mineral that is beneficial to the human body, and is used in the treatment of skin care and skin diseases, and the silt and / or silt extract and silt and / or silt extract , By mixing the extract and / or the fermentation broth with mixtures and / or mixtures of substances which have enhanced hair regrowth and gray hair melanin pigment regeneration and promoting skin regeneration, and the treatment and / or care and improvement of the skin, mucous membranes, hair, prevention and treatment of diseases and And / or to compositions in care and improvement.
  • White hair melanin pigment regeneration is normalized melanin pigment of hair itself, not dyeing or coating is turned into black hair.
  • the skin consists of two layers, the dermis layer and the epidermal layer.
  • the major cell population of the epidermis is composed of keratinocytes, which form a constantly regenerating stratum corneum. Its function is to protect the skin from foreign substances, whether physical or chemical.
  • the dermis is located more internally and is attached to the epidermis through the basement membrane. In the dermis, as well as hair follicles, sweat glands, sebaceous glands, apocrine glands are located, its function is to maintain the integrity and elasticity of the skin.
  • Proteins of the extracellular matrix are classified into two classes, glycosaminoglycans and fibrous proteins.
  • the elasticity and recovery properties of the extracellular matrix are due to the elastic fiber network.
  • Elastic fibers are important for maintaining the elasticity of the skin and are also important for other tissues and organs such as the lungs or large blood vessel walls. Elastic fibers have the purpose of maintaining elasticity throughout a person's life.
  • Adult dermis is formed by collagen.
  • Collagen fibers aid in the elasticity and tension of the skin and / or mucous membranes.
  • the atrophy of the dermis is not only natural aging, but also external factors such as ultraviolet radiation, tobacco, or certain treatments such as retinoic acid and derivatives, glucorotinoids or vitamin D and derivatives, and the skin, mucous membranes and / or scalp, and collagen You will notice that it affects the amount of. Due to the breakdown of collagen fibers, drooping and wrinkled skin in areas of skin exposed to sunlight, such as the face, ears, neck, scalp, arms and hands, which people always try to remove because they prefer skin that looks smooth and taut. Results in.
  • UVB rays with more intense wavelengths affect epidermal cells (keratinocytes) that act on DNA, and UVA rays have more permeability and also act on dermal cells such as fibroblasts and generate free radicals. It works indirectly.
  • the main changes associated with the dermis are a decrease in the amount of collagen and the thickness of the dermis.
  • this results in atrophy of the skin and / or mucous membranes.
  • the woman has a feeling of "dry skin” or a pulling of the skin, an increase in the amount of surface wrinkles and fine lines are observed.
  • the skin looks rough.
  • the skin is less supple. Women lose 2.1% of their collagen levels each year after menopause and 30% of their first five years after menopause.
  • Proteolytic enzymes play an important role in various skin, mucosal and / or scalp diseases and disorders in which the degradation and destruction of collagen and / or elastin is achieved.
  • Another skin and / or scalp disease or condition is acne.
  • substances which suitably increase collagen and / or elastin synthesis may be used by the synthesis of new pathways against the adverse effects of collagen and / or elastin degradation induced by proteolytic enzymes.
  • the decrease in protein synthesis of new pathways that accompanies with age may be at least partially compensated for by using active ingredients that increase collagen and / or elastin synthesis.
  • the terms “aging” and “aging skin”, as well as changes in the appearance of the skin visible to the naked eye for example, wrinkles, fine lines, roughness, impression lines, scratch marks in a non-limiting sense , Cracking, deep wrinkles, sagging, skin off (ball off, etc.), wrinkles under the eyes, double chin, increased pore size, loss of elasticity, loss of recovery, loss of skin hardness, elastic fibrosis, abnormal differentiation, hyperkeratosis, keratosis, skin color Change, hyperpigmentation site creation, loss of smoothness, orange-shell skin, loss of collagen structure, and other tissue changes in the stratum corneum, dermis, vascular system, or tissue adjacent to the skin.
  • Skin aging is a process that consists of two main factors: the chronological factor over time and the light-induced factor due to exposure to ultraviolet light.
  • some environmental factors such as exposure to tobacco smoke, exposure to pollution, and climatic conditions such as cold and / or wind also contribute to skin aging.
  • human hair is about 100,000-150,000 pieces, each hair has a different growth cycle.
  • the hair growth cycle consists of three stages: the anagen stage in which hair is most actively growing, the catagen stage in which hair degeneration begins, and the telogen stage in which hair growth stops or enters rest. Classified as This cycle is repeated over three to six years, resulting in an average of 50-200 hairs per day.
  • alopecia refers to the increase in the number of hairs that fall abnormally due to shortening of the hair growth rate in the growth phase and more hair in the degenerative or resting phase.
  • minoxidil minoxidil
  • pinastride Flinasteride
  • tricossaccharide which is mainly composed of female hormones for promoting blood circulation, enhancing hair root function, scalp moisturizing and male hormone inhibition in the treatment or prevention of such alopecia.
  • Formulations containing (trichosaccharide) have been developed.
  • the mechanism of action of minoxidil on the hair growth effect is not clear, but it is thought to induce hair growth due to the increase of nutrient supply through vasodilation and potassium channel opening effect.
  • Pinastide is a 5- ⁇ reductase. As an inhibitor, it is used as an agent for the treatment of prostate and hair loss by varying the dosage.
  • Finastide is an excellent drug in terms of convenience and efficacy, but the reagents used to prepare it are expensive or highly toxic, causing problems in manufacturing costs or polluting the environment. In particular, the purity of the target product may be reduced because it is not easy to remove by-products. In addition, there is a problem that mass production is difficult by using a reagent or an active derivative that activity is easily inhibited by water.
  • keratinocytes are the major component of about 95% of epidermal cells and originate in ectoderm. Because these cells function not only to produce the epidermal stratum corneum, but also to produce complex fibmental proteins called keratins, which form the structural proteins of hair and armor, to promote hair growth through keratinocyte proliferation. Many attempts have been made. In addition, research on skin regeneration through the growth of keratinocytes has been made.
  • Republic of Korea Patent No. 22442 is a homogeneous follicle hormone 0.0033-1.0 mg, corticosteroids 0.018-2.7 5mg and vitamin B2 0.085-25.5 mg as a main component and uniformly dissolved in 100 ml of purified water, and also vesicle hormone / corticosteroids
  • the hair regrowth composition which kept the weight ratio of in the range of 0.01-4.0 is disclosed.
  • Korean Patent No. 157667 discloses a hair regrowth and hair growth agent characterized in that it contains at least one extract of plant extracts of the genus Shrimp orchid, rock orchid, or other imitation caliber of an orchid family as an active ingredient.
  • Korean Patent No. 157667 discloses a hair regrowth and hair growth agent characterized in that it contains at least one extract of plant extracts of the genus Shrimp orchid, rock orchid, or other imitation caliber of an orchid family as an active ingredient.
  • Korean Patent No. 300816 discloses a hair growth agent or a wool agent containing N-acylamino acid ester having an acyl group having 13,15 and 17 carbon atoms as an active ingredient.
  • melanocytes melanocytes
  • melanocytes melanocytes making melanin pigment
  • the thickness of the skin and the human body such as carotenoids or bilirubin Factors
  • the most important factor is a black pigment called melanin produced by the action of various enzymes such as tyrosinase in melanocytes in the human body.
  • the formation of the melanin pigment is influenced by physiological factors such as contaminated environment and genetic factors, excessive or insufficient hormone secretion and increased stress caused by social environment, and environmental factors such as ultraviolet irradiation.
  • Melanin pigment produced by the melanocytes of the skin of the body is a phenolic polymer material having a complex form of a black pigment and protein, it is generated in the skin at the same time to protect the skin organs below the dermis by blocking ultraviolet radiation from the sun It plays a useful role in protecting proteins and genes in the skin, such as by holding free radicals.
  • the melanin produced by the internal and external stress stimulus is a stable substance that does not disappear until it is released to the outside through skin keratinization even when the stress disappears. However, when more melanin is produced than necessary, it causes hyperpigmentation such as blemishes, freckles, and spots, which may cause cosmetically bad results.
  • the color of the hair appears melanin cells in the hair root steadily supplying pigment to the hair. As you grow older, your baldness increases because aging degrades melanocytes. Although gray hairs appear during normal aging processes are influenced by congenital factors, however, young birds appearing at a young age are often caused by acquired factors such as environmental pollution and stress.
  • dyeing is a method that can be easily selected, the chemical components contained in the dye are often adversely affected on the hair and scalp.
  • Most dyes contain ammonia for effective color development, which has a low molecular weight that easily penetrates the scalp and causes skin problems. It is also a problem because of its high volatility, which causes irritation to the eyes. Toxic hazardous chemicals can potentially be fatal to your health.
  • Salting method (salt pickling) has been applied by both animal and vegetable foods as one of the traditional food storage method.
  • the salting method is used to make kimchi, soybean paste and salted fish as a way to prevent corruption and contamination by adding salt to foods and to help normal fermentation.
  • the present invention is to solve the conventional problems as described above, the purpose of which is mixed with products such as dyes, shampoos, soaps, BB creams soaked deep into the skin with excellent adsorptivity, which is deposited deep in the pores.
  • the present invention provides a substance composition capable of promoting regrowth and gray hair melanin pigmentation and skin regeneration by removing waste products, cosmetic residues and dead cells, excessive sebum secretion, acne, blemishes, and the like.
  • the present invention promotes skin regeneration by stimulating the blood circulation to provide oxygen to the blood vessel cells, remove the caustic wrinkles due to the strong pore contraction effect due to the strengthening of collagen, supplying nutrients to the skin membrane It provides a substance composition that promotes hair regrowth and gray hair melanin pigment regeneration and skin regeneration by strengthening the metabolism of the skin, preventing skin roughness, relieving wounds, and infiltrating various nutrients into the skin. It is.
  • Cosmetic or dermatological compositions i.e. a number of compounds that have the potential to promote endogenous synthesis of collagen or elastin in the skin, mucous membranes and / or scalp, or have activity against enzymes that degrade collagen or elastin and / or Or despite the presence of extracts, it is to provide new compounds and / or extracts that are more effective and selective than those known in the art.
  • the method provides a method characterized in that it is carried out in the solid or solution phase and gas phase have.
  • each one of the substances, mixtures and / or mixtures thereof and cosmetically or pharmaceutically acceptable compositions in cosmetic or pharmaceutically effective amounts, wherein each substance is cosmetically or pharmaceutically acceptable It is to provide a cosmetic or pharmaceutical composition comprising a possible excipient or adjuvant, an enzyme fermented for 6 months or more.
  • the present invention is a cosmetic comprising a single extract, in solution or dispersion, in a cosmetic or dermatologically acceptable carrier that can be applied locally to the skin or Dermatological compositions and / or pharmaceutical compositions.
  • the present invention provides for the maintenance of the structure of the skin, in particular by limiting the degradation of the extracellular matrix of the upper layer of the epithelium and dermis, and / or the aging effect of the skin, in particular the wrinkles.
  • a cosmetic or dermatological agent and / or as an anti-inflammatory agent to reduce or delay the formation of, and / or to obtain a protective, corrective or regenerative effect on the skin, cosmetic or dermatological compositions and / or pharmaceuticals It relates to the use of the composition.
  • the invention care for the skin comprising applying a composition of the cosmetic or dermatological composition and / or pharmaceutical composition of the first aspect of the invention to at least a portion of the body or skin
  • the present invention relates to a method for obtaining an effect of preventing or delaying the onset of skin aging phenomenon.
  • the present invention provides a solution to the above problems.
  • the inventors have found that they have very high efficiency in the skin, mucous membranes and / or scalp and are effective in treating, preventing and / or managing diseases, disorders and / or diseases of the skin, mucous membranes and / or scalp.
  • Compositions in the regrowth and bald melanin pigment regeneration and the treatment and / or management and improvement of the skin, mucous membranes, hair, prevention and treatment and / or management and disease of the present invention for achieving the above object is , 0.001 to 99.99% by weight of purified water, 0.001 to 99.99% by weight of Sisyl and / or Sisyl extract, 0.001 to 99.99% by weight of silt and / or silt extract, 0.001 to 99.99% by weight of extract and / or fermentation broth Or a mixed liquid.
  • the substance composition 1) purified water, 2) seasil and / or seasil extract, 3) silt and / or silt extract, 4) mixing the extract and / or fermentation broth into a mixture and / or mixed solution
  • Substances in hair regrowth and bald melanin pigment regeneration and treatment and / or care and improvement of skin, mucous membranes, hair, prevention and treatment and / or management and improvement of diseases characterized by containing at least two substances selected from the group consisting of Composition.
  • the care method using a cosmetic and / or dermatological composition and / or pharmaceutical composition comprising an extract can reduce or delay the effect of skin aging and also skin inflammation
  • representative components include far-infrared radiation of SiO2 (silicon dioxide), removal effect of waste and sebum in the skin, and budding of Al (aluminum) Metabolism promoting effect, fe (iron) calms the mind, calms the liver, and heals the swelling Efficacy in detoxification, promoting the excretion of waste products from Mg (magnesium) components, collagen binding effect, p (phosphorus) DNA and RNA components, regulating the acidity and alkalinity of body fluids, helping metabolism of
  • K potassium
  • nerve function to form tissues of body (ca)
  • Ca tissues of body
  • Na sodium
  • osmotic pressure control the balance of the balance between the body and the electrolyte, the effect of further promoting hair growth and skin regeneration.
  • Sisilt and / or Sisilt extract in Russia began the research from the 15th century, and has been used in hospitals and rehabilitation treatment centers, nursing homes, etc. as a therapeutic agent since about 1892.
  • Skin disease-skin sclerosis chronic eczema, dermatitis, dry ringworm, scaled ringworm, young, hair loss cause, dandruff, ringworm, scabies, swelling, acne, symptoms after burns, frostbite, skin infections, wounds Skin changes, bruises, bruises, abrasions, collagen deficiency
  • the present invention is a representative of the extract and / or fermentation broth extract is a seaweed extract, grape fermentation, gardenia extract and the form of extraction can be obtained using a juice or hot water extraction, cold needle extraction method.
  • it can be extracted in various ways by using foods registered in the Food Code such as bell pepper, pepper, spinach, bruccoli, carrot, safflower, bamboo leaf, and the extract can be extracted from natural plants, stems of trees, fruits or vegetables, It can be used in various ways such as leaves and fruits.
  • the fermentation broth has the advantage that it can use the active ingredient as it has a plant because it does not apply heat.
  • the seaweed extract has a lot of ingredients beneficial to the human body such as sodium and other various minerals, such as sodium contains 1000 to 1000mg of sodium per 100g of raw seaweed.
  • This seaweed extract has the effect of replenishing minerals. It can complement hair growth prevention functions such as hair damage prevention, scalp irritation prevention, and new hair follicle activation.
  • Grape and grape seed of grape fermentation broth contains polyphenols, resveratrol, linoleic acid, tocopherol, catechins, sterols and the like. Dual polyphenols are potent antioxidants that inhibit the production of melanin pigment, help skin regeneration and prevent skin aging. In addition, it prevents the formation of blemishes, freckles, and whitening effects, and quickly removes scars without scarring. In addition, the terrapine ingredient sucks up the waste products of the skin and leaves moisture intact, which is effective in preventing skin regeneration and wrinkles.
  • Chloride of the gardenia extract is the balance of minerals (alkali and acid) in the human body to activate the metabolism of the cell, Magnesium promotes cell metabolism and activates the enzyme, Sodium is in the body It maintains proper moisture, strengthens muscle activity and releases cellular wastes, Calcium strengthens cell membranes and bones, and is involved in heart muscle and nerves, and Potassium releases wastes through the body by retaining moisture. It is related to metabolism, essential properties for muscle contraction and nervous system, and Bromide is known to have a healing effect and strengthen resistance to various skin diseases.
  • skin is understood to be a layer comprising the outermost or stratum corneum to the lowest or subcutaneous tissue (including both layers). These layers are composed of different types of cells, in particular keratinocytes, fibroblasts, melanocytes and / or adipocytes.
  • the term “skin” includes the scalp.
  • care of skin, mucous membranes and / or hair includes the prevention of disorders and / or diseases of the skin, mucous membranes and / or hair.
  • the term "aging" refers to environmental factors such as photoaging or tobacco smoke, very cold or windy weather, chemical contaminants or pollution by aging or exposure to the sun with age.
  • changes that the skin experiences, and all but visible, external and / or salient through the touch such as, but not limited to, the occurrence of discontinuities on the skin, such as wrinkles, fine lines, cracks, bumps or Roughness, increased pore size, loss of elasticity, loss of firmness, loss of resilience, loss of ability to recover from deformation, sagging of the skin, for example, sagging cheeks, the appearance of sagging flesh under the eyes or the appearance of a double jaw , Changes in skin color, eg the appearance of marks, redness, sagging flesh or hyperpigmented sites, for example blotch or freckles, abnormal differentiation, hyperkeratosis Irritation, elastic fibrosis, keratosis, hair loss, orange peel skin, especially loss of collagen structuring to the stratum
  • photoaging refers to premature aging of the skin due to prolonged exposure of the skin to ultraviolet radiation and staining of lethargy, sagging, color change or pigmentation, without the same physical properties as aging, for example and not exclusively. Form a group of sets of processes that provide abnormal and / or excessive keratinization.
  • photoprotection is understood to be the ability of the composition and extract and / or fermentation to prevent or delay the appearance of photoaging symptoms when the compound or formulation is applied prior to exposure to UV radiation. do.
  • the present invention provides a composition for preventing hair loss or promoting hair growth comprising the composition and the extract and / or fermentation broth as an active ingredient.
  • extract as used herein has the meaning commonly used as crude extract in the art as described above, but broadly also includes the solvent fraction described above.
  • Fermentation process of the present invention is between 4 to 40 °C, so that enough fermentation can occur 30 days to 1 year, preferably 6 months to 1 year. If it is less than 4 °C, growth of useful microorganisms is not well, and if it exceeds 40 °C, the growth of the microorganisms may be excessive, which may affect the performance of the herbal medicine.
  • compositions and extracts and / or fermentation broths of the present invention include not only those obtained by using the above-described solvent, but also those obtained by further applying a purification process thereto.
  • a purification process for example, fractions obtained by passing the extract through an ultrafiltration membrane having a constant molecular weight cut-off value, separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity), etc. Fractions obtained through the purification method are also included in the composition, extract and / or fermentation broth of the present invention.
  • the extraction solvent used in the step purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol, propylene glycol, dichloromethane and hexane selected from the group consisting of hexane alone or two or more mixed Can be used.
  • the extraction temperature is preferably 10 to 80 °C, it can be extracted for 6 hours to 24 hours. If the extraction temperature and extraction time is out of the extraction efficiency may decrease or change of components may occur.
  • composition and the extract of the present invention and / or the fermentation broth are liquids obtained by cooling, heating and filtration at room temperature in a conventional manner known in the art or additionally the solvent is distilled under reduced pressure, spray drying or lyophilized to extract and / or Or fermentation broth can be prepared.
  • composition of the present invention is very effective in preventing hair loss or promoting hair growth.
  • anti-hair loss or "promoting hair growth” is used in the same sense, which has the same meaning as another term wool or hair growth promotion used in the art.
  • Extract and / or fermentation broth according to the present invention is not particularly limited to use, for example, it can be used for additives, health care compositions and pharmaceutical compositions of health food.
  • it may be used as a cosmetic composition for whitening
  • the content of the extract and / or fermentation broth may be mixed 0.001 ⁇ 99.99% by weight based on the total weight of the composition.
  • Extraction may be prepared by various extraction methods known to those of ordinary skill in the art.
  • this plant portion Prior to contacting at least a portion of the plant with at least one polar solvent, this plant portion may optionally be dried and / or ground.
  • the plant material Prior to the extraction step itself, the plant material may be dried and / or ground.
  • the plant material is in a dry and ground state.
  • the product of this extraction step may be lyophilized or atomized to allow processing in the form of a powder.
  • Cosmetic or dermatological and / or pharmaceutical compositions according to the present invention comprise an effective amount of an extract of the present invention to obtain the desired effect.
  • the extract used is preferably an aqueous extract.
  • the extract and / or fermentation broth according to the present invention comprises 0.001 ⁇ 99.99% by weight of the extract and / or the dry weight of the fermentation broth.
  • the present invention also relates to a case where the composition also comprises black pearls, in cases where there is a great deal of significant cosmetic and / or dermatological and / or pharmaceutical properties associated with the composition and extract and / or fermentation broth. It is greatly improved.
  • the plant material from which the extract of the present invention is prepared may comprise one or more extracts of other plants in the form of extracts of all or part of the plant.
  • These plants can be plants from other families known to have similar or supplemental properties to those demonstrated for seaweed, grapes, and gardenia.
  • Plants known to retard or prevent the effect of skin aging or the action of wrinkles by various mechanisms, such as the extract maintaining the complete structure of the skin, can be chosen in particular.
  • composition may be prepared into a composition further comprising an enzyme fermented for 6 months or more.
  • the pharmaceutical composition of the present invention may further include a lubricant, a humectant, a sweetener, a flavoring agent, an emulsifier, a suspending agent, a preservative, and the like.
  • a lubricant e.g., a talc, a kaolin, a kaolin, a kaolin, a kaolin, a kaolin, a kaolin, kaolin, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, a sorbitol, a sorbitol, a talcrate, a glycerol, a sorbitol, mannitol, mannitol, mannitol
  • One form of the present invention relates to compositions and extracts and / or fermentation broths as described herein for the treatment and / or care of skin, mucous membranes and / or hair.
  • the abnormalities, disorders and / or diseases which are ameliorated or prevented by the composition and the extract and / or fermentation broth include bullous epidermal detachment and alopecia (alopecia caused by chemotherapy treatment for cancer. ) Is selected from the group consisting of.
  • the present invention provides for the reduction, delay, reduction of cellular damage induced by UV radiation, thermal stress, oxidative stress, osmotic shock, inflammation, hypoxia, exposure to contaminants, poor nutrition and lack of hydration, And / or compositions and extracts and / or fermentation broths as described herein for the treatment and / or care of skin, mucous membranes and / or hair to prevent.
  • the invention provides compositions and extracts as described herein for the treatment and / or care of skin, mucous membranes and / or hair that reduce and / or prevent signs of aging and / or photoaging and And / or fermentation broth.
  • the present invention relates to a composition, an extract and / or a fermentation broth as described herein for the treatment and / or care of skin and / or mucous membranes that stimulate wound healing and / or re-epithelialization. will be.
  • the present invention provides a composition and extract as described herein for the treatment and / or care of skin and / or hair that delays and / or prevents hair loss or induces hair growth. Or a fermentation broth.
  • the pharmaceutical composition of the present invention includes a pharmaceutically acceptable carrier.
  • Pharmaceutically acceptable carriers included in the pharmaceutical compositions of the present invention are those commonly used in the preparation, such as lactose, dextrose, sucrose, sorbitol, mannitol, starch, acacia rubber, calcium phosphate, alginate, gelatin, Calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, methyl cellulose, methyl hydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil, and the like It doesn't happen.
  • compositions and extracts and / or fermentations of the invention may also be adsorbed onto talc, bentonite, silica, starch or maltodextrin, in particular, but not limited to, solid organic polymers or solid mineral supports.
  • compositions of the present invention and compositions containing extracts and / or fermentations are also incorporated into fabrics, nonwoven fabrics, and medical devices that are in direct and indirect contact with the skin, and thus binding systems for fabrics, nonwoven fabrics, or medical devices. Biodegradation, or friction between them and the body, due to body moisture, pH or body temperature of the skin, by any of these can release the composition containing the composition of the present invention and the extract and / or fermentation broth. Will be. Moreover, fabrics and nonwovens can be used to make garments that are in direct contact with the body.
  • the fabrics, nonwoven fabrics and medical devices containing the compositions of the present invention are for the treatment and / or management of disorders and / or diseases, which are ameliorated or prevented by the compositions and extracts and / or fermentations. Used.
  • fabrics, nonwoven fabrics, garments, medical devices and compositions, and means for immobilizing extracts and / or fermentation broths are found in the literature. And known in the art.
  • Preferred fabrics, nonwoven fabrics, garments and medical devices are bandages, gauze, t-shirts, socks, tights, underwear, girdle, gloves, outerwear, diapers, sanitary napkins, dressings, bedspreads, wipes, adhesive patches, non-adhesive Patches, occlusive patches, micro electrical patches and / or face masks.
  • Cosmetic or pharmaceutical compositions containing the compositions of the present invention and extracts and / or fermentation broths may be of different types of topical, optionally comprising cosmetically or pharmaceutically acceptable excipients necessary to formulate the desired dosage form. Or in transdermal application compositions.
  • Topical or transdermal application compositions can be prepared in any solid, liquid or semisolid, gaseous formulation, including but not limited to creams, multiple emulsions (eg, but not limited to oil in water and / or Or water-in-silicone emulsions, water-in-oil and / or water-in-silicone emulsions, water / oil / water or water / silicone / water type emulsions, and oil / water / oil or silicone / water / silicone type emulsions), anhydrous compositions, aqueous dispersions, Oils, milk, balms, foams, lotions, gels, cream gels, hydrous alcohols, hydroglycol solutions, hydrogels, stains, ceras, soaps, shampoos, conditioners, serums, polysaccharide films, ointments, mousses, pomades, powders, bars , Pencils and sprays or aerosols (sprays), smog devices
  • Topical or transdermal application formulations use, but are not limited to, different types of solid accessories, such as, but not limited to, bandages, gauze, t-shirts, socks, tights, underwear, girdle, gloves, outerwear, diapers, sanitary napkins. , Dressings, bedspreads, wipes, adhesive patches, non-adhesive patches, occlusive patches, microelectric patches or face masks, or they may be incorporated into different makeup products, such as in particular makeup foundations (eg, fluid foundations and Compact foundation), makeup removal lotion, makeup removal milk, under eye concealer, eyeshadow, lipstick, lip protector, lip gloss and powder.
  • makeup foundations eg, fluid foundations and Compact foundation
  • the pharmaceutical composition of the present invention may be administered orally or non-orally, preferably applied by topical administration by non-oral administration, more preferably by application.
  • Cosmetic and pharmaceutical compositions of the present invention may include the composition of the present invention and agents that increase the transdermal absorption of extracts and / or fermentation broths, including but not limited to, for example, dimethyl sulfoxide Side, dimethylacetamide, dimethylformamide, surfactant, azone (1-dodecylazacycloheptan-2-one), alcohol, urea, ethoxydiglycol, acetone, propylene glycol or polyethylene glycol.
  • agents that increase the transdermal absorption of extracts and / or fermentation broths including but not limited to, for example, dimethyl sulfoxide Side, dimethylacetamide, dimethylformamide, surfactant, azone (1-dodecylazacycloheptan-2-one), alcohol, urea, ethoxydiglycol, acetone, propylene glycol or polyethylene glycol.
  • compositions of the present invention may be subjected to iontophoresis, ultrasonography, electroporation, microelectro patch, mechanical pressure, osmotic pressure gradient to achieve greater penetration of the compositions of the present invention and extracts and / or fermentations.
  • Cosmetic or pharmaceutical compositions containing the compositions and extracts and / or fermentation broths of the present invention may also be administered by the topical or transdermal route as well as by any other suitable route, for example as oral or non-oral route.
  • suitable route for example as oral or non-oral route.
  • they will include the pharmaceutically acceptable excipients required for the formulation of the desired dosage form.
  • oral refers to nasal, auricular, ophthalmic, rectal, urethral, intravaginal, subcutaneous, intradermal, intravascular injections (eg, intravenous, intramuscular, Intraocular, intravitreous, intracorneal, intramedullary, intramedullary, intracranial, intracervical, cerebral, intramedullary, intraarticular, intrahepatic, intrathoracic, intratracheal, transcutaneous Intrathecal and intraperitoneal injection), and any other similar injection or infusion technique.
  • intravascular injections eg, intravenous, intramuscular, Intraocular, intravitreous, intracorneal, intramedullary, intramedullary, intracranial, intracervical, cerebral, intramedullary, intraarticular, intrahepatic, intrathoracic, intratracheal, transcutaneous Intrathecal and intraperitoneal injection
  • Suitable dosages of the pharmaceutical compositions of the present invention may be determined by factors such as formulation method, mode of administration, age, weight, sex, morbidity, food, time of administration, route of administration, rate of excretion and response to response of the patient. It can be prescribed in various ways.
  • the compositions and extracts and / or fermentation broths which are the bioactive substances included in the pharmaceutical compositions of the present invention are non-toxic, but in an amount sufficient to provide the desired effect and / or the fermentation broth or compositions and extracts and / or Or the amount of fermentation broth.
  • Compositions and extracts and / or fermentations of the present invention are used in the cosmetic or pharmaceutical compositions of the present invention at a cosmetically or pharmaceutically effective concentration to achieve the desired effect.
  • the pharmaceutical composition of the present invention may be formulated using a pharmaceutically acceptable carrier and / or excipient according to a method which can be easily carried out by one of ordinary skill in the art. It may be prepared in the form or prepared by incorporation into a multi-dose container.
  • the formulation may be in the form of solutions, suspensions, syrups or emulsions in oils or aqueous media, or in the form of extracts, powders, powders, granules, tablets or capsules, and may further comprise dispersants or stabilizers.
  • the compositions and extracts and / or fermentation broths of the present invention may be incorporated into any form of functional food or fortified food, such as, but not limited to, dietary bars or compressed or uncompressed powders.
  • compositions and extracts and / or fermentation broths of the invention may be formulated with conventional excipients and auxiliaries for oral compositions or food supplements, such excipients and auxiliaries being, for example, but not limited to, those conventional in the food industry.
  • Phosphorus fat component, aqueous component, humectant, preservative, tissue sensitizer, flavoring agent, aroma, antioxidant and coloring agent are conventional excipients and auxiliaries.
  • the composition of the present invention when the composition of the present invention is made of a cosmetic composition, the composition of the present invention includes not only the composition and extract and / or fermentation liquid, but also components commonly used in cosmetic compositions, such as antioxidants, stabilizers, etc. , Conventional adjuvants such as solubilizers, vitamins, pigments and flavorings, and carriers.
  • composition of the present invention in addition to the above-described composition and extract and / or fermentation broth, the wool or hair-forming agent that has been conventionally used so long as it does not impair its action (hair growth action by the composition and extract and / or fermentation broth). Can be mixed together.
  • purified water purified water, monohydric alcohols (ethanol or propyl alcohol), polyhydric alcohols (glycerol, 1,3-butylene glycol or propylene glycol), higher fatty acids (palmitylic acid or linolenic acid), fats and oils (wheat) Embryo oil, camellia oil, jojoba oil, olive oil, squalene, sunflower oil, macadamia peanut oil, avocado oil, soybean hydrous lecithin or fatty acid glycerides), and the like.
  • monohydric alcohols ethanol or propyl alcohol
  • polyhydric alcohols glycerol, 1,3-butylene glycol or propylene glycol
  • higher fatty acids palmitylic acid or linolenic acid
  • fats and oils wheat
  • Embryo oil camellia oil
  • jojoba oil olive oil
  • squalene sunflower oil
  • macadamia peanut oil avocado oil, soybean hydrous lecithin or
  • Surfactants include polyoxyethylene, hardened castor oil, polyoxyethylene, oleyl ether, monooleic acid polyoxyethylene, polyoxyethylene, glyceryl monostearate, sorbitan monostearate, polyoxyethylene monooleate, It may be optionally included in the group consisting of grief, sucrose fatty acid ester, hexaglycerin monolauric acid, polyoxyethylene reduced lanolin, POE, glyceryl pyroglutamic acid, isostearic acid, diester, N-acetylglutamine and isostearyl ester have.
  • the fungicides are optionally included in the group consisting of hydroxy thiol, trichromic acid, chlorohexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid and zinc pyrithaone. can do.
  • Antioxidants can be used in any of butylhydroxyanisole, molten acid, molten acid propyl and erythorbic acid.
  • UV absorbers include benzophenones such as dihydroxy benzophenone, melanin, ethyl paraaminobenzoic acid, paradimethylaminobenzoic acid 2-ethylhexyl ester, synoxite, paramethoxy cinnamic acid 2-ethylhexyl ester, 2- ( 2-hydroxy-5-methylphenyl) benzotriazole, urokanoic acid and metal oxide particulates such as, but not limited to, in particular anthranilate, cinnamate, salicylate, derivatives of dibenzoylmethane, derivatives of camphor, Derivatives of triazine, derivatives of benzophenone, derivatives of ⁇ , ⁇ '-diphenylacrylate, derivatives of benzotriazole, derivatives of benzyl malonate, derivatives of benzimidazole, imidazolines, derivatives of benzoallyl, p Derivatives of aminobenzoic acids, polymers and
  • di-potassium glytilinate or allantoin may be used, and as the refreshing agent, red pepper tink or 1-menthol may be used.
  • the formulation of the composition may be any formulation that can combine the composition with the extract and / or fermentation as an active ingredient, and in the form of cosmetics for preventing hair loss or hair growth, hair tonic, hair cream, hair lotion, hair shampoo, hair Rinsing, hair conditioner, hairspray, hair aerosol, pomade, powder, gel, etc. may be prepared in various forms such as solution, sol gel, emulsion, oil, wax, aerosol, but is not limited thereto.
  • composition of the present invention is made of a food composition, as an active ingredient, as well as the composition and / or extracts and / or fermentation broth, as well as components commonly added during food production, for example, proteins, carbohydrates Contains fats, nutrients, seasonings and flavorings.
  • carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose, oligosaccharides and the like; And sugars such as conventional sugars such as polysaccharides such as dextrin, cyclodextrin and the like and xylitol, sorbitol, erythritol.
  • flavoring agent natural flavoring agents (tauumatin, stevia extract (for example rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be used.
  • the food composition of the present invention is prepared with a drink
  • citric acid liquid fructose, sugar, glucose, acetic acid, malic acid, fruit juice, tofu extract, jujube extract, licorice Extracts, pine needle extracts and the like may be further included.
  • the hair loss preventing or hair growth composition of the present invention promotes keratinocyte cell proliferation and ultimately plays a very good role in preventing hair loss and promoting hair growth in a living body.
  • Fermentation broth or extract is obtained by fermenting a natural plant or extracted by adding a solvent to the natural plant.
  • the solvent is at least one selected from the group of water, ethanol, methanol, propanol, butanol, glycerin, propylene glycol or butylene glycol.
  • composition may be prepared into a composition further comprising an enzyme fermented for 3 years or more.
  • the washed raw seaweed is dried to dry to about 11-13% of the raw seaweed weight.
  • the dried seaweed is cut into 2 ⁇ 3cm size and mixed with water and put into a heating container and extracted by heating.
  • 200 to 300 parts by weight of water is mixed with respect to 100 parts by weight of dried seaweed, and heated about 110 to 130 degrees for about 5 to 7 hours.
  • the solids are filtered using a strainer or nonwoven to obtain a seaweed extract.
  • Red grapes are washed with water and then drained.
  • Grape and earth sugar are mixed at a weight ratio of 1: 0.2.
  • Fermentation is carried out at 18 to 20 °C for about 3 months.
  • the solids are filtered out and aged for two more months to prepare grape fermentation broth.
  • the substance composition of the present invention is made by mixing Cylsilt and / or Cyltyl extract, silt and / or siltic extract, extract and / or fermentation broth with purified water purified by removing impurities.
  • the purified water may be mixed in an amount of 0.001 to 99.99% by weight based on 100% by weight of the material composition.
  • the Sisilt and / or Sisilt extract may be mixed as a main component of the substance composition, and 0.001 to 99.99 wt% may be mixed with respect to 100 wt% of the substance composition.
  • the sea silt and / or sea silt extract is a natural mineral containing more than 99% of clean seabed natural mud, and ancient volcanic ash combines with numerous nutrients in the sea, and has been aged for tens of millions of years. It is known to have an excellent effect on skin beauty and skin troubles because it contains a large amount of amine, rare earth, and salt.
  • Table 1 ingredient Impact on the human body brimstone Treatment of scabies, eczema, skin diseases, external treatment by anti-customization Steel, silver Nervous system stabilization, relaxes the heart Phosphorus, zinc carbonate, calcium, etc. Dizziness, Headache, Ringing, Deafness, Detoxification, Insecticide, Restoration Sodium, potassium, alumina, silicon, etc. Skin osmotic pressure control, moisture balance, skin sebum waste removal, blood circulation smoothly Oxygen, germanium Decreased skin contraction, helps skin breathing
  • the silt and / or silt extract may be mixed in an amount of 0.001 to 99.99% by weight based on 100% by weight of the material composition.
  • Silt and / or silt extracts are minerals produced by volcanic ash and lava due to volcanic eruptions, which have been deposited in the sea for a long time, and then raised to the land due to crustal changes. Used as ashes.
  • the silt and / or silt extract contains a large amount of SiO 2 (silicon dioxide) component. Therefore, among the main components of the SiSyl and / or SiSylt extract, the content of insufficient SiO 2 (silicon dioxide) is further increased, thereby increasing the elasticity of the SiO 2 (silicon dioxide), that is, increasing skin elasticity and moisturizing by high swelling ratio.
  • the cation exchange method improves nutrient supply, excellent hydrophilicity, pore reduction and acne soothing.
  • the extract and / or fermentation broth may be mixed in an amount of 0.001 to 99.99% by weight based on 100% by weight of the material composition.
  • the seaweed extract for example, the seaweed has many beneficial components such as sodium and various minerals, among which sodium contains 1000 to 1000 mg of sodium per 100 g of plant raw grass. These plant extracts have the effect of replenishing minerals. It can supplement hair growth prevention function such as hair damage prevention, scalp stimulation prevention, and activation of new hair cells.
  • the seaweed extract may be mixed in an amount of 0.001 to 99.99% by weight based on 100% by weight of the material composition.
  • grapes and grape seeds of grape fermentation broth contain polyphenols, resveratrol, linoleic acid, tocopherol, catechins, sterols, and the like.
  • Dual polyphenols are potent antioxidants that inhibit the production of melanin pigment, help skin regeneration and prevent skin aging. In addition, it prevents the formation of blemishes, freckles, and whitening effects, and quickly removes scars without scarring.
  • the terrapine ingredient sucks up the waste products of the skin and leaves moisture intact, which is effective in preventing skin regeneration and wrinkles.
  • the grape fermentation broth may be mixed in an amount of 0.001 to 99.99% by weight based on 100% by weight of the material composition.
  • the extract of Gardenia jasminoides Chloride of Gardenia jasminoides extract balances minerals (alkali and acid) in the human body and activates cell metabolism, and Magnesium promotes cell metabolism and activates enzymes.
  • Sodium maintains proper moisture in the body and strengthens muscle activity while releasing intracellular waste
  • Calcium strengthens cell membranes and bones, and is involved in heart muscle and nerves
  • Potassium pollinates It is known for its metabolism by discharging waste products out of the body through maintenance, essential for muscle contraction and nervous system, and Bromide is known for its healing effects and strengthening resistance to various skin diseases.
  • the gardenia extract may be mixed in an amount of 0.001 to 99.99% by weight based on 100% by weight of the material composition.
  • Such a substance composition is characterized in that natural minerals beneficial to the human body are SiO 2 (silicon dioxide) components, Alo 2 (aluminum), feo 2 (iron), mg (magnesium), p (phosphorus), K (potassium), and Ca (calcium). ),
  • the silt and / or silt extract is mixed with the seed and / or silt extracts containing natural minerals such as Na, sodium, etc., to remove far-infrared radiation of the SiO2 (silicon dioxide) component, waste products and sebum in the skin.
  • Efficacy metabolism promoting effect of Al (aluminum), fe (iron) calms the mind, calms the liver, improves swelling and detoxification, Mg (magnesium) component It promotes waste excretion, collagen binding effect, p (phosphorus) DNA and RNA, and regulates the acidity and alkalinity of body fluids, helps metabolize lipids and sugars, forms various enzymes, makes bones and teeth and keeps them healthy.
  • K (potassium) component Mon secretion promoting nerve function promoting effect
  • Ca (calcium) component in the body tissue formation skeletal strengthening effect
  • Na (sodium) component fluid osmotic pressure control
  • the balance between the in vitro and external electrolytes thereby increasing the hair growth And it is effective to further promote skin regeneration.
  • the material composition of the present invention was prepared by various examples and comparative examples to examine the efficacy.
  • Example 1 it is possible to improve the bald melanin pigment regeneration function and to promote hair growth and scalp regeneration, so that the mixing amount of the substance to the purified water at the optimum composition ratio I knew it was lost.
  • Example 2 although the ratio of the substance to the purified water was slightly increased, it was possible to improve hair growth and scalp regeneration, but the gray hair melanin pigment regeneration was slightly decreased.
  • Example 3 the gray hair melanin pigment regeneration function was maintained as the ratio of the substance to the purified water slightly decreased, but the efficacy of promoting hair growth and scalp regeneration was slightly insufficient.
  • Example 4 it is possible to improve the hair growth and scalp regeneration promotion while maintaining the function of the shampoo liquid, so that the mixing amount of the substance in the purified water to the optimum composition ratio It was found out.
  • Example 5 although the ratio of the substance to the purified water was slightly increased, it was possible to improve hair growth and scalp regeneration, but the original function of the shampoo liquid was slightly decreased.
  • Example 6 as the ratio of the substance to the purified water slightly decreased, the original function of the shampoo liquid was maintained, but the effect of promoting hair growth and scalp regeneration was slightly insufficient.
  • Comparative Example 4 as the ratio of the substance to the purified water was reduced below the set range, the original function of the shampoo liquid was maintained, but the effect of promoting hair growth and scalp regeneration was very weak and difficult to apply.
  • the substance composition may be included in biopharmaceuticals and may be used as medicines, quasi-drugs, functional cosmetics, cosmetics, industrial goods, and the like.
  • It can also be used for the purification of air and water pollution.

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Abstract

L'invention concerne une composition contenant un mélange de vase marine et/ou d'un extrait de vase marine et/ou d'un extrait de vase et d'un extrait et/ou d'une solution de fermentation, contenant un ingrédient de SiO2 (dioxyde de silicium), renfermant uniformément des minéraux naturels utiles pour le corps humain, et des ingrédients minéraux naturels tels que Al (aluminium), Fe (fer), Mg (magnésium), P (phosphore), K (potassium), Ca (calcium), Na (sodium) et similaires en grande quantité. Ladite composition permet la production de produits médicaux, de quasi-médicaments, de produits cosmétiques et similaires pour éliminer les matières résiduaires et les résidus cosmétiques déposés profondément dans les pores, les cellules mortes, l'excès de sébum, les boutons, les imperfections et similaires absorbés profondément dans la peau en raison d'une adsorption remarquables, même lorsque la composition est mélangée à d'autres produits, afin de favoriser la régénération de la peau par apport d'oxygène aux cellules vasculaires par stimulation de la circulation sanguine, éliminer les pseudo-rides avec un fort effet de rétrécissement des pores par renforcement au collagène, favoriser une peau saine par fourniture de nutriments à la membrane dermique, et en outre favoriser la croissance des cheveux, la régénération de la mélanine des cheveux gris et la régénération de la peau par prévention de la rugosification de la peau, favoriser la cicatrisation d'une plaie et favoriser l'absorption de divers nutriments dans la peau par activation du métabolisme de la peau. En outre, la régénération de la mélanine des cheveux gris est réalisée par coloration des cheveux gris en cheveux noirs par normalisation de la mélanine des cheveux plutôt que par teinture ou revêtement. Ladite composition pour stimuler la croissance des cheveux, la régénération de la mélanine des cheveux gris et la régénération de la peau, qui est utilisée pour le traitement et/ou la gestion, l'amélioration et la protection de la peau, des muqueuses et des cheveux, et le traitement, la gestion et le soulagement de maladies, contient au moins deux substances choisies dans le groupe constitué d'un mélange et/ou d'une solution de mélange obtenues par mélange de 0,001 à 99,99 % en poids d'eau purifiée, 0,001 à 99,99 % en poids de vase marine et/ou d'un extrait de vase marine, 0,001 à 99,99 % en poids de vase et/ou d'un extrait de vase, et de 0,001 à 99,99 % en poids d'un extrait et/ou d'une solution de fermentation, et mélange 1) d'eau purifiée, 2) de vase marine et/ou d'un extrait de vase marine, 3) de vase et/ou d'un extrait de vase, et 4) d'un extrait et/ou d'une solution de fermentation.
PCT/KR2014/003119 2013-04-09 2014-04-10 Composition pour favoriser la croissance des cheveux, la régénération de la mélanine des cheveux gris et la régénération de la peau Ceased WO2014168433A2 (fr)

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CN112645733A (zh) * 2021-02-06 2021-04-13 景德镇陶瓷大学 一种含釉的具有梯度孔结构的闭孔泡沫陶瓷及其制备方法
CN112957609A (zh) * 2021-02-04 2021-06-15 义乌柒派生物科技有限公司 一种头皮毛囊激活的再生处理系统
CN117599247A (zh) * 2023-12-14 2024-02-27 浙江来益美生物医药有限公司 丝素蛋白微载体皮肤填充制剂及其制备方法和应用

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KR101138411B1 (ko) * 2009-01-29 2012-04-26 김경자 발효액을 이용한 샴푸 조성물의 제조방법 및 이를 이용한 샴푸 조성물
KR101190333B1 (ko) * 2010-05-27 2012-10-11 김승원 발모 및 피부재생 촉진용 광물질 조성물

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CN111388371A (zh) * 2020-04-03 2020-07-10 广州骐源生物科技有限公司 一种含蚕丝蛋白的防脱固发生发液组合物及其制备方法
CN112957609A (zh) * 2021-02-04 2021-06-15 义乌柒派生物科技有限公司 一种头皮毛囊激活的再生处理系统
CN112645733A (zh) * 2021-02-06 2021-04-13 景德镇陶瓷大学 一种含釉的具有梯度孔结构的闭孔泡沫陶瓷及其制备方法
CN112645733B (zh) * 2021-02-06 2022-08-02 景德镇陶瓷大学 一种含釉的具有梯度孔结构的闭孔泡沫陶瓷及其制备方法
CN117599247A (zh) * 2023-12-14 2024-02-27 浙江来益美生物医药有限公司 丝素蛋白微载体皮肤填充制剂及其制备方法和应用
CN117599247B (zh) * 2023-12-14 2024-05-31 浙江来益美生物医药有限公司 丝素蛋白微载体皮肤填充制剂及其制备方法和应用

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