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WO2014071532A1 - Implant de lentille intraoculaire - Google Patents

Implant de lentille intraoculaire Download PDF

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Publication number
WO2014071532A1
WO2014071532A1 PCT/CH2012/000249 CH2012000249W WO2014071532A1 WO 2014071532 A1 WO2014071532 A1 WO 2014071532A1 CH 2012000249 W CH2012000249 W CH 2012000249W WO 2014071532 A1 WO2014071532 A1 WO 2014071532A1
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WO
WIPO (PCT)
Prior art keywords
lens implant
lens
viewing
spring element
spring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CH2012/000249
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English (en)
Inventor
Eduard Anton Haefliger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to PCT/CH2012/000249 priority Critical patent/WO2014071532A1/fr
Publication of WO2014071532A1 publication Critical patent/WO2014071532A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1629—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing longitudinal position, i.e. along the visual axis when implanted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1648—Multipart lenses

Definitions

  • the invention relates to an intraocular lens implant, a method for manufacturing an intraocular lens implant, and a kit for manufacturing an intraocular lens implant.
  • Replacing the lens of a human eye by means of an intraocular lens implant may be indicated when due to aging processes the natural lens hardens and accommodation may no longer be achievable.
  • lens implants allowing accommodation include a replacement of the natural lens mass of the human eye by means of a synthetic lens mass.
  • the materials to manufacture such lens implant from are difficult to elect in view of the diverging needs of the lens implant being ac- commodatable on the one hand and persistent and long- living on the other hand.
  • the lens implant comprises an anterior portion including an anterior viewing element and an anterior biasing element.
  • the lens further comprises a posterior portion including a posterior viewing element and a posterior biasing element.
  • the anterior portion and the posterior portion and/or the apices are responsive to force the separation between the viewing elements to change.
  • the lens implant is designed for being implanted into a lens capsule of the eye.
  • this lens implant takes a shape in which the viewing elements are at their maximum separation along the optical axis.
  • the viewing elements may be moved towards each other in response to a ciliary muscle relaxation in order to reach a shape corresponding to a state of the lens implant suitable for distant vision, which is also denoted in this document as unaccommodated state.
  • a relaxation of the ciliary muscle makes the zonule fibres become tense and pull the lens capsule radially outwards which invokes a force against the spring element of the lens implant in the lens capsule and compresses the viewing elements.
  • the lens capsule including the lens implant takes a flatter shape.
  • the ciliary muscle contracts such that the zonule fibres relax.
  • the lens implant and in particular its spring element extends from its tense state into its relaxed state such that the viewing elements are moved away from each other.
  • the lens implant takes a spherical shape corresponding to a state for near vision which is also denoted as accommodated state .
  • the lens implant provides next to the two viewing elements two biasing elements dimensioned such that their apices abut the zonule fibres and the ciliary muscle when in the unaccommodated state.
  • the lens implant is configured such that it will remain in the unaccommodated state in the absence of external forces.
  • the relaxed state of the lens implant provides spaced apart viewing elements resulting in a shape representing the accommodated state of the lens implant suited for near vision. This does not reflect the shape of the natural lens mass without its capsule when not being exposed to any external forces: The natural lens mass rather takes a flattened shape representing the unaccommodated state suited for distant vision.
  • the relaxed state of the lens implant seems to be reversed with respect to the first variant and the shape of the lens implant represents an unaccommodated state of the lens suitable for distant vision.
  • the actuation of such lens implant as well as the shape of such lens implant is not considered to be a best fit in terms of adaptability of such lens implant to its environment.
  • One of the reasons is that in the human eye the ciliary muscle typically does not directly drive and engage with the lens .
  • the problem to be solved by the invention is to provide an intraocular lens implant which is adapted to the physiology of the eye, and which is suited for a long term deployment in the lens capsule.
  • an intraocular lens implant eomp-ri-s-i-ng—a ⁇ f- ⁇
  • the lens implant is designed to take a shape suitable for distant vision when the spring element is in its relaxed state.
  • a spacer is arranged between the first and the second viewing element. Such spacer is designed for limiting a distance the first and the second viewing element can minimally take with respect to each other which distance is also denoted as minimum distance. This means that the spacer prevents the spring from any compression beyond the minimum distance between the first and the second viewing element, and as such prevents the first and the second viewing elements being approximated more than the minimum distance.
  • the spring element is designed for allowing an increase of the distance between the first and the second viewing element based on the spring element in its relaxed state, i.e. for being stretched.
  • a spring constant of the spring element is dimensioned such that a force produced by a lens capsule of the eye for holding the lens implant transforms the spring element from its relaxed state into a stretched state.
  • an intraocular lens implant com- prising a first viewing element, a second viewing element, and a spring element for varying a distance between the first and the second viewing element along an optical axis of the lens implant for varying the focal length of the lens implant.
  • the lens implant is designed to take a shape suitable for distant vision when the spring element is in its relaxed state.
  • a spring constant of the spring element has a value of less than 550 mN/mm.
  • a spacer is provided between the first and the second viewing element for limiting a distance the first viewing element and the second viewing element can take with respect to each other— o—a—minimm—dd-s a-nce ⁇
  • the lens implant is designed to take a shape suitable for near vision when the spring element is in a stretched state such that the distance between the first and the second viewing element in the stretched state of the spring element exceeds the distance between the first and the second viewing element in the relaxed state of the spring element.
  • the lens implant is designed to require an external stretch force preferably originating from the lens capsule acting on the spring element for stretching the spring element from its relaxed state into its stretched state.
  • Such lens implant is designed to reflect properties of the natural lens and its actuation mechanism as much as possible and respects the physiology of the eye.
  • the lens implant although being designed by several components comprising two or more viewing elements and a spring element between the viewing elements is designed to - absent any external forces - take a flattened shape, which shape represents the shape of a natural lens enabling distant vision, i.e. what also sometimes is referred to as the lens being in an unaccommodated state.
  • This shape reflects the shape of the natural lens and as such serves best for any accommodation processes as well as for any other physiological processes .
  • the lens implant in its relaxed state takes a shape suitable for distant vision it needs to be convertible from there into a shape suitable for near vision. While in the state of the art this is achieved by members protruding from the viewing elements of the lens implant trying to directly engage with the ciliary muscle such actuation does not reflect the actuation used by the human eye .
  • the ciliary muscle is not itself pushing the lens imp-La-nt— ⁇ r—the—tens—capsule—f r-the re son tiicTt such ac- tuation is not conform with the natural accommodation and may only be achieved by training of the ciliary muscle and the human brain in order to switch to such actuation mechanism different to the one used for the natural eye. Instead, as is with the human eye, upon contraction of the ciliary muscle the zonule fibres relax and no longer stretch the lens capsula which stretching held the lens capsule in a flattened elongated state before.
  • the lens capsule itself which causes the lens mass transitioning from the flat shape representing distant vision into the more spherical shape representing near vision.
  • the lens capsule is formed by a basement membrane which was built during the growth of the lens mass at its periphery by building subcapsular epithelium cells.
  • the lens capsule encompassing the lens is elastic, and without any other external forces its surface tends to take a shape of lowest surface per volume which is a sphere. This is why absent any external forces the combination of lens mass and lens capsule takes a sphere-like shape which is the desired one for near vision.
  • the tension built by the lens capsule needs to overcome the spring force generated by the spring element of the lens implant in a direction for stretching the spring element.
  • the spring constant of the spring element may preferably have a value of less than 20 mN/mm.
  • the spring constant of the spring element may preferably have a value of less than 550 mN/mm, and more preferably of equal to or less than 500 mN/mm, and more preferably of less than 300 mN/mm.
  • the spring constant of the spring element of the lens implant is dimensioned such that a force produced by the lens capsule transforms the spring—eieme -fe—f-r-om—its— eia-xed—state ⁇ in:txr-a ⁇ ⁇ tretclle ⁇ c ⁇ state, i.e. pulls the spring element.
  • the direction of transition is determined by means of the action direction of the spring element which typically is the optical axis of the lens implant.
  • the spring constant is not only dimensioned such that it enables the lens capsule to stretch the spring element and by this enlarges the distance between the viewing elements along the optical axis, but is dimensioned such that the lens capsule is enabled to separate the viewing elements up to a distance which represents a state for near vision.
  • the transition shall preferably be effected solely by means of tensions in the lens capsule.
  • the present lens although comprising two spaced apart viewing elements may be closely aligned to the shape and the dimension of the natural lens mass and the lens implant as well as its actuation may be conform to the natural lens and its actuation.
  • actuation being the same as with the natural lens, i.e. in particular without the ciliary muscle directly acting on the lens implant, a lens implanted person is not needed to experience, learn and adapt a different way of actuation / accommodation whereas a direct engagement of. the ciliary muscle with a clamp of the lens implant may be irritating.
  • the basement membrane forming the lens capsule will likely better engage with the lens implant for the reason of a better fit and which may better prevent from corrosion and clouding. It is believed that the subcapsular epithelium from which the basement membrane is built will show a better sustainability when engaged with an aligned lens implant which follows the natural lens in the shape and actuation.
  • a spacer between the first and the second viewing element.
  • a lens jjnplan-t—su-rge-ry-,— -e—!lens—e-ap-suie—m y— hange—irtsrnape and specifically may shrink to some extent.
  • the subcapsular epithelium from which the basement membrane of the lens capsule is built may become active and cause the lens capsule to shrink.
  • the lens capsule shrinkage may cause at least a local approximation of the first and the second viewing element. In order not to allow such process to impact distant viewing, it is preferred to limit such approximation between the first and the second viewing element to a minimum distance by means of the spacer.
  • the spacer may include a bar or other element that may limit the distance the first and the second viewing element can take with respect to each other.
  • the bar may be attached to either of the first and the second viewing element, and its height may define the minimum distance between the first and the second viewing element.
  • the spacer may be embodied as a spring which prevents an approximation of the first and the second viewing element beyond the minimum distance.
  • the present spring element for allowing the first and the second viewing element to diverge from each other starting from the relaxed state of the spring element may simultaneously serve as spacer, e.g. when such spring is not compressible beyond the minimum distance.
  • the minimum distance between the first and the second viewing element is equal to the distance of the first and the second viewing element with the spring element being in the relaxed state. In another embodiment, however, the minimum distance defined by the spacer is less than the distance defined by the spring element being in the relaxed state.
  • the minimum distance preferably is selected sueh—hat—it—ee-r-r-es onds—to—a—refra ⁇ ctiT ⁇ o " f ⁇ tire-1ens IS " plant of between 18 and 24 diopter, preferably for a per- son with normal vision.
  • the refraction of the lens implant may be different at the minimum distance and in particular may be selected such that the associated impaired vision is compensated.
  • the minimum distance is selected such that it corresponds to a width of the lens implant of not less than 2.5 mm, and preferably not less than 2 mm.
  • a method for manufacturing a lens implant according to any one of the previous embodiments.
  • the natural lens is measured. In particular its shape and dimensions are measured, e.g. by any imaging technique.
  • the data derived from such measurement may be used for forming the lens implant.
  • a spring element may be formed with a spring constant such that the spring element is expected to be stretchable by tension forces induced by the lens capsule surrounding the natural lens. Such tension forces may be measured or be estimated.
  • At least one of the two viewing elements may be formed with a desired optical power which desired optical power may be derived from the measurement.
  • Such kit may comprise multiple viewing elements with different focal lengths and/or different shapes, and a spring element for holding the viewing elements .
  • Fig. 1 shows a longitudinal cut of a schematic intraocular lens implant according to an embodiment of the present invention, in Fig la in its relaxed state, and in Fig. lb in its stretched state;
  • Fig. 2 shows a longitudinal cut of a schematic intraocular lens implant according to an embodiment of the present invention, implanted in a lens capsule, in Fig. 2a in the stretched state of the lens capsule, and in Fig, 2b in the relaxed state of the capsule;
  • Fig. 3 shows a longitudinal cut of a front portion of the human eye
  • Fig. ' 4 shows a longitudinal cut of a front p_artion_of—an—eye—wi —an—im l-an- ⁇ accord ng " tO ⁇ an ⁇ mb ⁇ i ⁇ ment of the present invention in a state accommodated to distant vision;
  • Fig. 5 shows a longitudinal cut of a front portion of an eye with an implant according to an embodiment of the present invention in a state accommodated to near vision.
  • Figure 3 it is referred to a simplified cross section of a front part of the human eye which comprises a cornea 5, an iris 4 and a lens 1 comprising a lens mass 3 arranged in a lens capsule 2.
  • the lens 1 is connected via zonule fibres 7 to a ciliary muscle 6.
  • the ciliary muscle 6 takes the form of a ring that may con- tract and relax.
  • a contraction of the ciliary muscle 6 shall lead to accommodation which is understood as the eye focusing to an object in the near vision.
  • Relaxation of the ciliary muscle 6 shall lead to a less accommodated state also referred to as unaccommodated state in which the eye is prepared for distant vision.
  • the lens capsule 2 In a state in which the lens 1 is adapted for distant vision, the ciliary muscle 6 is relaxed as shown in Figure 3. In such state the zonule fibres 7 are tense and pull the edge of the lens capsule 2 radially outwards such that the lens 1 takes a rather flat shape in view of the drag force generated by the ciliary muscle 6 and transmitted by the zonule fibres 7 to the lens capsule 2. Hence, the lens capsule 2 itself is not in a relaxed state but is radially pulled such that it takes a rather flat shape instead of a spherical shape.
  • the ciliary muscle 6 contracts such that a diameter of the ciliary muscle 6 around the lens 1 decreases.
  • the tension in the zonule fibres 7 drops and the zonule fibres 7 may only hold the lens 1 but not add any additional radial forces to the lens 1.
  • the lens 1 relaxes from its flat shape and returns to the near spherical shape for near vision in which the focal length of the lens 1 is much smaller than for distant vision.
  • the lens mass 3 takes a rather flat ,shape suited for distant vision.
  • the lens mass 3 will be encapsulated in the lens capsule 2 it will be deformed and transform from the flat shape into a more spherical shape suited for near vision, again, absent any external forces.
  • the lens capsule contains fibres built during the building of the lens mass Absent any external forces these fibres make the lens capsule to take a shape of lowest energy which results in a form with the smallest surface per volume which presently is a sphere - or better a sphere-like - structure.
  • the lens mass / lens capsule combination will take a rather spherical form representing a lens suited for near vision.
  • the forces generated by the lens capsule are sufficient for effecting such deformation of the lens mass 3 as the zonule fibres 7 are effete with the cilicary muscle 6 being contracted.
  • the surface tension paradigm prevailing for the near view will be overridden by zonula fibres 7 pulling the edge of the lens capsule 2 -O-U-twa-rds—:n— esponse—ro—trhe—crtrary ⁇ miiHcie ⁇ 6 ⁇ Te ⁇ lax wh cIT- makes the zonula fibres 7 become tense.
  • the lens capsule 2 is radially stretched and takes a rather flat form suitable for distant vision.
  • a lens implant in the present context is understood as an implant for replacing the lens mass but not the lens capsule. Accordingly, the lens implant is meant to be inserted into the lens capsule.
  • Fig. 1 shows a longitudinal cut of a schematic intraocular lens implant 11.
  • the lens implant 11 includes two viewing elements 12 and 13 and a spring element 14 between the viewing elements 12 and 13.
  • the present lens implant 11 is a simplified version as the person skilled may easily comprehend that other shapes of the viewing elements, different forms of spring elements etc. may be encompassed by such lens implant 11, too.
  • the spring element 14 may contain multiple members between the first and the second viewing element 12, 13 which in combination form the spring element 14 containing the defined spring constant.
  • members joining the first and the second viewing element 12, 13 may be arranged at the circumference of the first and the second viewing element 12, 13.
  • the members may take a curved, convex shape between the first and the second viewing element 12, 13 while at the same time being arranged at the circumference of the first and the second viewing element 12, 13.
  • Axis A - A" denotes the optical axis of the lens implant 1.
  • Axis B - B denotes the longitudinal axis of the lens implant 1.
  • the spring element 14 is connected to both viewing elements 13 and 14 and is arranged such that a distance between the viewing elements 12, 13 along the optical axis can be varied subject to the force applied to the viewing elements 12, 13.
  • a sample focal point on the optical axis is denoted as FP.
  • Fig. la represents a lens implant 1 e.g. after manufacture and prior to implantation.
  • the spring element 14 is dimensioned such that in its relaxed state the viewing elements 12, 13 are spaced from each other at a distance which implements a lens implant 1 focusing in the distance .
  • a width w of the lens implant 11 along the optical axis A-A x between outer surfaces of the first and the second viewing element 12, 13 may preferably be between 2.5 mm and 5.5 mm in the relaxed state of the spring element 14, and in a very preferred embodiment be between 3.8 mm and 4.0 mm in the relaxed state of the spring element 14.
  • the spring element 14 is in a stretched, extended state, i.e. external forces are applied to the spring element 14 or the viewing elements 12, 13 and make the distance between the viewing elements 12, 13 increase, and in particular exceed the distance between the viewing elements 12, 13 compared to a situation when the spring element 14 is unloaded according to Fig. la.
  • the viewing elements 12, 13 are spaced apart at a distance which results in a lens implant 1 focusing to the near, e.g. on focal point FP.
  • the spring element 14 is under tension in this example.
  • the width w of the lens implant 11 along the optical axis A-A" between outer surfaces of the first and the second viewing element 12, 13 may preferably be between 2.7 mm and 5.7 mm in the stretched state of the spring element 14, and in a very preferred embodiment be between 4.0 mm and 4.2 mm in the stretched state of the spring element 14.
  • Fig. 2 shows a longitudinal cut of a schematic intraocular lens implant 11 according to an embodiment of the present invention, now implanted in a lens -capsule—2—For--iliu-s-tr-a-tio --purpas s ⁇ ⁇ t ⁇ ⁇ s assumecTTfra (except for gravitation, of course) no other forces than the spring force of the spring element 13 and tension forces inherent in the lens capsule 2 are interacting.
  • Fig. 2b the lens capsule 2 is in its relaxed state and takes a shape of lowest energy. No external forces are assumed to apply to such implant/capsule combination. It is apparent that the relaxed state of the combination of the lens implant 11 and the lens capsule 2 is not equivalent to the relaxed state of the lens implant 11 on its own. Rather, the lens implant 11 is in its stretched state and is accommodated to the near. The force responsible for transitioning the lens implant 11 from its inherent relaxed state according to Fig. la to its stretched state according to Fig. 2b is evoked by the lens capsule 2.
  • the lens capsule 2 - without any external forces applied - is taking a shape of lowest energy which - as far as the spring element 14 of the lens implant 1 is not counteracting - is a spherical-like shape. Tension and in particular surface tension built in the lens capsule 2 is responsible for such transition.
  • the spring element 14 of the lens implant 1 would have been designed with a very high spring constant such that only for a large force applied the spring element 14 may stretch, the counteracting forces evoked by the lens capsule 2 would not suffice to exceed the spring force and the distance between the viewing elements 12, 13 would not change significantly.
  • the spring constant of the spring element 14 has a value of less than 550 mN/mm.
  • the spring constant of the spring element 14 has a value of less than 20 mN/mm.
  • the spring constant of the spring element 14 has a value of more than 2.5 mN/mm. In another preferred embodiment, the spring constant of the spring element 14 has a value of more than 10 mN/mm.
  • the spring constant may be designed in one of a range between 2.5 mN/mm and 20 mN/mm, a range between 10 mN/mm and 20 mN/mm, a range between 2.5 mN/mm and 550 mN/mm, and a range between 10 mN/mm and 550 mN/mm.
  • the above ranges may be described as one of less than 55 g/mm, more than 0.25 g/mm, more than 1 g/mm, a range between 0.25 g/mm and 55 g/mm, a range between 1 g/mm and 55 g/mm, a range between 0.25 g/mm and 2 g/mm, or a range between 1 g/mm and 2 g/mm.
  • the spring constant of the spring element 14 is dimensioned such that a force produced by the lens capsule 2 transforms the spring element 14 from its relaxed state into a stretched state.
  • the forces generated by the lens capsule 2 need to exceed the counteracting force of the spring element 14.
  • the force generated by the lens capsule 2 in such direction needs to overcome the spring force by an amount that allows the two viewing elements 12, 13 travelling away from each other until the lens implant 11 is in a condition that allows viewing to the near which is illustrated in Fig. 2b.
  • a force induced by a mass of the order of g or mg may allow to pull the spring in a mm or sub-mm range.
  • the lens capsule 2 is far from taking its preferred shape of a spherical-like capsule but is rather lengthy and flattened.
  • the lens implant 11 within the lens capsule 2 now is -dose—to—tts—reia-xed—s-t-ate—wh ch ⁇ rs ⁇ defrneti ⁇ as s a e - " ⁇ " where the spring element 14 is in a relaxed state.
  • the spring element 14 on its own would traverse from a stretched state as shown in Fig. 2b to a relaxed state as shown in Fig. 2a , it would have to overcome the tension exerted by the lens capsule 1 .
  • Such tension may be overcome by forces applied to upper edges of the lens capsule 2 , as indicted by arrows E.
  • Such forces may be evoked through relaxing of the ciliary muscle 6 which in turn strains the zonule fibres 7 .
  • the lens implant of Figures 2a and 2b further comprises a spacer in form of a bar 15 arranged between the first and the second viewing element 12 , 13 .
  • the bar 15 protrudes from the first viewing element 12 in form of a ring.
  • the bar 15 preferably is manufactured in one piece together with the first viewing element 12 .
  • the bar 15 defines a minimum distance the first and the second viewing element 12 , 13 can approach each other. In the present embodiment, the minimum distance corresponds to the distance the first and the second viewing element 12 , 13 take when the spring element 14 is in a relaxed state such as also shown in Figure la.
  • the minimum distance between the first and the second viewing element 12 , 13 corresponds of the width w of the lens implant 11 when the spring element 14 is in its relaxed state.
  • any additional compression force acting on the lens implant 11 e.g. exerted by a shrinkage process of the lens capsule 2 may not lead to a further approximation between the first and the second viewing element 12 , 13 in view of the spacer.
  • a lens implant 11 implanted in the eye is schematically illustrated in the longitudinal cut of Fig. 4 , wherein the spacer of the lens implant is not shown for the sake of a clear illustration but which spacer may actually be present.
  • the lens capsule 2 encapsulates the lens implant 11 .
  • Zonule fibres 7 radially attached to the lens capsule 2 are in a stretched state. A rather flat
  • a relaxing of the ciliary muscle 6 in turn evokes straining the zonule fibres 7 which in turn stretch the lens capsule 2.
  • Fig. 5 in turn shows a longitudinal cut of the eye of Figur 4, however, in a state accommodated to near vision.
  • the actor i.e. the ciliary muscle 6 has contracted in order to accommodate to the near.
  • the zonule fibres 7 relax and do no longer pull the edges of the lens capsule 2.
  • the lens capsule 2 takes the shape of lowest energy which is a spherical like shape to the extent the spring element 14 of the lens implant 11 allows.
  • a longitudinal extension of the lens implant along the optical axis in the relaxed state of the spring element is less than a longitudinal extension of the lens implant along the optical axis in the stretched state. This makes the lens implant be suitable for near vision in its excited state rather than to distant vision. In near vision, the focal length as distance between the focal point on the optical axis and the lens implant is less than the focal length in distant vision .
  • the lens implant lacks of elements to engage with the ciliary muscle of the eye upon contraction of the ciliary muscle.
  • the lens implant is not directly or indirectly controllable in its shape by a contraction of the ciliary muscle.
  • the shape of the lens implant will not be affected by a contracting ciliary muscle.
  • the shape of the lens implant is solely affected by forces induced via the two viewing elements.
  • the lens implant lacks of elements exceeding a height of the lens capsule in its relaxed state wherein the height is defined along the axis B - ⁇ of Figure la.
  • the lens implant lacks of elements projecting above the height of the viewing elements in a direction of a longitudinal axis of the viewing elements. In other word, upper edges of the viewing elements may terminate the lens in a direction of a longitudinal axis of the lens.
  • the viewing elements and the spring element may advantageously be formed integrally, as a single piece, or alternatively, may be formed from at least the individual viewing elements and the spring element.
  • the viewing elements may comprise a lens with plus power, and a lens with negative power.
  • Kits for manufacturing a lens implant according to one of the preceding embodiments may be provided such kit comprising multiple viewing elements with different focal lengths and/or different shapes, and at least one spring element for holding the viewing elements. From such kit an individual lens implant may be assembled in an ophthalmic clinic where a patients lens is replaced by the lens implant. From the kit lenses are chosen that match the refractive index, dimension and shape of the patients needs.
  • the lens implant preferably is adapted to the natural lens of the patients eye it shall replace.
  • the lens implant preferably comprise outside surfaces for being in contact with the lens capsule in an implanted state which outside surfaces take the dimension and form of the specific natural lens mass.
  • the lens implant may be formed according the rn.Qd.eX-and—as—such—aeeo-di-ng— o-the ⁇ dimenslon and shape of " the natural lens as far as the individual viewing elements and spring elements allow.
  • the lens capsule 2 is closed after inserting the lens implant 11.
  • precise cuts for example, a circular cut may be generated at the front portion of the lens capsule 2 by means of laser technology which cut is aligned with the optical axis A - A such that such cut may not even be closed after inserting the lens implant 11 and may remain open.

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  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un implant de lentille intraoculaire, qui comprend deux éléments de visualisation (12, 13) et un élément de ressort (14) entre eux. Une distance entre les premier et second éléments de visualisation (12, 13) le long d'un axe optique (A-A') de l'implant de lentille (11) peut varier pour ajuster la longueur focale de l'implant de lentille (11). L'implant de lentille (11) est conçu pour adopter une forme appropriée pour une vision à distance lorsque l'élément de ressort (14) est dans son état détendu. Une constante d'élasticité de l'élément de ressort (14) est dimensionnée de telle sorte qu'une force produite par une capsule de lentille (2) de l'œil, pour maintenir l'implant de lentille (11), transforme l'élément de ressort (14) de son état détendu en un état étiré. A l'aide d'une telle conception, l'implant de lentille (11) peut suivre les mêmes principes d'actionnement que la lentille naturelle.
PCT/CH2012/000249 2012-11-08 2012-11-08 Implant de lentille intraoculaire Ceased WO2014071532A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CH2012/000249 WO2014071532A1 (fr) 2012-11-08 2012-11-08 Implant de lentille intraoculaire

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CH2012/000249 WO2014071532A1 (fr) 2012-11-08 2012-11-08 Implant de lentille intraoculaire

Publications (1)

Publication Number Publication Date
WO2014071532A1 true WO2014071532A1 (fr) 2014-05-15

Family

ID=47296876

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH2012/000249 Ceased WO2014071532A1 (fr) 2012-11-08 2012-11-08 Implant de lentille intraoculaire

Country Status (1)

Country Link
WO (1) WO2014071532A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10159562B2 (en) 2014-09-22 2018-12-25 Kevin J. Cady Intraocular pseudophakic contact lenses and related systems and methods
US10299910B2 (en) 2014-09-22 2019-05-28 Kevin J. Cady Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US10945832B2 (en) 2014-09-22 2021-03-16 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US11109957B2 (en) 2014-09-22 2021-09-07 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US11938018B2 (en) 2014-09-22 2024-03-26 Onpoint Vision, Inc. Intraocular pseudophakic contact lens (IOPCL) for treating age-related macular degeneration (AMD) or other eye disorders
US12447007B2 (en) 2014-09-22 2025-10-21 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030060881A1 (en) * 1999-04-30 2003-03-27 Advanced Medical Optics, Inc. Intraocular lens combinations
US20050228401A1 (en) 2001-01-25 2005-10-13 Gholam-Reza Zadno-Azizi Method of preparing an intraocular lens for implantation
WO2012045186A1 (fr) * 2010-10-06 2012-04-12 Eduard Anton Haefliger Implant de lentille intraoculaire

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030060881A1 (en) * 1999-04-30 2003-03-27 Advanced Medical Optics, Inc. Intraocular lens combinations
US20050228401A1 (en) 2001-01-25 2005-10-13 Gholam-Reza Zadno-Azizi Method of preparing an intraocular lens for implantation
WO2012045186A1 (fr) * 2010-10-06 2012-04-12 Eduard Anton Haefliger Implant de lentille intraoculaire

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10159562B2 (en) 2014-09-22 2018-12-25 Kevin J. Cady Intraocular pseudophakic contact lenses and related systems and methods
US10299910B2 (en) 2014-09-22 2019-05-28 Kevin J. Cady Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US10842614B2 (en) 2014-09-22 2020-11-24 Onpoint Vision, Inc. Intraocular pseudophakic contact lenses and related systems and methods
US10945832B2 (en) 2014-09-22 2021-03-16 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US11109957B2 (en) 2014-09-22 2021-09-07 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US11432921B2 (en) 2014-09-22 2022-09-06 Onpoint Vision, Inc. Intraocular pseudophakic contact lenses and related systems and methods
US11571293B2 (en) 2014-09-22 2023-02-07 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US11583386B2 (en) 2014-09-22 2023-02-21 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US11903818B2 (en) 2014-09-22 2024-02-20 Onpoint Vision, Inc. Intraocular pseudophakic contact lenses and related systems and methods
US11938018B2 (en) 2014-09-22 2024-03-26 Onpoint Vision, Inc. Intraocular pseudophakic contact lens (IOPCL) for treating age-related macular degeneration (AMD) or other eye disorders
US12447007B2 (en) 2014-09-22 2025-10-21 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method

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