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WO2013119964A3 - Identification and enrichment of cell subpopulations - Google Patents

Identification and enrichment of cell subpopulations Download PDF

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Publication number
WO2013119964A3
WO2013119964A3 PCT/US2013/025361 US2013025361W WO2013119964A3 WO 2013119964 A3 WO2013119964 A3 WO 2013119964A3 US 2013025361 W US2013025361 W US 2013025361W WO 2013119964 A3 WO2013119964 A3 WO 2013119964A3
Authority
WO
WIPO (PCT)
Prior art keywords
enrichment
identification
cell subpopulations
subpopulations
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2013/025361
Other languages
French (fr)
Other versions
WO2013119964A2 (en
Inventor
Scott J. Dylla
Marianne Santaguida
Wade C. Anderson
Bob Y. LIU
Samuel A. WILLIAMS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Stemcentrx LLC
Original Assignee
Stemcentrx inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/369,277 external-priority patent/US20130061342A1/en
Priority claimed from US13/414,666 external-priority patent/US20130061340A1/en
Application filed by Stemcentrx inc filed Critical Stemcentrx inc
Publication of WO2013119964A2 publication Critical patent/WO2013119964A2/en
Publication of WO2013119964A3 publication Critical patent/WO2013119964A3/en
Priority to US14/454,107 priority Critical patent/US9778264B2/en
Anticipated expiration legal-status Critical
Priority to US15/698,839 priority patent/US20180067120A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C12N5/0695—Stem cells; Progenitor cells; Precursor cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Markers useful for the identification, characterization and, optionaily, the enrichment or isolation of tumorigenic cells or cell subpopulations are disclosed.
PCT/US2013/025361 2010-09-03 2013-02-08 Identification and enrichment of cell subpopulations Ceased WO2013119964A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US14/454,107 US9778264B2 (en) 2010-09-03 2014-08-07 Identification and enrichment of cell subpopulations
US15/698,839 US20180067120A1 (en) 2010-09-03 2017-09-08 Identification and enrichment of cell subpopulations

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13/369,277 2012-02-08
US13/369,277 US20130061342A1 (en) 2011-09-02 2012-02-08 Identification and Enrichment of Cell Subpopulations
US13/414,666 2012-03-07
US13/414,666 US20130061340A1 (en) 2011-09-02 2012-03-07 Identification and Enrichment of Cell Subpopulations

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US13/414,666 Continuation US20130061340A1 (en) 2010-09-03 2012-03-07 Identification and Enrichment of Cell Subpopulations
US201313820061A Continuation-In-Part 2010-09-03 2013-06-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/454,107 Continuation US9778264B2 (en) 2010-09-03 2014-08-07 Identification and enrichment of cell subpopulations

Publications (2)

Publication Number Publication Date
WO2013119964A2 WO2013119964A2 (en) 2013-08-15
WO2013119964A3 true WO2013119964A3 (en) 2013-11-28

Family

ID=47754997

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/025361 Ceased WO2013119964A2 (en) 2010-09-03 2013-02-08 Identification and enrichment of cell subpopulations

Country Status (1)

Country Link
WO (1) WO2013119964A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106164672A (en) * 2014-01-17 2016-11-23 麦诺米克国际有限公司 Cell Surface Prostate Cancer Antigen for Diagnosis

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013005116A2 (en) 2010-09-03 2019-09-24 Stem Centrx Inc modulators and methods of use
SG10201506767QA (en) 2010-09-03 2015-10-29 Stemcentrx Inc Identification and enrichment of cell subpopulations
US9778264B2 (en) 2010-09-03 2017-10-03 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
SG10201601792UA (en) 2010-12-08 2016-04-28 Stemcentrx Inc Novel modulators and methods of use
SA112330278B1 (en) 2011-02-18 2015-10-09 ستيم سينتركس، انك. Novel modulators and methods of use
US9534058B2 (en) 2012-02-08 2017-01-03 Abbvie Stemcentrx Llc Anti-CD324 monoclonal antibodies and uses thereof
KR20150003169A (en) 2012-02-24 2015-01-08 스템 센트알엑스 인코포레이티드 Dll3 modulators and methods of use
CA2865415C (en) 2012-02-24 2022-06-21 Stem Centrx, Inc. Anti sez6 antibodies and methods of use
JP2016509014A (en) 2013-02-08 2016-03-24 ステムセントリックス， インコーポレイテッド New multispecific construct
CN105164159A (en) 2013-02-22 2015-12-16 施特姆森特克斯股份有限公司 Novel antibody conjugates and uses thereof
MX377339B (en) 2013-08-28 2025-03-06 Abbvie Stemcentrx Llc SITE-SPECIFIC ANTIBODY CONJUGATION METHODS AND COMPOSITIONS.
RU2016111139A (en) 2013-08-28 2017-10-03 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи NEW SEZ6 MODULATORS AND WAYS OF THEIR APPLICATION
US9381205B2 (en) 2013-11-04 2016-07-05 Pfizer, Inc. Anti-EFNA4 antibody-drug conjugates
JP6515111B2 (en) 2013-11-06 2019-05-22 アッヴィ・ステムセントルクス・エル・エル・シー Novel anti-claudin antibodies and methods of use
JP2017500028A (en) 2013-12-12 2017-01-05 アッヴィ・ステムセントルクス・エル・エル・シー Novel anti-DPEP3 antibody and method of use
BR112016018891A2 (en) 2014-02-21 2017-10-10 Abbvie Stemcentrx Llc anti-dll3 antibodies and drug conjugates for use in melanoma
NZ725480A (en) 2014-04-30 2024-08-30 Pfizer Anti-ptk7 antibody-drug conjugates
TW201617368A (en) 2014-09-05 2016-05-16 史坦森特瑞斯公司 Novel anti-MFI2 antibodies and methods of use
MA43342A (en) * 2015-09-30 2018-08-08 Medimmune Ltd COMPOSITIONS AND METHOD OF INHIBITION OF CANCERY STEM CELLS
AU2017254674A1 (en) 2016-04-21 2018-11-01 Abbvie Stemcentrx Llc Novel anti-BMPR1B antibodies and methods of use
WO2020033971A1 (en) 2018-08-10 2020-02-13 New York University Use of igf-2 receptor agonist ligands for treatment of angelman syndrome and autism

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US20100272636A1 (en) * 1999-05-10 2010-10-28 The Ohio State University Anti-CD74 Immunoconjugates and Methods of Use

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US4703004A (en) 1984-01-24 1987-10-27 Immunex Corporation Synthesis of protein with an identification peptide
US4745055A (en) 1985-05-07 1988-05-17 California Biotechnology Inc. Fused protein for enzyme immunoassay system
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US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106164672A (en) * 2014-01-17 2016-11-23 麦诺米克国际有限公司 Cell Surface Prostate Cancer Antigen for Diagnosis

Also Published As

Publication number Publication date
WO2013119964A2 (en) 2013-08-15

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