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WO2013190357A8 - A process for the preparation of gabapentin - Google Patents

A process for the preparation of gabapentin Download PDF

Info

Publication number
WO2013190357A8
WO2013190357A8 PCT/IB2013/001264 IB2013001264W WO2013190357A8 WO 2013190357 A8 WO2013190357 A8 WO 2013190357A8 IB 2013001264 W IB2013001264 W IB 2013001264W WO 2013190357 A8 WO2013190357 A8 WO 2013190357A8
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
gabapentin
compound
formula
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2013/001264
Other languages
French (fr)
Other versions
WO2013190357A1 (en
Inventor
Swapnil Gulabrao YERANDE
Rajesh Mataprasad THAKUR
Sundarakrishna S. SHARMA
Ashok Kumar Gangopadhyay
Helmut Rupp
Hitesh KUBAVAT
Kuppuswamy Nagarajan
Arul Selvan
Rambabu Nunna
Vivekananda Indudharappa JALAJAKSHI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hikal Ltd
Original Assignee
Hikal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hikal Ltd filed Critical Hikal Ltd
Publication of WO2013190357A1 publication Critical patent/WO2013190357A1/en
Publication of WO2013190357A8 publication Critical patent/WO2013190357A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention provides an improved process for the preparation of a compound of formula (I),
PCT/IB2013/001264 2012-06-18 2013-06-18 A process for the preparation of gabapentin Ceased WO2013190357A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2398CH2012 2012-06-18
IN2398/CHE/2012 2012-06-18

Publications (2)

Publication Number Publication Date
WO2013190357A1 WO2013190357A1 (en) 2013-12-27
WO2013190357A8 true WO2013190357A8 (en) 2014-03-13

Family

ID=49768188

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/001264 Ceased WO2013190357A1 (en) 2012-06-18 2013-06-18 A process for the preparation of gabapentin

Country Status (1)

Country Link
WO (1) WO2013190357A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104402796A (en) * 2014-11-26 2015-03-11 太仓运通生物化工有限公司 Preparation method for 3,3-amylidene butyrolactam
CN107235850B (en) * 2017-05-31 2019-07-26 浙江工业大学 The method that utilizes 1-cyanocyclohexylacetic acid to directly synthesize gabapentin
CN111285782B (en) * 2018-12-10 2023-06-23 上海科胜药物研发有限公司 Preparation method of 1-cyano-cyclohexyl acetonitrile
CN113234698B (en) * 2021-05-07 2023-06-09 深圳瑞德林生物技术有限公司 Preparation method of cyano reductase and gabapentin
WO2025062312A1 (en) * 2023-09-19 2025-03-27 Granules India Limited One-pot process for the preparation of gabapentin intermediate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9812351A (en) * 1997-09-18 2000-09-19 Warner Lambert Co New stereoselective process for the preparation of analogous gabapentins

Also Published As

Publication number Publication date
WO2013190357A1 (en) 2013-12-27

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