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WO2013168176A3 - Process for preparation of fosaprepitant and salt thereof - Google Patents

Process for preparation of fosaprepitant and salt thereof Download PDF

Info

Publication number
WO2013168176A3
WO2013168176A3 PCT/IN2013/000182 IN2013000182W WO2013168176A3 WO 2013168176 A3 WO2013168176 A3 WO 2013168176A3 IN 2013000182 W IN2013000182 W IN 2013000182W WO 2013168176 A3 WO2013168176 A3 WO 2013168176A3
Authority
WO
WIPO (PCT)
Prior art keywords
fosaprepitant
salt
preparation
relates
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2013/000182
Other languages
French (fr)
Other versions
WO2013168176A2 (en
Inventor
Shekhar Bhaskar Bhirud
Bhargav Krishnaji Upadhye
Navin Ganesh BHATT
Mahendra Joma CHORAGHE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glenmark Generics Ltd
Original Assignee
Glenmark Generics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Generics Ltd filed Critical Glenmark Generics Ltd
Publication of WO2013168176A2 publication Critical patent/WO2013168176A2/en
Publication of WO2013168176A3 publication Critical patent/WO2013168176A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

The present invention relates to an improved process for the preparation of fosaprepitant and salt thereof.
PCT/IN2013/000182 2012-03-30 2013-03-19 Process for preparation of fosaprepitant and salt thereof Ceased WO2013168176A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1030MU2012 2012-03-30
IN1030/MUM/2012 2012-03-30
US201261702852P 2012-09-19 2012-09-19
US61/702,852 2012-09-19

Publications (2)

Publication Number Publication Date
WO2013168176A2 WO2013168176A2 (en) 2013-11-14
WO2013168176A3 true WO2013168176A3 (en) 2014-01-09

Family

ID=49551412

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2013/000182 Ceased WO2013168176A2 (en) 2012-03-30 2013-03-19 Process for preparation of fosaprepitant and salt thereof

Country Status (1)

Country Link
WO (1) WO2013168176A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104650143B (en) * 2013-11-25 2018-10-02 山东新时代药业有限公司 The method for preparing fosaprepitant dimeglumine intermediate
IN2013MU03772A (en) * 2013-12-02 2015-07-31 Piramal Entpr Ltd
CN106432337A (en) * 2015-08-08 2017-02-22 陕西合成药业股份有限公司 Fosaprepitant derivative, synthesis thereof, and use thereof in long acting preparation
EP3383829B1 (en) 2015-12-01 2020-10-21 Piramal Enterprises Limited A process for preparation of fosaprepitant dimeglumine and an intermediate thereof
CN107353303B (en) * 2016-05-09 2020-09-01 上海奥博生物医药技术有限公司 Preparation method of fosaprepitant phosphate intermediate
WO2018211410A1 (en) * 2017-05-17 2018-11-22 Glenmark Pharmaceuticals Limited Improved process for preparation of fosaprepitant or salt thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691336A (en) * 1994-03-04 1997-11-25 Merck & Co., Inc. Morpholine compounds are prodrugs useful as tachykinin receptor antagonists
US20030158173A1 (en) * 2001-12-18 2003-08-21 Schering Corporation NK 1 antagonists
WO2006060110A2 (en) * 2004-11-05 2006-06-08 Merck & Co., Inc. Process for preparing {3-[2(r)-[(1r)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(s)-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid
WO2010018595A2 (en) * 2008-07-17 2010-02-18 Glenmark Generics Limited Fosaprepitant dimeglumine intermediate, neutral fosaprepitant, and amorphous fosaprepitant dimeglumine and processes for their preparations
WO2011045817A2 (en) * 2009-10-15 2011-04-21 Sandoz Private Limited Process for the preparation of fosaprepitant, intermediate and pharmaceutical acceptable salt thereof
CN102558232A (en) * 2011-12-31 2012-07-11 江苏奥赛康药业股份有限公司 Preparation method of fosaprepitant dimeglumine
CN102850398A (en) * 2011-06-27 2013-01-02 上海医药工业研究院 Fosaprepitant preparation method

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691336A (en) * 1994-03-04 1997-11-25 Merck & Co., Inc. Morpholine compounds are prodrugs useful as tachykinin receptor antagonists
US20030158173A1 (en) * 2001-12-18 2003-08-21 Schering Corporation NK 1 antagonists
WO2006060110A2 (en) * 2004-11-05 2006-06-08 Merck & Co., Inc. Process for preparing {3-[2(r)-[(1r)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(s)-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid
WO2010018595A2 (en) * 2008-07-17 2010-02-18 Glenmark Generics Limited Fosaprepitant dimeglumine intermediate, neutral fosaprepitant, and amorphous fosaprepitant dimeglumine and processes for their preparations
WO2011045817A2 (en) * 2009-10-15 2011-04-21 Sandoz Private Limited Process for the preparation of fosaprepitant, intermediate and pharmaceutical acceptable salt thereof
CN102850398A (en) * 2011-06-27 2013-01-02 上海医药工业研究院 Fosaprepitant preparation method
CN102558232A (en) * 2011-12-31 2012-07-11 江苏奥赛康药业股份有限公司 Preparation method of fosaprepitant dimeglumine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JEFFREY J.: "Hale Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs.", J.MED.CHEM., vol. 43, no. 6, 25 February 2000 (2000-02-25), pages 1234 - 1241 *

Also Published As

Publication number Publication date
WO2013168176A2 (en) 2013-11-14

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