WO2013030202A1 - Device and method for producing aqueous aerosols charged with an active substance - Google Patents

Abstract

The present invention relates to a device and a method for producing aqueous aerosols charged with an active substance, the device comprising as its essential component a compartment that is charged with an adsorption agent which adsorbs water in an exothermic process when it comes into contact with water, part of the water evaporating and entering the gaseous phase. If the water is charged with an active substance or, for example, the adsorption agent is mixed with an active substance, an aqueous aerosol charged with an active substance is formed. More particularly, the present invention relates to devices for inhalation of aerosols containing nicotine or pharmaceutical active substances in stable nanoparticles (mean diameter < 1-2 μm).

Description

 Apparatus and method for producing drug-loaded aqueous aerosols

The present invention relates to an apparatus and a method for producing drug-loaded aqueous aerosols, comprising as an essential part of a compartment which is loaded with an adsorbent, which adsorbs ontaktierung with water water in an exothermic process, wherein also a part of Water evaporates and into the

Gas phase passes. In the event that the water is loaded with an active ingredient or, for example, the adsorbent is mixed with an active ingredient, a drug-loaded aqueous Ae rosol is formed. In particular, the present invention relates to devices for inhalation of aerosols, the nicotine or pharmaceutical agents in stable nanoparticles (average diameter <l-2 μιη) contained th. From the prior art, a variety of devices are known with which aerosols can be produced by atomization of liquid substances.

For example, a number of nicotine inhalers are published and sometimes available on the market. The consumer, this künstli ^¬ chen cigarettes have not enforced until now. One of the reasons is that these devices are unable to provide nicotine, the beneficial agent, directly to the body in sufficient quantity.

Most devices, either by design, either deliver too low concentrations of nicotine in the gas phase or do not produce a suitable aerosol with inhalable stable particles.

Systems that do not produce heat do not produce an aerosol. In the device approved as Nicotrol Inhaler for the support of nicotine withdrawal nicotine is dissolved in the saliva and z. absorbed through the oral cavity, the remainder swallowed and taken up via the intestine.

In addition, what are known as "electronic cigarettes" are known in which nicotine is bound to a substrate or a pure film is vaporized by means of thermal evaporation methods For example, refer to the patent application KR-2010035429. A disadvantage of such electronic cigarettes is the risk of abuse with the nicotine cartridges that can be filled with very high nicotine amounts or with drugs beforehand. NK Cobb et al. show in N. Engl. J. Med. 365: 3, 193, 2011 the typical structure of an e-cigarette and discuss, among other things, the dangers of misuse with the nicotine cartridges, which are very high

Nicotine quantities or even with drugs can be filled.

In addition, it is known that electronic cigarettes can not be used to provide satisfactory airway nicotine delivery to subjects (see, e.g., A. R. Vansickel et al., Cancer Epidemiology, Biomarkers & Prevention, 2010, 19 (8), 1945). A similar result is shown by C. Bullen et al. {Tobacco Control, 2010, 19, 98-103) that with an electronic cigarette only one tenth of the nicotine concentration of the normal smoker can be achieved.

Further aerosol devices with which active substances can be brought into the aerosol phase also show that in this case sufficient absorption of, for example, nicotine is not possible (B. Caldwell et al.,

Nicotine & Tobacco Research, 2009, 11 (4), 342-347). Also the one of P.G. Andrus et al. described aerosol

Inhaler (Can Respir J., 1999, 6 (6), 509) does not meet the requirements, since the aerosol particles obtained are not small enough. Also disclosed are systems which utilize the energy released during chemical reactions, such as e.g. in the reaction of calcium oxide or

Diphosphorus pentoxide with water (WO 2008/017298).

Furthermore, devices are published whose energy supply is based on the principle of latent heat. rest, for example, releasing heat of crystallization. The energy yield in these systems is relatively low.

But even devices that deliver enough nicotine, far from achieving the effect of a normal cigarette. This is essentially due to the aerosol composition, which in the known systems is based almost exclusively on aqueous or hydrophilic media. The decisive disadvantage of hydrophilic aerosols is that they instantly become unstable, in particular in the humid environment of the respiratory tract (accumulation of droplets), the aerosol droplets are essentially precipitated on the walls of the bronchi / bronchioles and thus do not reach sufficient active substance to the alveoli. The desired effect of a rapid increase in the concentration of the drug in the blood is not possible.

Based on this, it is an object of the present invention to provide a device with which particularly good aerosols can be achieved, i. Aerosols that have the smallest possible aerosol particles and are stable. It is also an object of the present invention to provide a corresponding method for producing such aerosols.

This object is achieved with respect to the device having the features of patent claim 1 and with respect to the method having the features of patent claim 16. The respective dependent claims are advantageous developments.

According to the invention, therefore, a device for producing active substance-laden aqueous aerosols is provided. give that

a) at least one compartment for stockpiling

 an adsorbent for water adsorbing water with the release of adsorption, wherein due to the released heat of adsorption of a portion of the water in the

 Gas phase is transferred,

b) at least one compartment for storing water, which is configured in such a way that, when the device is activated, water can be transferred into the at least one compartment for storing the adsorbent,

c) at least one active ingredient dissolved, emulsified or suspended in the water contained in the compartment and / or mixed with the adsorbent contained in the compartment for the adsorbent and / or on a separate substrate or a storage vessel between the compartment for the adsorbent and a Outlet arranged or contained, is applied, as well

d) at least one outlet for the generated aerosol which is in fluid communication with the at least one compartment for the adsorbent and / or the substrate or the storage vessel,

includes.

The device according to the invention thus comprises at least two different compartments, which are spatially separated from one another. The first compartment serves to store an adsorbent which adsorbs water when contacted in an exothermic reaction. Due to the released heat of adsorption, part of the water is converted into the gas phase, for example by the fact that the Adsorptionsmit- When heated with water, it is heated to temperatures above the boiling point of water. In addition, the device comprises at least one other

Compartment (second compartment), keeps the water ^¬ ent.

The optionally present substrate is selected in particular from substances which, for example, can accumulate, admit or absorb a liquid active substance or can be impregnated with solutions, emulsions or dispersions of the active substance. In particular, it is preferred if the substrate is formed, for example, from cellulose or modified cellulose (for example hydrophobicized cellulose).

In the event that a separate storage vessel for the active ingredient is present, this is in fluidic communication with the compartment for the adsorbent, for example via a Venturi nozzle.

Upon activation of the device, water from the second compartment is now transferred to the first compartment, i. the compartment containing the adsorbent is transferred, whereby a portion of the water is adsorbed to the adsorbent and a portion of the water introduced into the first compartment is converted to the gas phase by the above-described released adsorption heat. This can e.g. be done by the water is heated by the released heat of adsorption above the boiling point.

This produces an aqueous aerosol. According to the invention, it is provided that either the water in the second compartment has an active ingredient which is converted by the resulting water vapor into the aerosol phase. The active ingredient, depending on its nature, dissolved in water, as an emulsion, suspension but also as a dispersion.

Alternatively or in addition, it is also possible that the adsorbent itself with a

Active ingredient is mixed, for example, the active ingredient may be added in powder or liquid form to the adsorbent. As a third possibility, as an alternative or in addition to the previously described embodiments, it may likewise be provided that the active substance is applied to a separate substrate which, when the device is activated, is acted upon by the water aerosol generated in the first compartment, whereby the active substance contained in the substrate is involved is transported into the aerosol phase.

For the further given case that the active ingredient is present in a separate storage vessel, the generated aqueous aerosol stream can be led into this storage vessel in order to expel the active substance as an aqueous aerosol. In addition, an indirect removal from the storage vessel is possible, wherein the active ingredient can be removed from the storage vessel via a Venturi nozzle.

The device also has an outlet from which the aqueous aerosol streams laden with active substance can escape. Depending on the embodiment of

Device is the outlet at the first compartment ment (the compartment containing the adsorbent), attached to the substrate (if present) or possibly to the storage vessel (if present) or in fluidic communication with the first compartment or substrate.

According to the invention, compartments or storage vessels are understood to mean separate spaces separated from each other for storing the respective substances, which are e.g. may have a separate wall.

Furthermore, according to the invention, active ingredients are understood to mean substances with which a certain result can be achieved, for example the

Active ingredients show pharmaceutically active action, but also a mechanical result, such as a lubricating effect, for example, lubricants (eg mineral oils, synthetic oils, greases, oS _2, etc.) achieve. Decisive here is that the

Active ingredients can be brought in the form of an aqueous aerosol in the gas phase.

According to the invention aerosol is a mixture of fine water droplets as suspended particles and a

Gas, or gas mixture, in particular air understood. The water droplets may contain the active ingredient in dissolved, emulsified and / or dispersed form. The size {mean diameter) of the water droplets ranges according to the invention from 2 nm to 2 μm, preferably from 50 nm to 2 μm. In particular, water droplets having a size of 0.1 to 1 .mu.m can be produced with the device according to the invention or the method according to the invention. The present invention is thus based on the following general principle, which will be examined in more detail below: In the adsorption of polar substances, such as water on uncoated surfaces of an adsorbent, heat of adsorption is released. It is possible to distinguish between polar (hydrophilic) and nonpolar (hydrophobic) adsorbents. The hydrophilic adsorbents are, for example, silica gel, aluminum oxide,

Zeolites and some keys counted. Zeolites are particularly suitable for the separation of polar components such as water. In addition, zeolites have a shape-selective effect due to the ordered pore channel system (= u .a., Defined pore openings). If the surfaces are sufficiently large, it is also possible to produce temperatures that are significantly above 100 ° C.

A preferred embodiment of the device according to the invention provides that the compartment, which is the

Storage of the adsorbent is used, if necessary, the existing substrate, which serves to store the active substance, or also both provided for storing the adsorbent compartment and the substrate comprises at least one projecting into its interior and out of the compartment or the substrate pipe, the wall of which has perforations at least in the part projecting into the compartment for the adsorbent, into the substrate or into the storage vessel. The perforations are designed as recesses or holes through the wall of the tube. According to this embodiment, it is further preferred that the compartment serving for the storage of the adsorbent or the sub- strat can be arranged concentrically around this tube.

Analogous to the above construction, apparatuses are also conceivable with several perforated inner tubes of smaller diameter.

According to this embodiment, the drug-loaded aerosols either in the compartment provided for the adsorbent or in the substrate produced can be entered through the perforations into the tube and be discharged there from the compartment or the substrate. Thus, the generated aerosol streams can be brought together and discharged from the device.

A further advantageous embodiment provides that the compartment serving for storing the adsorbent and / or the substrate is bounded by a plate through which the tube described above is carried out. This plate or wall is impermeable to preferably water, water vapor or the aerosols produced, so that an efficient delimitation of Diff sion space for the aerosols generated, but also the discontinued water or water vapor generated is given. The generated aerosols must thus pave the way into the described tube through the perforation.

The tube described above may also have a valve which serves to regulate the aerosol flow. The valve can be designed so that it opens automatically when there is a need for the aerosol stream, this can for example be done so that on the pipe Subdr ck is applied (for example, when a user with his mouth on the opening of the previously described pipe, etc.), otherwise the valve is closed. According to this embodiment, therefore, aerosols can escape from the device only when needed.

In order to heat up the entire charge of the adsorbent all too quickly in the compartment provided for this purpose, e.g. In order to avoid the zeolite filling, this compartment can also be subdivided into segments, e.g. by a plastic film, which can gradually decrease or melt or shrink at a temperature rise, are separated from each other. This ensures that the excess water does not flood the entire absorption medium, for example the zeolites, in a short time and releases the active substance massively right at the beginning.

Another alternative is film windings, from which the individual Komparti duck are formed, which consist of several layers. In the bottom layer, water is trapped between plastic sheets, e.g. welded polyethylene films. The middle layer contains a water-absorbent fleece that provides a relatively even distribution of the aqueous phase at start-up by damaging the film. In the uppermost layer is the zeolite filling with the substrate. There perforated tubes can be stored, through which the aerosol is transported by the air flow during the removal, for example, during "smoking".

According to another variant, it is possible to spray the heated substrate with the aid of the liberated nitrogen. The device here consists of a metal pressure vessel as a compartment for the adsorbent, which can be used, for example, with embroidery Contains zeolites containing zeolites, furthermore, in this pressure vessel there is at the end a plastic container (compartment for the water) filled with water, which at relatively low temperatures (eg 50 ° C. to 250 ° C., preferably 60 ° C. to 150 ° C.)

melts or shrinks. When the end of the device is heated, the water container melts, water passes through, for example, felt material lying on the zeolite material and the desorption of nitrogen is started. This escapes through the nozzle in the front part of the pressure vessel. Analogous to a Venturi system, the heated active ingredient is atomised. The nozzle contains a valve, which can be used to regulate the removal via the air flow during inhalation. If the pressure in the metal container rises, the adsorption of water is suppressed, gas production does not continue unchecked.

In a preferred embodiment, the device comprises a compartment for the adsorbent which is connected to a further compartment for water. This compartment for water can for example also be designed as a separate water connection or a water supply for the compartment with adsorbent. As a result, a water addition in the compartment for the adsorbent is possible. The aqueous aerosols thus formed in the compartment for adsorbents with the addition of water can be discharged from this compartment via an outlet opening. Likewise, a separate storage vessel may be present, which comprises the active ingredient. The outlet of the compartment for the adsorbent (aqueous aerosol outlet) can be connected to the separate container for the active substance, for example via a Venturi nozzle, so that when the device is activated the aerosol Ström, which is expelled from the compartment with adsorbent, via the Venturi nozzle the active ingredient, which is located in the storage container, can entrain. For example, an efficient production of lubricant-containing aerosols can be intended.

Aerosol technology is already used in the lubricant sector:

In doing so, a specially suitable lubricant is atomised with the aid of the venturi technique and the resulting aerosol is brought to the hollow tool with compressed air via machine-internal supply lines.

There are often considerable distances (up to 7 m) to be overcome. This is also the disadvantage of this known from the prior art method, as lubricant settles in the Zulei- lines over time. Then this transport system acts as a liquid separator, the effectiveness of lubrication inevitably decreases considerably.

The advantage of an apparatus described above lies in its compactness, so that it would be possible to place it immediately in the vicinity of the tool, e.g. on a spindle, to install. Furthermore, one is completely independent of the type of lubricant as well as of external compressed air and further energy supply (electric current).

A further preferred embodiment provides that at least one filter and / or an intermediate between the outlet and the compartment for the adsorbent and / or the substrate or the storage vessel. is arranged. The filter may be formed, for example, of activated carbon or cellulose acetate.

According to this embodiment, the aerosols are again filtered before exiting. The intermediate space, which can be arranged, for example, between the filter and the storage compartment of the adsorbent or the substrate, can serve to set dynamic equilibrium conditions in the aerosol, and further structural components of the apparatus can be arranged in this intermediate space, such as For example, the valve described above, which is attached to the pipe.

It is also advantageous if the compartment serving for storing the adsorbent has an inlet area for water originating from the compartment serving for storing the water, the compartment for storing water being arranged at the inlet area. In this case, it is particularly advantageous if the two compartments, ie the compartment which serves to store the adsorbent and the compartment which serves to store the water, are separated from one another by a layer of a porous material, in particular a layer of a nonwoven. This embodiment provides that the two different compartments and thus the two reactants, ie adsorbents and water, are arranged in the immediate vicinity of each other, so that activation of the device is particularly simple. The porous material, for example the nonwoven fabric, is suitable for absorbing water, ie water is absorbed by the capillary forces of the water used to store water. To remove partiment and to supply the adsorbents located in the adjacent compartment.

Alternatively or additionally, it may be given that the serving of the water

Compartment is arranged within the storage of the adsorbent serving compartment. In both cases mentioned above, it is advantageous if at least the wall of the compartment serving for the storage of water is formed from a material which is destructible by mechanical action of force or can be melted by the action of external heat, that is, in any case loses its structural integrity that the boundary of this compartment is lost and water leaks from this compartment. In particular, it is preferred if the compartment serving to store the water comprises a wall with at least one predetermined breaking point and at least one mechanical means for breaking through the wall at least in the region of the at least one predetermined breaking point. The mechanical means is preferably arranged in the interior of the compartment. The predetermined breaking point can be embodied, for example, in that the wall of the compartment is made thinner at the predetermined breaking point than at the other locations of the wall of this compartment. A preferred mechanical means for breaking the wall may be formed for example in the form of a mandrel or a plunger, so that in flexible design of the compartment of the compartment for storing the water by mechanical pressure on the wall, the means for opening the wall pressed to the breaking point and this can finally be broken so that water can escape from this compartment. Alternatively or additionally, it is also possible that the water-containing compartment is under mechanical tension, so that upon activation, ie breaking the wall of this compartment, for example, at the predetermined breaking point or by melting the wall accelerated release of the water takes place because The compartment can now contract due to the mechanical stress and thus can empty. This can for example be realized in that the water is in the compartment under pressure, that the wall of the compartment is designed so that a contraction of the compartments takes place upon breaking a point of the wall or that a mechanical element that a tensile stress, for example, on opposite Widening of the compartment exerts {eg a tension spring) in the interior of the compartment is present. In this case, it is advisable to flexibly execute the walls of the compartment. A further preferred embodiment provides that between the storage compartment of the adsorbent serving (first compartment) and the storage of water serving compartment (second compartment) is arranged a further (third) compar- timent, which also includes an adsorbent. In contrast to the first compartment for storing the adsorbent, which is loaded in this case with the drug, but the adsorbent in the third compartment is free of drugs. The third compartment is preferred in the immediate vicinity of the second compartment. Particle arranged and separated from these, for example, by the above-mentioned porous material, such as a nonwoven fabric. Thus, this third compartment is used exclusively for the production of water vapor, which is supplied after generation of the first compartment for storing the adsorbent (loaded with active ingredient) and there the actual aerosol loaded with active substances is generated. Preferably, the device has a casing of all components, for example a cylindrical casing, which may be formed for example of a thermally insulating material or a composite material. Inside this cylinder, all components of the device are thus arranged in this casing. In the case of a horizontal cylinder, for example, from left to right, the outlet, if appropriate the filter, if appropriate the intermediate space, may optionally be filled with the active substance in this cylinder

Substrate, the compartment for storing the adsorbent, optionally the third compartment, optionally the nonwoven fabric, as well as subsequently the compartment for storing water are arranged. This arrangement of the components thus enables as short a path as possible (in the abovementioned exemplary arrangement on the right) generation of the aerosol and the removal of the aerosol (left in the exemplary arrangement described above).

In a further preferred embodiment, the sheath on the inner side at least partially comprises a (thermal) insulation, which includes the components of the device. Preferably, the insulation is only in the range formed in which the compartments are arranged, which have the adsorbent and thus generate heat when contacted with water. However, it is also possible that the insulation is formed continuously over the entire length of the cylindrical casing. The sheathing and insulation can be identical, but it is also possible that the insulation is a separate component.

It is also advantageous if a bypass is present in the device, which can be formed, for example, in the sheath but also in the insulation. The bypass can be designed as a supply line, the fresh air, for example, on the one or more filled with adsorbent compartments, can pass. Alternatively, however, it is also possible that the bypass may be formed as a lateral opening in the device, for example as an opening made through the sheath and / or the insulation, which may be arranged in the region of the intermediate space. In any case, fresh air, i. Air not laden with aerosol is supplied into the area of the device where ready aerosol is already present, so that the aerosol generated can be mixed with fresh air before it is removed from the device. For example, fresh air is drawn into the device when aerosol is withdrawn via the outlet, by a user pulling on the device via the outlet or mouthpiece attached thereto to inhale the generated aerosol.

In the event that the bypass passes by the respective compartments of the device, it may also be the case that the inlet of the bypass is performed through the entire device and also passes to the storage of the water serving compartment. The air flow supplied through the bypass thus runs parallel to the cylindrical casing in all compartments. The air flow through the bypass, which is generated when the aerosol is withdrawn via the outlet, can be used in a further advantageous embodiment to activate the possibly existing valve. It may be given that the valve has a means which is arranged in the region of the exiting air flow from the bypass. The valve can be actuated via the air flow leaving the bypass. The agent is designed such that it opposes the emerging from the bypass air flow resistance; For example, the means may be formed as a planar element, on which mechanical pressure is exerted by the air flow emerging from the bypass. This mechanical pressure can be used to actuate the valve.

The adsorbent is particularly preferably selected from the group consisting of silica gel, aluminum oxide, clays and / or zeolites, in particular zeolite 3A, zeolite 4A, zeolite 5A, zeolite 13X and mixtures and combinations thereof. Among the aforementioned adsorbents, zeolites are particularly preferred. In particular, in this case are the

Zeolite yps, with which a high heat generation at

Adsorption of water is achieved. In particular, it is advantageous in this case to use those zeolites which can be loaded with an inert gas, in particular nitrogen. During the loading process, before placing the zeolites in the each compartment can be carried out, the inert gas is introduced into the cavity of the zeolites. These loading processes are known to the person skilled in the art and can be carried out, for example, as follows: Water adsorbed on the zeolite is desorbed at 300 ° C. under reduced pressure. After cooling, the zeolite material is exposed to dry nitrogen, which is then partially adsorbed to the material. A particular embodiment of the invention thus provides that the zeolites contained in the compartment or the compartments are partially or completely loaded with an inert gas, in particular nitrogen. The purpose of this is that, when water is added to these zeolites loaded with inert gas, the inert gas is replaced by water, so that the inert gas, in particular nitrogen, is liberated from the zeolites. The liberated inert gases, in particular nitrogen, thus act as a propellant and support the aerosol formation particularly advantageous, so that a particularly efficient aerosol formation is made possible.

The amount of adsorbent and thus the size of the compartment or compartments containing the adsorbent is determined in each case according to the application. In devices that can be used for stationary purposes, for example, relatively large amounts of adsorbent in the compartment or the compartments can be stored. Exemplary amounts of adsorbent are between 1 cm ³ and 1,000 cm ³ , but are not limited thereto. In portable applications, in particular in the case where the device is designed as an artificial "cigarette", the size of the device is based overall on the orders of magnitude of, for example, a commercial conventional cigarette, ie the device is preferably cylindrical and about 5 to 30 cm, preferably 7.5 to 20 cm, more preferably 8 to 12 cm, in particular 10 cm long and 0.5 to 5 cm, preferably 0, 6 to 2 cm, more preferably 0.8 to 1.2 cm, in particular dimensioned 1 cm in diameter, the compartment that contains the adsorbent, or the compartments 10.1 to 10.9 of the Volu ^¬ mens this device can take. However, the details given are to be understood as examples and not limited thereto.

Further advantageously, the active ingredient is selected from a) pharmacologically active substances, in particular medicaments and / or nicotine,

b) flavorings, fragrances and / or flavorings,

c) lubricants as well

d) mixtures or combinations thereof.

As pharmacologically active substances substances can be used which are able to be converted into an aqueous aerosol. Suitable substances, in particular medicaments, are selected from the following particularly preferred substances, but are not limited thereto:

Proteins, polysaccharides, lipids, nucleic acid and combinations or mixtures thereof,

Nucleotides and / or oligonucleotides,

 - insultin, calcitonin, leuprolite and albuterol,

- Antibiotics, antivirals, fungicides, immunosuppressive drugs, non-steroidal anti-inflammatory drugs, surfactants, prostaglandins, mucolytics, antitussives, against Cough medication, throat pain medication, gene therapy vectors, heparin, ergotamine, human growth hormone,

Sildenaphil, antiproteases, vaccines, morphines, phentanyl,

 Antihistamines, decongestants,

Alkaline, mineral supplements, laxatives, vitamins, eg vitamin D3, antrazid, anticholesterolemic, anti-lipid, antiarrhythmic, antipyretics, analgesics, appetite suppressants, expectorants, anxiolytics, anti-ulcer, anti-inflammatory, heart medicines, medicines that act on the cerebral system, peripheral vasodilators, anti-infective agents, psychotropic drugs, antimanic drugs, stimulants, gastrointestinal agents, sedatives, diarrhea medications, angina medications, vasodilators, anti-hypertensive drugs, vasoconstrictors, migraine drugs, antibiotics, Sedatives, antipsychotics, antitumor drugs, anticoagulants, antithrombotic drugs, hypnotics, antimet- tics, drugs for the treatment of nausea, anticonvulsants, diuretics, antispastic agents, nontoxic supplements, mineral and nutritional supplements, anti-obesity preparations, anab ole substances, erythropoietic medicines, antiasthmatics, cough suppressants, mucin and anti-uricemic medicines, weight loss / anti-adiposity, acidotherapeutic, analeptics / antihypoxaemic, analgesics / antirheumatics, anthelminthics, antiallergic, antianemic, antiarrhythmic, antibiotics / anti-infective, antidementia (nootropics ), Antidiabetics, antidotes, antiemetics / antivertiginosa, antiepileptics, antihaemorrhagics (antifibri- antitumor agents, antihypoglycemics, antihypotonics, anticoagulants, antifungals, antiphlogistics, antitussives / expectorants, atherosclerosis agents, beta-receptors, calcium channel blockers and inhibitors of the renin-angiotensin-aldosterone system, broncholytics / antiasthmatics, cholagogues and Bile duct therapeutics, cholinergics, corticoids, diuretics, circulation-promoting agents, weaners / agents for the treatment of addictions, enzyme inhibitors / enzyme-deficient drugs and transport proteins, fibrinolytics, geriatrics

 Gout, anticonvulsants and cold remedies, gynecologics, hepatics, hypnotic / sedative drugs, hypophyseal / hypothelial hormones / - other regulatory peptides and their inhibitors, immunomodulators, ardiaka, coronary drugs, lipid-lowering drugs, gastrointestinal medications, migraine preparations, mineral preparations , Pharyngeal, neuropathic and other neurotropic agents, osteoporosis / calcium / bone metabolism regulators, Parkinson's and other anti-pyramidal drugs, psychotropic drugs, thyroid therapeutics, sera / immunoglobulins and vaccines, sex hormones and their inhibitors, antispasmodics / anticholinergics, antiplatelet agents, tuberculosis drugs, Umstimmungsmittel, urologics, venous therapeutics, vitamins, cytostatics / other antineoplastic agents u. Protectives.

The device according to the invention is particularly preferably suitable for producing an aqueous, nicotine-containing aerosol.

Furthermore, flavoring substances or flavorings can be mixed with the device according to the invention or the invention. The process according to the invention can be converted into an aqueous aerosol. Among flavors or

Flavored substances are understood as substances, as they are covered, for example, in the Flavor Regulation EC No. 1334/2008. Under fragrances are present in accordance with the sense of smell stimulating, chemicals ver ^¬ stood; For example, natural, nature-identical or synthetic fragrances, in particular substances from the organic aldehydes, esters and ethers, may be included.

The content of active ingredient is designed for the particular purpose. Pharmaceutically active substances can thus, based on the total amount of adsorbent, be contained in a concentration or total amount in the device that, for example, an aerosol is produced which contains the respective active substance in an effective concentration and thus a sufficient pharmacological effect can be achieved ,

Nicotine as well as a variety of drugs have strong hygroscopic properties. The consequence of this is that in the humid environment the lung is watery

Aerosol droplets containing nicotine can grow dramatically in fractions of a second and thus can not reach the peripheral lung tissue where resorption occurs. Aerosols in which the maximum of the droplet size distribution on the order of about two microns, are at bends not with the flow (bumps by particle or molecule) carried away, but drift due to the centrifugal force of its mass and ^"eventually collide with the wall and deposit because they are not hydrophobic in an area of the lung from which only has a ver ^¬ tively low resorption. Therefore, systems based on pure water do not work.

The dramatic growth of droplets has hitherto merely been counteracted by the addition of propylene glycol (1,2-propanediol). Propylene glycol is water-soluble; the significantly higher viscosity compared to water, the droplet growth in a humid environment, if at all, only slightly inhibited.

Already published are nebulizers that use lipids and phospholipids as solvents for nicotine but do not create stable aerosols with the background.

Laboratory experiments have shown that some hydrophobic substance classes can form very stable aerosols, which are not dramatically adsorbed by moist walls. They are substances that fall under the group of terpenes, liquid at room temperature as well as solid paraffins, fatty acids from C10 to C18 as well as fatty alcohols and cyclic

Siloxanes.

It is thus further preferred if in the device at least one hydrophobic substance, in particular selected from the group consisting of paraffin oils, terpenes, terpenoids, alkanecarboxylic acids, alkanecarboxylic acid esters, organic esters, fatty alcohols,

Siloxanes and / or mixtures or combinations thereof is contained. The hydrophobic substance can be dissolved, suspended or dispersed, for example, in the compartment containing water. Likewise it is possible that the hydrophobic substance is mixed with the adsorbents, which in the respective Compartments or the compartment are present. Furthermore, it may be possible for the optionally present substrate to contain the hydrophobic substance. The hydrophobic substance is thus entrained in the generation of the aerosol from the resulting water vapor or aerosol droplets and is deposited on the surface of the per se polar water droplets. This leads to a

Hydrophobing of the respective water droplets in Aerosol, so that agglomeration or condensation of the drug-loaded water droplets of the aerosol generated is largely prevented. This hydrophobing by the hydrophobic substance thus leads to an efficient stabilization of the aerosol produced, which, for example, has a markedly positive effect on the service life and the respiratory passability of the aerosol, since it can thus be prevented that the aerosol is already on the oral mucosa, for example during inhalation or the bronchial tubes. The generated aerosol can thus be conducted particularly efficiently up to the alveoli.

Examples of substances for the o.g. Substance classes are for example:

AI no

 Liquid paraffin oil

Isohexadecan

Terpenes / terpenoids

 Squalene, squalane, farnesene

Alkanecarboxylic acids

Saturated, eg isostearic acid, caprylic acid; unge ^¬ saturates fatty acid ester

 Fatty acid triglycerides, isopropyl palmitate,

Octyl palmitate, octyl isostearate, isopropyl palmitate, isononyl stearate, ethylhexyl palmitate, oleyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate

ester

 C12-C15 alkyl benzoate, butyl octyl salicylate

fatty alcohols

from C8 to C14

siloxanes

 Polydimethylsiloxane (dimethicone),

Decamethylcyclopentasiloxane

From the group of terpenes there are some physiologically acceptable compounds such as

 • Farnesol (boiling point approx. 157 ° C)

 • Fenchol (boiling point about 68 ° C) (smell!)

 • Phytol (boiling point approx. 202 ° C) u.a.

 • Squalene (boiling point approx. 175 ° C)

 • Sgualan (boiling point approx. 350 ° C)

From the group of cyclisehen siloxanes comes

Cyclopentasiloxane (decamethylcyclopentasiloxane) and cyclohexasiloxane (Dodecamethylcyclohexasiloxan) in question. The former is often found in cosmetics such as hair sprays, skin creams, deodorants and the like. and it is also completely odorless.

The best results were obtained at room temperature with solid paraffins and with all the fatty acids mentioned above. In experimental use, the substances were heated above the melting point and finely atomized by means of apparatus. The cooled aerosol is made of the finest solid particles, which then turns out to be very inert. In addition, the water-soluble nicotine dissolves significantly better in these substances than in water. Also suitable as good aerosol fatty alcohols.

It is further preferred if the device contains an evaporation accelerator, in particular selected from the group consisting of 2-oxo acids, in particular pyruvic acid. Like the hydrophobic substance described above, the evaporation accelerator may also be dissolved, suspended or dispersed in the water of the hydrous compartment. Alternatively or additionally, however, it is also possible that the evaporation accelerator mixed with the adsorbents or applied to the substrate is contained in the device. The evaporation accelerator brings about an efficient conversion of the active ingredient into the aerosol phase, so that it is particularly preferred

Execution form can be ensured that the active ingredient is transferred as completely as possible in the aqueous aerosol. It is also possible that the device includes both a hydrophobic material and an evaporation accelerator. Preferred evaporation accelerators are selected from the group consisting of 2-oxo acids, in particular pyruvic acid. In order to evaporate e.g. of nicotine with one

Boil point of 360 ° C or to promote drugs at significantly lower temperatures, evaporation accelerators are used. It is shown experimentally that a small group of 2-oxo acids, such as pyruvic acid, improve the passage of nicotine into the gas phase, while by far the largest Part of organic as well as some inorganic acids such as phosphoric acid affect the evaporation very negative. The best results have so far been achieved with pyruvic acid.

The reason for this phenomenon lies in the more or less strong interactions between the organic acids and the basic nicotine and the resulting entropy effects in the evaporation. On closer understanding of the mechanisms, the substance classes in question can be expanded. It can be seen that strong organic acids which contain no carboxyl group as well as some heteroaromatics can be used for this purpose.

Evaporation accelerators can be metered, for example, stoichiometrically or slightly more than stoichiometrically to the active ingredient component. The present invention also relates to a process for producing drug-loaded aqueous aerosols in which water is applied to an adsorbent for water that adsorbs water to release heat of adsorption, wherein a portion of the water is adsorbed by the adsorbent and another portion of the water is evaporated by the heat of adsorption, wherein at least one active ingredient is dissolved, emulsified or suspended in the water and / or mixed with the adsorbent and / or contained in a separate substrate, which is acted upon by the water vapor, wherein the active ingredient dissolves in water vapor and so an aerosol is formed.

Preferred embodiments of the method will be described below. The method according to the invention can be carried out particularly preferably with the device described above. In this embodiment, the process according to the invention is characterized in that water is taken from the water-containing compartment and fed to the compartment containing the adsorbent. The water is partially adsorbed by the adsorbent with heat generation, wherein the heat development is preferably controlled so that temperatures> 100 ° C, more preferably between 100 and 200 ° C, in particular between 140 and 160 ° C, are achieved. In this case, part of the discontinued water is transferred into the vapor and / or aerosol phase. The generated aerosol is carried out via the outlet. This can take place automatically, since an increase in volume takes place when liquid-supplied water is transferred into the aerosol phase, so that the aerosol is squeezed out of the outlet. The active ingredient may be contained in the water, which is fed into the compartment containing the adsorbent, for example in the form of a solution, emulsion or dispersion. Alternatively or additionally, it is also possible that already the adsorbent is loaded with an active ingredient. This loading can be designed, for example, such that prior to introduction of the adsorbent into the compartment or compartments provided, the adsorbent is mixed with the active substance, for example in the case of a liquid active substance by mixing this liquid active substance or a solution or emulsion or dispersion thereof the adsorbent. It is also possible that in the case of solid active ingredients, a physical mixing of the adsorbent with this solid active ingredient, for example in the form of a Powder, before introducing the Adsorptionsmi els in the space provided compartment.

Additionally or alternatively, it is also possible that the substrate - in the event that it from the

Device is - loaded with the drug. The loading of the substrate is also preferably carried out before introducing the substrate into the device.

The transfer of the water from the compartment provided for this purpose into the compartment or the compartments containing the adsorbent can be carried out in any desired manner according to the process of the invention. For the particularly preferred case that the adsorbent-containing and water-containing compartments are arranged in close proximity to each other, it is preferred if the water-containing compartment is equipped with a predetermined breaking point and a mechanical means for breaking this predetermined breaking point. Thus, for example, when applying a pressure on the mechanical means, the wall of this water-containing compartment can be broken at the predetermined breaking point and thus leak water from the compartment. Thus, an in-situ activation of the device according to the invention is possible.

Alternatively, it is also possible that the water-containing compartment is disposed within the adsorbent-containing compartments or compartment and has a wall which becomes mechanically unstable upon exertion of pressure or upon application of external heat and bursts, breaks or melts, for example so that water can escape from the compartment. Beispiels- For example, the wall of the water-containing compartments can be formed from a thermoplastic elastomer which becomes mechanically unstable when heated above the melting range.

A further alternative envisages that the water from the compartment provided for this purpose can be metered into the compartment for the adsorbent so that both a continuous and metered release of water is possible.

This dosage may e.g. by means of a valve or cock placed between the water compartment and the adsorbent compartment. Thus, according to this embodiment, the amount and the nature of the application of the water (continuous / discontinuous) can be used to control the amount and intensity of the generated aerosol stream. This is particularly advantageous when used in the lubricant sector.

The removal of the aerosol from the device according to the invention takes place automatically in a basic embodiment of the method according to the invention, ie upon a single activation of the device pressurized aerosol is generated which flows out via the outlet. In the event that there is a perforated tube as described above, which carries out the aerosol from the place of production, this tube can be particularly advantageously equipped with a valve that controls the aerosol removal, so that the aerosol only removed when needed can be. The valve is preferably designed such that it opens when generating an air flow through the device according to the invention and automatically closes again after removal of this air flow at removal. The present invention will be explained in more detail with reference to the following embodiments and the attached figures, but without limiting the invention to the preferred embodiments shown there.

1 shows a first embodiment of a device according to the present invention,

FIG. 2 shows a cross section through the device according to the invention shown in perspective in FIG. 1,

FIG. 3 shows a detail of the device according to the invention, which represents the water-containing compartment, as well as FIG

Figure 4 shows a further embodiment of the device according to the present invention in perspective and in section. The reference symbols used in the figures have the following meaning:

1 device

 2 compartment for adsorbents

2 'compartment for adsorbents

 2a inlet

 3 compartment for water

 4 water-wicking fleece

 5 perforated tube

6 plate

7 outlet 8 filters

 9 gap

 10 predetermined breaking point

 11 thorn

 IIa punching tube

 12 insulation

 13 substrate

 13a opening

 14 sheathing

 15 bypass

 15a inlet

 15b outlet

 16 valve

 17 nozzle

 18 levers

 19 spacers

FIG. 1 shows an embodiment of the device 1 for producing active substance-laden aqueous aerosols according to the present invention, which according to the embodiment shown in FIG. 1 is designed as an inhaler, for example as a smoke-free cigarette. The device 1 is cylindrical and bounded by a casing 14. The sheath 14 is formed continuously over the entire length of the cylinder. The apparatus comprises a (first) compartment 2 containing an adsorbent, for example a zeolite. This compartment 2 is shown in Figure 1 on the left and limited by a plate 6, which is impermeable to the aerosol or water vapor and / or water. The compartment 2 is bounded on the right by a water-wicking web 4; this point represents the water inlet 2a for the compartment 2. In the compartment 2 protrudes a perforated tube 5, wherein the perforations as a dotted Positions are shown in Figure 1. The tube 5 can, as shown in FIG. 1, be centered and fixed by a spacer 19 in the compartment 2. The tube 5 is passed through the plate 6 and thus guarantees the fluidic communication of

Compartment 2 via the perforations with the left of the compartment 2 arranged intermediate space 9. To the left of the gap 9, a filter 8 may be arranged, via which the generated aerosol emerges at the outlet 7. In the illustrated in Figure 1 the case of the filter 8 may represent the mouthpiece with associated outlet 7, as well, it is possible that another sepa rates ^¬ mouthpiece is attached to the outlet. 7 Shown on the right in FIG. 1, next to the water-wicking nonwoven, is a water-containing compartment 3. This compartment 3 has a wall which adjoins the nonwoven 4. As shown in FIG. 1, this wall has a plurality of predetermined breaking points 10, via which a respective mandrel 11 is arranged, with which the predetermined breaking point 10 can be broken. The device 1 is activated by pressure on the mandrels 11, wherein the mandrels 11 pierce the predetermined breaking points 10. When piercing water from the compartment 3 reaches the water-absorbent nonwoven fabric 4, so that by capillary forces emptying of the compartment 3 takes place by water is absorbed by the nonwoven fabric 4. The nonwoven 4 transfers the absorbed water to the compartment 2, which contains the adsorbent, for example zeolites. The zeolites begin

Adsorb water with heat generation, ie store it, so that a water vapor development of aerosols begins. The aerosols gradually fill the entire space of the adsorbent-filled compartment 2 and pass through the perforations of the tube 5. Due to the resulting over- pressure during the formation of aerosol, the resulting aerosols are also forced out through the interspace 9 through the filter 8 and finally exit via the outlet 7. According to the invention, it is provided that at least one active substance, for example nicotine, is contained in the device. This active ingredient may be dissolved, emulsified or dispersed, for example, in the water of compartment 3. It is likewise possible that the active ingredient is mixed with the adsorbents contained in Part 2.

It is also possible that another adsorption ^¬ medium 2 * is included in the apparatus 1, for example as shown in Figure 1, may be disposed between the spacer 19 and nonwoven fabric. 4 In this case, only the compartment 2 is filled with adsorbents which are drug-loaded, ie mixed with active ingredient, while the adsorbent contained in compartment 2 is free of active ingredient. This design requires a predominantly aerosol development in the compartment

2, the loading of the aerosol with active ingredient then takes place only in compartment 2. For example, in the case of nicotine as active ingredient, this may be present in compartment 2.

Figure 2 shows a cross section through the device shown in perspective in Figure 1, in particular, the implementation of the tube 5 is shown in more detail by the plate 6. It can also be seen that in the compartment 3 an opening is present in order to be able to compensate for any resulting overpressure in the device 1 when activated. In Figure 2, the exemplary dimensioning of the device 1 is also shown, for example, the length of the device 1 can be 100 mm and 10 mm in diameter ^¬ ser. The compartment 3 is, for example, 15 mm, starting from the right side of the device 1, while the tube 5 for discharging the aerosols can be for example 65 mm long. The compartment 2 may, for example, occupy up to 75 mm of the entire length of the device 1.

Figure 3 shows a detailed view of the water-containing compartment 3. Figure 3 also shows a punch tube IIa as further mechanical ele- ment to break the respective frangible Stel ^¬ len.

The autonomous energy supply of the device according to the invention for the production of aerosols is based on the principle of the release of heat of adsorption by the addition of water to, for example zeolites with simultaneous desorption of a gaseous

Propellant. Particularly suitable are zeolites of the type 3A, 4A, 5A and 13X, which are specially prepared in the preparation of the aerosol device 1 according to the desired properties. The preferred type is 4A, since relatively large amounts of nitrogen can be adsorbed thereon. Upon initiation of the device, it is desorbed by the zeolite and can function as a propellant for the resulting aerosol. Large molecules such as nicotine are not adsorbed by the zeolite material due to the small mesh size of the selected types. Upon initiation of the inhaler 1 e.g. by perforation of the water tank 3, water is distributed in the adjacent tile 4 and enters the with

Zeolite filled room. The zeolite adsorbs the water, releasing heat. Temperatures of more than 150 ° C. are produced directly on the zeolite particles. Excess water evaporates. ser. Due to the air flow generated during inhalation, the moisture front reaches all zeolite particles in a short time. The active substance or part of the active substance can be present in zeolite particles which act as a porous carrier material. These loaded zeolite particles are located in the zeolite filling between

uncharged zeolites. As a result of the heating process, assisted by the released nitrogen, nicotine, like a steam distillation, enters the gas space together with the other feed components as an aerosol. This aerosol is transported with the help of the air flow when inhaling directly in the direction of the perforated inner tube 5. This arrangement ensures that the aerosol only takes a very short path through the zeolite layer. This prevents a large proportion of aerosol droplets from re-precipitating on the very porous zeolite material.

The inhaler is thus constructed in principle as follows.

The device 1 consists of an approximately 10 to 12 cm long outer tube 14 with about 8 mm to 12 mm in diameter, which consists of a very good heat insulating material 12 is.

Inside, the apparatus 1 is divided into three parts:

1) The water tank 3 at the end of the cigarette with a filling volume of 0.4 to 0.5 ml and an integrated starting device. 1 2) The zeolite filling of about 5 to 7 cm ³

 Filling volume in the middle part 2.

 3) in the front part directly on the mouthpiece

 There is a void (9), which acts as a buffer for the resulting aerosol.

The water tank 3 can easily be under tension, e.g. with the help of a small spring, so that an almost complete emptying during operation is guaranteed. The attached to the water tank starter 11 or IIa is initiated by destroying a predetermined breaking point 10. If the chamber 3 filled with water at the end of the cigarette 1 is opened by a mechanism, for example a mandrel 11, water flows into the water-sucking fleece 4 which is directly in connection with the zeolite filling 2.

The zeolite adsorbs water and the resulting heat of adsorption is sufficient to produce water vapor. If the smoker breathes over the cigarette, the water vapor produced at the tip wanders through the zeolite filling and causes a rise in temperature in the cigarette body to approx. 150 ° C. Despite the higher boiling point of nicotine (about 270 ° C) then relevant amounts of nicotine-containing aerosol are in the gas phase. The perforated inner tube 5 is used for rapid removal of the aerosol to the mouthpiece 7,

The previously made functional embodiments also apply to the embodiment shown in Fig. 4.

FIG. 4 shows a further embodiment of a device 1 according to the present invention (in perspective in FIG. 4a, in FIG. 4b in FIG Cut) . This device 1 is also cylindrical in shape and limited by a sheath 14 which is formed over the entire length of the cylinder. As shown in Figures 1 to 3, the device 1 has a compartment

2 for storing an adsorbent, such as a zeolite, which is bounded on the right side by a water-wicking nonwoven, followed by a compartment 3 for storing the water is connected. In this case, the compartment 3 may be formed as shown for example in FIG. In addition, the device 1 according to FIG. 4 has a substrate 13, which may be formed, for example, from cellulose. This substrate 13 is loaded with active ingredient. The compartment 2 and the

Substrate 13 are sealed off from the intermediate space 9 by a vapor-tight and aerosol-tight plate 6, wherein a perforated tube 5 is guided through this plate and protrudes into the substrate 13. According to the already in the previous ones

Figures explained principle, the activation of the device 1 takes place by abandoning the originating from the compartment 3 water through the nonwoven fabric 4 via the inlet 2a in the compartment 2, wherein a vaporization and aerosol formation of the water takes place.

The water aerosol can penetrate into the substrate 13 via the opening 13a and receive the active substance there. The active substance-laden aqueous aerosol thus becomes through the perforations in the tube 5 from the compartment 2 or the substrate 13 into the intermediate space

9 discharged. The tube 5 projects into the intermediate space 9 and has a nozzle 17 at the end. In addition, a valve 16 on the pipe 5 is formed, which can be switched between a closed and an open position, so that only geöffne ^¬ ter position of the valve the aerosol into the intermediate space 9 and thus finally reach the outlet 7 of the device 1 via the filter 8. The device 1 according to FIG. 4 furthermore comprises an insulating layer 12 which is formed between the casing 14 and the compartment 2, the compartment 3 and the nonwoven fabric 4. The insulation 12 prevents resulting heat from being conducted to the outer surface of the shroud 14 and allowing a user to burn on the device 1 when activated. In addition, a bypass 15 is passed through the insulating layer 12 and is in fluid communication with the environment of the device 1 via an opening 15a. In addition, the valve 16 has an actuating element 18, for example a lever or a spring, via which the valve 16 can be opened. In the event that a user removes aerosol, for example by creating a negative pressure by pulling on the outlet 7 (eg with the mouth), air flows from the opening 15a through the bypass 15 and flows through the outlet 15b of the bypass. The air flow acts on the lever 18 of the valve 16, whereby the lever 18 is deflected and the valve 16 is opened. When the valve is opened, the aerosol flows out through the tube 5 via the nozzle 17 and mixes with the air volume located in the intermediate space 9. Pull on the outlet 7

(Generation of negative pressure) can thus be removed from the aerosol. By the valve 16 thus control of the aerosol removal is only possible if necessary, so that a targeted dosage of the drug-loaded aerosol is possible.

Claims

claims Device (1) for producing drug-loaded aqueous aerosols, comprising a) at least one compartment (2) for storing an adsorbent for water, which adsorbs water with the release of heat of adsorption, wherein due to the released adsorption arms, a part of the water is transferred into the gas phase, b) at least one compartment (3) for storing water, which is configured in such a way that, when the device (1) is activated, water can be transferred into the at least one compartment (2) for storing the adsorbent, c) at least one active substance which is used in the  Compartment (3) dissolved water, emulsified or suspended and / or mixed with the adsorbent contained in the compartment (2) and / or on a separate substrate (13) or a storage vessel between the compartment (2) and an exhaust (7) is arranged, applied or contained, as well as d) at least one outlet (7) for the generated aerosol, which is in fluid communication with the at least one compartment {2) and / or the substrate (13) or the storage vessel. Device (1) according to claim 1, characterized in that the compartment (2) and / or the substrate (13) at least one projecting into its interior and from the compartment (2) and the substrate (13) leading out tube (5) comprises whose wall has perforations at least in the part projecting into the compartment (2) or into the substrate (13) or the storage vessel. Device (1) according to the preceding claim, characterized in that the compartment (2) and / or the substrate (13) is delimited by a plate (6) impermeable to water, water vapor and / or aerosols, through which the tube (5) is performed. Device (1) according to one of the two preceding claims, characterized in that the tube (5) has at least one valve (16) for regulating the aerosol flow. Device (1) according to one of the preceding claims, characterized in that arranged between the outlet (7) and compartment (2) and / or the substrate (13) or the storage vessel at least one filter (8) and / or an intermediate space (9) is. Device (1) according to one of the preceding claims, characterized in that a) the compartment (2) an inlet area (2a) for water originating from the compartment (3) and the compartment (3) is arranged at the inlet area (2a), the compartment (2) and the compartment (3) preferably being supported by a layer (4) of a porous sen material, in particular a layer of a non-woven are separated from each other and / or b) the compartment (3) is arranged within the compartment (2). Device (1) according to one of the preceding claims, characterized in that the compartment (3) a) has a wall with at least one predetermined breaking point (10) and at least one mechanical means (11) for breaking the wall at least in the region of at least one predetermined breaking point (10) and / or b) is under mechanical tension. Device (1) according to one of the preceding claims, characterized in that between the compartment (2) and the compartment (3) at least one further compartment (2 ^l ) is arranged, wherein the compartment (2) mixed with active substance adsorbent and the further compartment (2 ¹ ) contains active ingredient-free adsorbent. Device (1) according to any one of the preceding claims, characterized in that the compartment (2) and / or the further compartment (2 ¹ ) are segmented, preferably by a plastic film, which in particular melt at temperatures between 60 ° C and 250 ° C. or can shrink. Device (1) according to one of the preceding claims, comprising a casing (14), the compartment (2), the compartment (3) and includes any other existing components. Device according to the preceding claim, characterized in that the casing (14) a) on the inside at least at locations an Isolie ^¬ tion (12), in which the compartments (2, 3) and optionally existing further components are embedded and / or b) a bypass (15) for guiding a flow of fresh air past the compartments (2, 3) as well as optionally existing further components having . Device (1) according to one of the preceding claims, characterized in that the adsorbent is selected from the group consisting of silica gel, alumina, clays and / or zeolites, in particular zeolite 3A, zeolite 4A, zeolite 5A, zeolite 13X and mixtures and combinations thereof , Device (1) according to the preceding claim, characterized in that the zeolites are at least partially or completely loaded with an inert gas, preferably nitrogen. Device (1) according to one of the preceding claims, characterized in that the active substance is selected from the group consisting of a) pharmacologically active substances, especially drugs and / or nicotine, b) flavorings, fragrances and / or Flavored, c) lubricants as well d) mixtures or combinations thereof. Device (1) according to one of the preceding claims, characterized in that the compartment (2) and / or the compartment (2 ') and / or the compartment (3) and / or the substrate (13) or the storage vessel additionally a) at least one hydrophobic substance, in particular a hydrophobic substance selected from the group consisting of paraffin oils, terpenes, terpenoids, alkanecarboxylic acids, alkanecarboxylic acid esters, organic esters, fatty alcohols, siloxanes and / or mixtures or combinations thereof, b) an evaporation accelerator, preferably selected from the group consisting of 2-oxo acids, in particular Brenzt aubensäure and c) combinations or mixtures thereof. A process for producing drug-loaded aqueous aerosols, wherein water is applied to an adsorbent for water that adsorbs water to release heat of adsorption, wherein a portion of the water is adsorbed by the adsorbent and another portion of the water is vaporized by the heat of adsorption, wherein at least one active ingredient is dissolved, emulsified or suspended in the water and / or mixed with the adsorbent and / or contained in a separate substrate, which is supplied with the water vapor, wherein the active ingredient dissolves in water vapor and so an aerosol is formed.