RU125072U1 - NOSE INHALER - Google Patents

Abstract

The invention relates to devices for the inhalation method of delivering various drugs, including essential oils and plant extracts, to the nasal cavity of the human body for prophylactic, restorative and wellness purposes by forming a cloud of volatile components of the active substance in the immediate vicinity of the nasal receptors for their inhalation. by man.

The inventive inhaler for the nose in all variants contains a hollow body 1, inside of which, with a gap, a source of the active substance is placed, made in the form of a molded porous cartridge 2 and filled with the active substance.

On the upper end surface of the housing 1 there is an outlet 3, at the base of the housing 1 in its side surface there are holes 4 for the passage of atmospheric air into the cavity of the housing 1, and a stopper 5 is placed at the lower end of the housing 1.

The housing 1 is provided with a sealing cap 6.

To ensure the safety of the active substance placed in the porous cartridge 2, and at the same time its directed supply to the outlet 3 of the housing 1, at least one of the closed surfaces of the cartridge 2, for example, the lateral surface of the cylinder, is enclosed in a moisture-proof casing 7, whose thickness is 0 , 03-5.35 mm (figure 1).

In the second embodiment, the area of the outer surface of the cartridge 1, not enclosed in a moisture-proof casing 7 and placed at the outlet 3 of the housing 1, is equal to the area of the outer surface of the cartridge 2, not enclosed in a moisture-proof casing 7 and placed on the opposite side of the cartridge 1.

In the third embodiment, the area of the outer surface of the cartridge 1, not enclosed in a moisture-proof casing 7 and placed at the outlet 3 of the housing 1, is larger than the area of the outer surface of the cartridge 2, not enclosed in a moisture-proof casing 7 and located on the opposite side of the cartridge.

In the fourth embodiment, the area of the outer surface of the cartridge 1, not enclosed in a moisture-proof casing 7 and placed at the outlet 3 of the housing 1, is smaller than the area of the outer surface of the cartridge 2, not enclosed in a moisture-proof casing 7 and located on the opposite side of the cartridge. 4 bp F., 9 ill.

Description

The invention relates to devices for the inhalation method of delivering various drugs, including essential oils and plant extracts, to the nasal cavity of the human body for prophylactic, restorative and wellness purposes by forming a cloud of volatile components of the active substance in the immediate vicinity of the nasal receptors for their inhalation. by man.

The advantage of inhalation therapy over other methods is a more rapid flow of drugs to the nasal receptors, increasing the active surface of the substance, depositing it in the submucosal layer (rich in blood and lymphatic vessels), creating high concentrations of active substances directly in the source of consumption.

It is well known that the surface area of the human nasopharyngeal mucosa is about two square meters and the distribution of volatile particles of active agents on the nasal mucosa has an effective prophylactic value.

Passive aerosol clouds of liquid fractions are divided by particle size into high, medium and low dispersed.

The smaller the aerosol particles, which, as a rule, are the volatile component of all substances, the longer they remain in the flow of inhaled air and the deeper they penetrate into the nasal respiratory tract.

Particles with a diameter of 8-10 microns usually settle in the oral cavity, 5-8 microns - in the pharynx and larynx, 3-5 microns - in the trachea and bronchi, 1-3 microns - in the bronchioles, 0.5-2 microns - in the alveoli, and volatile components of substances are distributed in the nasal zone of perception of the surrounding aromatics.

The restorative and recreational use of the volatile components of essential oils and plant extracts is called "aromatherapy" and is generally accepted as a valuable branch of complex cosmetic effects, and its popularity is growing rapidly.

Exposure to biologically active substances present in the air at human receptors is due to the fact that they perceive volatile aromatic substances and a part of nonvolatile, but useful, directional ingredients directly applied to them, depending on the state of the person.

The volatile components of essential oils, plant extracts as components of amplification and preservation of the aromatic component, as a rule, used in therapy with their “aromas”, also have their own various chemical and biological properties that require specific delivery and storage conditions and should be convenient to use.

The introduction of certain volatile substances into the air mass as close as possible to human receptors should have a positive effect associated with the improvement of microcirculation, diffusion of oxygen and nutrients into the cells, activation of excretion of "slags" and for this it is necessary to meet certain storage and delivery requirements.

The first is the distance between the outlet of the air inhalation device and human receptors.

The second is the delivery to the place of perception of a single volatile dose of a substance without losing its functional properties, which are accumulated in the storage of the device.

The third is to eliminate as much as possible the effect on the active substance of the external environment during storage and use.

Fourth, to exclude as much as possible the unauthorized release of the liquid and volatile component of the active substance to the outside of the device storage.

Components of active substances, as a rule, essential oils and / or extracts should be ingested in the body in unchanged form (native), i.e. in such that it is contained in nature and carry out an effect on a living organism, based on the task set before the design of the device for nasal inhalation.

The storage should be easily filled, but at the same time provide storage of the substance with minimization of losses and negative environmental effects.

We believe that the theory and practice of using porous bodies should be used as a convenient and highly efficient system of storage and supply of liquid to the place of its use.

Porous bodies have long been used for storing, for example, aromatherapy agents, but basically they are porous bodies that are not formed into a specific structure and are not of origin for this purpose, for example, part of a woven or nonwoven material.

For example, a well-known inhaler "Inkamf", which is a plastic tube with a lid, in which a piece of felt and fabric is impregnated with a composition comprising camphor, menthol, mentholy salicylic acid ester and eucalyptus oil (see,).

A pocket inhaler is known, in which a cotton swab is impregnated with 1-2 drops of essential oil (see).

The period of active action of such inhalers is low no more than 2-3 hours.

Known inhaler, consisting of two parts: a small container filled with essential oils at the bottom and an oil dispenser on top (see).

Known are more complex in design pocket inhalers, for example, using ultrasound vibrations to spray the active mixture (see), or an inhaler containing a reservoir with a solution of a medicinal substance, a pressure tube passes through the bottom of the reservoir, which is connected to a rubber balloon, while the suction tube is at one end immersed in the solution, and the other end is located above the outlet of the injection tube, the ends of which form a pneumatic nozzle (see).

Known inhaler, comprising a housing with a lid, forming a mixing chamber, connected to the outlet of the lid, placed in the cavity of the housing absorbent with a smell substance, while the lid is mounted on the housing to move in the axial direction, the hole in the lid is made triangular at an angle to the central axis , in the upper part of the cover a flexible membrane is installed, and the body tip is made of a material that allows landing with pressure on the writing element (see RF patent №2150965, IPC А61М 15/00, publ. 20.0 6.2000

A disadvantage of the known design of the inhaler is the inconvenience of use due to the fact that the supply of the active substance is carried out only by creating excessive pressure by mechanical action on the membrane.

Known inhaler, housing with an outlet, a replaceable cartridge with the active substance, installed in the cavity of the housing and adjacent to one of its sides, while in the housing from the junction of the cartridge made movable stop, and on the other hand - the membrane (see patent KR 20100032662, IPC А61М 15/00; А61М 15/02; А61М 16/00, published on September 18, 2008).

The disadvantage is the dependence of the concentration of the diluted air flavor of the drug on the container in which the undiluted substance is stored and it is not possible to provide the concentration of the active substance in the amount that can have the desired effect on the human body.

In addition, a disadvantage of the known design of the inhaler is the inconvenience of use due to the fact that the supply of the active substance is carried out by creating an indefinite volume of air mass due to uncontrolled mechanical action on the membrane.

Known inhaler, comprising a housing, inside of which is made a mixing chamber with a breathing hole, in which is placed a cartridge impregnated with an inhalation mixture, while the inhaler further comprises a saturation chamber in communication with the mixing chamber, with air holes on the side surface of the housing located near the boundary between the mixing chamber and the saturation chamber, while the cartridge is preferably made of acetate fiber wrapped in an insulating Umag (see. RF №110643 patent IPC A61M 15/00, publ. 27.11.2011 city).

A disadvantage of the known utility model is the unreasonably increased distance of the saturation chamber behind the source of biologically active substance and the place of its consumption, since the design does not provide for the separation and / or mixing of the respiratory mixture and its odor part.

The description of the patent does not reflect the influence of the design on this process, since it is obvious that in a single closed space the composition of the aerosol cloud is one and adding the smell part from the cartridge to it is not explained, nor is it clear what is meant by this definition.

It also does not follow from the description of what the difference between the concentration of the odor substance in the "respiratory" and "inhalation" mixtures is provided for and how, since the flow of volatile matter from the cartridge into the air medium presupposes its saturation to the extent that the air medium contains some of the volatile substances.

From the description it follows that the saturation chamber and the mixing chamber do not have any closures between themselves, i.e. in fact, they form a single cavity at the “working end” of which the cartridge is located and it is from this place that the outside air is flavored.

Therefore, the creation of an additional camera behind the cartridge with a larger volume than the saturation chamber unreasonably reduces the concentration of the substance in the air, and the design does not reduce the negative impact on the cartridge's substance from the environment, reduces the activity and effectiveness of the substance on the human body.

According to the well-known utility model, the cartridge is cylinder-shaped of acetate fiber wrapped with an insulating paper, i.e. acetate fiber, which can be a porous body only under certain conditions and has low moisture-absorbing properties, with not properly formed pores of the material with respect to the outlet, which cannot guarantee the direction of fluid supply and the integrity of the substance’s origin and the necessary duration of work.

In addition, the paper does not provide for its functional properties the necessary protection of the substance in the cartridge, both from environmental exposure and from unauthorized penetration of the liquid component of the substance to the outside of the cartridge.

The closest is an inhaler containing a hollow cylindrical body inside which a source of medicinal substance is placed, and an outlet opening is made at the end of the body, and it contains a protective cap connected to the body by means of a threaded connection, on the lower part of the body there is an annular base, the outer surface of which made ribbed, above the base of the case there is a section with an external thread; above the indicated section there is a cylindrical landing pad, in the side surface These radial holes are made, and a protective plug is fixed at the base of the case from its lower end, and an elastic porous material impregnated with a composition of medicinal substances is used as the source of the medicinal substance (see RF Patent No. 34868, IPC А61М 15/08, publ. 20.12 .2003)

A disadvantage of the known design of the device for medicinal therapy is that in the design of the storage of medicinal substance as the main element of aeration of air during inhalation, there is no possibility of safe and effective conditions for the storage and use of liquid substances containing volatile components.

Known inhaler does not provide constructive control of the process of accumulation and issuance into the chamber of accumulation of a significant part of the volatile component of the active means, including when combined with drugs, as well as the liquid medium, which is the basis for issuing the volatile component, as the source of drugs According to the drawing, it is not formed into a single body, which has the design features of a molded porous body and fills the entire space of the body cavity without restriction.

This prevents the formation of an effective air movement to the place of consumption, which should include in its composition the volatile substances of drugs and form an air mass containing volatile substances before use in the form of an accumulated cloud.

In addition, the well-known design limits the possibility of its use to preserve the quality and nativity of the most volatile components of active substances, since the description directly contains an indication of the use of the device mainly by the method of introducing it into the nasal cavity.

The device does not provide, therefore, ensuring the barrier-protective function of the substance’s storage as from the penetration of negative factors from the environment, from unauthorized release of the liquid component to the outside of the substance storage, and the possibility of providing a directional supply of a certain portion of the volatile components of the active substance.

The form uncertainty of the source of active substances that fills the entire cavity eliminates the creation of a single stream of air and volatile substances along the source of substances and the walls of the body to facilitate the process of inhalation of useful substances with the least effort in a shorter period.

The description indicates the uncertainty in the design of the porous component of the source of substances, porous orientation and structure, which excludes the supply of the substance to the place of consumption in an effective composition for a shorter period of time.

The objective of this utility model is to increase the efficiency of storage and delivery when using the active substance with volatile components in an unchanged quality and in sufficient quantity.

The technical result achievable as a result of the solution of the task is to provide a barrier function for maintaining the effectiveness of the active substance and at the same time directing it from the porous substance in less time and with less effort for the consumer to the outlet of the body while maintaining the dose of the biologically active substance of unchanged quality, by constructive influence on the phase equilibrium of liquid-vapor media (volatile components of the active substance).

The task is achieved by the fact that in the inhaler for the nose in the first embodiment, containing a hollow body inside which is located a source of active substances, and a protective cap, while the outlet and the passage of atmospheric air into the body cavity are made on the body, and at the base the casing is located at its bottom end; according to the utility model, the source of active substances is made in the form of a molded porous cartridge, at least one part of at least one of them is closed x external surfaces of which are enclosed in a moisture-proof shell, the thickness of which is 0.03-5.35 mm, while the cartridge is placed relative to the inner surface of the housing with a gap.

In this case, the gap between the inner surface of the housing and the cartridge is at least 0.1 mm.

The task is achieved by the fact that in the inhaler for the nose according to the second embodiment, comprising a hollow body inside which is placed a source of active substances, and a protective cap, while the outlet and the passage of atmospheric air into the body cavity are made on the body, and at the base the casing is located at its bottom end; according to the utility model, the source of active substances is made in the form of a molded porous cartridge, at least one part of at least one of them is closed x external surfaces of which are enclosed in a moisture-proof casing, whose thickness is 0.03-5.35 mm, and the area of the external surface of the cartridge, not enclosed in a waterproof casing and placed at the outlet of the housing, is equal to the area of the external surface of the cartridge not enclosed in a waterproof casing and placed on the opposite side of the cartridge, while the cartridge is placed relative to the inner surface of the housing with a gap.

In this case, the gap between the inner surface of the housing and the cartridge is at least 0.1 mm.

The task is achieved by the fact that in the inhaler for the nose according to the third variant, comprising a hollow body inside which is placed a source of active substances, and a protective cap, while the outlet and the passage for atmospheric air into the body cavity are made on the body, and at the base the casing is placed at the bottom end of the casing; according to the utility model, the source of active substances is made in the form of a molded porous cartridge, at least one part of at least one of the closed external surfaces of which is enclosed in a moisture-proof casing, whose thickness is 0.03-5.35 mm, and the area of the outer surface of the cartridge, not enclosed in a moisture-proof casing and placed at the outlet of the housing, is larger than the area of the external surface of the cartridge that is not enclosed in a moisture-proof casing and placed on the opposite side of the cartridge, while the cartridge is placed relative to the inner surface of the housing with a gap.

In this case, the gap between the inner surface of the housing and the cartridge is at least 0.1 mm.

The task is achieved by the fact that in the inhaler for the nose according to the fourth variant, comprising a hollow body inside which is placed a source of active substances, and a protective cap, while the outlet and the passage of atmospheric air into the body cavity are made on the body, and at the base the casing is located at its bottom end; according to the utility model, the source of active substances is made in the form of a molded porous cartridge, at least one part of at least one of the closed The outer surfaces of which are enclosed in a moisture-proof casing, whose thickness is 0.03-5.35 mm, and the area of the external surface of the cartridge that is not enclosed in a waterproof casing and placed at the outlet of the housing is less than the area of the external surface of the cartridge that is not enclosed in a waterproof casing and placed on the opposite side of the cartridge, while the cartridge is placed relative to the inner surface of the housing with a gap.

In this case, the gap between the inner surface of the housing and the cartridge is at least 0.1 mm.

The claimed combination of features allows you to increase the efficiency of storage and delivery when using the active substance with volatile components in constant quality and sufficient quantity by providing a barrier function to preserve the effectiveness of the active substance and at the same time its directional flow from the porous substance to the outlet of the body while maintaining the dose of biologically active substances of unchanged quality by acting on the phase equilibrium of “liquid-vapor” media (volatile components of active Nogo material). "

Performing an active-active substance source in the form of a molded porous cartridge with one of the closed external surfaces enclosed in a moisture-proof casing provides for the performance of several functions:

- reliable retention of the active substance inside the cartridge due to the structure of the molded porous body of the cartridge;

- the ability to move the fluid in a given direction due to the action of capillary forces in the molded porous body;

- exclude unauthorized contact of the active substance with the atmosphere, uncontrolled release of the liquid component of the active substance to all external surfaces of the cartridge and penetration of the volatile components of the active substance accumulated in the body cavity back into the cartridge due to the moisture-proof shell;

- to ensure the possibility of the formation of a two-phase medium with different aggregative states - “liquid-vapor” due to the external surfaces of the cartridge that are not enclosed in a moisture-proof casing;

- to ensure the efficiency of the supply of volatile components of the evaporated substance in the direction of its consumption by the influence on the phase equilibrium of the media.

This is due to the fact that the fluid in the molded porous body is retained in it due to the cumulative effect of surface tension forces in each pore and cannot spontaneously be removed from the porous body without external influence.

As a result of the complete filling of the pores of the body, the liquid is supplied and distributed on the unprotected moisture-proof layer of the external surface of the cartridge, from which the volatile components of the active substance evaporate from the liquid.

The intensive evaporation process continues until the closed volume of the hollow body is completely saturated with volatile components.

When removing the cap and inhaling the volatile components with the nose, the accumulated volume of volatile components leaves the body cavity, while at the interface of “liquid-vapor” media formed by the unprotected shell of the cartridge surface, the phase equilibrium of the media is disrupted, and the evaporation process of the volatile components resumes with the same intensity after the amount of time and the use of a certain portion of the substance.

At the same time, the presence of a gap between the cartridge and the housing provides additional movement of the air mass, which, when combined with volatile components, forms a more mobile cloud of evaporated liquid, which in turn facilitates the human effort during the inhalation process.

When the outlet closes, intensive filling of the body cavity with volatile components occurs as a result of impaired phase equilibrium.

With full saturation of the volume of the body cavity with volatile components of the substance, the phase equilibrium is restored, and the evaporation process is sharply slowed down.

Thus, the design features of the source of the active substance and its placement in the housing provide the cumulative functional properties of the inhaler.

In this application for the grant of a patent for a utility model, the requirement of unity of technical solution options is met, since all the declared options relate to the design of a nasal inhaler and solve one problem - increasing the efficiency of storage and delivery when using the active substance with volatile components in a constant quality and quantity at the expense of achieving the same or better technical result when using a technical solution - providing a barrier function for the safety of the effect activeness of the active substance and at the same time its directional supply from the porous substance in less time and with less effort for the consumer to the outlet of the housing while maintaining the dose of biologically active substance of unchanged quality by constructively influencing the phase equilibrium of the “liquid-vapor (volatile components of the active substance) ".

The claimed utility model is illustrated by drawings, where figure 1 and 2 shows examples of the device in the first embodiment; Figures 3 and 4 show exemplary embodiments of the device in the second embodiment; figure 5 and 6 are examples of the device according to the third option; 7 and 8 are examples of the device according to the fourth option; figure 9 is an illustration of the operation of the device in all variants.

Positions in the drawings for all variants mean the following: 1 - a hollow body; 2 - formed porous cartridge; 3 - outlet; 4 - holes in the housing 1 for the passage of atmospheric air; 5 - cork; 6 - protective cap; 7 - moisture-proof layer of the molded porous cartridge 2.

The inventive inhaler for the nose in the first embodiment contains a hollow body 1, within which with a gap is placed a source of active substance, made in the form of a molded porous cartridge 2 and filled with active-active substance.

In this case, the gap between the inner surface of the housing and the cartridge is determined empirically and is at least 0.1 mm.

Experiments have shown that the gap of less than 0.1 mm is not advisable, since in this case it is difficult to observe the manufacturability of the process of assembling the inhaler.

The maximum size of the gap is determined by the design features of the inhaler, which should be placed in the hand, have an outlet opening, which provides directional release of volatile components into the nasal cavity.

The porous cartridge 2 may have a different shape, for example, a cylinder or a prism, depending on the aesthetic design of the inhaler body 1.

The formed cartridge 2 can be obtained, for example, by casting a foamed polymer mass or by pressing natural or artificial fibers into a form of a given size using additional thermal or chemical means of shape retention.

In this case, it is possible to form individual layers of a porous material into a single structure without chemical penetration of one layer into another, for example, using adhesive or pressing.

The molded porous cartridge 2 can be made, for example, of cotton, synthetic or polymeric fibers, the body molding and discrete structure of which form a capillary system with a random capillary pattern, which determines the movement of the active substance both along the axis of the porous cartridge 2 with a constant or increasing speed, and in the direction perpendicular to the axis of the porous cartridge 2 until it is completely saturated.

On the upper end surface of the housing 1 there is an outlet 3, at the base of the housing 1 in its side surface there are holes 4 for the passage of atmospheric air into the cavity of the housing 1, and a stopper 5 is placed at the lower end of the housing 1.

The housing 1 is provided with a sealing cap 6 (FIGS. 1 and 2).

To ensure the safety of the active substance placed in the porous cartridge 2, and at the same time its directed supply to the outlet 3 of the housing 1, at least one of the closed surfaces of the cartridge 2, for example, the lateral surface of the cylinder, is enclosed in a moisture-proof casing 7, whose thickness is 0 , 03-5.35 mm (figures 1 and 2).

The conclusion of the molded cartridge 2 in a waterproof shell 7 can be carried out by various technological methods, for example, wrapping.

As a material for moisture-proof casing 7, commercially available products can be used, for example, polyethylene, polystyrene, polyvinyl chloride films, fluoroplastic tape and other materials.

The choice of material for moisture-proof casing 7 and its specific thickness depends on the technological conditions of manufacturing the cartridge and ensuring the safety of its shape, as well as on the physicochemical properties of the composition of the active substance and is chosen empirically.

It has been experimentally established that with a thickness of the moisture-proof casing 7 less than 0.03 mm, layer breaks are possible during the formation of the cartridge, as well as an unstable dimensional stability of the cartridge in the filled state.

The thickness of the moisture-proof casing 7 more than 5.35 mm is not advisable, since in this case, when forming the cartridge, the use of elevated temperatures and special bonding compositions are required.

For a moisture-proof casing 7 with a thickness of 0.03-1.32 mm, a mono-layer of moisture-proof material can be used, and for a moisture-proof casing 7 with a thickness of 1.32 to 5.35 mm, several layers of moisture-proof material can be used.

The moisture-proof casing 7 can be made, for example, from a polyethylene film with a thickness of 0.03-0.5 mm, which can provide 100% moisture-tightness (the water absorption rate of the film for 24 hours at 20 ° C is 0.01%).

The moisture-proof casing 7 can be made, for example, from a polystyrene film with a thickness of 0.01-0.1 mm, which is characterized by mechanical strength and impermeability to moisture, steam and gas.

The moisture-proof casing 7 can be made, for example, from fluoroplastic and / or polyethylene tape, which is characterized by high chemical resistance and hydrophobicity.

The qualitative and dimensional characteristics of the moisture impermeable shell 7 are selected depending on the physicochemical properties of the composition of the active substance and on the activity of its volatile components.

As an active substance for the procedure inhalation can be used, for example, essential oils of plants, which include from 120 to 500 different organic and inorganic substances.

For volatile fractions of essential oils, their activity increases in the following sequence of their constituent components: hydrocarbons, oxides, phenols, aldehydes, ketones, alcohols, esters.

Depending on the predominance of a volatile component in a substance, it can be easily evaporated or more difficult to evaporate.

The first inhaler for the nose can be made as follows.

The molded porous cartridge 2, made in the form of, for example, a cylinder, the outer lateral surface of which, for example, is enclosed in the entire length of the waterproof casing 7, is filled by impregnation with the active substance.

The impregnated cartridge 2 is placed in the housing 1, the cartridge is fixed to the bottom by the stopper 5, and the cap 6 is mounted on the housing 1 (Figures 1 and 2).

As an active substance can be used a mixture of essential oil of mint and eucalyptus.

The composition of peppermint oil as volatile components include menthol, pinene, phellandrene, tsineol, limonene, and others, which determine its action as an antiseptic tonic and antispasmodic.

The composition of eucalyptus oil as volatile components include cineol, tannins, flavonoids, organic acids and various aldehydes.

The high content of the volatile component of cineol determines the therapeutic effect of eucalyptus oil.

Eucalyptus essential oil has pronounced phytoncidal, analgesic and antiseptic properties.

The inventive inhaler for the nose according to the second embodiment contains a hollow body 1, inside of which, with a gap, is placed a source of active substance, made in the form of a molded porous cartridge 2 and filled with active-active substance.

In this case, the gap between the inner surface of the housing and the cartridge is determined empirically and is at least 0.1 mm.

Experiments have shown that the gap of less than 0.1 mm is not advisable, since in this case it is difficult to observe the manufacturability of the process of assembling the inhaler.

The maximum size of the gap is determined by the design features of the inhaler, which should be placed in the hand, have an outlet opening, which provides directional release of volatile components into the nasal cavity.

The porous cartridge 2 may have a different shape, for example, a cylinder or a prism, depending on the aesthetic design of the inhaler body 1.

The formed cartridge 2 can be obtained, for example, by casting a foamed polymer mass or by pressing natural or artificial fibers into a form of a given size using additional thermal or chemical means of shape retention.

It is possible to form individual layers of porous material into a single structure without chemical penetration of one layer into another, for example, using an adhesive.

The porous cartridge 2 can be made, for example, of cotton, synthetic or polymer fibers, the body molding and discrete structure of which form a capillary system with a chaotic direction of the capillaries, which determines the movement of the active substance both along the axis of the porous cartridge 2 with a constant or increasing speed, and in the direction perpendicular to the axis of the porous cartridge 2 to its full saturation.

On the upper end surface of the housing 1 there is an outlet 3, at the base of the housing 1 in its side surface there are holes 4 for the passage of atmospheric air into the cavity of the housing 1, and a stopper 5 is placed at the lower end of the housing 1.

The housing 1 is provided with a sealing cap 6 (FIGS. 3 and 4).

To ensure the safety of the active substance placed in the porous cartridge 2, and at the same time its directed supply to the outlet 3 of the housing 1, at least one of the closed surfaces of the cartridge 2, for example, the lateral surface of the cylinder, is enclosed in a moisture-proof casing 7, whose thickness is 0 , 03-5.35 mm (figure 3 and 4).

The conclusion of the molded cartridge 2 in a waterproof shell 7 can be carried out by various technological methods, for example, wrapping.

As a material for moisture-proof casing 7, commercially available products can be used, for example, polyethylene, polystyrene, polyvinyl chloride films, fluoroplastic tape and other materials.

The choice of material for moisture-proof casing 7 and its specific thickness depends on the technological conditions of manufacturing the cartridge and ensuring the safety of its shape, as well as on the physicochemical properties of the composition of the active substance and is chosen empirically.

It has been experimentally established that with a thickness of the moisture-proof casing 7 less than 0.03 mm, layer breaks are possible during the formation of the cartridge, as well as an unstable dimensional stability of the cartridge in the filled state.

The thickness of the moisture-proof casing 7 more than 5.35 mm is not advisable, since in this case, when forming the cartridge, the use of elevated temperatures and special bonding compositions are required.

For a moisture-proof casing 7 with a thickness of 0.03-1.32 mm, a mono-layer of moisture-proof material can be used, and for a moisture-proof casing 7 with a thickness of 1.32 to 5.35 mm, several layers of moisture-proof material can be used.

The moisture-proof casing 7 can be made, for example, from a polyethylene film with a thickness of 0.03-0.5 mm, which can provide 100% moisture-tightness (the water absorption rate of the film for 24 hours at 20 ° C is 0.01%).

The moisture-proof casing 7 can be made, for example, from a polystyrene film with a thickness of 0.01-0.1 mm, which is characterized by mechanical strength and impermeability to moisture, steam and gas.

The moisture-proof casing 7 can be made, for example, from fluoroplastic and / or polyethylene tape, which is characterized by high chemical resistance and hydrophobicity.

The qualitative and dimensional characteristics of the moisture impermeable shell 7 are selected depending on the physicochemical properties of the composition of the active substance and on the activity of its volatile components.

As an active substance for the procedure inhalation can be used, for example, essential oils of plants, which include from 120 to 500 different organic and inorganic substances.

For volatile fractions of essential oils, their activity increases in the following sequence of their constituent components: hydrocarbons, oxides, phenols, aldehydes, ketones, alcohols, esters.

Depending on the predominance of a volatile component in a substance, it can be easily evaporated or more difficult to evaporate.

For the possibility of formation of the necessary rate of evaporation of volatile components, depending on their activity, the area of the outer surface of the cartridge 1, not enclosed in a moisture-proof casing 7 and placed at the outlet 3 of the housing 1, is equal to the area of the outer surface of the cartridge 2, not enclosed in a moisture-proof casing 7 and placed on the opposite side of the cartridge 1 (figure 3 and 4).

The equality of the lower and upper surfaces of the areas of the cartridge contributes to the fact that the amount of liquid transported per unit of time is equal in the porous body of the cartridge 2 and the amount of liquid released to the outer upper surface of the cartridge 2.

With this design of the cartridge, it is most expedient to use one active substance, or a composition, which includes more volatile components of the same activity.

The inhaler for the nose according to the second embodiment can be manufactured as follows.

The molded porous cartridge 2, made in the form of, for example, a tetrahedral prism, the outer side surface of which along the entire length is enclosed in a moisture-proof casing 7, is filled by impregnation with an active-active substance.

The impregnated cartridge 2 is placed in the housing 1, the cartridge is fixed to the bottom by the stopper 5, and the cap 6 is mounted on the housing 1 (Figures 3 and 4).

As an active substance can be used a mixture of essential oil of mint and sage.

The composition of peppermint oil as volatile components include menthol, pinene, phellandrene, tsineol, limonene, and others, which determine its action as an antiseptic tonic and antispasmodic.

The composition of sage oil includes linalol, camphene, cineoleum, limonene, myrcene, the oil has an antimicrobial effect.

The volatile components of the mint and sage oils have an equal activity, their properties have a synergistic effect during the inhalation procedure for different microbes.

The inventive inhaler for the nose in the third embodiment contains a hollow body 1, inside of which, with a gap, is placed a source of active substance, made in the form of a molded porous cartridge 2 and filled with active-active substance.

The porous cartridge 2 may have a different shape, for example, a cylinder or a prism, depending on the aesthetic design of the inhaler body 1.

The formed cartridge 2 can be obtained, for example, by casting a foamed polymer mass or by pressing natural or artificial fibers into a form of a given size using additional thermal or chemical means of shape retention.

It is possible to form individual layers of porous material into a single structure without chemical penetration of one layer into another, for example, using an adhesive.

The porous cartridge 2 can be made, for example, of cotton, synthetic or polymer fibers, the body molding and discrete structure of which form a capillary system with a chaotic direction of the capillaries, which determines the movement of the active substance both along the axis of the porous cartridge 2 with a constant or increasing speed, and in the direction perpendicular to the axis of the porous cartridge 2 to its full saturation.

On the upper end surface of the housing 1 there is an outlet 3, at the base of the housing 1 in its side surface there are holes 4 for the passage of atmospheric air into the cavity of the housing 1, and a stopper 5 is placed at the lower end of the housing 1.

The housing 1 is provided with a sealing cap 6 (FIGS. 5 and 6).

To ensure the safety of the active substance placed in the porous cartridge 2, and at the same time its directed supply to the outlet 3 of the housing 1, at least one of the closed surfaces of the cartridge 2, for example, the lateral surface of the cylinder, is enclosed in a moisture-proof casing 7, whose thickness is 0 , 03-5.35 mm (figure 5 and 6).

The conclusion of the molded cartridge 2 in a waterproof shell 7 can be carried out by various technological methods, for example, wrapping.

As a material for moisture-proof casing 7, commercially available products can be used, for example, polyethylene, polystyrene, polyvinyl chloride films, fluoroplastic tape and other materials.

The choice of material for moisture-proof casing 7 and its specific thickness depends on the technological conditions of manufacturing the cartridge and ensuring the safety of its shape, as well as on the physicochemical properties of the composition of the active substance and is chosen empirically.

It has been experimentally established that with a thickness of the moisture-proof casing 7 less than 0.03 mm, layer breaks are possible during the formation of the cartridge, as well as an unstable dimensional stability of the cartridge in the filled state.

The thickness of the moisture-proof casing 7 more than 5.35 mm is not advisable, since in this case, when forming the cartridge, the use of elevated temperatures and special bonding compositions are required.

For a moisture-proof casing 7 with a thickness of 0.03-1.32 mm, a mono-layer of moisture-proof material can be used, and for a moisture-proof casing 7 with a thickness of 1.32 to 5.35 mm, several layers of moisture-proof material can be used.

The moisture-proof casing 7 can be made, for example, from a polyethylene film with a thickness of 0.03-0.5 mm, which can provide 100% moisture-tightness (the water absorption rate of the film for 24 hours at 20 ° C is 0.01%).

The moisture-proof casing 7 can be made, for example, from a polystyrene film with a thickness of 0.01-0.1 mm, which is characterized by mechanical strength and impermeability to moisture, steam and gas.

The moisture-proof casing 7 can be made, for example, from fluoroplastic and / or polyethylene tape, which is characterized by high chemical resistance and hydrophobicity.

The qualitative and dimensional characteristics of the moisture impermeable shell 7 are selected depending on the physicochemical properties of the composition of the active substance and on the activity of its volatile components.

As an active substance for the procedure inhalation can be used, for example, essential oils of plants, which include from 120 to 500 different organic and inorganic substances.

For volatile fractions of essential oils, their activity increases in the following sequence of their constituent components: hydrocarbons, oxides, phenols, aldehydes, ketones, alcohols, esters.

Depending on the predominance of a volatile component in a substance, it can be easily evaporated or more difficult to evaporate.

For the possibility of formation of the required evaporation rate of volatile components depending on their activity, the outer surface area of the cartridge 1, not enclosed in a moisture-proof casing 7 and placed at the outlet 3 of the housing 1, is larger than the outer surface area of the cartridge 2, not enclosed in a moisture-proof casing 7 and placed on the opposite side of the cartridge 1 (figure 5 and 6).

This embodiment of the cartridge 2 helps to ensure the release per unit of time of a larger amount of liquid to the unprotected upper surface of the cartridge 2, which allows the formation of a large evaporation area for compositions with heavier volatile components of the substance.

With such a cartridge design, it is most expedient to use compositions that may include, for example, liquid vegetable oil, plant essential oil, and plant extract.

The vegetable oil in the composition plays the role of a base, which reduces the concentration of volatile components of the essential oil and extracts to their safe use, and also increases the overall viscosity of the composition and reduces the activity of volatile components.

Introduction to the composition of vegetable oils is due to the need to respect the safety of the procedure inhalation in accordance with the recommendations of scientists and aromatherapists in the scientific and popular literature on the use of specific types of essential oils and extracts as an aromatherapy agent.

Inhaler for the nose according to the third option can be made as follows.

The molded porous cartridge 2, made in the form of, for example, a four-sided truncated pyramid, the outer side surface of which is enclosed in a moisture-proof shell 6 along its entire length, is filled by impregnation with an active-active substance.

The impregnated cartridge 2 is placed in the housing 1, the cartridge is fixed to the bottom by the stopper 5, and the cap 6 is mounted on the housing 1 (FIGS. 5 and 6).

For example, wheat germ oil, orange essential oil and extract of nutmeg can be used as the active substance placed in cartridge 2.

The uniqueness of the properties of wheat germ oil is due to the presence in its composition of three active complexes: antioxidants - tocopherols and carotenoids; essential polyunsaturated fatty acids (linolenic, linoleic, oleic, palmetinic, arachidonic); vitamins of group B, D, F, pantothenic and folic acid.

Wheat germ oil has the ability to exert an antioxidant and tonic effect, increase the general body resistance and exert a protective effect on the nervous system.

Orange oil contains as volatile components - limonene, linalyl acetate, citral, geraniol, citronellol, terpineol, linalool, which cause its anti-toxic, anti-depressant, antiseptic actions.

Nutmeg extract has a fresh, sweet floral scent, restores strength, relieves fatigue and fatigue.

Included in the composition of volatile components have a synergistic effect during the inhalation procedure in relation to various microbes.

The inventive inhaler for the nose according to the fourth embodiment contains a hollow body 1, inside of which, with a gap, is placed a source of active substance, made in the form of a molded porous cartridge 2 and filled with active-active substance.

The porous cartridge 2 may have a different shape, for example, a cylinder or a prism, depending on the aesthetic design of the inhaler body 1.

The formed cartridge 2 can be obtained, for example, by casting a foamed polymer mass or by pressing natural or artificial fibers into a form of a given size using additional thermal or chemical means of shape retention.

It is possible to form individual layers of porous material into a single structure without chemical penetration of one layer into another, for example, using an adhesive.

The porous cartridge 2 can be made, for example, of cotton, synthetic or polymer fibers, the body molding and discrete structure of which form a capillary system with a chaotic direction of the capillaries, which determines the movement of the active substance both along the axis of the porous cartridge 2 with a constant or increasing speed, and in the direction perpendicular to the axis of the porous cartridge 2 to its full saturation.

On the upper end surface of the housing 1 there is an outlet 3, at the base of the housing 1 in its side surface there are holes 4 for the passage of atmospheric air into the cavity of the housing 1, and a stopper 5 is placed at the lower end of the housing 1.

The housing 1 is equipped with a sealing cap 6 (Fig.7 and 8).

To ensure the safety of the active substance placed in the porous cartridge 2, and at the same time its directed supply to the outlet 3 of the housing 1, at least one of the closed surfaces of the cartridge 2, for example, the lateral surface of the cylinder, is enclosed in a moisture-proof casing 7, whose thickness is 0 , 03-5.35 mm (Fig.7 and 8).

The conclusion of the molded cartridge 2 in a waterproof shell 7 can be carried out by various technological methods, for example, wrapping.

As a material for moisture-proof casing 7, commercially available products can be used, for example, polyethylene, polystyrene, polyvinyl chloride films, fluoroplastic tape and other materials.

The choice of material for moisture-proof casing 7 and its specific thickness depends on the technological conditions of manufacturing the cartridge and ensuring the safety of its shape, as well as on the physicochemical properties of the composition of the active substance and is chosen empirically.

It has been experimentally established that with a thickness of the moisture-proof casing 7 less than 0.03 mm, layer breaks are possible during the formation of the cartridge, as well as an unstable dimensional stability of the cartridge in the filled state.

The thickness of the moisture-proof casing 7 more than 5.35 mm is not advisable, since in this case, when forming the cartridge, the use of elevated temperatures and special bonding compositions are required.

For a moisture-proof casing 7 with a thickness of 0.03-1.32 mm, a mono-layer of moisture-proof material can be used, and for a moisture-proof casing 7 with a thickness of 1.32 to 5.35 mm, several layers of moisture-proof material can be used.

The moisture-proof casing 7 can be made, for example, from a polyethylene film with a thickness of 0.03-0.5 mm, which can provide 100% moisture-tightness (the water absorption rate of the film for 24 hours at 20 ° C is 0.01%).

The moisture-proof casing 7 can be made, for example, from a polystyrene film with a thickness of 0.01-0.1 mm, which is characterized by mechanical strength and impermeability to moisture, steam and gas.

The moisture-proof casing 7 can be made, for example, from fluoroplastic and / or polyethylene tape, which is characterized by high chemical resistance and hydrophobicity.

The qualitative and dimensional characteristics of the moisture impermeable shell 7 are selected depending on the physicochemical properties of the composition of the active substance and on the activity of its volatile components.

As an active substance for the procedure inhalation can be used, for example, essential oils of plants, which include from 120 to 500 different organic and inorganic substances.

For volatile fractions of essential oils, their activity increases in the following sequence of their constituent components: hydrocarbons, oxides, phenols, aldehydes, ketones, alcohols, esters.

Depending on the predominance of a volatile component in a substance, it can be easily evaporated or more difficult to evaporate.

For the possibility of formation of the required evaporation rate of volatile components depending on their activity, the outer surface area of the cartridge 1, not enclosed in a moisture-proof shell 7 and placed at the outlet 3 of the housing 1, is less than the outer surface area of the cartridge 2, not enclosed in a moisture-proof shell 7 and placed on the opposite side of the cartridge 1 (Fig.7 and 8).

This embodiment of the cartridge 2 helps to ensure the output per unit of time a smaller amount of liquid on the unprotected upper surface of the cartridge 2, which allows you to form a smaller area of evaporation for compositions with lighter volatile components of the substance.

With this design of the cartridge, it is most expedient to use compositions that may include, for example, plant extracts.

Extracts are extracts from vegetable raw materials with a high content of the concentration of active substances.

The use of the composition of the plant extract is due to the high content of valuable biologically active substances in the volatile phase, which determine their synergistic effect as aromatizing, pharmacoactive and biocosmetic components of the active substance.

The inhaler for the nose according to the fourth embodiment can be manufactured as follows.

The molded porous cartridge 2, made in the form of, for example, a tetrahedral truncated pyramid, the outer side surface of which along the entire length or part of it is enclosed in a moisture-proof casing 6, is filled by impregnation with an active substance.

The impregnated cartridge 2 is placed in the housing 1, the cartridge is fixed to the bottom by the stopper 5, and the cap 6 is mounted on the housing 1 (Fig.7 and 8).

For example, a mixture of extracts of calendula and bergamot can be used as the active substance placed in cartridge 2.

Calendula extract contains more than 54 active compounds, which include pinene, thujone, cubinene, palmitic, linoleic, oleic and stearic acids, tocopherols and other substances causing its anti-toxic, anti-depressant, antiseptic actions.

Extract of bergamot as active ingredients contains linalyl acetate, limonene, terpineol, bergapten, bisabolene, nerol, fatty acids and in the composition has a disinfectant, anti-inflammatory and refreshing effect.

Included in the composition of volatile components have a synergistic effect during the inhalation procedure in relation to various microbes.

The use of the inhaler according to any one of the options is as follows (Fig.9).

In the inhaler assembled and closed by the cap 6, the active liquid active substance in the molded porous cartridge 2 is stationary and practically does not evaporate from the surface of the cartridge 2 not protected by the shell 7.

At the same time, the liquid active ingredient is protected by a moisture-proof casing 7 from exposure to outside air and from unauthorized access to most of the surface of the formed cartridge 2, in this case, on its outer side surface.

On the end surfaces of the cartridge 2, not protected by the shell 7, a liquid active substance accumulates, from which volatile components are released into the closed space between the inner surface of the housing 1 and the outer surface of the cartridge 2.

When opening the cap 6 of the device, the phase equilibrium of the media - “liquid-vapor” is disturbed and an intensive process of evaporation of volatile components in the field of consumption takes place and, at the same time, they enter and accumulate in the closed space of the hollow body 1.

The presence of a gap between the cartridge and the housing provides additional movement of the air mass, which, when combined with volatile components, forms a more mobile cloud of evaporating liquid, which in turn facilitates the human effort during the inhalation process.

When using the inhaler, the cap 6 is removed from the housing 1, the cavity in which the volatile components of the active substance are accumulated is depressurized, and the air is drawn in by the nose to create a directional flow of volatile components through the outlet 3 of the housing 1 to the outside towards the nasal receptors.

This is also facilitated by the pores formed during the formation of a porous body and the differently directed flows of differently active liquids and raznetyazhelyh or light fractions of volatile components.

When the cap is closed, the volume of the substance discharged, its directionality into the external environment sharply decreases, which ensures complete saturation of the specified volume of the device case with volatile components and the phase equilibrium of the media - “liquid-vapor” - is restored.

Until the time of its recovery in the body cavity, the phase equilibrium of the media is again disturbed and intensive evaporation of volatile components with the unprotected moisture-proof cover 7 of the surface of the cartridge 2 occurs and they accumulate in the cavity of the body 1.

At the same time in the cartridge 2, a new portion of the liquid is replaced by the part of the evaporated from its unprotected surface due to pressure equalization in the cavity of the housing 1.

This is because when removing the cap 6 in the lower part of the cavity of the housing 1 through the openings 4 enters the atmospheric air, exerting pressure from the lower unprotected shell 7 of the cartridge 2, facilitating its movement along the pores of the cartridge in the direction of issuing volatile components until it leaves on the surface of the unprotected part of the cartridge.

The process of release of volatile components from the surface of the liquid active substance will continue until the space above the liquid is again filled with volatile components.

The design features of the proposed inhaler contribute to the effective use of the volatile components of biologically active substances of plant origin - extracts of medicinal plants and essential oils.

The claimed inhaler allows the introduction through the nasal respiratory tract into the body of extracts of medicinal plants and essential oils, as the most acceptable and safe method of prevention and therapy.

Claims (4)

1. An inhaler for the nose, containing a hollow body, inside which is placed a source of active substances, and a protective cap, with an outlet opening and openings for the passage of atmospheric air into the body cavity, and a plug at the base of the body , characterized in that the source of active substances is made in the form of a molded porous cartridge, at least one part of which, at least, one of the closed external surfaces is enclosed in a moisture-proof bolochku, wherein a thickness of 0,03-5,35 mm, while the cartridge is placed in relation to the inner surface of the housing with clearance. 2. An inhaler for the nose, containing a hollow body, inside which is placed a source of active substances, and a protective cap, with an outlet opening and openings for the passage of atmospheric air into the body cavity, and a plug at the base of the body , characterized in that the source of active substances is made in the form of a molded porous cartridge, at least one part of which, at least, one of the closed external surfaces is enclosed in a moisture-proof the bolus, whose thickness is 0.03-5.35 mm, and the area of the external surface of the cartridge, not enclosed in a moisture-proof casing and placed at the outlet of the housing, is equal to the area of the external surface of the cartridge, not enclosed in a moisture-proof casing and placed on the opposite side of the cartridge, while the cartridge is placed in relation to the inner surface of the housing with a gap. 3. An inhaler for the nose, containing a hollow body, inside which is placed a source of active substances, and a protective cap, with an outlet opening and openings for the passage of atmospheric air into the body cavity, and a plug at the base of the body , characterized in that the source of active substances is made in the form of a molded porous cartridge, at least one part of which, at least, one of the closed external surfaces is enclosed in a moisture-proof a bolka whose thickness is 0.03-5.35 mm, and the area of the external surface of the cartridge not enclosed in a moisture-proof casing and placed at the outlet of the housing is larger than the area of the external surface of the cartridge not enclosed in a moisture-proof casing and placed on the opposite side of the cartridge, while the cartridge is placed in relation to the inner surface of the housing with a gap. 4. An inhaler for the nose, containing a hollow body, inside which is placed a source of active substances, and a protective cap, with an outlet opening and openings for the passage of atmospheric air into the body cavity, and a plug at the base of the body , characterized in that the source of active substances is made in the form of a molded porous cartridge, at least one part of which, at least, one of the closed external surfaces is enclosed in a moisture-proof a bolka whose thickness is 0.03-5.35 mm and the area of the external surface of the cartridge not enclosed in a moisture-proof casing and placed at the outlet of the housing is smaller than the area of the external surface of the cartridge not enclosed in a moisture-proof casing and placed on the opposite side of the cartridge, while the cartridge is placed in relation to the inner surface of the housing with a gap.

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