WO2013013439A1 - No-puncture bottle plug and method for use thereof - Google Patents

Abstract

A no-puncture bottle plug and a method for the use thereof. The bottle plug has a bottle plug main body (Y) and a cover (X) for sealing said bottle plug main body (Y) and the bottle mouth (Z1). The bottle plug main body (Y) is provided with an infusion/suction channel for connection to an injection or transfusion apparatus. In use, after removal of the cover (X) sealing the bottle plug main body (Y) and the bottle mouth (Z1), the injection or transfusion apparatus can be connected with or inserted directly into the infusion/suction channel, then drug solvent or solution can be infused into the bottle or sucked out of the bottle by said injection or transfusion apparatus, with no puncturing required. The present no-puncture bottle plug ensures the sealing efficacy of the rubber plug and rubber felt, and as no debris is produced due to puncturing, greater safety is achieved in the use of medicines.

Description

 Puncture-free stopper and method of use thereof Technical Field

 The invention belongs to a packaging stopper for medicines, in particular to a puncture-free stopper; in addition, the invention relates to a method for using the puncture-free stopper.

Background Art

Rubber stopper and rubber felt have the characteristics of low moisture absorption rate, good chemical property, good air tightness and no physiological side effects. They are especially suitable for sealing medicines. They are widely used in sealed glass vials, large infusion glass bottles and large infusions. Packaging of plastic bottles and plastic soft bags. The currently used plastic stoppers, rubber felts and rubber stoppers and rubber felts for large-sized bottles are all designed as a whole. Before clinical use, they must be puncture with a needle tip of a syringe or an infusion set and penetrate the rubber plug and rubber felt. In order to dispense medicine, use medicine, even in the course of one medication, it is necessary to puncture multiple times (often there are more than ten times of puncture). When the rubber plug or rubber felt is puncture, a large amount of puncture debris will be generated. These falling debris fall in the drug solution. , Will enter the body with the drug solution, thereby clogging the blood vessels, causing adverse effects. Therefore, there is an urgent need to develop a pharmaceutical bottle stopper that can solve the above-mentioned hidden dangers and ensure the safety of the drug.

Technical Problem

The technical problem to be solved by the present invention is to provide a puncture-free bottle stopper, which overcomes the safety hazard of the puncture and chipping when the rubber or the felt is puncture in the injection package which is sealed with the rubber stopper or the rubber felt. In addition, the present invention also provides a method of using the puncture-free stopper.

Technical Solution

 In order to solve the above technical problems, The invention provides a puncture-free stopper, comprising a stopper body and a cover for sealing the stopper body and the bottle mouth, wherein the bottle body is provided with a syringe or an infusion set suction joint passage.

The shape of the stopper body is designed into different geometric shapes according to different shapes of the bottle mouth; the stopper body is made of one or more of rubber, butyl rubber, halogenated butyl rubber, and plastic. The cover for sealing the stopper body and the mouth of the bottle may be made of aluminum and/or plastic.

The stopper body is composed of an outer plug body and a downward flange, the flange is embedded in the bottle mouth; or the stopper body has a cylindrical shape and directly covers the bottle mouth.

 The syringe or infusion set filler channel is designed in a variety of geometries depending on the shape of the syringe or infusion set.

The number of the syringe or infusion set suction joint passages is one or more; when the number of syringe or infusion set injection joint passages is one, the injection and aspiration solutions are all in the same joint passage; when the syringe or the infusion set is injected When the number of suction joint passages is plural, the injection and suction solutions are respectively from different joint passages.

The syringe or the infusion set injection connection channel is disposed in the middle of the stopper body, and runs through the entire stopper body from top to bottom; or the syringe or the infusion set injection connection channel is disposed at the upper part of the stopper body, and the lower part is provided There is a drug solution channel; or the syringe or infusion device injection port is provided in the middle of the bottle body, the upper part is provided with an insertion hole of a syringe or an infusion set, and the lower part is provided with a medical liquid channel capable of automatically opening and closing.

 The syringe or infusion set filler channel is cylindrical, slitted or conical.

 The syringe or infusion set injection fitting channel is open or closed.

 The syringe or infusion set filler channel is closed, and an insertion mark is provided on the stopper body.

 In addition, the present invention also provides a method for using the puncture-free stopper, comprising the following steps:

 (1) opening the lid of the sealed stopper body and the bottle mouth;

(2) The syringe or infusion set is connected or inserted into the syringe or the infusion set inlet channel of the bottle body, and the drug solvent or drug solution can be injected into or withdrawn from the bottle through the syringe or the infusion device interface channel.

Advantageous Effects

 Compared with the prior art, the present invention has the following beneficial effects: The puncture-free bottle stopper of the invention is suitable for sealing the bottle mouth with a rubber stopper or a rubber felt, and requires the medicine package to penetrate the bottle stopper injection solution. The invention not only ensures the sealing effect of the rubber plug and the rubber felt, but also can directly connect the syringe or the infusion device into the syringe or the infusion set suction joint channel after opening the lid of the sealing stopper body and the bottle mouth. The drug solvent or drug solution can be injected into the bottle through the drug injector or infusion device or sucked out from the bottle to avoid puncture, and no chipping due to puncture, thereby increasing the safety of the drug.

Description of Drawings

 1A is a schematic structural view of Embodiment 1 of the puncture-free stopper of the present invention;

 1B is a schematic structural view of Embodiment 2 of the puncture-free stopper of the present invention;

 Figure 2 is a schematic view showing the structure of the embodiment 3 of the puncture-free stopper of the present invention;

 Figure 3 is a schematic view showing the structure of the puncture-free stopper of the present invention;

 Figure 4 is a schematic view showing the structure of the puncture-free stopper of the fifth embodiment of the present invention;

 Figure 5 is a schematic view showing the structure of the embodiment 6 of the puncture-free stopper of the present invention;

 Figure 6 is a schematic view showing the structure of the embodiment 7 of the puncture-free stopper of the present invention;

 Figure 7 is a schematic view showing the structure of the embodiment 8 of the puncture-free stopper of the present invention;

 Figure 8 is a schematic view showing the structure of the puncture-free stopper of the present invention;

 Figure 9 is a schematic view showing the overall structure of the puncture-free stopper of the present invention;

 Fig. 10 is a schematic view showing another overall structure of the puncture-free stopper of the present invention.

Best Mode

Mode for Invention

 The present invention will be further described in detail below with reference to the accompanying drawings and embodiments.

 As shown in Figures 9 and 10, the present invention The puncture-free stopper comprises a stopper body Y and a cover X for sealing the stopper body Y and the bottle mouth Z1 of the medicine bottle Z; the stopper body Y may be composed of an outer plug body and a downward flange, the flange Embedded in the mouth Z1 (see Figure 9); the stopper body Y can also be directly covered on the bottle mouth Z1 (the stopper body Y is cylindrical, no flange), and the cap X is used to seal the stopper body Y and the bottle Port Z1 (see Figure 10); the syringe body Y is provided with a syringe or an infusion set. The suction port can be in various forms, as described in the following examples.

 Example 1

As shown in Fig. 1A, the stopper body A is composed of an outer plug body 12 and a downward flange 13, and the flange 13 is embedded in the bottle mouth. The stopper body A is provided with a slit-shaped syringe or an infusion set injection joint passage 11 in the middle, and a slit-shaped syringe or an infusion set injection joint passage 11 runs through the entire stopper body A, and the syringe or the infusion set injection joint passage 11 is closed, that is, after opening the aluminum stopper of the sealed stopper body A and the bottle mouth, the stopper body A does not expose the syringe or the infusion set injection joint passage 11 on the outer plug body 12 of the stopper body A. Corresponding to the position of the syringe or infusion set suction port 11 is a mark 14 which can be inserted into the syringe or the infusion set through the syringe or the infusion set cone (ie, the syringe or the infusion set). 11 to inject the liquid in the bottle.

 Example 2

As shown in FIG. 1B, the stopper body A has a cylindrical shape (without a flange) and directly covers the bottle mouth (the stopper body A is suitable for the puncture-free stopper overall structure shown in FIG. 10), and the stopper body A is in the middle. a slit-shaped syringe or infusion set suction port passage 11 is provided, and a slit-shaped syringe or infusion set injection fitting passage 11 extends through the entire stopper body A, and the syringe or infusion set injection fitting passage 11 is closed. That is, after opening the aluminum stopper of the sealed stopper body A and the bottle mouth, the stopper body A does not expose the syringe or the infusion set injection joint passage 11, and the corresponding syringe or infusion set injection joint passage 11 on the stopper body A The position is provided with a mark 14 into which a syringe or infusion set cone (i.e., a syringe or an infusion set) can be inserted to penetrate the syringe or infusion set port 11 to inject the solution.

 Example 3

As shown in Fig. 2, the stopper body B is composed of an outer plug body 22 and a downward flange 23, and the flange 23 is embedded in the bottle mouth. The upper part of the stopper body B is provided with a slit-shaped syringe or an infusion set suction joint passage 21, and a lower portion is provided with a chemical liquid passage 25, and the position of the chemical liquid passage 25 corresponds to a syringe or an infusion set injection joint passage 21, the syringe or The infusion set injection port 21 is closed, that is, after opening the aluminum cap of the sealed stopper body B and the bottle mouth, the stopper body B does not expose the syringe or the infusion set suction port passage 21, in the stopper body B The outer plug body 22 is provided with a mark 24 corresponding to the position of the syringe or the infusion set injection port 21, and the syringe or the infusion set cone can be inserted into the mark to penetrate the syringe or the infusion set channel 21 and the drug solution channel. 25 to inject the liquid in the bottle.

 Example 4

As shown in Fig. 3, the stopper body C is composed of an outer plug body 32 and a downward flange 33, and the flange 33 is embedded in the bottle mouth. The middle of the stopper body C is provided with a conical syringe or an infusion set suction connection passage 35 (the conical shape is more convenient for the syringe or the infusion set cone to enter), and the upper part is provided with a syringe or an infusion set insertion hole 34 (the syringe or the infusion solution) The position of the insertion hole 34 corresponds to the syringe or the infusion set suction port channel 35), and the lower portion is provided with the drug solution passage 31, which is closed. That is, after opening the aluminum stopper of the sealing stopper body C and the bottle mouth, the stopper body C does not expose the liquid medicine passage 31, and the syringe or the infusion set cone can be inserted from the syringe or the infusion set provided at the upper portion of the stopper body C. The hole 34 is inserted through the syringe or the infusion set suction port channel 35 to open the drug solution channel 31 to inject the drug solution in the bottle. The drug solution channel 31 is automatically closed when the syringe or infusion set cone is withdrawn from the stopper body C.

 Example 5

As shown in Figure 4, the stopper body D is composed of an outer plug body 42 and a downward flange 43, which is embedded in the mouth of the bottle. A conical syringe or infusion set injection port 41 is provided in the middle of the stopper body D, and runs through the entire stopper body D from top to bottom; the syringe or the infusion set injection port passage 41 is open, that is, the seal is opened. After the stopper body D and the aluminum plastic cover of the bottle mouth, the stopper body D exposes the syringe or the infusion set suction joint passage 41, and the syringe or the infusion set cone can be directly placed into the syringe or the infusion set injection joint passage 41. Note the liquid medicine in the bottle.

 Example 6

As shown in Figure 5, the stopper body E is composed of an outer plug body 52 and a downward flange 53, which is embedded in the mouth of the bottle. There are two slit-shaped syringes or infusion set injection joint passages 511, 512 in the middle of the stopper body E. Two slit-shaped syringes or infusion set injection joint passages 511, 512 extend through the entire stopper body E, two The slit-shaped syringe or the infusion set suction port passages 511, 512 are closed, that is, after opening the aluminum cap of the sealed stopper body E and the bottle mouth, the stopper body E does not expose the syringe or the infusion set The joint passages 511, 512 are provided with marks 541, 542 on the outer plug body 52 of the stopper body E corresponding to the syringe or the infusion set suction joint passages 511, 512, and the syringe or the infusion set cone can be inserted into the mark 541, 542 can be inserted through the syringe or infusion set channel 511, 512 to inject or absorb the liquid medicine in the bottle, usually one of the two syringes or the infusion set injection port 511, 512 is used for injecting the drug solution, and the other is used for injecting the drug solution. To absorb the liquid.

 Example 7

As shown in Fig. 6, the stopper body F is composed of an outer plug body 62 and a downward flange 63, and the flange 63 is embedded in the bottle mouth. The upper part of the stopper body F is provided with two slit-shaped syringes or infusion set injection joint passages 611 and 612, and the lower part is provided with two chemical liquid passages 651 and 652, two chemical liquid passages 651 and 652 and two slits. The position of the syringe or infusion set suction port channels 611, 612 corresponds; the two slit-shaped syringes or the infusion set injection port channels 611, 612 are closed, that is, the sealed stopper body F and the bottle opening are opened After the aluminum plastic cover, the stopper body F does not expose the syringe or infusion set injection joint passages 611, 612, and the position of the syringe or infusion set injection joint passages 611, 612 on the outer plug body 62 of the stopper body F Markers 641, 642 are provided, and the syringe or the infusion set cone can be inserted into the markers 641, 642 to penetrate the syringe or the infusion set suction channel 611, 612 and the drug solution channels 651, 652 to inject or absorb the liquid medicine in the bottle. Typically one of the two syringe or infusion set injection ports 611, 612 is used to inject the drug solution and the other is used to draw the drug solution.

 Example 8

As shown in Fig. 7, the stopper body G is composed of an outer plug body 72 and a downward flange 73, and the flange 73 is embedded in the bottle mouth. The middle of the stopper body G is provided with two conical syringes or infusion set injection joint passages 751, 752, and the upper portion is provided with a syringe or an infusion set insertion hole 741, 742 (the position of the syringe or the infusion set insertion holes 741, 742 is corresponding) The syringe or the infusion set is filled with the suction passages 751, 752), and the lower portion is provided with two chemical liquid passages 711, 712, and the medical liquid passages 711, 712 are closed. That is, after opening the sealed stopper body G and the aluminum plastic cap of the bottle mouth, the syringe or the infusion set cone can be inserted into the syringe or the infusion set through the syringe or infusion set insertion holes 741, 742 provided in the upper part of the stopper body G. The channels 751, 752 can open the drug solution channels 711, 712 to inject or absorb the liquid medicine in the bottle, and the drug solution channels 711, 712 are automatically closed when the syringe or the infusion set cone is pulled out from the bottle body G. Typically one of the two syringe or infusion set injection ports 751, 752 is used to inject the drug solution and the other is used to draw the drug solution.

 Example 9

As shown in Fig. 8, the stopper body H is composed of an outer plug body 82 and a downward flange 83, and the flange 83 is embedded in the bottle mouth. The conical body H is provided with two conical syringes or infusion set injection joint passages 811, 812, and runs through the entire stopper body H from top to bottom; the syringe or infusion set injection joint passages 811, 812 are open After opening the sealed stopper body H and the aluminum plastic cover of the bottle mouth, the stopper body H exposes the syringe or the infusion set suction joint passages 811, 812, and the syringe or the infusion set cone can be directly placed into the syringe or The infusion set is filled with the suction channel 811, 812 to inject or draw the liquid medicine in the bottle. Usually, one of the two syringes or the infusion set injection port channels 811, 812 is used for injecting the liquid medicine, and the other is for sucking the liquid medicine.

 The stopper body of the embodiment 3-9 is configured in the manner of the syringe or the infusion set suction joint channel, and is also applicable to the method shown in FIG. Puncture-free stopper The overall structure.

The puncture-free bottle stopper of the invention is suitable for sealing the bottle mouth with a rubber stopper or a rubber felt, and requires the medicine package to penetrate the bottle stopper injection solution. In use, after opening the lid of the sealed stopper body and the mouth of the bottle, expose the syringe or infusion set suction joint channel or its mark, connect the syringe or the infusion set cone to the syringe or the infusion set suction joint channel (not required The tip of the syringe or the infusion set is punctured into the entire stopper to produce the debris of the stopper material, and the drug solvent or the drug solution can be injected into the bottle through the drug injector or the infusion set or sucked out from the bottle to avoid puncture. Falling debris.

Industrial Applicability

The puncture-free bottle stopper of the invention is suitable for sealing the bottle mouth with a rubber stopper or a rubber felt, and requires the medicine package to penetrate the bottle stopper injection solution. The invention not only ensures the sealing effect of the rubber plug and the rubber felt, but also can directly connect the syringe or the infusion device into the syringe or the infusion set suction joint channel after opening the lid of the sealing stopper body and the bottle mouth. The drug solvent or drug solution can be injected into the bottle through the drug injector or infusion device or sucked out from the bottle to avoid puncture, and no chipping due to puncture, thereby increasing the safety of the drug.

Sequence List Text

Claims (1)

1 A puncture-free stopper, comprising a stopper body and a lid for sealing the stopper body and the bottle mouth, wherein the stopper body is provided with a syringe or an infusion set suction joint passage. 2 The puncture-free stopper according to claim 1, wherein the shape of the stopper body is designed into different geometric shapes according to different shapes of the mouth; the stopper body is made of rubber, butyl rubber, halogenated One or more of butyl rubber and plastic; the cover for sealing the stopper body and the mouth of the bottle is made of aluminum and/or plastic. 3 The puncture-free stopper according to claim 2, wherein said stopper body is composed of an outer plug body and a downward flange, said flange being embedded in the bottle mouth; or said stopper body It is cylindrical and covers the bottle directly. 4 The puncture-free stopper according to claim 1, wherein the syringe or infusion set injection port is designed in various geometric shapes depending on the shape of the syringe or the infusion set. 5 The puncture-free stopper according to claim 1 or 4, wherein the number of the syringe or the infusion set suction joint passage is one or more; when the number of the syringe or the infusion set injection joint passage is one At the time, both the infusion and aspiration solutions are in the same joint channel; when the number of syringe or infusion set suction port channels is multiple, the infusion and aspiration solutions are respectively from different joint channels. 6 The puncture-free stopper according to claim 1, wherein said syringe or infusion set suction port is provided in the middle of the stopper body and extends through the entire stopper body from top to bottom; or said syringe Or the infusion set suction connection channel is arranged at the upper part of the stopper body, and the lower part is provided with the medical liquid passage; or the syringe or the infusion set injection connection passage is arranged in the middle of the stopper body, and the upper part is provided with the syringe or the infusion set insertion hole The lower part is provided with a liquid medicine passage which can automatically open and close. 7 The puncture-free stopper according to claim 4, wherein the syringe or the infusion set suction port is cylindrical, slit-shaped or conical. 8 The puncture-free stopper of claim 1 wherein said syringe or infusion set filler channel is open or closed. 9 The puncture-free stopper according to claim 8, wherein said syringe or infusion set suction port passage is closed, and an insertion mark is provided on the stopper body. 10. A method of using a puncture-free stopper according to any one of claims 1-9, comprising the steps of: (1) opening the lid of the sealed stopper body and the bottle mouth; (2) The syringe or infusion set is connected or inserted into the syringe or the infusion set inlet channel of the bottle body, and the drug solvent or drug solution can be injected into or withdrawn from the bottle through the syringe or the infusion device interface channel.

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