[go: up one dir, main page]

WO2012134990A1 - Dispositif de remodelage vasculaire - Google Patents

Dispositif de remodelage vasculaire Download PDF

Info

Publication number
WO2012134990A1
WO2012134990A1 PCT/US2012/030272 US2012030272W WO2012134990A1 WO 2012134990 A1 WO2012134990 A1 WO 2012134990A1 US 2012030272 W US2012030272 W US 2012030272W WO 2012134990 A1 WO2012134990 A1 WO 2012134990A1
Authority
WO
WIPO (PCT)
Prior art keywords
distal
struts
waist
proximal
face
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/030272
Other languages
English (en)
Inventor
Masoud Molaei
Evan David EPSTEIN
Gabriel Francis Wilgus NEWELL
Quang Tran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covidien LP
Original Assignee
Tyco Healthcare Group LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tyco Healthcare Group LP filed Critical Tyco Healthcare Group LP
Publication of WO2012134990A1 publication Critical patent/WO2012134990A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A61B17/12118—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm for positioning in conjunction with a stent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00526—Methods of manufacturing

Definitions

  • the present application generally relates to vascular remodeling devices and to the manner of their positioning in vessels, including their positioning at the junction of neurovascular bifurcations having an aneurysm, and the use of such devices to treat an aneurysm.
  • Neurovascular or cerebral aneurysms affect about 5% of the population.
  • Aneurysms may be located, for example, along arterial side walls (e.g., the aneurysm 10 illustrated in Figure 1) and at arterial bifurcations (e.g., the aneurysm 20 illustrated in Figure 2).
  • the direction of fluid flow is generally indicated by the arrows 16, 26.
  • the aneurysms 10, 20 each have a fundus 12, 22, a neck 14, 24, and a fundus-to-neck ratio or "neck ratio.” If the neck ratio is greater than 2 to 1 or if the neck 14, 24 is less than 4 mm, the aneurysm 10, 20 may be treated with embolization coils alone because the coils will generally constrain themselves within the aneurysm 10, 20 without herniating into parent vessels. If the neck ratio is less than 2 to 1 or if the neck 14, 24 is greater than 4 mm, the aneurysms 10, 20 may be difficult to treat with embolization coils alone because the coils may be prone to herniating into parent vessels, as illustrated in Figures 3A and 3B.
  • Herniation of coils may cause arterial occlusion, stroke, and/or death.
  • the efferent vessels of the bifurcation may be at substantially different angles, have substantially different sizes, and/or be a different quantity (e.g., three or more).
  • the aneurysm 20 of the bifurcation may be offset with respect to the junction (e.g., having a neck substantially open to one efferent vessel), tilted with respect to a plane created by the vessels (e.g., into or out of the page), etc. Each of these would still be accurately characterized as a "bifurcation" herein.
  • tubular neck remodeling devices for example Neuroform ® , available from Boston Scientific, and EnterpriseTM, available from Cordis Neurovascular, may be used to keep coils or other materials within the fundus of the aneurysm and out of the vessels.
  • Tubular remodeling devices generally consist of a braided wire or cut metallic stent or stents covering the neck of the aneurysm.
  • tubular remodeling devices 40 are generally useful for side wall aneurysms 10.
  • tubular remodeling devices 42, 44 are generally less useful for aneurysms 20 at bifurcations (e.g., the basilar tip area), for example because positioning/shaping the remodeling devices to preserve blood flow through the afferent and efferent vessels while also inhibiting herniation of coils 28 out of the aneurysm 20 can be difficult.
  • the present disclosure includes, without limitation, the following embodiments.
  • Various embodiments of the subject technology are described as numbered clauses (1, 2, 3, etc.) for convenience. These are provided as examples, and do not limit the subject technology or the present disclosure. It is noted that any of the dependent clauses may be combined in any combination, and placed into a respective independent clause. The other clauses can be presented in a similar manner.
  • an anchor portion radially expandable from a collapsed state to an expanded state in a blood vessel such that, when expanded, the anchor portion engages a wall of the vessel, the anchor portion having a longitudinal axis and a first waist comprising the radially largest region of the anchor portion in the expanded state;
  • a distal portion radially expandable from a collapsed state to an expanded state in a blood vessel and having a second waist comprising the radially largest region of the distal portion in its expanded state, the distal portion having a distal face located distal to the second waist;
  • an intermediate portion that couples a distal end of the anchor portion and a proximal end of the distal portion at about the longitudinal axis, the intermediate portion comprising the radially narrowest region of the device between the first waist and the second waist, the distal portion being pivotable radially away from the longitudinal axis about the intermediate portion.
  • distal portion comprises a plurality of distal struts that extend longitudinally and radially outwardly toward the second waist.
  • distal struts extend longitudinally and radially outwardly from the intermediate portion toward the second waist, and further extend longitudinally and radially inwardly from the second waist toward a radially central region of the device.
  • distal struts each have a proximal end and a distal end, and the distal struts are not joined to each other along their lengths between their proximal and distal ends.
  • each of the widened portions of the distal struts further comprises a first and second ramp, wherein the first ramp extends from an edge of its respective strut to an edge of the widened portion, and the second ramp extends from the edge of the widened portion to the edge of the respective strut.
  • the anchor portion comprises a plurality of anchor struts that extend longitudinally and radially outwardly toward the first waist and the distal portion comprises a plurality of distal struts that extend longitudinally and radially outward toward the second waist.
  • the anchor portion and distal portion are able to pivot multiaxially relative to each other at or near the intermediate portion.
  • a vascular remodeling device comprising:
  • an anchor portion sized for deployment in a blood vessel, the anchor portion radially expandable from a collapsed state to an expanded state such that, when expanded in a blood vessel, the anchor portion engages a wall of the vessel, the anchor portion having a longitudinal axis and a first waist comprising the radially largest region of the anchor portion when in the expanded state;
  • a distal portion sized and configured for deployment in a junction of two or more human blood vessels, the distal portion radially expandable from a collapsed state to an expanded state and having a second waist comprising the radially largest region of the distal portion when in the expanded state, the distal portion having a distal face, located distal to the second waist, sized and configured to occlude an aneurysm adjacent the junction when the second waist is in the junction and the distal portion is in the expanded state;
  • an intermediate portion that interconnects a distal end of the anchor portion and a proximal end of the distal portion, the intermediate portion being the radially narrowest region of the device between the first waist and the second waist, the anchor portion and distal portion being able to pivot relative to each other at or near the intermediate portion.
  • the intermediate portion comprises a radially central region of the device.
  • distal portion comprises a plurality of distal struts that extend radially outward toward the second waist.
  • distal struts extend distally away and radially outwardly from the intermediate portion toward the second waist, and further extend distally away and radially inwardly from the second waist toward a radially central region of the device.
  • distal struts each have a proximal end and a distal end, and the struts are not joined to each other anywhere along their length between their proximal and distal ends.
  • the anchor portion comprises a plurality of anchor struts that extend radially outward toward the first waist and the distal portion comprises a plurality of distal struts that extend radially outward toward the second waist.
  • the anchor portion forms a distal face located distal to the first waist; the distal portion forms a proximal face located proximal to the second waist; the distal face of the anchor portion tapers radially inward as it extends distally from the first waist to join the intermediate portion; and
  • the proximal face of the distal portion tapers radially inward as it extends proximally from the second waist to join the intermediate portion.
  • the anchor portion forms a distal face located distal to the first waist
  • the distal portion forms a proximal face located proximal to the second waist;
  • both the distal face of the anchor portion and the proximal face of the distal portion are less occlusive than the distal face of the distal portion.
  • a vascular remodeling device comprising:
  • an anchor portion comprising a plurality of anchor struts radially expandable from a collapsed state to an expanded state for engaging a wall of a blood vessel; a distal portion comprising distal struts radially expandable from a collapsed state to an expanded state for a engaging wall of a blood vessel, the distal struts forming a distal face;
  • At least one of a distal strut and an anchor strut is configured to flex along its length, allowing the distal portion to pivot multiaxially about the intermediate portion and relative to the anchor portion.
  • distal struts extend longitudinally and radially outwardly from the intermediate portion to form a waist of the distal portion and extend distally from the waist to converge toward each other.
  • distal struts each have a proximal end and a distal end, and the struts are not joined to each other along their length between their proximal and distal ends.
  • distal struts extend longitudinally and radially inwardly from the waist to form the distal face of the distal portion.
  • distal struts forming the distal face of the distal portion have widened portions, the widened portions configured to increase an occlusiveness of the distal face.
  • the widened portions of the distal struts further comprise a first and second ramp, wherein the first ramp extends from an edge of the distal strut to an edge of the widened portion, and the second ramp extends from the edge of the widened portion to the edge of the distal strut.
  • a method of treating an aneurysm located near a vascular bifurcation formed at a junction of a parent vessel and multiple branch vessels comprising:
  • vascular remodeling device comprising an anchor portion, a distal portion, and an intermediate portion that couples the anchor portion to the distal portion;
  • distal portion orienting the distal portion relative to the aneurysm such that (a) the distal face extends distally from the engagement region, and tapers radially inwardly, toward the aneurysm, and (b) a proximal face of the distal portion extends proximally, and tapers radially inwardly, away from the aneurysm; tilting, about the intermediate portion, the distal portion relative to the anchor portion; and
  • a vascular remodeling device comprising:
  • an anchor portion radially expandable from a collapsed state to an expanded state such that, when expanded in a blood vessel, the anchor portion engages a wall of the vessel, the anchor portion having a first waist comprising the radially largest region of the anchor portion when in the expanded state;
  • distal portion radially expandable from a collapsed state to an expanded state, the distal portion having a longitudinal axis and a second waist comprising the radially largest region of the distal portion when in the expanded state, the distal portion having a distal face located distal to the second waist;
  • the distal portion comprises a plurality of interconnected distal struts that extend distally from the proximal end of the distal portion such that (a) proximal to the second waist, the struts each (i) diverge from the longitudinal axis and (ii) divide into at least two struts; and (b) distal to the second waist, the struts each (i) merge with an adjacent strut, and (ii) converge toward the longitudinal axis.
  • each strut extends from an origination junction and is divided into a first and second branch, wherein the first branch is connected to a first adjacent strut and the second branch is connected to a second adjacent strut.
  • the widened portions of the struts further comprise a first and second ramp, wherein the first ramp extends from an edge of the strut to an edge of the widened portion, and the second ramp extends from the edge of the widened portion to the edge of the strut.
  • the anchor portion forms a distal face located distal to the waist of the anchor portion
  • the distal portion forms a proximal face located proximal to the waist of the distal portion;
  • both the distal face of the anchor portion and the proximal face of the distal portion are less occlusive than the distal face of the distal portion.
  • distal face is configured to perform a therapeutic blocking function at an aneurysm, the function comprising at least one of (a) supporting maintenance of a therapeutically effective amount and/or density of at least one filling material and/or device in the aneurysm, (b) promoting tlirombogenesis, and (c) diverting flow from the aneurysm.
  • a vascular remodeling device comprising:
  • an anchor portion sized for deployment in a blood vessel, the anchor portion having a longitudinal axis and being radially expandable from a collapsed state to an expanded state, the anchor portion having a first waist comprising the radially largest region of the anchor portion when in the expanded state;
  • a distal portion sized and configured for deployment at a junction of two or more blood vessels
  • the distal portion being radially expandable from a collapsed state to an expanded state, the distal portion comprising a second waist configured to engage a wall of the junction when the distal portion is in its expanded state, the second waist comprising the radially largest region of the distal portion when the distal portion is in its expanded state;
  • the distal portion comprising distal struts that form a distal face located distal to the second waist, the distal face configured to face an aneurysm adjacent the junction when the second waist engages the wall and the distal portion is in its expanded state;
  • the anchor portion comprises a plurality of interconnected distal struts that extend distally from the proximal end of the anchor portion such that (a) proximal to the first waist, the struts each (i) diverge from the longitudinal axis and (ii) divide into at least two struts; and (b) distal to the first waist, the struts each (i) merge with an adjacent stmt, and (ii) converge toward the longitudinal axis.
  • distal face is configured to perform a therapeutic blocking function at the aneurysm, the function comprising at least one of (a) supporting maintenance of a therapeutically effective amount and/or density of at least one filling material and/or device in the aneurysm, (b) promoting thrombogenesis, and (c) diverting flow from the aneurysm.
  • interconnected struts are formed by a first plurality of struts extending from a proximal end of the anchor portion, and a second plurality of struts extending from the distal end of the anchor portion, the first and second plurality being interconnected at the first waist by a third plurality of sub-struts.
  • each strut has a proximal end, a distal end, and a center portion between the proximal and distal ends, each center portion being connected to adjacent struts.
  • each strut extends from an origination junction and is divided into a first and second branch, wherein the first branch is connected to a first adjacent strut and the second branch is connected to a second adjacent strut.
  • shut extends proximally from the intermediate portion and is divided into a first and second branch at or near the first waist, the first branch connected to a first adjacent strut and the second branch connected to a second adjacent strut.
  • distal portion comprises a plurality of interconnected distal struts, wherein the distal struts extend longitudinally and radially inward from the second waist to form the distal face of the distal portion.
  • the widened portions of the struts further comprise a first and second ramp, wherein the first ramp extends from an edge of the strut to an edge of the widened portion, and the second ramp extends from the edge of the widened portion to the edge of the strut.
  • each distal strut has a proximal end, a distal end, and a center portion between the proximal end and distal end, each center portion being connected to adjacent distal struts.
  • each distal strut extends from an origination junction and is divided into a first and second branch, wherein the first branch is connected to a first adjacent distal strut and the second branch is connected to a second adjacent distal strut.
  • the distal portion forms a proximal face located proximal to the second waist;
  • both the distal face of the anchor portion and the proximal face of the distal portion are less occlusive than is the distal face of the distal portion.
  • Figure 1 illustrates an example embodiment of a side wall aneurysm
  • Figure 2 illustrates an example embodiment of a bifurcation having an aneurysm.
  • Figure 3A illustrates an example embodiment of a side wall aneurysm with herniating embolization coils.
  • Figure 3B illustrates an example embodiment of a bifurcation having an aneurysm with herniating embolization coils.
  • Figure 4A illustrates an example embodiment of a side wall aneurysm treated with embolization coils and a tubular remodeling device.
  • Figures 4B and 4C illustrates example embodiments of a bifurcation having an aneurysm treated with embolization coils and tubular remodeling devices.
  • Figure 5 illustrates an example embodiment of a vascular remodeling device.
  • Figure 6 illustrates a partial end view of the device of Figure 5, taken along the direction indicated by the arrows 6-6 in Figure 5.
  • Figure 7 illustrates a partial end view of the device of Figure 5, taken along the direction indicated by the arrows 7-7 in Figure 5.
  • Figure 8 illustrates the device of Figure 5 in an example of a use environment in a vascular bifurcation with an aneurysm.
  • Figure 9 illustrates the device of Figure 5 in an example of a use environment in a vascular bifurcation with an aneurysm and an angled or curving parent vessel.
  • Figure 10 illustrates a variation of the device of Figure 5, in which a proximal section of the device forms an extended waist portion.
  • Figure 11 illustrates the device of Figure 10 in an example of a use environment in a vascular bifurcation with an aneurysm.
  • Figure 12 illustrates an example configuration of a widened portion for use on struts of the device of Figure 5 or the device of Figure 10.
  • Figure 13 illustrates a cut pattern for use in making a device similar to the device of Figure 5, but with six struts in the distal section thereof.
  • Figure 14 is a detail view illustrating the distal section and part of the proximal section of the cut pattern of Figure 13.
  • Figure 15 is a detail view illustrating a proximal end portion of the cut pattern of Figure 13.
  • Figure 16 illustrates a cut pattern for use in making a device similar to the device of Figure 5, but with four struts in each of the proximal and distal sections thereof.
  • Figure 17 is a detail view illustrating the distal section and part of the proximal section of the cut pattern of Figure 16.
  • Figure 18 is a detail view illustrating a proximal end portion of the cut pattern of Figure 16.
  • Figure 19 illustrates part of a method of inserting a vascular remodeling device into a vascular bifurcation having an aneurysm, and/or of treating the aneurysm.
  • Figure 21 illustrates another part of the method of Figures 19-20.
  • Figure 22 illustrates part of a method of placing filling material in an aneurysm located near a bifurcation having a remodeling device therein.
  • Figure 23 illustrates another part of the method of Figure 22.
  • Figure 24 illustrates another part of the method of Figures 22-23.
  • Figure 25 illustrates a cut pattern for use in making another embodiment of the device.
  • Figure 26 illustrates a detail view of a proximal section of the cut pattern of Figure 25.
  • Figures 27 illustrates a detail view of a distal section of the cut pattern of Figure 25.
  • Figure 28 illustrates a device made with the cut pattern of Figures 25-27, in an expanded state.
  • Figure 29 illustrates a detail view of the proximal section of the device of Figure 28.
  • Figure 30 illustrates a proximal end view of the proximal section of the device of Figure 28.
  • Figure 31 illustrates a detail view of the distal section of the device of Figure 28.
  • Figure 32 illustrates a distal end view of the distal section of the device of Figure 28.
  • FIGs 5-7 illustrate an example embodiment of a vascular remodeling device 50.
  • the device 50 may be more compliant than the vasculature in which it is deployed such that it may be somewhat misshapen after being deployed, and that certain shapes described herein are when the device 50 is an expanded (e.g., further expanded) state with no restriction.
  • the device 50 comprises a proximal section 52 (or “bottom section” or “proximal portion” or “anchor portion”), an intermediate section 54 (or “middle section” or “junction” or “pivot junction”), and a distal section 56 (or “top section” or “distal portion”).
  • the device 50 can be delivered via a catheter (e.g., micro catheter) into a bifurcation to support an aneurysm filling device with minimal interruption of blood flow in afferent and efferent vessels.
  • the device 50 may be retrieved and/or repositioned.
  • the proximal section 52 can be radially self-expanding and comprise a plurality of radially self-expanding struts 58.
  • Six struts 58 are depicted in the proximal section 52 of Figures 5-6 (and only four of the struts 58 are visible in Figure 5), but more or fewer struts may be employed in the proximal section 52, as described in further detail herein.
  • the struts 58 converge toward the radial center of the proximal section 52 at the distal end of the proximal section 52, where the proximal section joins the proximal end of the intermediate section 54, and at the proximal end of the proximal section 52, where the proximal section joins a proximal end portion 60 of the device 50.
  • the proximal end portion 60 located at the proximal end of the device 50, may comprise a simple interconnection of the proximal ends of the struts 58, or it may comprise a coupling to facilitate delivery and/or re-sheathability and re-positionability of the device 50.
  • a coupling may comprise an electolytic, mechanical, chemical and/or instant detachment mechanism, configured to connect the device 50 to a delivery member such as a pusher wire.
  • the proximal struts 58 extend radially outward as they advance from the proximal and distal ends of the proximal section 52, thereby forming proximal and distal tapering portions or faces 62, 64 of the proximal section 52.
  • the struts 58 reach their radially outermost extent in a waist portion 66 of the proximal section 52, between the proximal and distal faces 62, 64.
  • the waist 66 may engage a vessel wall to hold the proximal section 52 and device 50 in place as desired.
  • the struts 58 are curved and form curving radial crests or peaks.
  • the struts 58 can be flat and generally straight and parallel, to form an elongate and/or cylindrical waist 66.
  • the struts 58 of the proximal section 52 can have a substantially rectangular or flat cross section (e.g., where the struts 58 comprise uncut portions of a metallic tube or sheet).
  • the struts 58 can alternatively have a substantially round (e.g., circular, elliptical, ovoid) cross section (e.g., where the struts 58 comprise round filaments).
  • the proximal section 52 can comprise two or more struts 58, or between two and twelve struts 58.
  • the proximal section 52 depicted in Figures 5-7 comprises six struts 58
  • the proximal section can alternatively comprise two, three, four, five, seven, eight, nine, ten, eleven or twelve struts 58. Still other numbers of struts are possible.
  • the proximal struts 58 may be equally angularly spaced and/or oriented around the central longitudinal axis of the device 50 (e.g., six struts 60° apart from each adjacent strut as shown in Figure 6, two struts 180° apart from each other, three stmts 120° apart, four struts 90° apart, etc.).
  • the arrangement of the struts are shown in the figures as substantially isometric, the arrangement can place the struts in various angles relative to each other (e.g., six struts varying about 20°, about 40°, about 50°, about 70°, and about 80° apart from each adjacent strut).
  • the proximal section allows flow to efferent vessels because the struts 58 do not block fluid flow.
  • the tapered proximal face 62 of the proximal section 52 may allow the device 50 or portions thereof (e.g., the proximal section 52) to be retrieved back (e.g., in the proximal direction) into a delivery catheter via a distal opening thereof. For example, if the device 50 is being pulled into a catheter, the tapered proximal face 62 may radially compress the proximal section 52. The ability to retrieve the device 50 or proximal section 52 facilitates removal or re-positioning of the device 50 if an initial placement is not satisfactory.
  • the distal section 56 can be radially self-expanding and comprise a plurality of radially self-expanding struts 68. Eight struts 68 are depicted in the distal section 56 of Figures 5 and 7 (and only five of the struts 68 are visible in Figure 5), but more or fewer struts may be employed in the distal section 56, as will be described in further detail below.
  • the struts 68 converge toward the radial center of the distal section 56 at the proximal end of the distal section 56, where the distal section joins the distal end of the intermediate section 54, and at the distal end of the distal section 56, where the distal section joins a distal end portion 70 of the device 50.
  • the distal struts 68 extend radially outward as they advance from the proximal and distal ends of the distal section 56, thereby forming proximal and distal tapering portions or faces 72, 74 of the distal section 56.
  • the struts 68 reach their radially outermost extent in a waist portion 76 of the distal section 56, between the proximal and distal faces 72, 74.
  • the waist 76 may engage a vessel wall to hold the distal section 56 and device 50 in place as desired.
  • the struts 8 are curved and form curving radial crests or peaks.
  • the struts 68 can be flat and generally straight and parallel, to form an elongate and/or cylindrical waist 76.
  • One or more of the struts 68 of the distal section 56 can optionally include or form widened portions or leaves 78 on the distal face 74 of the distal section.
  • the widened portions 78 can provide a blocking function to prevent or reduce the passage of materials or fluids through the distal face 74.
  • the widened portions may be wider than a width of the struts forming the proximal face of the distal section.
  • the widened portions may comprise a first and second ramp, where the first ramp extends from an edge of the strut to an edge of the widened portion, and the second ramp extends from the edge of the widened portion to the edge of the strut.
  • the widened portions 78 can help support aneurysm filling materials or devices (such as coils or embolic materials) within an aneurysm, and/or reduce or block fluid flow through the distal face 74 to promote thrombogenicity and increase the occlusiveness of the distal face.
  • a mesh, membrane or other covering may be employed on the distal face 74 to perform similar function(s). Notwithstanding the presence of the widened portion(s) 78, mesh, membrane or other covering, the distal face 74 can include sufficient open space to allow a microcatheter or other similar device to pass through, to place coils or other aneurysm filling materials or devices in an aneurysm covered by the distal face 74.
  • the distal section 56 can therefore allow for safe and controlled placement of coils, and can be designed to support a certain packing density of coil. If desired, the widened portion(s) 78, mesh, membrane or other covering can block fluid and material passage through the distal face 74 of the distal section 56 to a degree sufficient to provide a flow diversion effect, and serve as a flow diverter, which may allow omission of any coils or other aneurysm filling materials or devices.
  • the struts 68 of the distal section 56 can have a substantially rectangular or flat cross section (e.g., where the struts 68 comprise uncut portions of a metallic tube or sheet).
  • the struts 68 can alternatively have a substantially round (e.g., circular, elliptical, ovoid) cross section (e.g., where the struts 68 comprise round filaments).
  • a circular, elliptical or ovoid cross-section may be imparted to otherwise square or rectangular stmts 58/68 by processing steps such as electropolishing.
  • the distal section can comprise two or more struts 68, or between two and twelve stmts 68.
  • distal section 56 depicted in Figures 5-7 comprises eight struts 68
  • the distal section can alternatively comprise two, three, four, five, six, seven, nine, ten, eleven or twelve struts 68. Still other numbers of struts are possible.
  • the distal struts 68 may be equally angularly spaced and/or oriented around the central longitudinal axis of the device 50 (e.g., eight stmts 45° apart from each adjacent strut as shown in Figure 6, two struts 180° apart from each other, three struts 120° apart, four struts 90° apart, etc.).
  • the tapered proximal face 72 of the distal section 56 may allow the device 50 or portions thereof (e.g., the distal section 56) to be retrieved back (e.g., in the proximal direction) into a delivery catheter via a distal opening thereof. For example, if the device 50 is being pulled into a catheter, the tapered proximal face 72 may radially compress the distal section 56. The ability to retrieve the device 50 or distal section 56 facilitates removal or repositioning of the device 50 if an initial placement is not satisfactory.
  • One or both of the proximal and distal sections 52, 56 can optionally be generally spherical in shape when in the expanded or deployed state,
  • the intermediate section 54 connects the proximal section 52 and the distal section 56, and can be relatively short and relatively narrow (relative to the length and width of the proximal and distal sections 52, 56 when they are expanded).
  • the intermediate section 54 can be located in a radially central region of the device 50, and can be confined to that radially central region (e.g., the device 50 can lack any interconnection between the proximal and distal sections 52, 56 radially outward of the intermediate section 54). So configured, the intermediate section 54 allows the distal section 56 to pivot with respect to the proximal section and thereby allow the device 50 to be deployed in tortuous vasculature.
  • the intermediate section 54 may permit "multiaxial" pivoting or tilting, e.g. at least about a first axis through the intermediate section 54 and orthogonal to the plane of the page in Figures 5 and 8-9, and about a second axis through the intermediate section 54 and orthogonal to the first axis.
  • the intermediate section 54 may permit "omniaxial" pivoting or tilting, about the first and second axes described above, and any radially-oriented axis passing through the intermediate section 54.
  • the intermediate section 54 may comprise a relatively short uncut tube defining a generally tubular outer surface and the proximal and distal struts 58, 68 can comprise proximal and distal extensions of the intermediate section 54 and its tubular outer surface, and be integral and monolithic with the intermediate section 54 and its outer surface.
  • the struts 58, 68 can extend radially outward as they extend proximally (proximal struts 58) and distally (proximal struts 68) from the proximal and distal ends, respectively, of the intermediate portion 54.
  • the proximal struts 8 and/or the distal struts 68 can be co- cylindrical with the intermediate portion 54 where they join the intermediate portion 54 at its proximal and distal ends, respectively. Where they join the intermediate portion 54, the proximal struts 58 and/or the distal struts 68 can be wider (in the circumferential direction with respect to the tubular form of the intermediate portion) than they are thick, and of similar thickness as the sidewall of the intermediate portion 54.
  • the two groups of struts are independent of each other in that forces acting solely on, and/or deflections occurring solely in, the proximal struts 58 do not significantly affect the ability of the distal struts 68 to maintain their expanded state and/or maintain engagement with adjacent portions of the bifurcation 25, and forces acting solely on, and/or deflections occurring solely in, the distal struts 68 do not significantly affect the ability of the proximal stmts 58 to maintain their expanded state and/or maintain engagement with adjacent portions of the bifurcation 25.
  • the struts 58 may be independent of each other (within the group of struts 58), and/or the struts 68 may be independent of each other (within the group of struts 68).
  • the proximal struts 58 are independent of each other and the distal struts 68 are independent of each other.
  • Each proximal strut 58 can bend or pivot with respect to the intermediate section 54 independently of the other proximal struts 58, and each distal strut 68 can bend or pivot with respect to the intermediate section 54 independently of the other distal struts 68.
  • Independence is promoted within each group of struts 58, 68 by interconnecting them only at their proxrmal and distal ends, and in a radially central region of the device 50.
  • independence as used herein does not exclude interconnecting independent components by members (e.g. membranes, very fine wires and the like) that are insufficiently rigid to cause one component to significantly affect the action of the other.
  • proximal struts 58 and/or the distal stmts 68 can also be independent of each other, but only within a limited region of the proximal section 52 and/or distal section 58.
  • the proximal struts 58 may be independent of each other within the distal face 64 of the proximal section, and/or the distal struts 68 may be independent of each other within the proximal face 72 of the distal section 56.
  • tapered distal face 64 of the proximal section 52 and tapered proximal face 72 of the distal section 56 also allow the sections 52, 56 to pivot significantly without contact between the sections 52, 56 other than at the mtermediate section 54.
  • the intermediate section 54 can be rigid or flexible. Where the intermediate section 54 is rigid, the pivotability of the device 50 can be provided by the flexibility and/or independence of the struts 58 in the distal face 64 of the proximal section 52 and of the struts 68 in the proximal face 72 of the distal section 56. In this example, the proximal and distal sections are able to pivot multiaxially relative to each other without requiring plastic deformation of the mtermediate section.
  • Each of struts 58 and struts 68 may be capable of flexing, extending, bowing, straightening, bending, or other elastic or plastic deformation along the length or a portion thereof.
  • sections 52, 56 can pivot about intermediate section 54 and relative to each other.
  • struts on one side of a section may flex (e.g., bend), and struts on an opposing side of a section may extend (e.g., straighten), whereby the section pivots about the region where the struts connect to intermediate section 54.
  • such action is facilitated along one or more sections of the device.
  • this pivot action is provided without requiring plastic deformation of intermediate section 54 or any action along the length of intermediate section 54.
  • the intermediate section 54 can comprise a short length of hypotube (e.g., a short length of uncut hypotube when the proximal and/or distal sections 52, 56 are cut from the hypotube) which may be flexible or rigid.
  • the intermediate section 54 can comprise a flexible coil, longitudinally oriented such that its winds spiral around the central longitudinal axis of the device 50, or the intermediate section 54 can comprise a ball-and-socket joint, a length of flexible wire, or other flexible member.
  • the device 50 can further comprise one or more radiopaque markers (e.g. coils) coupled to or wound around portions of the device.
  • the device 50 can include radiopaque markers on one, two or all three of the proximal end portion 60, intermediate section 54, and distal end portion 70.
  • the device 50 can include radiopaque markers on one or more of the struts 58, and/or on one or more of the struts 68.
  • radiopaque material may be placed within some, one or all of those lumens to make the portion(s) 60/54/70 radiopaque.
  • radiopaque material maybe provided within a lumen of at least one of portion(s) 60/54/70 with securement at one or both of the ends of the lumen.
  • the device 50 can comprise a self-expanding, super elastic, and/or a shape-memory material (e.g., comprising Nitinol, CoCr alloy, shape memory polymers (e.g., polyglycolic acid, polylactic acid), etc.), thereby causing the device 50 to be self-expanding under certain conditions (e.g., when not restrained by a catheter).
  • a shape-memory material e.g., comprising Nitinol, CoCr alloy, shape memory polymers (e.g., polyglycolic acid, polylactic acid), etc.
  • the proximal section 52, the intermediate section 54, and/or the distal section 56 may comprise different materials.
  • the distal section 56 may comprise polymer material while the proximal section 52 and the intermediate section 54 comprise metallic material, a different polymer material, etc.
  • the distal section 56 may comprise metallic material while the proximal section 52 and the intermediate section 54 comprise different metallic materials, polymer material, etc. Other combinations of materials are also possible.
  • the device 50 can assume a low profile compressed state (e.g., confined within a catheter) for delivery. When cut from a tube or sheet, the device 50 may assume substantially the diameter of the tube or rolled sheet when in the compressed state. Upon deployment from the catheter, the device 50 expands from the compressed state to an expanded state.
  • Figure 8 depicts one example of the device 50 in use, positioned at a junction 36 of a bifurcation 25 (e.g., a neurovascular bifurcation (e.g., the basilar tip area)) comprising at least one afferent or parent vessel 30, efferent or branch vessels 32, 34, the junction 36 of the vessels 30, 32, 34, and an aneurysm 20 having a fundus 22 and a neck 24.
  • the proximal section 52 is positioned in the parent vessel 30 in an expanded state, such that the waist 66 contacts the inner wall of the vessel 30.
  • the friction force developed between the proximal section 52 and the inner wall of the parent vessel 30, and/or the friction force developed between the distal section 56 and the inner wall of the junction 36 may suffice to prevent the device 50 from moving significantly in the proximal direction, away from the aneurysm 20 and in the distal direction, toward the aneurysm 20.
  • the distal face 74 of the distal section 56 extends into and occupies at least a portion of the neck 24 of the aneurysm 20.
  • the struts 68 and widened portion(s) 78 (or another structure, such as a mesh or membrane) make the distal face 74 sufficiently low in porosity that the face 74 and device 50 can act as a scaffolding to inhibit or prevent herniation or prolapse of objects (e.g., embolization coils or materials, thrombi, etc.) out of the neck 24 of the aneurysm 20.
  • the device 50 can permit blood to flow from the parent vessel 30 to the efferent vessels 32, 34 of the bifurcation.
  • the proximal section 52 presents minimal axially- facing or proximally-facing surface area (see Figure 6) toward oncoming blood flow in the parent vessel 30 so that blood passes through the proximal section 52 with little or no blockage.
  • the proximal face 72 of the distal section 56 likewise presents minimal axially- facing or proximally-facing surface area toward blood flow that has passed through the proximal section 52, so that such blood passes into or through the distal section 56 with little or no blockage.
  • blood that has passed through the proximal section 52 may flow around the distal section 56 and into one or both efferent vessels 32, 34 (mdicated by arrow 80 in Figure 8), instead of or in addition to blood that flows through the distal section 56 and into the vessel(s) 32, 34.
  • the depicted distal face 74 of the distal section 56 is configured to impede or block blood flow therethrough, via the widened portions 78 and/or other structures as disclosed elsewhere herein. Accordingly, blood tends to stagnate in and around the distal face 74, promoting thrombogenesis, occlusion of the aneurysm 20, and retention of any filling materials and thrombi the aneurysm.
  • Figure 9 depicts another example of the device 50 in use, positioned at a junction of a bifurcation 25 which is similar to that depicted in Figure 8, with the exception that the parent vessel 30 is significantly angled or curved with respect to the efferent vessels 32, 34, the junction 36, and/or the aneurysm 22.
  • the central axis of the parent vessel 30 can be non-coaxial and non-parallel with a central axis of the junction 36 and/or a centr al axis of the aneurysm 20.
  • the various components of the device 50 perform the same functions in the same manner as described with regard to Figure 8, except that the proximal and distal portions 52, 56 are not coaxial, but are in a tilted orientation (e.g., their respective central axes form an included angle of less than 180 degrees), hi addition, one, two or all three of (a) the intermediate portion 54, (b) the struts 58 of the distal face 64 of the proximal portion 52, and (c) the struts 68 of the proximal face 72 of the distal portion 56, may flex or pivot to accommodate the tilted orientation of the portions 52, 56 with respect to each other.
  • a tilted orientation e.g., their respective central axes form an included angle of less than 180 degrees
  • the proximal portion 52 can engage the parent vessel 30 and support the distal portion 56 in the junction 36 and neck 24 sufficiently to prevent significant migration of the device 50 in the distal or pro imal directions, and the distal portion 56 can be approximately centered within the junction 36 and neck 24 (and, where appropriately configured, can engage the inner wall of the junction 36 to provide additional anti-migratory support).
  • connections of the struts 58 and/or the struts 68 to the intermediate portion 54 may be configured to provide pivoting action, such as by making the struts 58/68 slightly thinner where they meet or connect to the intermediate portion 54.
  • Such a pivotable arrangement of the struts and intermediate portion may allow the portions 52 and 56 to tilt with respect to each other without significantly buckling or deformirig the struts and altering the expanded shape of the portions 52, 56.
  • the pivoting connections of the struts 58/68 to the intermediate portion can relieve some or all of the bending stress imparted to the struts 58/68 when the device 50 takes on a tilted orientation as in Figure 9.
  • These structural features may be employed instead of or in addition to others disclosed herein to promote pivoting/tilting the sections 52, 56 without substantially affecting their ability to remain expanded or engage adjacent portions of the bifurcation.
  • the device 50 may be configured to allow the portions 52, 56 to tilt/flex/pivot with respect to each other up to 90 degrees.
  • FIGS 10-11 depict another example of the device 50, which can be similar in structure, function, methods of use and construction, etc. to the device 50 described herein with reference to Figures 5-9, except as further described herein. Accordingly, like reference numerals refer to like components in Figures 5-9, on the one hand, and Figures 10- 11 on the other hand, except where a description or depiction to the contrary is provided expressly herein.
  • the waist 66 comprises a number of waist members 67 that interconnect both laterally (e.g., circumferentially) and longitudinally.
  • the waist members 67 can thus form a number of bands of diamond forms 69 which are expandable in circumference to engage or grip the inner wall of the parent vessel 30 when the device 50 is in use.
  • the waist members 67 can be arranged in circumferentially expandable patterns other than the one depicted in Figures 10-11, with or without the use of diamond forms 69.
  • the struts 58, and the proximal and distal faces 62, 64 of the proximal section 52 can be similar to those described herein with reference to the device 50 of Figures 5-9.
  • the proximal face 62 of the proximal section 52 and the proximal end portion 60 may be omitted altogether, to create a device 50 with an open proximal end.
  • the waist 66 can comprise an expandable woven mesh, woven from filaments of any material disclosed herein as suitable for constructing the device 50.
  • a woven mesh can be cylindrical in form, with the distal edge thereof connected to the proximal ends of the struts 58 of the distal face 64 of the proximal portion 52.
  • the proximal edge of the cylindrical mesh can be connected to the distal ends of the struts 58 of the proximal face 62 of the proximal portion 52.
  • the proximal face 62 of the proximal section 52 and the proximal end portion 60 may be omitted altogether, to create a device 50 with an open proximal end.
  • Figure 12 depicts one example of a widened portion 78 that may be employed with any of the embodiments of the device 50 disclosed herein.
  • One, some or all of the widened portions 78 (and struts 68) of the device 50 may take the form depicted in Figure 12 and further described herein.
  • the strut 68 can be longitudinally split into sub-struts 82 that surround an opening 84 in the widened portion 78.
  • the opening 84 can be left as an open space, in which case the thrombogenicity of the distal face 74 of the distal section 56 is enhanced by the division of the struts 68 of the distal face into a larger number of narrower, spread-apart sub-struts 82.
  • the opening 84 can be filled or covered with radiopaque material, and/or radiopaque coils can be wound around the sub-struts 82.
  • a combination of open and covered/filled radiopaque widened portions 78, and sub-struts 82 bearing radiopaque coils can be employed. The widened portions may also alternate or vary in size from one strut 68 to the next.
  • the struts 68 can be configured to form the sub-struts 82 and opening 84 via tapering portions 86 on either side of the opening 84. Distal and proximal of the tapering portions 86, the struts 68 can be of substantially uniform width. The proximal portion 88 of the strut 68 (proximal of the widened portion 78) can be wider than the distal portion 90 of the strut 68 (distal of the widened portion 78).
  • the width of the proximal strut portion 88 can nonetheless be substantially uniform from the proximal tapering portion 86 to the intermediate portion 54, and the width of the distal strut portion 90 can be substantially uniform (but narrower than the width of the proximal strut portion 88) from the distal tapering portion 86 to the distal tip portion 70 of the device 50.
  • the distal face of the distal portion 56 can be made relatively compliant and therefore more easily conformable to any embolic material in the aneurysm 20, while retaining a desired degree of stiffness in the proximal components of the device 50.
  • the various versions of the vascular remodeling device 50 disclosed herein can be manufactured in a process comprising cutting (or electrochemically etching) and shaping a metallic tube or sheet (e.g., a laser cut hypotube or sheet).
  • a laser or electrochemical etcher may cut out portions of the tube, leaving in place the various structural elements of the proximal section 52, the intermediate section 54, and/or the distal section 56.
  • the proximal section 52, the intermediate section 54, and the distal section 56 can be integrally formed from a metallic tube and not cut away from each other.
  • the device 50 is of single-piece construction, taking the form of a single, partial tube or sheet.
  • the sections 52, 54, 56 can be formed separately and then assembled together using any suitable technique, such as welding, gluing, interlocking, crimping, swaging, braiding, deposition, etc.
  • the intermediate section 54 comprises a coil
  • the sections 52 and 56 may be formed from the same or separate tubes, and then attached to either end of the coil using any such suitable technique.
  • the device 50 or section(s) 52/54/56 thereof may be reshaped and heat treated to impart shape setting to the device or section(s).
  • the shape setting process may include several steps comprising, for example, stretching and confining the cut tube into a new shape during the heat treatment.
  • the cut tube assumes the shape in which it was confined during the heat treatment process.
  • the final shape (e.g., expanded state) and size may obtained by several such steps.
  • the device 50 or cut tube may be electropolished during manufacture, which can reduce the initial wall thickness of the tube to a final, desired thickness.
  • the device 50 can have a contracted state in which the proximal and distal sections 52, 56 take on a smaller diameter than in the expanded state.
  • the sections 52, 56 can have a diameter small enough to fit within a delivery device, such as a microcatheter.
  • the diameter of one or both of the proximal and distal sections 52, 56 when in the contracted state can be substantially equal to the diameter of the tube from which the device 50 is cut, and/or substantially equal to the diameter of the intermediate section 54.
  • the table below provides an example set of dimensions that can be employed in constructing the device 50 of Figures 5-9 and 12.
  • a device 50 can have a proximal section 52 with six struts 58, and a distal section 56 with eight struts 68.
  • the table below also provides an example set of dimensions for all components of the device 50 of Figures 10-12 that are common with the device 50 of Figures 5-9 and 12.
  • the dimensions provided below should not be taken as limiting with respect to the device 50 of Figures 5-9 and 12 or the device 50 of Figures 10-12. One, several or all of these dimensions can be disregarded when constructing the device 50 of Figures 5-9 and 12 or the device 50 of Figures 10-12.
  • Figures 13-15 depict an example of a cut pattern 100 that can be employed (e.g., in laser cutting or etching a hypotube or sheet) to construct the device 50 of Figures 5-9 and 12.
  • the cut pattern 100 of Figures 13-15 is suitable for a device 50 having six struts 68 in the distal portion 56; otherwise, the device 50 formed via the cut pattern 100 can be similar in structure, function and method of use to the device 50 depicted in Figures 5-9 and 12 and described elsewhere herein.
  • the cut pattern 100 provides uncut areas that form the various components of the device 50. Those components of the device 50 are marked in Figures 13- 15 with the same reference numerals as in Figures 5-9 and 12 (and, for common components, as in Figures 10-11).
  • Figures 16-18 depict another example of a cut pattern 200 that can be employed (e.g., in laser cutting or etching a hypotube or sheet) to construct the device 50 of Figures 5-9 and 12.
  • the cut pattern 200 of Figures 16-18 is suitable for a device 50 having four struts 58 in the proximal portion 52 and four struts 68 in the distal portion 56.
  • the cut pattern 200 also forms widened portions 78 whose longitudinal midpoints are on the waist 66 of the distal portion 56, rather than on the distal face 74 thereof.
  • the device 50 formed via the cut pattern 200 can be similar in structure, function and method of use to the device 50 depicted in Figures 5-9 and 12 and described elsewhere herein.
  • the cut pattern 200 provides uncut areas that form the various components of the device 50. Those components of the device 50 are marked in Figures 16-18 with the same reference numerals as in Figures 5-9 and 12 (and, for common components, as in Figures 10-11).
  • Figures 8, 9 and 11 illustrate examples of the placement of the device 50 at a bifurcation 25.
  • the proximal section 52 is anchored in the afferent or parent vessel 30, the intermediate section 54 allows perfusion to the branch or efferent vessels 32, 34, and the distal section 56 acts as scaffolding to inhibit herniation of embolic material from the aneurysm 20, and/or to induce thrombogenesis in the aneurysm 20.
  • Positioning of the device 50 using the parent vessel 30 as the delivery path for the device 50 may be accomplished via, for example, the method illustrated in Figures 19-21.
  • a delivery catheter 300 e.g., a microcatheter or other catheters that can be tracked through and reach the location of the aneurysm 20
  • a distal tip 302 of the catheter 300 is placed in the junction 36, or in the parent vessel 30 proximal of but near the junction 36, or in the aneurysm 22.
  • the device 50 is then is inserted in the proximal end of the catheter 300 (or it may be positioned in the catheter 300 prior to placement of the distal tip 302).
  • the distal section 56 of the device 50 is then pushed out of the distal end of the catheter 300 (e.g., using a push wire and pulling the catheter back), allowing the distal section 56 to expand (e.g., self-expand). While the proximal section 52 remains at least partially contracted within the catheter 300 as shown in Figure 20, the position of the expanded distal section 56 relative to the junction 36, aneurysm neck 24 and parent vessel 30 can be adjusted via manipulation of the catheter 300 (and/or push wire, etc.).
  • FIG. 20 One example of a desired placement of the distal section 56 is depicted in Figure 20, in which the distal face 74 of the distal section 56 spans the aneurysm neck 24 and/or reduces the effective size of the neck. Such spanning and/or reduction can involve positioning the distal section 56 such that the distal face 74 projects into the neck 24, as depicted in Figure 20. The placement of the distal section 56 can also involve causing the expanded waist 76 to engage the inner wall of the junction 36.
  • Such engagement of the waist 76 (and/or other portions of the distal section 56) with the inner wall of the junction 36 can establish and/or maintain both the longitudinal (proximal-distal) and lateral (transverse to the longitudinal direction) position of the distal section 56 relative to the aneurysm neck 24.
  • the presently described method can include determining the size, width or diameter of the junction 36, and selecting a device 50 whose distal section 56 has an unconstrained expanded size, width or diameter (e.g. at the waist 76 thereof) which is larger than that of the junction 36.
  • the selected distal section 56 is somewhat larger than the junction 36, for example by about 0.5-1.0 mm.
  • the inward-tapering, minimally occlusive struts 68 of the proximal face 72 can allow blood to flow with minimal or no obstruction from the parent vessel 30 to the branch vessels 32, 34, either through the proximal face 72 (arrow 79) or around the proximal face 72 (arrow 80).
  • the relatively highly occlusive distal face 74 can span the neck 24 and/or reduce the effective size of the neck.
  • the deployment of the device 50 can further proceed with additional proximal withdrawal of the catheter 300 (and/or distal pushing of the device 50) so that the intermediate section 54 emerges from the catheter 300, followed by the proximal section 52, which is allowed to expand (e.g. self-expand).
  • the waist 66 can engage the inner wall of the parent vessel 30 as shown in Figure 21, and the proximal section 52 can secure the position of the device 50, particularly against longitudinal movement.
  • the extension of the proximal section 52 into the parent vessel 30 can prevent rotation of the distal section 56 in the junction 36 (or, where applicable, the neck 24 or aneurysm 20), and help maintain the waist 76 in engagement with the inner wall of the junction (or neck, or aneurysm).
  • the presently described method can involve tilting, flexing or pivoting the distal section 56 relative to the proximal section 52 (or vice versa), e.g. as the device 50 is advanced into position, and/or adjusted in position or orientation once advanced and deployed or partially deployed.
  • the device may be a maneuvered around the bend allowing the distal section and the proximal section to pivot relative to each other at or near the intermediate section.
  • the device 50 can be left in its tilted/flexed/pivoted configuration following deployment, as depicted in Figure 9.
  • portions of the proximal section 52 other than the waist 66 may engage the inner wall of the parent vessel 30, depending on the degree to which the sections 52, 56 are tilted with respect to each other.
  • the proximal and/or distal faces 62, 64 of the proximal section 52 may engage the inner wall of the parent vessel 30.
  • the proximal section 52 can be tilted within the parent vessel 30 such that one side of the proximal face 62 and the opposite side of the distal face 64 both engage the inner wall of the vessel.
  • the intermediate section 54 may engage or contact the vessel wall as well.
  • the device 50 can be detached from the catheter 300, pusher wire, etc. electrolytically, mechanically, or chemically, and the catheter 300 withdrawn (see Figure 21).
  • the catheter 300 may then be withdrawn from the bifurcation 25, thereby leaving or permanently positioning the device 50 at the junction 36 of the bifurcation 25.
  • Embolic material may be placed in the aneurysm 20 before, after, and/or during positioning of the device 50.
  • a catheter which can comprise the catheter 300 or a separate catheter 310 as shown in Figure 22, is advanced distally through the parent vessel 30 and the proximal and distal sections 52, 56 of the device 50 until a distal tip 312 thereof passes through and is positioned distal of the distal section 56, in the fundus 22.
  • one or more coils 320 can then be advanced distally through the catheter 310 and into the fundus 22.
  • Sufficient coils 320 and/or other material can be so delivered into the fundus 22 to create a mass 330 of filling material in the fundus (Figure 24).
  • the device 50 in particular the distal face 74 of the distal section 56, can act as a scaffolding to support the mass 330 in the aneurysm 20 and prevent herniation of coils or other material through the neck 24.
  • Figures 25-32 depict a version of the device 50 (and a cut pattern 300 for constructing it) that can be similar to any of the other versions or embodiments of the device 50 disclosed or summarized herein, in structure, configuration, function, method of manufacture, method of use, and material choice, except as further discussed herein.
  • the struts 58 of the proximal section 52 comprise a number (e.g. 6, as depicted, or any other suitable number) of proximal strut portions 58a and a corresponding number of distal strut portions 58b.
  • each proximal portion 58a and the distal portions 58b are rotated or shifted laterally with respect to each other, such that each proximal portion 58a opposes (e.g., approximately one-half of each of) two distal portions 58b, and vice versa.
  • two sub-struts 58c extend distally to the two distal portions 58b that oppose (or are longitudinally adjacent) the proximal portion 58a from which the sub- struts 58c extend.
  • each proximal portion 58a is connected to the two adjacent or opposing distal portions 58b (and vice versa) via sub-struts 58c.
  • each strut may have a proximal end, a distal end, and a center portion therebetween, the center portion connected to adjacent struts.
  • each strut may extend from an origination junction and be divided into a first and second branch, wherein the first branch is connected to a first adjacent strut and the second branch is connected to a second adjacent strut.
  • a length of the first branch and a length of the second branch may be different such that a connecting point between the strut and the first adjacent strut is disposed at a different longitudinal position than a connecting point between the strut and the second adjacent strut.
  • the length of the first branch and the length of the second branch may be the same.
  • at least one strut may extend proximally from the intermediate section and be divided into a first and second branch at or near the waist of the proximal section.
  • the first branch may be connected to the first adjacent strut and the second branch may be connected to the second adjacent strut.
  • the first and second adjacent struts may extend proximally from the waist of the proximal section toward the radially central region of the device.
  • one or more sections 52, 56 may have a first plurality of struts extending from a proximal end of the section and a second plurality of struts extending from the distal end of the section.
  • the first and second plurality of struts may be interconnected at the waist or middle portion of the section by a third plurality of struts.
  • Each of the first plurality of struts may be connected to two or more of the third plurality of struts.
  • Each of the second plurality of struts may be connected to two or more of the third plurality of struts.
  • the number of the first plurality of struts may equal the number of the second plurality of struts.
  • the number of the third plurality of stmts may be double, triple, or another multiple of one or each of the number of the first plurality of struts and the number of the second plurality of struts.
  • the sub-struts 58c extend both longitudinally to interconnect the proximal end portion 60 and the intermediate section 54, and laterally or circumferentially to each neighboring proximal or distal portion 58a or 58b.
  • the resulting lateral or circumferential interconnection of the struts 58 of the proximal section 52 increases the outward radial force exerted by the proximal section 52 (and the inward radial force that the proximal section 52 can withstand without collapse) when expanded and thereby improves the ability of the proximal portion 52 to "grip" the vessel wall (e.g.
  • the lateral/circumferential interconnection of the struts of the proximal section 52 reduces the tendency of the expanded struts 58 to bunch together in the vessel or "half-moon.” Further, the later al/circumferential interconnection of the struts of the proximal section maintains the three dimensional shape of the proximal section. Moreover, the lateral/circumferential interconnection of the struts of the proximal section provides structural support for the interconnected struts.
  • the sub-struts 58c (e.g., the peaks thereof) can form the waist 66 of the proximal portion 52, or otherwise comprise the radially outermost portion of the proximal portion 52.
  • the sub-struts 58c can optionally be approximately longitudinally centered on the longitudinal midpoint of the proximal portion 52, such that the midpoint approximately evenly divides the sub-struts 58c in the longitudinal direction. Such an arrangement is also depicted in Figures 25-26 and 28-29.
  • the widened portions 78 on the distal face 74 of the distal portion 56 can be formed via the lateral/circumferential interconnection arrangement employed in the proximal section 52 and discussed above.
  • the proximal strut portions 88 and distal strut portions 90 of the distal struts 68 are rotated or shifted laterally with respect to each other, such that each proximal portion 88 opposes (e.g., approximately one-half of each of) two distal portions 90, and vice versa.
  • each proximal portion 88 is connected to the two adjacent or opposing distal portions 90 (and vice versa) via sub-struts 82.
  • at least one strut may extend distally from the intermediate section and be divided into a first and second branch at or near the waist of the distal section.
  • the first branch may be connected to the first adjacent strut and the second branch may be connected to the second adjacent strut.
  • the first and second adjacent struts may extend distally from the waist of the distal section toward the radially central region of the device.
  • the sub-struts 82 extend both longitudinally to interconnect the mtermediate section 54 and the distal end portion 70, and laterally or circumferentially to each neighboring proximal or distal strut portion 88 or 90.
  • the widened portions 78 having openings 84 in a configuration that increases the outward radial force exerted by the distal section 56 and its ability to grip the inner wall of a vessel, e.g. at the junction 36.
  • the lateral/circumferential interconnection of the struts 68 of the distal section 56 reduces the tendency of the expanded struts 68 to bunch together in the vessel or "half-moon.” Further, the lateral/circumferential interconnection of the struts of the distal section maintains the three dimensional shape of the distal section. Moreover, the lateral/circurnferential interconnection of the struts of the distal section provides structural support for the interconnected struts.
  • the widened portions 78 and the sub-struts 82 can be located on the distal face 74 of the distal portion 56.
  • the widened portions 78 and sub-struts 82 can optionally be located wholly distal of the waist 76 of the distal portion 56.
  • Such an arrangement is also depicted in Figures 25-26 and 28-29.
  • the widened portions may resemble the structures as disclosed elsewhere herein.
  • the device 50 of Figures 25-32 can be employed in performing any of the methods disclosed herein, e.g. any of the disclosed metliods for treating aneurysms or blood vessels such as those depicted and described with reference to Figures 8-9 or 19-24.
  • the device 50 of Figures 25-32 can be deployed in vasculature, e.g. at a bifurcation, in the manner depicted in Figures 8, 9 or 19-24.
  • the features, components, materials or properties of the device 50 of Figures 25-32 can be combined with any of the features, components, materials or properties of any of the other versions or embodiments of the device 50 depicted, described or summarized herein.
  • proximal and distal sections 52, 56 of the device 50 of Figures 25-32 can be employed when constructing the proximal and/or distal sections of any of .the other versions or embodiments of the device 50 depicted, described or summarized herein.
  • the device 50 can be configured as a flow diverter by making the distal face 74 of the distal section 56 sufficiently occlusive to inhibit blood flow out of the fundus 22 and promote formation of thrombus therein.
  • the device 50 can be used as a "rescue device” to push the herniated material back into the aneurysm and to act as a scaffolding to inhibit or prevent further herniation or prolapse of the embolic material.
  • deployment of the device 50 may advantageously avoid traversal of the junction comprising the herniated material by wires or a catheter, which may cause the herniated material to become tangled and/or dislodged and which may cause rupture of the aneurysm.
  • Tt should be understood that various features and aspects of the disclosed embodiments/examples can be combined with, or substituted for, one another in order to form varying modes of the embodiments/examples of the disclosed invention(s). Thus, it is intended that the scope of the invention(s) herein disclosed should not be limited by the particular embodiments/examples described above.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Surgical Instruments (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne un dispositif de remodelage vasculaire. Ledit dispositif comprend une partie d'ancrage, d'une taille telle à permettre son déploiement dans un vaisseau sanguin, ladite partie pouvant se déployer radialement pour passer d'une configuration repliée à une configuration déployée. Ledit dispositif comprend également une partie distale d'une taille telle à permettre son déploiement dans un vaisseau sanguin. Ladite partie distale peut se déployer radialement pour passer d'une configuration repliée à une configuration déployée et, dans certains modes de réalisation, elle comporte une face distale qui est suffisamment occlusive en allant de la partie distale vers la partie proximale pour faire office de dispositif thérapeutique d'obstruction au niveau d'un anévrysme. Dans certains modes de réalisation, une partie intermédiaire relie l'extrémité distale d'une partie d'ancrage à l'extrémité proximale de la partie distale, tandis que dans certains modes de réalisation la partie d'ancrage et la partie distale peuvent pivoter l'une par rapport à l'autre au niveau de la partie intermédiaire ou à proximité de celle-ci.
PCT/US2012/030272 2011-03-25 2012-03-23 Dispositif de remodelage vasculaire Ceased WO2012134990A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161467771P 2011-03-25 2011-03-25
US61/467,771 2011-03-25
US201161487648P 2011-05-18 2011-05-18
US61/487,648 2011-05-18

Publications (1)

Publication Number Publication Date
WO2012134990A1 true WO2012134990A1 (fr) 2012-10-04

Family

ID=45937630

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/030272 Ceased WO2012134990A1 (fr) 2011-03-25 2012-03-23 Dispositif de remodelage vasculaire

Country Status (2)

Country Link
US (4) US9089332B2 (fr)
WO (1) WO2012134990A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11241321B2 (en) 2016-10-04 2022-02-08 Yasuhiro Shobayashi Flexible stent
EP4279025A4 (fr) * 2021-01-15 2025-02-12 Suzhou Lavamed Co., Ltd. Appareil d'élimination de thrombus

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007047851A2 (fr) 2005-10-19 2007-04-26 Pulsar Vascular, Inc. Procedes et systemes d'agrafage et de reparation par voie endovasculaire d'anomalies dans des lumieres ou des tissus
US20090287291A1 (en) 2008-04-21 2009-11-19 Becking Frank P Embolic Device Delivery Systems
US10716573B2 (en) 2008-05-01 2020-07-21 Aneuclose Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm
US10028747B2 (en) 2008-05-01 2018-07-24 Aneuclose Llc Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm
WO2009140437A1 (fr) 2008-05-13 2009-11-19 Nfocus Neuromedical, Inc. Systèmes de pose d'implant tressé
AU2009274126A1 (en) 2008-07-22 2010-01-28 Covidien Lp Vascular remodeling device
CA2736251C (fr) 2008-09-05 2017-11-28 Pulsar Vascular, Inc. Systemes et procedes pour soutenir ou fermer une ouverture ou cavite physiologique
ES2922979T3 (es) 2009-09-04 2022-09-22 Pulsar Vascular Inc Sistemas para encerrar una abertura anatómica
CN102791205B (zh) 2009-11-09 2016-02-03 恩福克斯神经医学股份有限公司 栓塞装置
US9358140B1 (en) 2009-11-18 2016-06-07 Aneuclose Llc Stent with outer member to embolize an aneurysm
CN102770091B (zh) 2010-01-28 2015-07-08 泰科保健集团有限合伙公司 脉管重塑装置
EP2528542A4 (fr) 2010-01-28 2013-07-03 Covidien Lp Dispositif de remodelage vasculaire
EP2672900B1 (fr) 2011-02-11 2017-11-01 Covidien LP Dispositifs d'embolisation d'anévrisme à déploiement en deux étapes
WO2012134990A1 (fr) 2011-03-25 2012-10-04 Tyco Healthcare Group Lp Dispositif de remodelage vasculaire
JP6563192B2 (ja) 2011-06-03 2019-08-21 パルサー バスキュラー インコーポレイテッド 動脈瘤装置と動脈瘤治療システム
JP6219270B2 (ja) 2011-06-03 2017-10-25 パルサー バスキュラー インコーポレイテッド 動脈瘤装置
WO2013049448A1 (fr) 2011-09-29 2013-04-04 Covidien Lp Dispositif de remodelage vasculaire
EP3738527A1 (fr) 2011-10-05 2020-11-18 Pulsar Vascular, Inc. Dispositifs de fermeture d'une ouverture anatomique
US9314248B2 (en) 2012-11-06 2016-04-19 Covidien Lp Multi-pivot thrombectomy device
US10342546B2 (en) * 2013-01-14 2019-07-09 Microvention, Inc. Occlusive device
US9295571B2 (en) 2013-01-17 2016-03-29 Covidien Lp Methods and apparatus for luminal stenting
US9463105B2 (en) 2013-03-14 2016-10-11 Covidien Lp Methods and apparatus for luminal stenting
CN105142545B (zh) 2013-03-15 2018-04-06 柯惠有限合伙公司 闭塞装置
US9629635B2 (en) * 2014-04-14 2017-04-25 Sequent Medical, Inc. Devices for therapeutic vascular procedures
BR112017017882B1 (pt) 2015-02-25 2023-04-11 Galaxy Therapeutics, Inc Aparelho para o tratamento de um aneurisma em um vaso sanguíneo
WO2017035275A1 (fr) * 2015-08-24 2017-03-02 Neurvana Medical Llc Dispositifs, procédés, processus et systèmes d'occlusion intrasaculaire
US10478194B2 (en) 2015-09-23 2019-11-19 Covidien Lp Occlusive devices
DE102015121757A1 (de) * 2015-12-14 2017-06-14 Phenox Gmbh Implantat
EP3456272B1 (fr) * 2016-02-10 2022-10-05 Microvention, Inc. Dispositifs pour occlusion vasculaire
EP3484559B1 (fr) 2016-07-18 2023-08-23 Merit Medical Systems, Inc. Dispositif gonflable de compression d'artères radiales
US11185335B2 (en) * 2018-01-19 2021-11-30 Galaxy Therapeutics Inc. System for and method of treating aneurysms
US11284902B2 (en) * 2018-02-01 2022-03-29 Boston Scientific Scimed, Inc. Method of making a vascular occlusion device
US12102327B2 (en) 2019-05-25 2024-10-01 Galaxy Therapeutics, Inc. Systems and methods for treating aneurysms
EP4284263A4 (fr) 2021-01-27 2024-06-26 Galaxy Therapeutics, Inc. Systèmes et méthodes pour traiter des anévrismes

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000139A1 (fr) * 2000-06-23 2002-01-03 Frantzen John J Stent expansible radialement pour le traitement d'anevrismes
US20060064151A1 (en) * 2004-09-22 2006-03-23 Guterman Lee R Cranial aneurysm treatment arrangement
WO2006034166A2 (fr) * 2004-09-17 2006-03-30 Cordis Neurovascular, Inc. Dispositifs metalliques a couche mince utilises pour colmater des anevrismes ou des vaisseaux
WO2008151204A1 (fr) * 2007-06-04 2008-12-11 Sequent Medical Inc. Procédés et dispositifs pour le traitement de défauts vasculaires

Family Cites Families (448)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3108593A (en) 1961-03-13 1963-10-29 Jacob A Glassman Surgical extractor
DE1283434B (de) 1963-06-25 1968-11-21 Dr Jacob A Glassmann Instrument zum Einfuehren in natuerliche Koerperkanaele und zum Erfassen und Herausbringen darin befindlicher Fremdkoerper
US4425908A (en) 1981-10-22 1984-01-17 Beth Israel Hospital Blood clot filter
SE445884B (sv) 1982-04-30 1986-07-28 Medinvent Sa Anordning for implantation av en rorformig protes
US5190546A (en) 1983-10-14 1993-03-02 Raychem Corporation Medical devices incorporating SIM alloy elements
FR2556210B1 (fr) 1983-12-08 1988-04-15 Barra Jean Aubert Prothese veineuse et son procede d'obtention
US5749920A (en) 1983-12-09 1998-05-12 Endovascular Technologies, Inc. Multicapsule intraluminal grafting system and method
DK151404C (da) 1984-05-23 1988-07-18 Cook Europ Aps William Sammenklappeligt filter til implantation i en patients blodkar
EP0556940A1 (fr) 1986-02-24 1993-08-25 Robert E. Fischell Stent intravasculaire
SE453258B (sv) 1986-04-21 1988-01-25 Medinvent Sa Elastisk, sjelvexpanderande protes samt forfarande for dess framstellning
WO1988000813A1 (fr) 1986-08-05 1988-02-11 St. Jude Medical, Inc. Prothese vasculaire tressee en polyester et procede de fabrication
FR2624747A1 (fr) 1987-12-18 1989-06-23 Delsanti Gerard Dispositifs endo-arteriels amovibles destines a reparer des decollements de parois des arteres
US4921484A (en) 1988-07-25 1990-05-01 Cordis Corporation Mesh balloon catheter device
EP0408245B1 (fr) 1989-07-13 1994-03-02 American Medical Systems, Inc. Dispositif d'introduction d'un dilatateur
IE73670B1 (en) 1989-10-02 1997-07-02 Medtronic Inc Articulated stent
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US6083220A (en) 1990-03-13 2000-07-04 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5354295A (en) 1990-03-13 1994-10-11 Target Therapeutics, Inc. In an endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE42625E1 (en) 1990-03-13 2011-08-16 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5122136A (en) 1990-03-13 1992-06-16 The Regents Of The University Of California Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5221261A (en) 1990-04-12 1993-06-22 Schneider (Usa) Inc. Radially expandable fixation member
US5158548A (en) 1990-04-25 1992-10-27 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5064435A (en) 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
WO1992001425A1 (fr) 1990-07-26 1992-02-06 Rodney James Lane Endoprothese vasculaire a autodilatation pour anevrismes
US5222971A (en) 1990-10-09 1993-06-29 Scimed Life Systems, Inc. Temporary stent and methods for use and manufacture
USRE38653E1 (en) 1991-03-08 2004-11-16 Kabushikikaisha Igaki Iryo Sekkei Luminal stent, holding structure therefor and device for attaching luminal stent
USRE38711E1 (en) 1991-03-08 2005-03-15 Kabushikikaisha Igaki Iryo Sekkei Luminal stent, holding structure therefor and device for attaching luminal stent
US5766151A (en) 1991-07-16 1998-06-16 Heartport, Inc. Endovascular system for arresting the heart
US5232648A (en) 1991-07-19 1993-08-03 United States Surgical Corporation Bioabsorbable melt spun fiber based on glycolide-containing copolymer
US5527338A (en) 1992-09-02 1996-06-18 Board Of Regents, The University Of Texas System Intravascular device
US5250071A (en) 1992-09-22 1993-10-05 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking clasps and method of use
EP0596145B1 (fr) 1992-10-31 1996-05-08 Schneider (Europe) Ag Disposition d'introduction d'une endoprothése autoexpansible
US5308356A (en) 1993-02-25 1994-05-03 Blackshear Jr Perry L Passive perfusion angioplasty catheter
WO1994021170A1 (fr) 1993-03-16 1994-09-29 Ep Technologies, Inc. Ensembles de circuits souples mettant en ×uvre un cable en ruban
US5476495A (en) 1993-03-16 1995-12-19 Ep Technologies, Inc. Cardiac mapping and ablation systems
US5334210A (en) 1993-04-09 1994-08-02 Cook Incorporated Vascular occlusion assembly
US5545209A (en) 1993-09-30 1996-08-13 Texas Petrodet, Inc. Controlled deployment of a medical device
RU2089131C1 (ru) 1993-12-28 1997-09-10 Сергей Апполонович Пульнев Стент
FR2714815B1 (fr) 1994-01-10 1996-03-08 Microfil Ind Sa Prothèse élastique pour élargir un conduit, notamment un vaisseau sanguin.
US5549635A (en) 1994-01-24 1996-08-27 Solar, Rita & Gaterud, Ltd. Non-deformable self-expanding parallel flow endovascular stent and deployment apparatus therefore
US20030032963A1 (en) 2001-10-24 2003-02-13 Kyphon Inc. Devices and methods using an expandable body with internal restraint for compressing cancellous bone
DE69529216T2 (de) 1994-03-04 2007-08-30 Coloplast A/S Selbstdichtende injektionsvorrichtung und verfahren zu deren herstellung
US5634942A (en) 1994-04-21 1997-06-03 B. Braun Celsa Assembly comprising a blood filter for temporary or definitive use and a device for implanting it
US6001092A (en) 1994-06-24 1999-12-14 Target Therapeutics, Inc. Complex coils having fibered centers
EP1695673A3 (fr) 1994-07-08 2009-07-08 ev3 Inc. Filtre intravasculaire
US6123715A (en) 1994-07-08 2000-09-26 Amplatz; Curtis Method of forming medical devices; intravascular occlusion devices
US5725552A (en) 1994-07-08 1998-03-10 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5846261A (en) 1994-07-08 1998-12-08 Aga Medical Corp. Percutaneous catheter directed occlusion devices
US5702419A (en) 1994-09-21 1997-12-30 Wake Forest University Expandable, intraluminal stents
US5690671A (en) 1994-12-13 1997-11-25 Micro Interventional Systems, Inc. Embolic elements and methods and apparatus for their delivery
US5879366A (en) 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US5814062A (en) 1994-12-22 1998-09-29 Target Therapeutics, Inc. Implant delivery assembly with expandable coupling/decoupling mechanism
CA2173023C (fr) 1995-03-30 2001-08-28 David Kupiecki Serpentins configurables
BE1009278A3 (fr) 1995-04-12 1997-01-07 Corvita Europ Tuteur auto-expansible pour dispositif medical a introduire dans une cavite d'un corps, et dispositif medical muni d'un tel tuteur.
AU4632196A (en) 1995-04-14 1996-10-30 Schneider (Usa) Inc. Rolling membrane stent delivery device
US5911731A (en) 1995-04-20 1999-06-15 Target Therapeutics, Inc. Anatomically shaped vasoocclusive devices
US5645558A (en) 1995-04-20 1997-07-08 Medical University Of South Carolina Anatomically shaped vasoocclusive device and method of making the same
US5624461A (en) 1995-06-06 1997-04-29 Target Therapeutics, Inc. Three dimensional in-filling vaso-occlusive coils
NO962336L (no) 1995-06-06 1996-12-09 Target Therapeutics Inc Vaso-okklusiv spiral
US5713907A (en) 1995-07-20 1998-02-03 Endotex Interventional Systems, Inc. Apparatus and method for dilating a lumen and for inserting an intraluminal graft
US5758562A (en) 1995-10-11 1998-06-02 Schneider (Usa) Inc. Process for manufacturing braided composite prosthesis
US6689162B1 (en) 1995-10-11 2004-02-10 Boston Scientific Scimed, Inc. Braided composite prosthesis
EP0775470B1 (fr) 1995-11-14 1999-03-24 Schneider (Europe) GmbH Dispositif pour l'implantation d'une endoprothèse
WO1997025919A1 (fr) 1996-01-19 1997-07-24 Ep Technologies, Inc. Systemes et procedes de chauffage et ablation de tissus a l'aide de structures d'electrodes multi-fonctionnelles
US6168622B1 (en) 1996-01-24 2001-01-02 Microvena Corporation Method and apparatus for occluding aneurysms
IL125417A (en) 1996-02-02 2004-03-28 Transvascular Inc Apparatus for blocking flow through blood vessels
US5733294A (en) 1996-02-28 1998-03-31 B. Braun Medical, Inc. Self expanding cardiovascular occlusion device, method of using and method of making the same
JP3804690B2 (ja) 1996-03-11 2006-08-02 鹿島塩ビモノマー株式会社 １，２−ジクロロエタンの熱分解工程における熱回収方法及び熱回収装置
US5853422A (en) 1996-03-22 1998-12-29 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
AR001590A1 (es) 1996-04-10 1997-11-26 Jorge Alberto Baccaro Dispositivo oclusor de comunicaciones vasculares anormales y cartucho aplicador de dicho dispositivo
US5792154A (en) 1996-04-10 1998-08-11 Target Therapeutics, Inc. Soft-ended fibered micro vaso-occlusive devices
US5718159A (en) 1996-04-30 1998-02-17 Schneider (Usa) Inc. Process for manufacturing three-dimensional braided covered stent
US6440088B1 (en) 1996-05-24 2002-08-27 Precision Vascular Systems, Inc. Hybrid catheter guide wire apparatus and method
US6666883B1 (en) 1996-06-06 2003-12-23 Jacques Seguin Endoprosthesis for vascular bifurcation
US6190402B1 (en) 1996-06-21 2001-02-20 Musc Foundation For Research Development Insitu formable and self-forming intravascular flow modifier (IFM) and IFM assembly for deployment of same
US6077295A (en) 1996-07-15 2000-06-20 Advanced Cardiovascular Systems, Inc. Self-expanding stent delivery system
US6096034A (en) 1996-07-26 2000-08-01 Target Therapeutics, Inc. Aneurysm closure device assembly
US5980514A (en) 1996-07-26 1999-11-09 Target Therapeutics, Inc. Aneurysm closure device assembly
US5968069A (en) 1996-08-23 1999-10-19 Scimed Life Systems, Inc. Stent delivery system having stent securement apparatus
US5941249A (en) 1996-09-05 1999-08-24 Maynard; Ronald S. Distributed activator for a two-dimensional shape memory alloy
US5968068A (en) 1996-09-12 1999-10-19 Baxter International Inc. Endovascular delivery system
JP2001500987A (ja) 1996-09-23 2001-01-23 ピーエスシー・スキャニング・インコーポレイテッド バーコード走査器用ディザリング機構
US5957974A (en) 1997-01-23 1999-09-28 Schneider (Usa) Inc Stent graft with braided polymeric sleeve
JP3523765B2 (ja) 1997-01-24 2004-04-26 テルモ株式会社 生体器官拡張器具
US6096073A (en) 1997-02-25 2000-08-01 Scimed Life Systems, Inc. Method of deploying a stent at a lesion site located at a bifurcation in a parent vessel
US5830230A (en) 1997-03-07 1998-11-03 Micro Therapeutics, Inc. Method of intracranial vascular embolotherapy using self anchoring coils
US5980554A (en) 1997-05-05 1999-11-09 Micro Therapeutics, Inc. Wire frame partial flow obstruction for aneurysm treatment
US5951599A (en) 1997-07-09 1999-09-14 Scimed Life Systems, Inc. Occlusion system for endovascular treatment of an aneurysm
US5928260A (en) 1997-07-10 1999-07-27 Scimed Life Systems, Inc. Removable occlusion system for aneurysm neck
US7569066B2 (en) 1997-07-10 2009-08-04 Boston Scientific Scimed, Inc. Methods and devices for the treatment of aneurysms
GB9715241D0 (en) 1997-07-18 1997-09-24 Jeffree Martin A Device for treating aneurysms
JP4060528B2 (ja) 1997-08-04 2008-03-12 ボストン サイエンティフィック コーポレーション 動脈瘤治療のための閉塞システム
DE69834920T2 (de) 1997-08-05 2007-05-24 Boston Scientific Ltd., St. Michael Ablösbares system zum verschliessen eines aneurysmashalses
US6063070A (en) 1997-08-05 2000-05-16 Target Therapeutics, Inc. Detachable aneurysm neck bridge (II)
US6086577A (en) 1997-08-13 2000-07-11 Scimed Life Systems, Inc. Detachable aneurysm neck bridge (III)
US5916235A (en) 1997-08-13 1999-06-29 The Regents Of The University Of California Apparatus and method for the use of detachable coils in vascular aneurysms and body cavities
US6860893B2 (en) 1997-08-29 2005-03-01 Boston Scientific Scimed, Inc. Stable coil designs
US6322576B1 (en) 1997-08-29 2001-11-27 Target Therapeutics, Inc. Stable coil designs
US6066149A (en) 1997-09-30 2000-05-23 Target Therapeutics, Inc. Mechanical clot treatment device with distal filter
US6511468B1 (en) 1997-10-17 2003-01-28 Micro Therapeutics, Inc. Device and method for controlling injection of liquid embolic composition
ATE452598T1 (de) 1997-11-07 2010-01-15 Salviac Ltd Embolieschutzvorrichtung
US6443972B1 (en) * 1997-11-19 2002-09-03 Cordis Europa N.V. Vascular filter
US6036720A (en) 1997-12-15 2000-03-14 Target Therapeutics, Inc. Sheet metal aneurysm neck bridge
US6626939B1 (en) 1997-12-18 2003-09-30 Boston Scientific Scimed, Inc. Stent-graft with bioabsorbable structural support
US7070607B2 (en) 1998-01-27 2006-07-04 The Regents Of The University Of California Bioabsorbable polymeric implants and a method of using the same to create occlusions
US5873907A (en) 1998-01-27 1999-02-23 Endotex Interventional Systems, Inc. Electrolytic stent delivery system and methods of use
US20070093889A1 (en) 1999-01-27 2007-04-26 Wu Benjamin M Non-Fragmenting Low Friction Bioactive Absorbable Coils for Brain Aneurysm Therapy
US5944738A (en) 1998-02-06 1999-08-31 Aga Medical Corporation Percutaneous catheter directed constricting occlusion device
ATE454098T1 (de) 1998-02-10 2010-01-15 Artemis Medical Inc Okklusions-, verankerungs-, span- oder stromsteuergerät
US6676696B1 (en) 1998-02-12 2004-01-13 Thomas R. Marotta Endovascular prosthesis
AU754966B2 (en) 1998-02-12 2002-11-28 Thomas R. Marotta Endovascular prosthesis
US5925060A (en) 1998-03-13 1999-07-20 B. Braun Celsa Covered self-expanding vascular occlusion device
US6063111A (en) 1998-03-31 2000-05-16 Cordis Corporation Stent aneurysm treatment system and method
US6168615B1 (en) 1998-05-04 2001-01-02 Micrus Corporation Method and apparatus for occlusion and reinforcement of aneurysms
ATE484247T1 (de) 1998-06-01 2010-10-15 Kyphon S Rl Entfaltbare, vorgeformte strukturen zur auffaltung in regionen innerhalb des körpers
AU756080B2 (en) 1998-06-04 2003-01-02 New York University Endovascular thin film devices and methods for treating and preventing stroke
US6139564A (en) 1998-06-16 2000-10-31 Target Therapeutics Inc. Minimally occlusive flow disruptor stent for bridging aneurysm necks
US5935148A (en) 1998-06-24 1999-08-10 Target Therapeutics, Inc. Detachable, varying flexibility, aneurysm neck bridge
US6165193A (en) 1998-07-06 2000-12-26 Microvention, Inc. Vascular embolization with an expansible implant
US6093199A (en) 1998-08-05 2000-07-25 Endovascular Technologies, Inc. Intra-luminal device for treatment of body cavities and lumens and method of use
US7410482B2 (en) 1998-09-04 2008-08-12 Boston Scientific-Scimed, Inc. Detachable aneurysm neck bridge
WO2000013593A1 (fr) 1998-09-04 2000-03-16 Boston Scientific Limited (Incorporated In Ireland) Piece de fermeture detachable pour collet anevrysmal
US6544278B1 (en) 1998-11-06 2003-04-08 Scimed Life Systems, Inc. Rolling membrane stent delivery system
US6152144A (en) 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US7044134B2 (en) * 1999-11-08 2006-05-16 Ev3 Sunnyvale, Inc Method of implanting a device in the left atrial appendage
US7128073B1 (en) 1998-11-06 2006-10-31 Ev3 Endovascular, Inc. Method and device for left atrial appendage occlusion
US6059813A (en) 1998-11-06 2000-05-09 Scimed Life Systems, Inc. Rolling membrane stent delivery system
US6569179B2 (en) 1998-11-10 2003-05-27 Scimed Life Systems, Inc. Bioactive three loop coil
US6723112B2 (en) 1998-11-10 2004-04-20 Scimed Life Systems, Inc. Bioactive three loop coil
US6325820B1 (en) 1998-11-16 2001-12-04 Endotex Interventional Systems, Inc. Coiled-sheet stent-graft with exo-skeleton
US7018401B1 (en) 1999-02-01 2006-03-28 Board Of Regents, The University Of Texas System Woven intravascular devices and methods for making the same and apparatus for delivery of the same
DK1148839T3 (da) 1999-02-01 2008-12-15 Univ Texas Vævede togrenede og tregrenede stenter og fremgangsmåder til fremstilling heraf
US6695876B1 (en) 1999-02-12 2004-02-24 Thomas R. Marotta Endovascular prosthesis
US6368338B1 (en) 1999-03-05 2002-04-09 Board Of Regents, The University Of Texas Occlusion method and apparatus
US6613074B1 (en) 1999-03-10 2003-09-02 Cordis Corporation Endovascular aneurysm embolization device
US6428558B1 (en) 1999-03-10 2002-08-06 Cordis Corporation Aneurysm embolization device
US6682505B2 (en) 1999-03-12 2004-01-27 Arteria Medical Science, Inc. Catheter for removing emboli from saphenous vein grafts and native coronary arteries
US6709465B2 (en) 1999-03-18 2004-03-23 Fossa Medical, Inc. Radially expanding ureteral device
US6258099B1 (en) 1999-03-31 2001-07-10 Scimed Life Systems, Inc. Stent security balloon/balloon catheter
US6585756B1 (en) 1999-05-14 2003-07-01 Ernst P. Strecker Implantable lumen prosthesis
US6375676B1 (en) 1999-05-17 2002-04-23 Advanced Cardiovascular Systems, Inc. Self-expanding stent with enhanced delivery precision and stent delivery system
AU5280600A (en) 1999-05-20 2000-12-12 Scimed Life Systems, Inc. Stent delivery system with nested stabilizer and method of loading and using same
US6375668B1 (en) 1999-06-02 2002-04-23 Hanson S. Gifford Devices and methods for treating vascular malformations
ATE377395T1 (de) 1999-06-02 2007-11-15 Sethel Interventional Inc Intrakorporale verschlussvorrichtung
US20020169473A1 (en) 1999-06-02 2002-11-14 Concentric Medical, Inc. Devices and methods for treating vascular malformations
US6280412B1 (en) 1999-06-17 2001-08-28 Scimed Life Systems, Inc. Stent securement by balloon modification
US6309367B1 (en) 1999-07-23 2001-10-30 Neurovasx, Inc. Aneurysm shield
US6602261B2 (en) 1999-10-04 2003-08-05 Microvention, Inc. Filamentous embolic device with expansile elements
US6689150B1 (en) 1999-10-27 2004-02-10 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
US6551303B1 (en) 1999-10-27 2003-04-22 Atritech, Inc. Barrier device for ostium of left atrial appendage
US6652555B1 (en) 1999-10-27 2003-11-25 Atritech, Inc. Barrier device for covering the ostium of left atrial appendage
US6994092B2 (en) 1999-11-08 2006-02-07 Ev3 Sunnyvale, Inc. Device for containing embolic material in the LAA having a plurality of tissue retention structures
US6331184B1 (en) 1999-12-10 2001-12-18 Scimed Life Systems, Inc. Detachable covering for an implantable medical device
US6312458B1 (en) 2000-01-19 2001-11-06 Scimed Life Systems, Inc. Tubular structure/stent/stent securement member
US6350270B1 (en) 2000-01-24 2002-02-26 Scimed Life Systems, Inc. Aneurysm liner
US20020043456A1 (en) 2000-02-29 2002-04-18 Ho Ken K. Bimorphic, compositionally-graded, sputter-deposited, thin film shape memory device
US6346117B1 (en) 2000-03-02 2002-02-12 Prodesco, Inc. Bag for use in the intravascular treatment of saccular aneurysms
US6391037B1 (en) 2000-03-02 2002-05-21 Prodesco, Inc. Bag for use in the intravascular treatment of saccular aneurysms
US6632241B1 (en) 2000-03-22 2003-10-14 Endovascular Technologies, Inc. Self-expanding, pseudo-braided intravascular device
US6530934B1 (en) 2000-06-06 2003-03-11 Sarcos Lc Embolic device composed of a linear sequence of miniature beads
AU2001275376A1 (en) 2000-06-08 2001-12-17 John J Frantzen Radially expandable stent featuring covering tip primarily for bifurcated arteryaneurysms
US8298257B2 (en) 2000-06-29 2012-10-30 Concentric Medical, Inc. Systems, methods and devices for removing obstructions from a blood vessel
US6855154B2 (en) 2000-08-11 2005-02-15 University Of Louisville Research Foundation, Inc. Endovascular aneurysm treatment device and method
US6969401B1 (en) 2000-08-18 2005-11-29 Marotta Thomas R Endovascular prosthesis
US6605101B1 (en) 2000-09-26 2003-08-12 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US6635069B1 (en) 2000-10-18 2003-10-21 Scimed Life Systems, Inc. Non-overlapping spherical three-dimensional coil
US6589265B1 (en) 2000-10-31 2003-07-08 Endovascular Technologies, Inc. Intrasaccular embolic device
BE1013757A6 (fr) 2000-12-12 2002-07-02 Frid Noureddine Endoprothese luminale modulable.
US8192484B2 (en) 2000-12-12 2012-06-05 Cardiatis S.A. Stent for blood flow improvement
US6547804B2 (en) 2000-12-27 2003-04-15 Scimed Life Systems, Inc. Selectively permeable highly distensible occlusion balloon
US6699274B2 (en) 2001-01-22 2004-03-02 Scimed Life Systems, Inc. Stent delivery system and method of manufacturing same
JP4673987B2 (ja) 2001-02-27 2011-04-20 株式会社トップ ステント及びステント部材
US6579302B2 (en) 2001-03-06 2003-06-17 Cordis Corporation Total occlusion guidewire device
JP2005508201A (ja) 2001-03-08 2005-03-31 アトリテック， インコーポレイテッド 心房フィルターインプラント
US6878384B2 (en) 2001-03-13 2005-04-12 Microvention, Inc. Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
US6855153B2 (en) 2001-05-01 2005-02-15 Vahid Saadat Embolic balloon
US6814739B2 (en) 2001-05-18 2004-11-09 U.S. Endoscopy Group, Inc. Retrieval device
ATE491821T1 (de) 2001-06-11 2011-01-15 Ev3 Inc Verfahren zum training von nitinoldraht
US6692510B2 (en) 2001-06-14 2004-02-17 Cordis Neurovascular, Inc. Aneurysm embolization device and deployment system
US6454780B1 (en) 2001-06-21 2002-09-24 Scimed Life Systems, Inc. Aneurysm neck obstruction device
US6599307B1 (en) 2001-06-29 2003-07-29 Advanced Cardiovascular Systems, Inc. Filter device for embolic protection systems
US20030100945A1 (en) 2001-11-23 2003-05-29 Mindguard Ltd. Implantable intraluminal device and method of using same in treating aneurysms
US7011671B2 (en) 2001-07-18 2006-03-14 Atritech, Inc. Cardiac implant device tether system and method
US8715312B2 (en) 2001-07-20 2014-05-06 Microvention, Inc. Aneurysm treatment device and method of use
US8252040B2 (en) 2001-07-20 2012-08-28 Microvention, Inc. Aneurysm treatment device and method of use
US7572288B2 (en) 2001-07-20 2009-08-11 Microvention, Inc. Aneurysm treatment device and method of use
FR2828091B1 (fr) 2001-07-31 2003-11-21 Seguin Jacques Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
US20030028209A1 (en) 2001-07-31 2003-02-06 Clifford Teoh Expandable body cavity liner device
US7687053B2 (en) 2001-08-20 2010-03-30 Boston Scientific Scimed, Inc. Embolic compositions with non-cyanoacrylate rheology modifying agents
JP4460289B2 (ja) 2001-08-23 2010-05-12 シー． ガム、ダレル カテーテルアセンブリ
US7485088B2 (en) 2001-09-05 2009-02-03 Chase Medical L.P. Method and device for percutaneous surgical ventricular repair
US6811560B2 (en) 2001-09-20 2004-11-02 Cordis Neurovascular, Inc. Stent aneurysm embolization method and device
US6802851B2 (en) 2001-09-20 2004-10-12 Gordia Neurovascular, Inc. Stent aneurysm embolization method using collapsible member and embolic coils
WO2003037191A1 (fr) 2001-10-26 2003-05-08 Concentric Medical Dispositif destine a une occlusion vasculaire
JP4429589B2 (ja) 2001-11-15 2010-03-10 コーディス・ニューロバスキュラー・インコーポレイテッド 閉塞部材を用いる動脈瘤塞栓装置
JP2003190175A (ja) 2001-11-15 2003-07-08 Cordis Neurovascular Inc 動脈瘤を密閉するための動脈瘤頚部プラグ
US20060292206A1 (en) 2001-11-26 2006-12-28 Kim Steven W Devices and methods for treatment of vascular aneurysms
US6723116B2 (en) 2002-01-14 2004-04-20 Syde A. Taheri Exclusion of ascending/descending aorta and/or aortic arch aneurysm
WO2003071926A2 (fr) * 2002-02-21 2003-09-04 Persidsky Maxim D Appareil et procede de realisation d'un acces percutane pour orifice a dimension variable
US6989024B2 (en) 2002-02-28 2006-01-24 Counter Clockwise, Inc. Guidewire loaded stent for delivery through a catheter
US6773448B2 (en) 2002-03-08 2004-08-10 Ev3 Inc. Distal protection devices having controllable wire motion
US20030176884A1 (en) 2002-03-12 2003-09-18 Marwane Berrada Everted filter device
US7695488B2 (en) 2002-03-27 2010-04-13 Boston Scientific Scimed, Inc. Expandable body cavity liner device
US20030195609A1 (en) 2002-04-10 2003-10-16 Scimed Life Systems, Inc. Hybrid stent
US20030195553A1 (en) 2002-04-12 2003-10-16 Scimed Life Systems, Inc. System and method for retaining vaso-occlusive devices within an aneurysm
US6698877B2 (en) 2002-06-28 2004-03-02 Kimberly-Clark Worldwide, Inc. Offset printing apparatus for applying a substance
US20040172056A1 (en) 2002-07-12 2004-09-02 Guterman Lee R. Bifurcated aneurysm buttress arrangement
US6746890B2 (en) 2002-07-17 2004-06-08 Tini Alloy Company Three dimensional thin film devices and methods of fabrication
JP2004049585A (ja) 2002-07-22 2004-02-19 Piolax Medical Device:Kk ステント型治療具
US20040015224A1 (en) 2002-07-22 2004-01-22 Armstrong Joseph R. Endoluminal expansion system
US20040034386A1 (en) 2002-08-19 2004-02-19 Michael Fulton Aneurysm stent
US8075585B2 (en) 2002-08-29 2011-12-13 Stryker Corporation Device and method for treatment of a vascular defect
US20040044391A1 (en) 2002-08-29 2004-03-04 Stephen Porter Device for closure of a vascular defect and method of treating the same
US7063679B2 (en) 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
FR2847155B1 (fr) 2002-11-20 2005-08-05 Younes Boudjemline Procede de fabrication d'un implant medical a structure ajouree et implant obtenu par ce procede
US20040111112A1 (en) 2002-11-20 2004-06-10 Hoffmann Gerard Von Method and apparatus for retaining embolic material
WO2004050137A2 (fr) 2002-11-29 2004-06-17 Mindguard Ltd. Dispositif intralumiere tresse pour la prevention d'accidents vasculaires cerebraux
US7169177B2 (en) 2003-01-15 2007-01-30 Boston Scientific Scimed, Inc. Bifurcated stent
US20040143286A1 (en) 2003-01-17 2004-07-22 Johnson Eric G. Catheter with disruptable guidewire channel
US8377035B2 (en) 2003-01-17 2013-02-19 Boston Scientific Scimed, Inc. Unbalanced reinforcement members for medical device
US20040153119A1 (en) 2003-01-30 2004-08-05 Kusleika Richard S. Embolic filters with a distal loop or no loop
US7744583B2 (en) 2003-02-03 2010-06-29 Boston Scientific Scimed Systems and methods of de-endothelialization
US20040193141A1 (en) 2003-02-14 2004-09-30 Leopold Eric W. Intravascular flow modifier and reinforcement device and deployment system for same
US7314480B2 (en) 2003-02-27 2008-01-01 Boston Scientific Scimed, Inc. Rotating balloon expandable sheath bifurcation delivery
US20040193246A1 (en) 2003-03-25 2004-09-30 Microvention, Inc. Methods and apparatus for treating aneurysms and other vascular defects
US20040193178A1 (en) 2003-03-26 2004-09-30 Cardiomind, Inc. Multiple joint implant delivery systems for sequentially-controlled implant deployment
US20040215229A1 (en) 2003-04-22 2004-10-28 Medtronic Ave, Inc. Stent delivery system and method
US7597704B2 (en) 2003-04-28 2009-10-06 Atritech, Inc. Left atrial appendage occlusion device with active expansion
EP1637176B1 (fr) 2003-05-23 2016-01-06 Kabushikikaisha Igaki Iryo Sekkei Dispositif d'amenee de stent
US7569626B2 (en) 2003-06-05 2009-08-04 Dfine, Inc. Polymer composites for biomedical applications and methods of making
US7470282B2 (en) 2003-06-30 2008-12-30 Boston Scientific Scimed, Inc. Stent grip and system for use therewith
ES2428967T3 (es) * 2003-07-14 2013-11-12 W.L. Gore & Associates, Inc. Dispositivo tubular de cierre de foramen oval permeable (FOP) con sistema de retención
US8480706B2 (en) * 2003-07-14 2013-07-09 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
DE10335649A1 (de) 2003-07-30 2005-02-24 Jotec Gmbh Flechtstent zur Implantation in ein Blutgefäß
JP2007020590A (ja) 2003-08-19 2007-02-01 Institute Of Physical & Chemical Research 動脈瘤治療用材料
US20050060017A1 (en) 2003-09-15 2005-03-17 Fischell Robert E. Means and method for the treatment of cerebral aneurysms
US20070135907A1 (en) 2003-10-02 2007-06-14 The Regents Of The University Of California Stent with expandable foam
US7232461B2 (en) 2003-10-29 2007-06-19 Cordis Neurovascular, Inc. Neck covering device for an aneurysm
US20050107867A1 (en) 2003-11-17 2005-05-19 Taheri Syde A. Temporary absorbable venous occlusive stent and superficial vein treatment method
US20050107823A1 (en) 2003-11-19 2005-05-19 Leone Jim E. Anchored stent and occlusive device for treatment of aneurysms
US7763011B2 (en) 2003-12-22 2010-07-27 Boston Scientific Scimed, Inc. Variable density braid stent
US8211140B2 (en) * 2004-01-22 2012-07-03 Rex Medical, L.P. Vein filter
US20110208233A1 (en) 2004-01-22 2011-08-25 Mcguckin Jr James F Device for preventing clot migration from left atrial appendage
US20050222605A1 (en) 2004-03-16 2005-10-06 Secant Medical, Llc Occluding coil delivery device and method
US8398670B2 (en) 2004-03-19 2013-03-19 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects and for occluding fluid flow through portions of the vasculature of the body
US20050228434A1 (en) 2004-03-19 2005-10-13 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects
US8313505B2 (en) * 2004-03-19 2012-11-20 Aga Medical Corporation Device for occluding vascular defects
US8777974B2 (en) 2004-03-19 2014-07-15 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects
WO2005094725A1 (fr) 2004-03-31 2005-10-13 Merlin Md Pte Ltd Procede pour traiter des anevrismes
US8500751B2 (en) 2004-03-31 2013-08-06 Merlin Md Pte Ltd Medical device
CA2549323C (fr) 2004-04-08 2009-07-21 Aga Medical Corporation Dispositifs d'occlusion a collet et methodes
JP2007535997A (ja) 2004-05-07 2007-12-13 エヌエムティー メディカル， インコーポレイティッド 管状中隔オクルーダーの捕捉機構
US8617234B2 (en) 2004-05-25 2013-12-31 Covidien Lp Flexible vascular occluding device
EP1750619B1 (fr) 2004-05-25 2013-07-24 Covidien LP Dispositif d'occlusion vasculaire flexible
US20060206200A1 (en) 2004-05-25 2006-09-14 Chestnut Medical Technologies, Inc. Flexible vascular occluding device
US8267985B2 (en) 2005-05-25 2012-09-18 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
BE1016067A3 (fr) * 2004-06-03 2006-02-07 Frid Noureddine Endoprothese luminale pour occlusion d'anevrisme et procede de fabrication d'une telle endoprothese.
US7699056B2 (en) 2004-06-10 2010-04-20 Conceptus, Inc. Medical devices and methods of making and using such devices
US20050288766A1 (en) 2004-06-28 2005-12-29 Xtent, Inc. Devices and methods for controlling expandable prostheses during deployment
US8317859B2 (en) 2004-06-28 2012-11-27 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
US20060025801A1 (en) 2004-07-30 2006-02-02 Robert Lulo Embolic device deployment system with filament release
US7393358B2 (en) 2004-08-17 2008-07-01 Boston Scientific Scimed, Inc. Stent delivery system
EP1827250B1 (fr) 2004-08-31 2018-05-16 Cook Medical Technologies LLC Dispositif de traitement d'anevrisme
US8357180B2 (en) 2004-09-17 2013-01-22 Codman & Shurtleff, Inc. Thin film metallic device for plugging aneurysms or vessels
USRE46662E1 (en) 2004-09-17 2018-01-09 DePuy Synthes Products, Inc. Vascular occlusion device with an embolic mesh ribbon
US7635383B2 (en) 2004-09-28 2009-12-22 Boston Scientific Scimed, Inc. Rotating stent delivery system for side branch access and protection and method of using same
US20060106421A1 (en) 2004-11-16 2006-05-18 Clifford Teoh Expansible neck bridge
US20060116714A1 (en) 2004-11-26 2006-06-01 Ivan Sepetka Coupling and release devices and methods for their assembly and use
US20060116713A1 (en) 2004-11-26 2006-06-01 Ivan Sepetka Aneurysm treatment devices and methods
US7608089B2 (en) 2004-12-22 2009-10-27 Boston Scientific Scimed, Inc. Vaso-occlusive device having pivotable coupling
US20060155323A1 (en) 2005-01-07 2006-07-13 Porter Stephen C Intra-aneurysm devices
US7306623B2 (en) 2005-01-13 2007-12-11 Medtronic Vascular, Inc. Branch vessel graft design and deployment method
US20060167494A1 (en) 2005-01-21 2006-07-27 Loubert Suddaby Aneurysm repair method and apparatus
ES2368857T3 (es) 2005-02-04 2011-11-23 Zuli Holdings, Ltd. Dispositivo para el tratamiento de un aneurisma.
US20060190070A1 (en) 2005-02-23 2006-08-24 Dieck Martin S Rail stent and methods of use
US7632296B2 (en) 2005-03-03 2009-12-15 Boston Scientific Scimed, Inc. Rolling membrane with hydraulic recapture means for self expanding stent
US20060200234A1 (en) 2005-03-03 2006-09-07 Hines Richard A Endovascular aneurysm treatment device and delivery system
CN101138009A (zh) 2005-03-07 2008-03-05 皇家飞利浦电子股份有限公司 关联管状对象的第一和第二3d图像的装置和方法
US20060206199A1 (en) 2005-03-12 2006-09-14 Churchwell Stacey D Aneurysm treatment devices
DE102005013547B4 (de) 2005-03-23 2009-02-05 Admedes Schuessler Gmbh Aneurysmen-Stent und Verfahren zu seiner Herstellung
US7402168B2 (en) 2005-04-11 2008-07-22 Xtent, Inc. Custom-length stent delivery system with independently operable expansion elements
US20060264907A1 (en) 2005-05-02 2006-11-23 Pulsar Vascular, Inc. Catheters having stiffening mechanisms
WO2006119422A2 (fr) 2005-05-02 2006-11-09 Pulsar Vascular, Incorporated Catheters ameliores
US20060264905A1 (en) 2005-05-02 2006-11-23 Pulsar Vascular, Inc. Improved Catheters
WO2006122279A2 (fr) 2005-05-11 2006-11-16 Mayo Foundation For Medical Education And Research Dispositif et procedes pour interventions chirurgicales internes
JP4945714B2 (ja) 2005-05-25 2012-06-06 タイコ ヘルスケア グループ リミテッド パートナーシップ 管路内に閉塞装置を供給して展開するためのシステム及び方法
US7708754B2 (en) 2005-06-02 2010-05-04 Codman & Shurtleff, Pc Stretch resistant embolic coil delivery system with mechanical release mechanism
US20060276826A1 (en) 2005-06-02 2006-12-07 Vladimir Mitelberg Stretch resistant embolic coil delivery system with mechanical release mechanism
US8435279B2 (en) 2005-06-14 2013-05-07 Advanced Cardiovascular Systems, Inc. Delivery system for a device such as a stent
US7963988B2 (en) 2005-06-23 2011-06-21 Boston Scientific Scimed, Inc. ePTFE lamination—resizing ePTFE tubing
US20080114439A1 (en) 2005-06-28 2008-05-15 Venkatesh Ramaiah Non-occluding dilation device
US20070016243A1 (en) 2005-06-28 2007-01-18 Venkatesh Ramaiah Non-occlusive, retrievable dilation system
US20080058856A1 (en) 2005-06-28 2008-03-06 Venkatesh Ramaiah Non-occluding dilation device
US20070021816A1 (en) 2005-07-21 2007-01-25 The Research Foundation Of State University Of New York Stent vascular intervention device and methods for treating aneurysms
US8187318B2 (en) 2005-08-31 2012-05-29 Advanced Bio Prosthetic Surfaces, Ltd. Covered stent with proximal and distal attachment, delivery catheter, and method of making same
FR2890306B1 (fr) 2005-09-08 2007-11-02 Beatrix Jean Dispositif pour le traitement d'une poche vasculaire
US7972359B2 (en) 2005-09-16 2011-07-05 Atritech, Inc. Intracardiac cage and method of delivering same
US7550053B2 (en) 2006-01-26 2009-06-23 Ilh, Llc Catheters with lubricious linings and methods for making and using them
US7722597B2 (en) 2005-10-05 2010-05-25 Balt Extrusion Safety catheter for injecting fluid
US8545530B2 (en) 2005-10-19 2013-10-01 Pulsar Vascular, Inc. Implantable aneurysm closure systems and methods
WO2007047851A2 (fr) 2005-10-19 2007-04-26 Pulsar Vascular, Inc. Procedes et systemes d'agrafage et de reparation par voie endovasculaire d'anomalies dans des lumieres ou des tissus
US20070219619A1 (en) 2005-10-27 2007-09-20 Cardiovasc, Inc. Partially covered stent devices and methods of use
US20070100414A1 (en) 2005-11-02 2007-05-03 Cardiomind, Inc. Indirect-release electrolytic implant delivery systems
CN101394955B (zh) 2005-11-17 2012-07-18 微排放器公司 三维的复合线圈
US20070135826A1 (en) 2005-12-01 2007-06-14 Steve Zaver Method and apparatus for delivering an implant without bias to a left atrial appendage
WO2007076480A2 (fr) 2005-12-23 2007-07-05 Levy Elad I Agencement destine a traiter un anevrisme
US7744652B2 (en) 2006-01-23 2010-06-29 Hesham Morsi Aneurysm sealing device
US7691124B2 (en) 2006-01-31 2010-04-06 Codman & Shurtleff, Inc. Delivery of therapeutic devices
WO2007095031A2 (fr) 2006-02-13 2007-08-23 Bay Street Medical, Inc. Systeme pour poser un stent
US8801777B2 (en) 2007-04-18 2014-08-12 David Elmaleh Intravascular device with netting system
US8157837B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
EP1998717A1 (fr) 2006-03-24 2008-12-10 Biomerix Corporation Dispositif endovasculaire auto-expansible pour occlusion d'anévrismes
DE102006013770A1 (de) 2006-03-24 2007-09-27 Occlutech Gmbh Occlusionsinstrument und Verfahren zu dessen Herstellung
US20070233244A1 (en) 2006-03-28 2007-10-04 Depuy Spine, Inc. Artificial Disc Replacement Using Posterior Approach
US8092508B2 (en) 2006-03-30 2012-01-10 Stryker Corporation Implantable medical endoprosthesis delivery system
JP5061181B2 (ja) 2006-04-07 2012-10-31 ピナンブラ、インク 動脈瘤を閉塞するシステム及び方法
US8777979B2 (en) 2006-04-17 2014-07-15 Covidien Lp System and method for mechanically positioning intravascular implants
ES2564780T3 (es) 2006-04-17 2016-03-29 Covidien Lp Sistema para colocar mecánicamente implantes intravasculares
EP1849440A1 (fr) 2006-04-28 2007-10-31 Younes Boudjemline Endoprothèses vasculaires avec des diamètres variables
WO2007134266A2 (fr) 2006-05-12 2007-11-22 Electroformed Stents, Inc. Dispositif d'exclusion et système d'apport
US20070293935A1 (en) 2006-06-07 2007-12-20 Cook Incorporated Stent deployment anchoring device
US7906066B2 (en) 2006-06-30 2011-03-15 Abbott Cardiovascular Systems, Inc. Method of making a balloon catheter shaft having high strength and flexibility
EP2460544A1 (fr) 2006-06-30 2012-06-06 Tyco Healthcare Group LP Dispositifs médicaux avec des métaux amorphes et procédés correspondants
WO2008005666A1 (fr) 2006-07-07 2008-01-10 Boston Scientific Limited Système d'acheminement d'endoprothèse à support de prothèse
AU2007285800A1 (en) 2006-08-17 2008-02-21 Nfocus Neuromedical, Inc. Isolation devices for the treatment of aneurysms
WO2008022336A2 (fr) 2006-08-17 2008-02-21 Nfocus Neuromedical, Inc. Dispositifs de recouvrement d'anévrisme et dispositifs d'administration
US20080051705A1 (en) 2006-08-18 2008-02-28 Randolf Von Oepen Bifurcation stent delivery catheter and method
US8460335B2 (en) 2006-09-11 2013-06-11 Embrella Cardiovascular, Inc. Method of deflecting emboli from the cerebral circulation
US8454681B2 (en) 2006-09-13 2013-06-04 Boston Scientific Scimed, Inc. Bifurcation delivery systems and methods
US8372114B2 (en) 2006-11-13 2013-02-12 Electroformed Stents, Inc. Over-the-wire exclusion device and system for delivery
DE602007009915D1 (de) 2006-11-20 2010-12-02 Septrx Inc Vorrichtung zur Verhinderung des nicht erwünschten Durchflusses der Embolis von den Venen in die Arterien
WO2008074027A1 (fr) 2006-12-13 2008-06-19 Biomerix Corporation Dispositifs d'occlusion d'anévrismes
US20080154286A1 (en) 2006-12-21 2008-06-26 Ryan Abbott Systems and Methods for Treating Septal Defects with Capture Devices and Other Devices
DE602008001444D1 (de) 2007-03-05 2010-07-15 Boston Scient Scimed Inc Ablage von embolie-spulen
CA2673213A1 (fr) 2007-03-20 2008-09-25 Minvasys Appareil et procedes pour une distribution de stent avec protection embolique
US20080243226A1 (en) * 2007-03-30 2008-10-02 Fernandez Jose E Implantable stents with radiopaque markers and methods for manufacturing the same
WO2008124603A1 (fr) 2007-04-05 2008-10-16 Nmt Medical, Inc. Dispositif de fermeture septale à mécanisme de centrage
EP2150259A1 (fr) 2007-04-27 2010-02-10 Wisconsin Alumni Research Foundation Copolymères de sel de polyuréthanne-butanediol-glycosaminoglycane bioactifs et biocompatibles
WO2008151205A2 (fr) 2007-06-05 2008-12-11 Worldcell, Inc. Systèmes et procédés pour le développement et la mise à l'essai d'applications de module d'identité d'abonné
WO2008157507A2 (fr) 2007-06-15 2008-12-24 Nfocus Neuromedical, Inc. Dispositif de dérivation du flux sanguin et dispositifs de revêtement d'anévrisme
US20080319533A1 (en) 2007-06-22 2008-12-25 Neurovasx, Inc. Aneurysm occlusion assist device
US20090112251A1 (en) 2007-07-25 2009-04-30 Aga Medical Corporation Braided occlusion device having repeating expanded volume segments separated by articulation segments
US8361138B2 (en) 2007-07-25 2013-01-29 Aga Medical Corporation Braided occlusion device having repeating expanded volume segments separated by articulation segments
EP2190380A1 (fr) 2007-09-11 2010-06-02 NFocus Neuromedical, Inc. Dispositif de coiffe d'anévrisme pour l'implantation et la retenue d'agents emboliques
US20090082803A1 (en) 2007-09-26 2009-03-26 Aga Medical Corporation Braided vascular devices having no end clamps
US9414842B2 (en) 2007-10-12 2016-08-16 St. Jude Medical, Cardiology Division, Inc. Multi-component vascular device
DE102008028308A1 (de) 2007-10-18 2009-04-23 Acandis Gmbh & Co. Kg Vaskuläres Implantat und Verfahren zum Herstellen eines derartigen Implantats
US20090118811A1 (en) 2007-11-05 2009-05-07 Medtronic Vascular, Inc. Globe Stent
US20090125094A1 (en) 2007-11-06 2009-05-14 Angiotech Pharmaceuticals, Inc. Sheath for intravascular inflatable structures, for example to expand stents
WO2009073553A1 (fr) 2007-11-30 2009-06-11 Cook Incorporated Procédé et dispositif pour une thérapie vasculaire
US8298276B2 (en) 2007-12-03 2012-10-30 Olympus Medical Systems Corp. Stent delivery system, stent placement method, and stent attachment method
AU2008335138A1 (en) 2007-12-11 2009-06-18 Cornell University Method and apparatus for sealing an opening in the side wall of a body lumen
US20100030220A1 (en) 2008-07-31 2010-02-04 Dfine, Inc. Bone treatment systems and methods
US8545573B2 (en) 2008-02-12 2013-10-01 Cook Medical Technologies Llc Spiral occluding device with an occlusion sail
US8163004B2 (en) 2008-02-18 2012-04-24 Aga Medical Corporation Stent graft for reinforcement of vascular abnormalities and associated method
ES2400494T3 (es) 2008-02-29 2013-04-10 Edwards Lifesciences Corporation Elemento expandible para desplegar un dispositivo protésico
US20090228029A1 (en) 2008-03-05 2009-09-10 Neuro Vasx, Inc. Aneurysm shield anchoring device
DE102008015781B4 (de) 2008-03-26 2011-09-29 Malte Neuss Vorrichtung zum Verschluss von Defekten im Gefäßsystem
US20090287291A1 (en) 2008-04-21 2009-11-19 Becking Frank P Embolic Device Delivery Systems
WO2009132141A1 (fr) 2008-04-22 2009-10-29 Coherex Medical, Inc. Dispositif, système et procédé pour embolisation d’anévrisme
US10028747B2 (en) 2008-05-01 2018-07-24 Aneuclose Llc Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm
US10716573B2 (en) 2008-05-01 2020-07-21 Aneuclose Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm
JP2011519300A (ja) 2008-05-01 2011-07-07 アニュクローズ エルエルシー 動脈瘤閉塞装置
US20160206321A1 (en) 2008-05-01 2016-07-21 Aneuclose Llc Aneurysm Occlusion Device with Sequence of Shape-Changing Embolic Members
CN102119040A (zh) 2008-05-02 2011-07-06 斯昆特医疗公司 用于治疗血管缺损的丝状装置
US8128617B2 (en) 2008-05-27 2012-03-06 Boston Scientific Scimed, Inc. Electrical mapping and cryo ablating with a balloon catheter
US7869889B2 (en) 2008-07-02 2011-01-11 Saudi Arabian Oil Company Distributed and adaptive smart logic with multi-communication apparatus for reliable safety system shutdown
AU2009274126A1 (en) 2008-07-22 2010-01-28 Covidien Lp Vascular remodeling device
US9351715B2 (en) 2008-07-24 2016-05-31 St. Jude Medical, Cardiology Division, Inc. Multi-layered medical device for treating a target site and associated method
CA2736251C (fr) 2008-09-05 2017-11-28 Pulsar Vascular, Inc. Systemes et procedes pour soutenir ou fermer une ouverture ou cavite physiologique
US20100069948A1 (en) 2008-09-12 2010-03-18 Micrus Endovascular Corporation Self-expandable aneurysm filling device, system and method of placement
US8470013B2 (en) 2008-10-20 2013-06-25 Imds Corporation Systems and methods for aneurysm treatment and vessel occlusion
US9211202B2 (en) 2008-10-24 2015-12-15 Wisconsin Alumni Research Foundation Apparatus and method for treating an aneurysm
US20100131002A1 (en) 2008-11-24 2010-05-27 Connor Robert A Stent with a net layer to embolize and aneurysm
WO2010068467A1 (fr) 2008-11-25 2010-06-17 Attenuex Technologies, Inc. Implant avec milieu à pression de vapeur élevée
CN101779992B (zh) 2009-01-19 2012-08-22 加奇生物科技(上海)有限公司 可回撤自弹式脑神经支架的输送装置
CA2750222C (fr) 2009-01-22 2018-02-27 Cornell University Procede et appareil de restriction d'ecoulement a travers la paroi d'une lumiere
EP2403439B1 (fr) 2009-03-06 2016-07-20 The Regents of The University of California Endoprothèse vasculaire en couche mince et traitement de surface biocompatible
US9980818B2 (en) 2009-03-31 2018-05-29 Edwards Lifesciences Corporation Prosthetic heart valve system with positioning markers
US8840952B2 (en) 2009-04-03 2014-09-23 Reshape Medical, Inc. Intragastric space fillers and methods of manufacturing including in vitro testing
US20100274276A1 (en) 2009-04-22 2010-10-28 Ricky Chow Aneurysm treatment system, device and method
WO2010147808A1 (fr) 2009-06-15 2010-12-23 Boston Scientific Scimed, Inc. Système de pose d'endoprothèses multiples
US8657870B2 (en) 2009-06-26 2014-02-25 Biosensors International Group, Ltd. Implant delivery apparatus and methods with electrolytic release
US20110106234A1 (en) * 2009-10-30 2011-05-05 Axel Grandt Interluminal medical treatment devices and methods
JP2013509914A (ja) 2009-11-05 2013-03-21 シークエント メディカル， インコーポレイテッド 複数層フィラメント状デバイスまたは血管障害処置
CN102791205B (zh) 2009-11-09 2016-02-03 恩福克斯神经医学股份有限公司 栓塞装置
US9814562B2 (en) 2009-11-09 2017-11-14 Covidien Lp Interference-relief type delivery detachment systems
DE102009056449A1 (de) 2009-12-01 2011-06-09 Acandis Gmbh & Co. Kg Medizinische Vorrichtung
US8016872B2 (en) 2009-12-22 2011-09-13 Cook Medical Technologies Llc Deployment and dilation with an expandable roll sock delivery system
US8906057B2 (en) 2010-01-04 2014-12-09 Aneuclose Llc Aneurysm embolization by rotational accumulation of mass
EP2528542A4 (fr) 2010-01-28 2013-07-03 Covidien Lp Dispositif de remodelage vasculaire
CN102770091B (zh) 2010-01-28 2015-07-08 泰科保健集团有限合伙公司 脉管重塑装置
BR112012025969B1 (pt) 2010-04-14 2021-01-05 Microvention, Inc. dispositivo de fornecimento de implante
US20110301630A1 (en) 2010-06-02 2011-12-08 Cook Incorporated Occlusion device
US9247942B2 (en) 2010-06-29 2016-02-02 Artventive Medical Group, Inc. Reversible tubal contraceptive device
US20130066357A1 (en) 2010-09-10 2013-03-14 Maria Aboytes Devices and methods for the treatment of vascular defects
EP2629827B1 (fr) 2010-10-20 2015-12-30 Stryker Corporation Cathéter de pose de stent ayant des capacités d'échange rapide
DE102010050569A1 (de) 2010-11-05 2012-05-10 Acandis Gmbh & Co. Kg Vorrichtung zum Entlassen eines selbstexpandierbaren medizinischen Funktionselements
US20120191174A1 (en) 2010-11-16 2012-07-26 Trivascular, Inc. Advanced endovascular graft and delivery system
US9351859B2 (en) 2010-12-06 2016-05-31 Covidien Lp Vascular remodeling device
KR102109781B1 (ko) 2011-01-17 2020-05-14 메타랙티브 메디컬, 인크. 블록스텐트 장치 및 사용방법
EP2672900B1 (fr) 2011-02-11 2017-11-01 Covidien LP Dispositifs d'embolisation d'anévrisme à déploiement en deux étapes
DE102011011510B4 (de) 2011-02-17 2022-12-29 Acandis Gmbh Medizinische Vorrichtung zum Entfernen von Konkrementen und System mit einer derartigen medizinischen Vorrichtung
US20140058436A1 (en) 2011-02-18 2014-02-27 Sequent Medical, Inc. Blood flow disruption devices and methods for the treatment of vascular defects
DE102011011869A1 (de) 2011-02-22 2012-08-23 Phenox Gmbh Implantat
US20120226343A1 (en) 2011-03-04 2012-09-06 Stryker Nv Operations Limited Stent delivery system
EP3871617B1 (fr) 2011-03-09 2025-03-26 Neuravi Limited Dispositif de récupération de caillot pour éliminer un caillot d'occlusion d'un vaisseau sanguin
WO2012134990A1 (fr) * 2011-03-25 2012-10-04 Tyco Healthcare Group Lp Dispositif de remodelage vasculaire
US10028745B2 (en) 2011-03-30 2018-07-24 Noha, Llc Advanced endovascular clip and method of using same
EP2693981A4 (fr) 2011-04-01 2015-07-01 Univ Cornell Procédé et appareil pour restreindre l'écoulement à travers une ouverture dans la paroi latérale d'une lumière corporelle, et/ou pour renforcer une faiblesse dans la paroi latérale d'une lumière corporelle, et/ou pour renforcer une faiblesse dans la paroi latérale d'une lumière corporelle, tout en maintenant encore un écoulement sensiblement normal à travers la lumière corporelle
US20120283768A1 (en) 2011-05-05 2012-11-08 Sequent Medical Inc. Method and apparatus for the treatment of large and giant vascular defects
US8641777B2 (en) 2011-06-03 2014-02-04 Reverse Medical Corporation Embolic implant and method of use
US20120316632A1 (en) 2011-06-13 2012-12-13 Bulang Gao Retrievable covered stent for bifurcation aneurysms
US20120330341A1 (en) 2011-06-22 2012-12-27 Becking Frank P Folded-Flat Aneurysm Embolization Devices
US20130018451A1 (en) 2011-07-12 2013-01-17 Boston Scientific Scimed, Inc. Delivery System
WO2013049448A1 (fr) 2011-09-29 2013-04-04 Covidien Lp Dispositif de remodelage vasculaire
US8261648B1 (en) 2011-10-17 2012-09-11 Sequent Medical Inc. Braiding mechanism and methods of use
US8826791B2 (en) 2011-10-17 2014-09-09 Sequent Medical, Inc. Braiding mechanism and methods of use
US9072519B2 (en) 2012-03-14 2015-07-07 Gyrus Acmi, Inc. Anti-retropulsion systems and methods
US9011513B2 (en) 2012-05-09 2015-04-21 Abbott Cardiovascular Systems Inc. Catheter having hydraulic actuator
US9211132B2 (en) 2012-06-27 2015-12-15 MicoVention, Inc. Obstruction removal system
WO2014028913A1 (fr) 2012-08-17 2014-02-20 The Regents Of The University Of California Appareil d'endoprothèse rotatif double et procédé de traitement endovasculaire d'anévrismes
BR112015003624B1 (pt) 2012-08-22 2021-03-02 Phenox Gmbh implante com uma estrutura de malhas para oclusão de aneurismas na região de ramificações vasculares
KR101996604B1 (ko) 2012-10-31 2019-07-04 이베이스크 뉴로베스쿨러 엔터프라이즈 유엘씨 혈관내 보철물
US9314248B2 (en) 2012-11-06 2016-04-19 Covidien Lp Multi-pivot thrombectomy device
US9295571B2 (en) 2013-01-17 2016-03-29 Covidien Lp Methods and apparatus for luminal stenting
US9463105B2 (en) 2013-03-14 2016-10-11 Covidien Lp Methods and apparatus for luminal stenting
US20140316012A1 (en) 2013-03-15 2014-10-23 Toby Freyman In-Situ Forming Foams for Embolizing or Occluding a Cavity
US8715314B1 (en) 2013-03-15 2014-05-06 Insera Therapeutics, Inc. Vascular treatment measurement methods
US9907684B2 (en) 2013-05-08 2018-03-06 Aneuclose Llc Method of radially-asymmetric stent expansion
GB2520482B (en) 2013-11-15 2015-12-23 Cook Medical Technologies Llc Aneurysm closure device
JP5695259B1 (ja) 2014-02-19 2015-04-01 株式会社World Medish 高柔軟性ステント
US20160066921A1 (en) 2014-02-21 2016-03-10 Neuravi Limited DEVICE AND METHOD FOR ENDOVASCULAR TREATMENT OF ANEURYSMS USING EMBOLIC ePTFE
JP2017515567A (ja) 2014-05-12 2017-06-15 トマス，ジェフリー，イー． 光子活性化ゲルでコーティングされた頭蓋内ステントおよび塞栓コイル
WO2015175537A1 (fr) 2014-05-16 2015-11-19 Silk Road Medical, Inc. Système et procédé d'assistance à l'accès et la fermeture de vaisseau
WO2016108241A1 (fr) 2014-12-31 2016-07-07 Endostream Medical Ltd. Dispositif de limitation du flux sanguin vers des anévrismes
JP6763864B2 (ja) 2015-01-20 2020-09-30 ニューロガミ メディカル インコーポレイテッド 頭蓋内動脈瘤の治療のためのマイクログラフトおよび使用方法
BR112017017882B1 (pt) 2015-02-25 2023-04-11 Galaxy Therapeutics, Inc Aparelho para o tratamento de um aneurisma em um vaso sanguíneo
WO2017074411A1 (fr) 2015-10-30 2017-05-04 Blockade Medical, LLC Dispositifs et procédés pour le traitement d'un anévrisme
CN108472043B (zh) 2015-12-30 2022-05-31 斯瑞克公司 栓塞装置及其制造方法
US20180049859A1 (en) 2016-08-16 2018-02-22 Spartan Micro, Inc. Intravascular flow diversion devices
CN109789008A (zh) 2016-09-14 2019-05-21 美帝诺有限公司 动脉瘤闭塞装置
CN108056798B (zh) 2016-11-08 2021-06-04 艾柯医疗器械(北京)有限公司 支架推送系统以及对应的血流导向装置和血流导向装置装配方法
US10561441B2 (en) 2016-12-05 2020-02-18 Daniel E. Walzman Alternative use for hydrogel intrasaccular occlusion device with an umbrella member for structural support
WO2018112203A1 (fr) 2016-12-14 2018-06-21 eLum Technologies, Inc. Endoprothèses électrofilées, déflecteurs d'écoulement et dispositifs d'occlusion et leurs procédés de fabrication
WO2018129194A1 (fr) 2017-01-06 2018-07-12 Incept, Llc Revêtements thromborésistants pour dispositifs de traitement d'anévrisme
GB2558920A (en) 2017-01-20 2018-07-25 Cook Medical Technologies Llc Aneurysm treatment apparatus
CN117297691A (zh) 2017-08-17 2023-12-29 阿里萨医疗股份有限公司 用于在治疗血管疾病中使用的栓塞装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000139A1 (fr) * 2000-06-23 2002-01-03 Frantzen John J Stent expansible radialement pour le traitement d'anevrismes
WO2006034166A2 (fr) * 2004-09-17 2006-03-30 Cordis Neurovascular, Inc. Dispositifs metalliques a couche mince utilises pour colmater des anevrismes ou des vaisseaux
US20060064151A1 (en) * 2004-09-22 2006-03-23 Guterman Lee R Cranial aneurysm treatment arrangement
WO2008151204A1 (fr) * 2007-06-04 2008-12-11 Sequent Medical Inc. Procédés et dispositifs pour le traitement de défauts vasculaires

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11241321B2 (en) 2016-10-04 2022-02-08 Yasuhiro Shobayashi Flexible stent
EP4279025A4 (fr) * 2021-01-15 2025-02-12 Suzhou Lavamed Co., Ltd. Appareil d'élimination de thrombus

Also Published As

Publication number Publication date
US10004511B2 (en) 2018-06-26
US20160015395A1 (en) 2016-01-21
US9089332B2 (en) 2015-07-28
US20120245674A1 (en) 2012-09-27
US20120245675A1 (en) 2012-09-27
US20180280029A1 (en) 2018-10-04
US11147563B2 (en) 2021-10-19

Similar Documents

Publication Publication Date Title
US11147563B2 (en) Vascular remodeling device
US11654037B2 (en) Vascular remodeling device
US11406405B2 (en) Multi-pivot thrombectomy device
JP7234190B2 (ja) ステントおよびステント送達装置
US9962164B2 (en) Wing bifurcation reconstruction device
US9277924B2 (en) Systems and methods for enclosing an anatomical opening
EP3861939B1 (fr) Dispositif de support d'implant d'anévrisme
AU2010289240B2 (en) Systems and methods for enclosing an anatomical opening

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12713507

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12713507

Country of ref document: EP

Kind code of ref document: A1