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WO2012167904A2 - Préparations cosmétiques ou dermatologiques comprenant du polyglycéryl-10-stéarate et de la polylysine - Google Patents

Préparations cosmétiques ou dermatologiques comprenant du polyglycéryl-10-stéarate et de la polylysine Download PDF

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Publication number
WO2012167904A2
WO2012167904A2 PCT/EP2012/002373 EP2012002373W WO2012167904A2 WO 2012167904 A2 WO2012167904 A2 WO 2012167904A2 EP 2012002373 W EP2012002373 W EP 2012002373W WO 2012167904 A2 WO2012167904 A2 WO 2012167904A2
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WO
WIPO (PCT)
Prior art keywords
stearate
polylysine
polyglyceryl
cosmetic
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/002373
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German (de)
English (en)
Other versions
WO2012167904A3 (fr
Inventor
Laura PRIEBE
Katrin Weinert
Michael WÖHRMANN
Bernd Traupe
Sabine KLÜTER
Sabrina Ahlheit
Szilvia MESAROS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE201110077048 external-priority patent/DE102011077048A1/de
Priority claimed from DE201110077039 external-priority patent/DE102011077039A1/de
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Priority to DE112012002397.8T priority Critical patent/DE112012002397B4/de
Publication of WO2012167904A2 publication Critical patent/WO2012167904A2/fr
Publication of WO2012167904A3 publication Critical patent/WO2012167904A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88—Polyamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/524—Preservatives

Definitions

  • the invention encompasses cosmetic or dermatological preparations with a content of polyglycerate MO stearate, in particular less than 2% by weight, based on the total mass of the preparation, and polylysine and optionally sclerotium gum.
  • the proportion of polylysine is advantageously in the range of 0.1 to 2 wt.%, In particular in the range of 0.25 wt.%. based on the total mass of the preparation selected.
  • the proportion of sclerotium gum is advantageously in the range of 0.05 to 2 wt.%, In particular in the range of 0.25 wt.%. based on the total mass of the preparation selected.
  • the preparations have no (0%) ethoxylated emulsifiers, polyethylene glycols and / or polyethylene glycol derivatives.
  • the preparations show improved stability and improved antimicrobial
  • Hydrodispersions are known. Hydrodispersions are dispersions of a liquid, semi-solid or solid internal (discontinuous) lipid phase in an external aqueous (continuous) phase. Hydrodispersions are - as well as emulsions characterized by a similar phase arrangement - metastable systems and therefore inclined to a state of two in to pass on coherent discrete phases. In a classic O / W emulsion, the choice of a suitable emulsifier prevents the
  • hydrodispersions contain only very small amounts of emulsifiers or can even be completely free from
  • Emulsions in particular W / O, O / W, O / W / O or W / O / W emulsions, are often used as cosmetic or medical preparations.
  • Emulsions are generally understood to mean heterogeneous systems which consist of two liquids which are immiscible or only slightly miscible with one another, which are usually referred to as phases.
  • one of the two liquids W / O
  • the liquids pure or as solutions
  • CONFIRMATION COPY Emulsion in a more or less fine distribution which is generally limited stability.
  • an oil-in-water emulsion O / W emulsion, eg milk.
  • the basic character for example electrical conductivity, sensor technology, dyeability of the continuous phase, an O W emulsion is characterized by the water.
  • a water-in-oil emulsion W / O emulsion, eg butter is the reverse principle, whereby the basic character is determined by the oil.
  • Emulsions generally require one or more emulsifiers, thickeners and / or bodying agents for their formation and stabilization to be stable over a cosmetically acceptable period of time, generally 1 year after opening a cosmetic preparation.
  • Council Directive 76/768 EEC only safe cosmetic products may be marketed. This also means that cosmetic products that allow the growth of microorganisms due to their chemical composition and physical properties must be preserved. To this end, the preservatives listed in Annex VI of the Council Directive 76/768 and assessed as safe in order to protect the user against microorganism-induced health hazards and by the growth of microorganisms caused product damage (degradation or modification of ingredients, microbial metabolic end products) to avert. Thus, the microbiological stability of the cosmetic product during the
  • Preservatives are responsible for killing bacteria, yeasts and fungi. Many of these substances are very reactive and have cytotoxic effects that can cause irritation and redness on the skin. After many years of use, there is also a residual risk for particularly sensitive consumers. When used for many years there is a risk that the substances sensitize the organism and allergic reactions occur. Of course, the sensitivity depends on many parameters:
  • cosmetic preparations must be formulated for long-term stability against microbial contamination and still have a very good skin compatibility.
  • preservatives are the compounds known as parabens, in particular 4-hydroxybenzoic acid and its esters, methylparaben, ethylparaben, propylparaben, isopropylparaben, butylparaben, isobutylparaben, phenylparaben. Furthermore, phenoxyethanol, ethylene glycol monophenyl ether, phenyl glycol,
  • Phenoxetol® known for the preservation of cosmetic products.
  • Availability of contained antimicrobial substances may influence. For example, high emulsifier levels may decrease the effectiveness and effectiveness of antimicrobials.
  • the availability of antimicrobial molecules can be reduced inter alia by complexing with emulsifiers.
  • the amount of bound antimicrobial agent is hereafter directly related to the amount of emulsifier used.
  • Cosmetic antiperspirants or deodorants / deodorants are used to eliminate body odor or to reduce their formation.
  • Body odor arises when the per se odorless fresh sweat by microorganisms such. Staphylococci and Corynebacteria is decomposed.
  • Antiperspirants are antiperspirants that, in contrast to the deodorants which generally prevent microbial decomposition of already formed perspiration, are said to prevent the secretion of sweat at all.
  • pure deodorants cause no active influence on the sweat secretion, but only the control or influence of the body or underarm odor (odor control agent).
  • Common mechanisms of action for this are antibacterial effects, odor neutralization (masking), influencing bacterial metabolisms, the pure perfuming as well as the use of precursors of certain perfume components, which are converted by enzymatic reactions to fragrant substances.
  • preparations may additionally contain substances which inhibit the microbial degradation of the perspiration, such as e.g. Triclosan.
  • Triclosan has an effect against gram-positive and gram-negative bacteria as well as against fungi and yeasts, which results in a deodorizing, but no antiperspirant effect, since no influence on the sweat secretion can be deduced from the influence on the bacterial skin flora.
  • Sweat odor consists to a large extent of branched-chain fatty acids, which are released by bacterial enzymes from odorless sweat.
  • Classic deodorizing agents counteract this by reducing the growth of bacteria.
  • the substances used here are also unselective against useful skin germs and, like certain emulsifiers, can cause sensitive skin to skin irritation.
  • a deodorising agent that seems to meet these requirements for naturalness, efficacy and tolerability is polylysine.
  • Polylysine (polylysine ( ⁇ -poly-L-lysine, EPL, CAS: 2821 1-04-3) is known as a cationic polymer for preserving foodstuffs.) Polylysine is water-soluble and due to the antimicrobial properties of polylysine a reduction of perspiration odor is observed ,
  • Polylysine is produced by fermentation and can therefore be called a natural active ingredient. Therefore, it is desirable to provide natural, cosmetic formula bases for the formulation of polylysine-containing deodorants.
  • ⁇ -Polylysine represents a polymer in which the ⁇ -terminal amino group of a lysine molecule is linked to the acid function of another lysine molecule
  • the index "n" (more precisely, the value n / 2) defines the degree of polymerization of the polylysine.
  • the INCI name is poly [imino [(2S) -2-amino-1-oxo-1,6-hexanediyl]], it has CAS no. 28211-04-3 and is described in various references: Shima, S. and Sakai H. (1977). "Polylysines produced by Streptomyces”. Agricultural and Biological Chemistry 41: 1807-1809; Shima, S. et al. (1984). "Antimicrobial action of ⁇ -poly-L-lysines". Journal of Antibiotics 37 (11): 1449-1455; GRAS Notice no. GRN 000135; Hiraki, J. et al. (2003).
  • Polylysine (polylysine) is used as an antimicrobial agent against yeasts, fungi and gram-pos. and gram-neg. Bacteria described and used. Currently it finds as
  • Production takes place via a fermentative process.
  • ethoxylated emulsifiers are frequently used which, as generally known, lead to loadable, stable emulsion preparations and can often cover a relatively wide sensory range.
  • ethoxylated emulsifiers act as Penetrationsenhancer by their PEG units. Polyethylene glycols and / or polyethylene glycol derivatives and their derivatives can make the skin more permeable and thus introduce harmful substances into the body. For this reason, the use of ethoxylated substances in cosmetics is controversial and ethoxylated emulsifiers are therefore not desired by the consumer.
  • the photoinstable polyethylene glycol (PEG) emulsifiers can be decomposed and cause unsightly skin reactions.
  • PEG-free emulsifiers known to those skilled in the art, such as, for example, cetearyl glucosides, methyl glucose sesquistearates; Potassium Cetyl Phosphate; Lauryl Glucoside / Polyglyceryl-2 Dipolyhydroxystearate or Sodium Stearoyl Glutamate in combination with Polylysine on just such interactions. These emulsifiers do not allow stable emulsion systems.
  • emulsifiers from the food industry such as glyceryl stearate citrate (Imwitor®) or polyglyceryl-10-stearate.
  • Glyceryl stearate citrate must be used in cosmetic preparations in such a high amount or in combination with co-emulsifiers to obtain stable emulsions, so that the desire for reduced emulsifier content with glyceryl stearate citrate is not met.
  • Polyglyceryl-10-stearate (PG-10 stearate, CAS No .: 79777-30-3) is a hydrophilic emulsifier and has an HLB of 12.
  • Polyglyceryl-10 stearates are commercially available as blends, for example, as Polyaldo 10-1-S (Lonza), Nikkol Decaglyn 1 -S (Nikko Chemicals Co., Ltd.) or Salacos PGMSV (The Nisshin OilliO Group, Ltd.).
  • Polyglyceryl-10-stearate is known from ice cream manufacture and has a brown color. Also due to this aesthetically problematic circumstance, the application in cosmetic emulsions seemed to ban itself.
  • Heliogel® which in addition to Sodium Acrylates Copolymer, Hydrogenated Polyisobutenes, Phospholipids, Helianthus Annuus (Sunflower) Seed Oil also contains polyglyceryl-10 stearates, is available for purchase.
  • PG-10 stearate is merely part of a
  • WO 2000/064408 A1 discloses wet wipes. Therein is mentioned polyglyceryl-10-stearate as one of many emulsifying substances.
  • polyglyceryl-10-stearate can be used as an emulsifier in cosmetic or dermatological preparations as an emulsifier, without showing the disadvantages of the coloring effect and the instability.
  • polyglyceryl-10-stearate shows an improved release of antimicrobial agents and thus exerts improved efficacy.
  • the invention is a cosmetic or dermatological preparation comprising
  • Polyglyceryl-10-stearate preferably less than 2 wt.%, In particular in the range of 0.1 to 1, 8 wt.%, Based on the total mass of the preparation, and polylysine.
  • Polylysine is water-soluble and can therefore be easily incorporated into cosmetic basics. Due to the antimicrobial properties, improved preservation of cosmetic or dermatological preparations can be achieved. Surprisingly, the combination of polylysine with polyglycerol-10-stearate showed synergism for antimicrobial efficacy.
  • the preparations according to the invention are advantageously based on an emulsion, preferably an O / W emulsion, or hydrodispersion.
  • the preparations thus prepared, preferably emulsions have a low emulsifier content of less than 2% and thus satisfy the desire for well-tolerated, mild products without compromising stability.
  • Less than 2% by weight of PG-10 stearate does not mean 0% by weight.
  • the minimum proportion of PG-10 stearate is preferably 0.1% by weight.
  • polyglyceryl-10-stearate also used as the only emulsifier, leads to stable emulsions. A waiver of additional emulsifiers is thus possible and comes so the desire for reduced
  • Preparations no instabilities, phase separation, coalescence, Ostwald ripening or change in droplet size with time or creaming.
  • the formulations as disclosed in the examples were optically stable for at least 6 months at room temperature and at 40 ° C. That is, no phase separation or phase separation was observed.
  • DSM 7171 C. jeikeium (DSM 7171) is spread out of a cryotube (EN 12353) on an agar plate and incubated at 30 ° C. for 48 h. Subsequently, a second passage is created on another agar plate. After 24h growth, a loop of the bacteria is removed and placed in a sterile baffled flask with 5g glass beads and 10ml AC medium (for Corynebacteria) and 3min. vortexed.
  • the emulsifiers were heated at 80 ° C in a water bath and then proportionally mixed with PE water to produce the emulsifier A / Vasser solution.
  • solid polylysine was dissolved in the emulsifier / water mixture.
  • a sample was prepared solely with polylysine in water.
  • 500 .mu.l of the bacterial suspension were added to 500 .mu.l of the initially introduced active ingredient solution and incubated on a thermo shaker (30.degree. C., 1200 rpm).
  • Figure 1 shows reduction factors of bacterial cutaneous kinetics after 180 min.
  • the diagram shows the reduction factors for the individual compounds polylysine and PG-10 stearate and those of the combination of polylysine and PG-10 stearate.
  • PG-10 stearate in combination with polylysine therefore results in improved antimicrobial effectiveness in cosmetic or dermatological preparations.
  • the proportion of polylysine is advantageously in the range of 0.1 to 2 wt.%, In particular in the range of 1 wt.%, Preferably in the range 0.8 to 1, 2 wt.%, Based on the total mass of the preparation selected.
  • necessary emulsifiers and microbially effective preservatives generally also thickeners contribute to the stabilization of the cosmetic or dermatological preparations.
  • the viscosity of lotions is adjusted by adding thickeners or bodying agents. As a result, for example, the outer phase of an O / W emulsion is stabilized.
  • hydrocolloids are generally used, which swell the outer aqueous phase of emulsions.
  • the hydrocolloids include i.a. Xanthan Gum, Carrageenan, Polyacrylates, Agar Agar or Magnesium Aluminum Silicate.
  • Sclerotium gum (CAS: 39464-87-4) is mentioned as a polymeric thickener and viscosity-affecting ingredient in cosmetics.
  • the PG-10 stearate containing polylysine and sclerotium gum preparations did not show instabilities, phase separation, coalescence, Ostwald ripening, or change in droplet size over time or creaming.
  • the formulations as disclosed in the examples were optically stable for at least 6 months at room temperature and at 40 ° C. That is, no phase separation or phase separation was observed.
  • the thickeners were swollen in 100 ml of water with stirring. Following the preparation of the thickener gel, 1 ml of a 0.1% Polylsyin solution was added, stirred and visually assessed.
  • emulsifiers may also be added to the preparations according to the invention. However, this is not required or mandatory in all cases according to the invention.
  • additional emulsifiers are added, these are preferably to be selected from the group of emulsifiers which are solid, pasty or liquid at 25 ° C and not ethoxylated. Particularly preferred additional emulsifiers are to be selected from the group 1, 2 Propandiolfettklar, acetoglycerides, acetylated mono- / diglycerides, alkali or Ammonium soaps, ammonium phosphatides, sorbitan monoisostearate, C10-C22 fatty acids, cetearyl sulfate, cetearyl glucosides, cetyl phosphate, cetylstearyl alcohol in combination with sodium cetyl stearyl sulphate, citroglyceride esters, citric acid monoglycerides,
  • Diacetyltartaric acid monoglycerides diisostearoyl polyglyceryl-3 diisostearate (Isolan PDI), egg lecithin, emulsifier YN (trade name), acetic acid monoglycerides, mixed propylene glycol glycerol esters, glyceryl laurate, glyceryl myristate, glyceryl oleate in combination with propylene glycol, glyceryl stearate, glyceryl stearate SE, glyceryl stearate citrate, glycol distearate, isostearyl diglyceryl succinate , Isostearylglyceryl ether, potassium cetyl phosphate,
  • Lactoglycerides Lactylated mono- / diglycerides, lecithin, methyl glucose sesquistearate,
  • Lactic acid monoglycerides mono- and diglycerides of fatty acids esterified with acetic acid and tartaric acid, monoglyceride acetate, monoglyceride citrate, monoglyceride diacetyl tartrate, monoglyceride lactate, monoglyceride tartrate, Na, K and Ca salts of stearoyl-2-lactyl lactic acid, Na, K and Ca; stearoyl-2-lactoyl-lactate, Na, K and Ca stearoyl-2-lactyllactate, Na, K and Ca stearoyl lactic acid, Na salt of lauryl sulfuric acid,
  • Polyglyceryl-1 dipolyhydroxystearate (Dehymuls PGPH), polyglyceryl-2-laurate, polyglyceryl-2-sesquiisostearate, polyglyceryl-3 beeswax (Cera Bellina), polyglyceryl-3 cetyl ether
  • Diisostearate / polyhydroxystearate / sebacate Isolan GPS
  • polyglyceryl-4 isostearate Isolan GI 34
  • polyoxyethylene stearic acid ester polyoxylstearate mono- / diglyceride
  • propylene glycol stearate SE propylene glycol fatty acid ester
  • propylene glycol mono- / di-fatty acid ester rapeseed lecithin
  • sucrose glycerides , Sucrose esters of fatty acids, soy lecithin, sorbates bsp.
  • Sorbitan monolaurate sorbate 20
  • sorbitan di-citrate sorbitan butucate
  • Sorbitan monostearate (sorbate 60), sorbitan monotartrate, sorbitan sesquiterate,
  • the preparations according to the invention preferably comprise no further additional emulsifier except PG-10 stearate.
  • the proportion of additional emulsifiers should therefore preferably be less than 0.01% by weight, based on the total mass of the preparation, in order to be considered to be present according to the invention-without additional emulsifier.
  • fatty alcohols such as myristyl alcohol, behenyl alcohol, stearyl alcohol, palmityl alcohol, etc. are often used.
  • the generic term fatty alcohols stands for monohydric primary alcohols with 8 to 22
  • Carbon atoms and branched or unbranched chains are obtained by a reduction of the triglycerides, fatty acids or fatty acid methyl esters and form elementary raw materials for the production of various chemical secondary products. As far as the chain length is concerned, an even number of C atoms is a characteristic of the natural origin.
  • the deodorant / AT preparations according to the invention are therefore free of fatty alcohols.
  • Fatty alcohol-free means that the proportion of fatty alcohols, in particular C8-22, less than 1%, based on the total mass of the preparation, more preferably below 0.25%, and especially below 0, 1%.
  • Variability can be achieved in terms of the adjusted skin feel of the preparation.
  • the cosmetic or dermatological preparations according to the invention may further contain cosmetic adjuvants and other active ingredients, such as are commonly used in such preparations, for.
  • Preservatives, preservatives, bactericides, anti-foaming agents, dyes and color pigments, thickeners, moisturizing and / or moisturizing substances, fats, oils, waxes or other common ingredients of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, Electrolytes, organic solvents or silicone derivatives, self-tanning agents, buffers, pH regulators, vegetable extracts, surfactants, propellants, powders, sebum-absorbing substances, UV filters, active ingredients such as Example anti-age, anti-cellulite, anti-acne, anti-rosacea, anti-eczema, antioxidants, moisturizers, chelating agents, antitraspirants, bleaches and dyes etc, provided that the addition does not hinder the required properties in terms of emulsifier content
  • the preparations according to the invention are preferably O / W, W / O, W / O / W, O / W / O emulsions and hydrodispersions, where O can also stand for silicone oils.
  • the preparation is preferably formulated on the basis of an O / W emulsion or hydrodispersion.
  • the following oils may preferably be used in accordance with the invention
  • polar oil components selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids having a
  • ester oils can advantageously be selected from the group consisting of phenethyl benzoate, 2-phenylethyl benzoate, propylheptyl caprylate, isopropyl lauroyl sarcosinate, dibutyl adipate, octyl palmitate, octyl cocoate, octyl isostearate, octyldodeceyl myristate, octyldodecanol, cetearyl isononanoate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate,
  • Isononyl isononanoate 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyl dodecyl palmitate, stearyl heptanoate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate, tridecyl stearate, tridecyl trimellitate, as well as synthetic, semi-synthetic and natural mixtures of such esters, e.g. B. jojoba oil.
  • dialkyl ethers and dialkyl carbonates may advantageously be selected, and z.
  • Dicaprylyl carbonate for example that available under the trade name Cetiol CC from Cognis. It is further preferred that the oil component (s) is selected from the group consisting of isoeicosane, neopentyl glycol diheptanoate, propylene glycol dicaprylate / dicaprate,
  • oil phase of the formulations of the invention has a content of C12-15-alkyl benzoate or consists entirely of this.
  • Other oil components may include: caprylic / capric triglycerides, octyldodecanol, C12-15 alkyl benzoates, Butylenglycol Dicaprylate / Dicaprate, Dicaprylyl Carbonate, Isopropyl Palmitate, Ethylhexyl Cocoate, Cera Microcristallina + Paraffin Liquidum, Butyrospermum Parkii, Dicaprylyl Ether, Hydrogenated Coco Glycerides, Simmondsia Chinensis Oil, Tridecyl Stearate, Tridecyl Trimellitate, Dipentaerythrityl Hexacaprylate / Hexacaprate, Lanolin Alcohol, C12 -15- alkyl benzo
  • Neopentanoates and Caprylic / Capric Triglycerides Neopentanoates and Caprylic / Capric Triglycerides.
  • non-polar oil components such as, for example, silicone oils such as, for example, D4, D5, D6, dimethicones, dimethiconecopolyol and other hydrocarbon-based oils such as Parafinum Liquidum, halogenated and perhalogenated hydrocarbons can be advantageously selected.
  • Preferred lipid components in the preparations according to the invention are C 12-15 alkyl benzoate, isopropyl palmitate, caprylic / capric triglycerides and / or octyldodecanol.

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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

L'invention concerne une préparation cosmétique ou dermatologique comprenant du polyglycéryl-10-stéarate et de la polylysine ainsi que, éventuellement, une gomme de Sclérotium, préparation qui conduit à une amélioration de la puissance d'action antimicrobienne.
PCT/EP2012/002373 2011-06-07 2012-06-05 Préparations cosmétiques ou dermatologiques comprenant du polyglycéryl-10-stéarate et de la polylysine Ceased WO2012167904A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112012002397.8T DE112012002397B4 (de) 2011-06-07 2012-06-05 Kosmetische oder dermatologische Zubereitungen mit Polyglyceryl-10-Stearat und Polylysin

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102011077039.9 2011-06-07
DE102011077048.8 2011-06-07
DE201110077048 DE102011077048A1 (de) 2011-06-07 2011-06-07 Kosmetische oder dermatologische Zubereitungen mit Polyglyceryl-10-Stearat und Polylysin
DE201110077039 DE102011077039A1 (de) 2011-06-07 2011-06-07 Kosmetische oder dermatologische Zubereitungen mit Polyglyceryl-10-Stearat, Polylysin und Sclerotium Gum

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WO2012167904A2 true WO2012167904A2 (fr) 2012-12-13
WO2012167904A3 WO2012167904A3 (fr) 2013-05-02

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DE102019207777A1 (de) * 2019-05-28 2020-12-03 Beiersdorf Ag Kosmetische O/W-Emulsion mit Skleroglucan

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