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EP2717970A2 - Compositions cosmétiques ou dermatologiques exemptes de polyéthylène glycol - Google Patents

Compositions cosmétiques ou dermatologiques exemptes de polyéthylène glycol

Info

Publication number
EP2717970A2
EP2717970A2 EP12727305.0A EP12727305A EP2717970A2 EP 2717970 A2 EP2717970 A2 EP 2717970A2 EP 12727305 A EP12727305 A EP 12727305A EP 2717970 A2 EP2717970 A2 EP 2717970A2
Authority
EP
European Patent Office
Prior art keywords
stearate
preparation
polyglyceryl
preparations
oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP12727305.0A
Other languages
German (de)
English (en)
Inventor
Stefanie Von Thaden
Manuela Köhler
Rainer Kröpke
Jens Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE201110077018 external-priority patent/DE102011077018A1/de
Priority claimed from DE201110077060 external-priority patent/DE102011077060A1/de
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP2717970A2 publication Critical patent/EP2717970A2/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients

Definitions

  • the invention encompasses cosmetic or dermatological preparations containing polyglyceryl-10-stearate, which are free of polyethylene glycols and / or
  • Polyethylene glycol derivatives are.
  • Hydrodispersions are known. Hydrodispersions are dispersions of a liquid, semi-solid or solid internal (discontinuous) lipid phase in an external aqueous (continuous) phase. Hydrodispersions are - as well as emulsions characterized by a similar phase arrangement - metastable systems and therefore inclined to a state of two in to pass on coherent discrete phases. In a classic O / W emulsion, the choice of a suitable emulsifier prevents the
  • hydrodispersions contain only very small amounts of emulsifiers or can even be completely free from
  • Emulsions in particular W / O, O / W, O / W / O or W / O / W emulsions, are often used as cosmetic or medical preparations.
  • Emulsions are generally understood to mean heterogeneous systems which consist of two liquids which are immiscible or only slightly miscible with one another, which are usually referred to as phases.
  • one of the two liquids W / O
  • the liquids pure or as solutions
  • an oil-in-water emulsion O / W emulsion, eg milk.
  • the basic character for example electrical conductivity, sensor technology, dyeability of the continuous phase, an O W emulsion is characterized by the water.
  • a water-in-oil emulsion W / O emulsion, eg butter is the inverse principle, the basic character here being determined by the oil.
  • Emulsions generally require one or more emulsifiers, thickeners and / or bodying agents for their formation and stabilization to be stable over a cosmetically acceptable period of time, generally 1 year after opening a cosmetic preparation.
  • ethoxylated emulsifiers are commonly used, which, as is well known, lead to strong, stable emulsion formulations and can often cover a relatively wide sensory range.
  • ethoxylated emulsifiers act as penetration enhancers through their PEG units.
  • Polyethylene glycols and / or polyethylene glycol derivatives and their derivatives can make the skin more permeable and thus introduce harmful substances into the body. For this reason, the use of ethoxylated substances in cosmetics is controversial and ethoxylated emulsifiers are therefore not desired by the consumer. Furthermore, under the action of solar radiation, the photoinstable
  • Polyethylene glycol-containing (PEG) emulsifiers are decomposed and unsightly
  • cosmetic or dermatological preparations must meet some aesthetic criteria in order to obtain sufficient consumer acceptance.
  • glyceryl stearate citrate Imwitor®
  • polyglyceryl-10-stearate In the search for suitable emulsifiers that meet the desired requirements of cosmetics or dermatology, these emulsifiers seem to be excluded.
  • Glyceryl stearate citrate must be used in cosmetic preparations in such a high amount or in combination with co-emulsifiers to obtain stable emulsions, so that the desire for reduced emulsifier content with glyceryl stearate citrate is not met.
  • Polyglyceryl-10-stearate (PG-10 stearate, CAS No .: 79777-30-3) is a hydrophilic emulsifier and has an HLB of 12.
  • Polyglyceryl-10 stearates are commercially available as blends, for example, as Polyaldo 10-1-S (Lonza), Nikkol Decaglyn 1-S (Nikko Chemicals Co., Ltd.) or Salacos PGMSV (The Nisshin OilliO Group, Ltd.).
  • Polyglyceryl-10-stearate is known from ice cream manufacture and has a brown color. Also due to this aesthetically problematic circumstance, the application in cosmetic emulsions seemed to ban itself.
  • Heliogel® which in addition to Sodium Acrylates Copolymer, Hydrogenated Polyisobutenes, Phospholipids, Helianthus Annuus (Sunflower) Seed Oil also contains polyglyceryl-10 stearates, is available for purchase.
  • PG-10 stearate is merely part of a
  • JP 2005162664 discloses PG-10 stearate in hair dye preparation comprising peroxides. A cosmetic topical application therefore excludes.
  • WO 0027197 A1 discloses preparations comprising besides PG-10-stearate one or more UV filters, lecithins, polyethylene glycols and parabens.
  • DE 102008028821 A1 and DE 102008028822 A1 disclose stick preparations with PG-10 stearate.
  • DE 10213955 A1 discloses PG-10 stearate in an aftershave lotion wherein the content of PG-10 stearate is 6% or more.
  • polyglyceryl-10-stearate can be used as an emulsifier in cosmetic or dermatological preparations without showing the disadvantages of the coloring effect and the instability.
  • the invention is a cosmetic or dermatological preparation comprising
  • Polyglyceryl-10-stearate in a proportion of less than 6 wt.%, In particular in the range of 0.1 to 2.8 wt.%, Based on the total mass of the preparation, and comprising less than 0.01 wt.% Ethoxylated emuigators , especially no PEG-40 stearate. In particular, the preparations have no (0%) ethoxylated emuigators,
  • Polyethylene glycols and / or polyethylene glycol derivatives are examples of polyethylene glycols.
  • Cyclic silicone oil 0 3 0 0
  • Citric acid 0.0050 0 0 0
  • Citric acid 0.0050 0 0 0
  • Polyglyceryl-10 Stearate 0.7 1, 8 1 1
  • the preparations according to the invention are advantageously based on an emulsion, preferably an O / W emulsion, or hydrodispersion.
  • the preparations thus prepared, preferably emulsions have a low emulsifier content of less than 6% and fulfill Thus, the desire for well-tolerated, mild products, without compromising the stability.
  • Less than 6% by weight or less than 3% by weight of PG-10 stearate does not mean 0% by weight.
  • the minimum proportion of PG-10 stearate is preferably 0.1% by weight.
  • polyglyceryl-10-stearate also used as the only emulsifier, leads to stable emulsions. A waiver of additional emulsifiers is thus possible and comes so the desire for reduced
  • fatty alcohols are often used.
  • the generic term fatty alcohols stands for monohydric primary alcohols with 8 to 22
  • Carbon atoms and branched or unbranched chains are obtained by a reduction of the triglycerides, fatty acids or fatty acid methyl esters and form elementary raw materials for the production of various chemical secondary products. Regarding the chain length, an even number of carbon atoms is a hallmark of the
  • Chain components of 16 and 18 C atoms are suitable as classical components for cosmetic or dermatological creams and ointments. Depending on their molecular weight, they are high-boiling oily liquids, waxy masses or solid products, e.g. Octanol (caprylic alcohol), octenol, octadienol, decanol (capric alcohol), decenol, decadienol, dodecanol (lauryl alcohol), dodecenol, dodecadienol, tetradecanol (myristyl alcohol), hexadecanol (cetyl alcohol), octadecanol (stearyl alcohol or isostearyl alcohol),
  • Octadecenol oleyl alcohol or erucyl alcohol
  • octadecene diol ricinoleic alcohol
  • fatty alcohols monohydric primary alcohols having 8 to 22 carbon atoms and branched or unbranched chains
  • proportion of fatty alcohols, monohydric primary alcohols having 8 to 22 carbon atoms and branched or unbranched chains is therefore advantageously not more than 1% by weight, preferably 0% by weight, based on the total mass of the preparation.
  • PG-10 stearate can be added to the emulsion formation both in the water and in the fat phase. In both cases, the same product is obtained. The differences in consistency are not significant and not relevant to a consumer.
  • Figure 1 shows these consistency studies. The consistency was determined using a consistency determination device according to Fligge (according to DE 29 09 087).
  • Formula A differs from formula B in that the PG-10 Stearate emulsifier was added to the water phase in case A and to the fat phase in case B. All further steps were identical for both formulations.
  • the consistency value is plotted on the y axis. It can be seen that both formulas even have the same consistency numerically after one day, ie they are identical in terms of consistency. After 30 days there is a numerical difference, but the consumer can not understand it.
  • a process for the preparation of cosmetic or dermatological emulsion preparations with polyglyceryl-10-stearate as emulsifier, preferably single emulsifier, allows the addition both in the water and / or in the oil phase of the emulsion.
  • PG-10-containing preparations can thus be produced more easily and give the person skilled an outstanding flexibility with regard to viscosity, sensor technology, application form and tolerance to a wide variety of ingredients and production.
  • Preparations no instabilities, phase separation, coalescence, Ostwald ripening or change in droplet size with time or creaming.
  • the formulations as disclosed in the examples were optically stable for at least 6 months at room temperature and at 40 ° C. That is, no phase separation or phase separation was observed.
  • Mildness can be described by various aspects. Mildness may mean that a product does not cause redness, burning or itching or that the skin does not dry out when using the product. However, these are all indicators that can only be fixed by the use of the consumer. However, the goal in the development of cosmetic or dermatological products is, inter alia, to bring products into the market which do not evoke the same reaction from the consumer. For this reason, there are various tests to show already such a potential of "mildness".
  • the expert knows such tests for example the Repetitive patch test.
  • the repetitive, occlusive epicutaneous test with up to four applications of the test sample on the same skin area for four consecutive days for a defined period of time serves to differentiate the skin compatibility of skin care products and to optimize products.
  • a test sample with a known irritation profile should be tested.
  • the termination criterion for further applications is the occurrence of a clearly recognizable skin irritation.
  • the evaluation it is stated whether, and if so, after how many applications a skin change has occurred. Reactions that occur at an early stage are to be evaluated more strongly than reactions after the later ones
  • Emulsifiers trigger significantly stronger effects with 14, 22 and 25 reactions, respectively. The lower the number of reactions observed, the milder the product.
  • Additional emulsifiers may be added to the preparations according to the invention. However, this is not required or mandatory in all cases according to the invention.
  • additional emulsifiers are added, these are preferably to be selected from the group of emulsifiers which are solid, pasty or liquid at 25 ° C and not ethoxylated. Particularly preferred additional emulsifiers are to be selected from the group 1, 2 Propandiolfettklareester, acetoglycerides, acetylated mono- / diglycerides, alkali or
  • Ammonium soaps ammonium phosphatides, sorbitan monoisostearate, C10-C22 fatty acids, cetearyl sulfate, cetearyl glucosides, cetyl phosphate, cetylstearyl alcohol in combination with sodium cetyl stearyl sulfate, citrate glyceride esters, citric acid monoglycerides,
  • Diacetyltartaric acid monoglycerides diisostearoyl polyglyceryl-3 diisostearate (Isolan PDI), egg lecithin, emulsifier YN (trade name), acetic acid monoglycerides, mixed propylene glycol glycerol esters, glyceryl laurate, glyceryl myristate, glyceryl oleate in combination with propylene glycol, glyceryl stearate, glyceryl stearate SE, glyceryl stearate citrate, glycol distearate, isostearyl diglyceryl succinate , Isostearylglyceryl ether, potassium cetyl phosphate,
  • Lactoglycerides Lactylated mono- / diglycerides, lecithin, methyl glucose sesquistearate,
  • Lactic acid monoglycerides mono- and diglycerides of fatty acids esterified with acetic acid and tartaric acid, monoglyceride acetate, monoglyceride citrate, monoglyceride diacetyl tartrate, monoglyceride lactate, monoglyceride tartrate, Na, K and Ca salts of stearoyl-2-lactyl lactic acid, Na, K and Ca; stearoyl-2-lactoyl-lactate, Na, K and Ca stearoyl-2-lactyllactate, Na, K and Ca stearoyl lactic acid, Na salt of lauryl sulfuric acid,
  • Polyglyceryl-1 dipolyhydroxystearate (Dehymuls PGPH), polyglyceryl-2-laurate, polyglyceryl-2-sesquiisostearate, polyglyceryl-3 beeswax (Cera Bellina), polyglyceryl-3 cetyl ether
  • Diisostearate / polyhydroxystearate / sebacate (Isolan GPS), polyglyceryl-4 isostearate (Isolan GI 34), polyoxyethylene stearic acid ester, polyoxylstearate mono- / diglyceride, propylene glycol stearate SE, propylene glycol fatty acid ester, propylene glycol mono- / di-fatty acid ester, rapeseed lecithin, sucrose glycerides , Sucrose esters of fatty acids, soy lecithin, sorbates bsp.
  • Isolan GPS Diisostearate / polyhydroxystearate / sebacate
  • Isolan GI 34 polyglyceryl-4 isostearate
  • polyoxyethylene stearic acid ester polyoxylstearate mono- / diglyceride
  • propylene glycol stearate SE propylene glycol fatty acid ester
  • Sorbitan monolaurate (sorbate 20), sorbitan di-citrate, sorbitan butucate, Sorbitan dihydroxystearate, sorbitan diisostearate, sorbitan adipate, sorbitan dioleate,
  • Sorbitan monostearate (sorbate 60), sorbitan monotartrate, sorbitan sesquiterate,
  • the preparations according to the invention preferably comprise no further additional emulsifier except PG-10 stearate.
  • the proportion of additional emulsifiers should therefore preferably be less than 0.01% by weight, based on the total mass of the preparation, in order to be considered to be present according to the invention-without additional emulsifier.
  • Lecithins is the classic name for a group of chemical compounds called phosphatidylcholines. These are phospholipids, which are composed of fatty acids, glycerol, phosphoric acid and choline. Lecithins are
  • Lecithins Components of the cell membrane of animal and plant organisms. They are accompanying substances in fats and oils. They allow the emulsification of fats and water and are therefore important natural surfactants (emulsifiers) for food and feed. Lecithins are widely accepted in the EU as a food additive (E 322) for foodstuffs with a maximum limit on infant formula only. In medicine and cosmetics, they are also used as an active ingredient, in dietetics as a dietary supplement. In addition to their structure-forming properties, lecithins are ascribed numerous functional tasks. They are actively involved in both anabolic lipid metabolism and catabolic lipid metabolism.
  • Lecithins are therefore excluded according to the invention.
  • the cosmetic or dermatological preparations according to the invention may further contain cosmetic adjuvants and other active ingredients, such as are commonly used in such preparations, for.
  • preservatives preservatives, bactericides, substances for preventing foaming, dyes and color pigments, thickeners, moisturizing and / or moisturizing substances, fats, oils, waxes or other conventional ingredients of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives, self-tanner, buffers, pH regulators, vegetable
  • Preferred lipid components in the preparations according to the invention are C 12-15 alkyl benzoate, isopropyl palmitate, caprylic / capric triglycerides and / or octyldodecanol.
  • Preferred auxiliaries are preferably to be selected from the group acetyl
  • Trifluoromethylphenyl Valylglycine Amaranthus Caudatus Extract, Amaranthus Extract, Andrographolide, Anthemis Nobilis Flower, Ascorbyl Tocopheryl Maleate, Essential Oils, Avena Aqua, BGT, Biosaccharides Gum 3, Butyl Hydroquinone, Cassia Alata,
  • Polycaprolactone Polyester-5, Polyglyceryl-2 Caprate, Polyglycerol-6 Polyricinoleate, Punica Granatum Fruit Juice, Pyracantha Fortuneana Extract, Pyrus Malus Water, Selaginella Tamariscina Extract, Shorea Robusta Butter, Sodium Dodecylbenzene Sulfonate, Sodium Hydroxyethyl Acrylate / Acryloyl Dimethyl Taurate Copolymer, Sodium Hydroxypropyl Starch Phosphate, Sodium Mannose Phosphate, Succinoglycan, Sucrose Polycarbonate Solvent, Tetrahydrobisdemethoxycurcumin, Tetrahydrobisdemethoxydiferuloylmethane,
  • Tetrahydrodemethoxycurcumin Tetrahydrodemethoxydiferuloylmethane, Thiodipropionic Acid, Thiotaurine, Tocopheryl Glucoside, Tri C14-15 Al ky Lead Rate, Trilon B, Trioctyl Dodecyl Citrate, Trioxaundecanedioic Acid and / or Xymenynic Acid.
  • the preparations according to the invention are preferably O / W, W / O, W / O / W, O / W / O emulsions and hydrodispersions, where O can also stand for silicone oils.
  • the preparation is based on a O / W emulsion or
  • the lipid phase used may preferably be the following oils in the emulsion preferred according to the invention, in particular O / W emulsion:
  • polar oil components selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids having a
  • ester oils can advantageously be selected from the group consisting of phenethyl benzoate, 2-phenylethyl benzoate, propylheptyl caprylate, isopropyl lauroyl sarcosinate, dibutyl adipate, octyl palmitate, octyl cocoate, octyl isostearate, octyldodeceyl myristate, octyldodecanol, cetearyl isononanoate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate,
  • Isononyl isononanoate 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyl dodecyl palmitate, stearyl heptanoate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate, tridecyl stearate, tridecyl trimellitate, as well as synthetic, semisynthetic and natural mixtures of such esters, e.g. B. jojoba oil.
  • dialkyl ethers and dialkyl carbonates may advantageously be selected, and z.
  • Dicaprylyl carbonate for example that available under the trade name Cetiol CC from Cognis. It is further preferred that the oil component (s) is selected from the group consisting of isoeicosane, neopentyl glycol diheptanoate, propylene glycol dicaprylate / dicaprate,
  • oil phase of the formulations of the invention has a content of C12-15-alkyl benzoate or consists entirely of this.
  • Other oil components may include: caprylic / capric triglycerides, octyldodecanol, C12-15 alkyl benzoates,
  • Neopentanoates and Caprylic / Capric Triglycerides Neopentanoates and Caprylic / Capric Triglycerides.
  • non-polar oil components such as silicone oils
  • silicone oils such as silicone oils
  • Cyclomethicones for example D4, D5, D6, Dimethicone, Dimethiconecopolyol and other hydrocarbon based oils such as Parafinum Liquidum, halogenated and perhalogenated hydrocarbons are selected.
  • Preferred lipid components in the preparations according to the invention are C 12-15 alkyl benzoate, isopropyl palmitate, caprylic / capric triglycerides and / or octyldodecanol.
  • the preparations according to the invention comprise no parabens, formalin-cleavers, organohalogens, benzoic acid and its salts, formates and tea tree oil, and advantageously also no benzyl alcohol and / or phenoxyethanol.
  • DMDM Hydantoin is a formaldehyde releaser.
  • formaldehyde is a toxic substance and its use in cosmetics is not uncontroversial.
  • Benzyl alcohol has a characteristic odor which must be masked in a formulation with perfume.
  • perfume ingredients are often suspected of irritating or sensitizing. Therefore it is desirable to keep the perfume concentration as low as possible. Phenoxyethanol is repeatedly suspected Type IV
  • Organic halides are relatively highly reactive substances and interact with the cell membrane and are thus strongly rejected by consumers.
  • Tea tree oil is not approved as a drug and is considered a risk substance for the occurrence of contact dermatitis.
  • Emulsion preparations with PG-10 stearate can be prepared in the cold-cold process. Normally, the fat phase is melted to 80-100 ° C and heats the water phase parallel to 80-100 ° C on. These two hot phases are combined and stirred. Subsequently, it is homogenized. In production, this often has to be cooled.
  • This process is called hot / hot process.
  • Cold / cold method is thus analogous, you have a water phase at room temperature and a fat phase at room temperature, which gives together and homogenized, which is energetically a big advantage.
  • thermally labile active substances for example natural oils, active substances, vitamins, perfume or else individual perfume ingredients.
  • Thermally labile substances are those which, when heated above 50 ° C., change in color, smell or in physical parameters or even degrade completely or partially.
  • Particularly preferred active ingredients therefore include biochinones, in particular ubiquinone Q10, isoflavone and isoflavonoids, genistein, arctiin, cardiolipin, lipoic acid, anti-freezing proteins, hop and hops malt extracts, and / or the restructuring of the connective tissue promoting substances, isoflavonoids and isoflavonoid -containing plant extracts such as soy and clover extracts, which can also be used very well in the preparations according to the invention and Hautauflagenmatrices.
  • biochinones in particular ubiquinone Q10, isoflavone and isoflavonoids, genistein, arctiin, cardiolipin, lipoic acid, anti-freezing proteins, hop and hops malt extracts, and / or the restructuring of the connective tissue promoting substances, isoflavonoids and isoflavonoid -containing plant extracts such as soy and clover extracts, which can also be used very well in the preparations according to
  • the combination product according to the invention is particularly suitable as active ingredients for supporting the skin functions in dry skin, such as, for example, vitamin C, biotin, creatine, creatinine, propionic acid, glycerol, green tea extracts, white tea extracts or solutions, to use.
  • agents such as sericosides, various extracts of licorice, licochalcone A, silymarin or silyphos, flavonoids, dexpanthenol, ethanol, inhibitors of
  • Prostaglandin metabolism in particular cyclooxygenase, and the
  • Leukotrienstoffops in particular the 5-lipoxygenase, but also the 5-lipoxygenase inhibitor protein, FLAP.
  • modulators of pigmentation also proved to be advantageous.
  • Reduce age spots and / or lighten existing age spots such as tyrosine sulfate, vitamin C, lipoic acid and liponamide, various extracts of licorice, kojic acid, hydroquinone, arbutin, fruit acids, especially alpha hydroxy acids (AHAs), bearberry (uvae ursi), ursolic acid, Ascorbic acid, green tea extracts, aminoguanidine and / or
  • active ingredients that promote enhanced / faster tanning of the skin (Advanced Glycation End Products (AGE), lipofuscins, nucleic acid oligonucleotides, purines and pyrimidines, NO-releasing substances, with or without the influence of UV light, have proven to be effective).
  • AGE Advanced Glycation End Products
  • lipofuscins lipofuscins
  • nucleic acid oligonucleotides nucleic acid oligonucleotides
  • purines and pyrimidines NO-releasing substances, with or without the influence of UV light
  • suitable active ingredients are, for example, folic acid, phytoene, urea, D-biotin, coenzyme Q10, flavone glycosides such. ⁇ -glucosylrutin, carnitine,
  • Such ingredients may preferably each be contained in a proportion of 0.01 to 30 wt.%, Based on the total weight of the preparation in this.
  • Formulations according to the invention which contain one or more anti-wrinkle active ingredients such as flavone glycosides, in particular ⁇ -glycosyl rutin, coenzyme Q10, retinol and its esters, vitamin E and its derivatives and other anti-wrinkle agents known to the skilled person, are particularly suitable for protection against aesthetically unattractive
  • Skin changes such as those that occur with tired skin or skin aging. These changes include e.g. Dryness, roughness and formation of dryness wrinkles, itching, reduced refatting especially after washing, visible vascular dilations such as tele-angiectasias or cuperosis, slackness and development of wrinkles and wrinkles, local hyper-, hypo- and Albertpigment michen age spots, increased susceptibility to mechanical stress such as cracking and other changes known to those skilled in the art. Further advantageous emulsions of the invention are suitable for the appearance of dry or rough skin.
  • the preparations 2, 4, 6, 8, 9 and 10 comprise as emulsifier according to the invention only polyglycerol-10-stearate and are still extremely stable.
  • Cyclic silicone oil (cyclomethicone) 12.5 15 25.0 10.0 7.5
  • Triglycerol diisostearate 1 0 0.5 0.25 2.0 3.0
  • Polyglyceryl 10 Stearate 0.2 1, 0 0.5 0.1 0.75
  • Myristyl alcohol 0.00 0.5 0.00 0.00 0.00 0.00
  • Caprylic / Capric Triglycerides 2.50 0.00 2.50 0.00 0.00 0.00
  • Polyglyceryl 10 Stearates 0.30 0.30 2.00 1, 00 4.00 1, 50
  • Methylisothiazolinone 0.00 0.00 0.05 0.00 0.04 0.04 Phenoxyethanol 0.00 0.00 0.60 0.60 0.60 0.60 0.60
  • Methylparaben 0.00 0.00 0.00 0.30 0.00 0.00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des compositions cosmétiques ou dermatologiques contenant du polyglycéryl-10-stéarate et aucun émulsifiant éthoxylé.
EP12727305.0A 2011-06-07 2012-06-05 Compositions cosmétiques ou dermatologiques exemptes de polyéthylène glycol Ceased EP2717970A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE201110077018 DE102011077018A1 (de) 2011-06-07 2011-06-07 Polyethylenglykol-freie kosmetische oder dermatologische Zubereitungen
DE201110077060 DE102011077060A1 (de) 2011-06-07 2011-06-07 Kosmetische oder dermatologische Zubereitungen mit einem geringen Gehalt an Polyglyceryl-10-Stearat Emulgator
PCT/EP2012/002374 WO2012167905A2 (fr) 2011-06-07 2012-06-05 Compositions cosmétiques ou dermatologiques exemptes de polyéthylène glycol

Publications (1)

Publication Number Publication Date
EP2717970A2 true EP2717970A2 (fr) 2014-04-16

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EP12727305.0A Ceased EP2717970A2 (fr) 2011-06-07 2012-06-05 Compositions cosmétiques ou dermatologiques exemptes de polyéthylène glycol

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WO2012167905A3 (fr) 2014-01-30

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