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WO2012150839A3 - Method for microencapsulating phosphatidylserine - Google Patents

Method for microencapsulating phosphatidylserine Download PDF

Info

Publication number
WO2012150839A3
WO2012150839A3 PCT/KR2012/003504 KR2012003504W WO2012150839A3 WO 2012150839 A3 WO2012150839 A3 WO 2012150839A3 KR 2012003504 W KR2012003504 W KR 2012003504W WO 2012150839 A3 WO2012150839 A3 WO 2012150839A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphatidylserine
microencapsulating
liquid
mixing
starch solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2012/003504
Other languages
French (fr)
Korean (ko)
Other versions
WO2012150839A2 (en
Inventor
한지영
한정준
이관형
정국훈
황성기
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Doosan Corp
Original Assignee
Doosan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Doosan Corp filed Critical Doosan Corp
Priority to CN201280033216.7A priority Critical patent/CN103635181A/en
Publication of WO2012150839A2 publication Critical patent/WO2012150839A2/en
Publication of WO2012150839A3 publication Critical patent/WO2012150839A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

The present invention provides a method for microencapsulating phosphatidylserine, comprising the steps of: (a) producing a liquid phosphatidylserine composition by melting phosphatidylserine in edible oil and fat; (b) preparing an aqueous starch solution, before, after or at the same time as step (a) by mixing with water modified starch, which has been modified to be lipophilic and hydrophilic; (c) emulsifying by mixing and homogenizing the aqueous starch solution with the liquid phosphatidylserine composition; and (d) drying the resulting emulsified liquid.
PCT/KR2012/003504 2011-05-04 2012-05-04 Method for microencapsulating phosphatidylserine Ceased WO2012150839A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201280033216.7A CN103635181A (en) 2011-05-04 2012-05-04 Microencapsulation method of phosphatidylserine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110042580A KR101763947B1 (en) 2011-05-04 2011-05-04 Method of microcapsulating phosphatidylserine
KR10-2011-0042580 2011-05-04

Publications (2)

Publication Number Publication Date
WO2012150839A2 WO2012150839A2 (en) 2012-11-08
WO2012150839A3 true WO2012150839A3 (en) 2013-01-03

Family

ID=47108156

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/003504 Ceased WO2012150839A2 (en) 2011-05-04 2012-05-04 Method for microencapsulating phosphatidylserine

Country Status (3)

Country Link
KR (1) KR101763947B1 (en)
CN (1) CN103635181A (en)
WO (1) WO2012150839A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103892281B (en) * 2014-04-11 2016-04-06 内蒙古伊利实业集团股份有限公司 Containing alimentation composition and preparation method thereof and the application of phosphatidylserine
CN109222109A (en) * 2017-12-15 2019-01-18 理星（天津）生物科技有限公司 A kind of phosphatidylserine pellet and its preparation method and application
CN108142950A (en) * 2017-12-27 2018-06-12 浙江健智元生物科技有限公司 A kind of acer truncatum seed oil composite Nano microcapsule powder for improving brain neuroblastoma and preparation method thereof
CN109568292A (en) * 2018-12-29 2019-04-05 中山百灵生物技术有限公司 A kind of microgel and preparation method thereof containing GPC
CN110368362B (en) * 2019-08-01 2022-10-04 聊城大学 A kind of preparation method of phosphatidylserine emulsion
CN110583801A (en) * 2019-10-17 2019-12-20 东北农业大学 Method for preparing powdered oil by compounding octenyl succinic anhydride modified starch and xanthan gum
CN110692893A (en) * 2019-11-12 2020-01-17 南通厚元生物科技有限公司 Preparation method of solid beverage containing phosphatidylserine and omega-3 fatty acid
CN111363767A (en) * 2020-04-22 2020-07-03 山东惠仕莱生物科技有限公司 Preparation method of phosphatidylserine for food
CN111418846A (en) * 2020-04-27 2020-07-17 南通厚元生物科技有限公司 Microcapsule powder containing industrial cannabis protein and phosphatidylserine and preparation method thereof
CN116570018B (en) * 2023-04-19 2024-01-02 广东萃怪香料有限公司 Perfume slow-release nanoparticle and preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011178A1 (en) * 1990-01-26 1991-08-08 Fluntera Ag Encapsulation of active substances in starch
KR20020091492A (en) * 2001-05-30 2002-12-06 문장조 Microencapsulation Using Porous Dextrin with Matrix Inside and Manufacturing Method the Same
KR20030058839A (en) * 2002-01-02 2003-07-07 주식회사 두산 Liquid Composition Comprising Phosphatidylserine and Method for the preparation
KR20030070798A (en) * 2002-02-26 2003-09-02 주식회사 국순당 Method for preparation of micoencapsulated lipid soluble antioxidant coated by polysaccharides and proteins
KR20080014379A (en) * 2006-08-11 2008-02-14 주식회사 두산 Phosphatidylserine-Containing Solid Lipid Nanoparticle Compositions and Methods for Manufacturing the Same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011178A1 (en) * 1990-01-26 1991-08-08 Fluntera Ag Encapsulation of active substances in starch
KR20020091492A (en) * 2001-05-30 2002-12-06 문장조 Microencapsulation Using Porous Dextrin with Matrix Inside and Manufacturing Method the Same
KR20030058839A (en) * 2002-01-02 2003-07-07 주식회사 두산 Liquid Composition Comprising Phosphatidylserine and Method for the preparation
KR20030070798A (en) * 2002-02-26 2003-09-02 주식회사 국순당 Method for preparation of micoencapsulated lipid soluble antioxidant coated by polysaccharides and proteins
KR20080014379A (en) * 2006-08-11 2008-02-14 주식회사 두산 Phosphatidylserine-Containing Solid Lipid Nanoparticle Compositions and Methods for Manufacturing the Same

Also Published As

Publication number Publication date
WO2012150839A2 (en) 2012-11-08
CN103635181A (en) 2014-03-12
KR20120124745A (en) 2012-11-14
KR101763947B1 (en) 2017-08-01

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