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WO2012150487A1 - Dispositifs de diagnostic peu coûteux - Google Patents

Dispositifs de diagnostic peu coûteux Download PDF

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Publication number
WO2012150487A1
WO2012150487A1 PCT/IB2011/052753 IB2011052753W WO2012150487A1 WO 2012150487 A1 WO2012150487 A1 WO 2012150487A1 IB 2011052753 W IB2011052753 W IB 2011052753W WO 2012150487 A1 WO2012150487 A1 WO 2012150487A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydrophilic
matrix
diagnostic device
hydrophobic
silk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2011/052753
Other languages
English (en)
Inventor
Paridhi Bhandari
Dhananjaya Dendukuri
Tanya NARAHARI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Achira Labs Pvt Ltd
Original Assignee
Achira Labs Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achira Labs Pvt Ltd filed Critical Achira Labs Pvt Ltd
Publication of WO2012150487A1 publication Critical patent/WO2012150487A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0845—Filaments, strings, fibres, i.e. not hollow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Definitions

  • FIG. 2 shows an alternate embodiment of a configuration of the hydrophilic matrix
  • the hydrophilic matrix is characterized by having at least one thread derived from degummed silk and at least one thread made of a hydrophilic material.
  • Degummed silk is known in the art. Briefly, silk is a fiber obtained from silkworms, more specifically from the larvae of mulberry silkworms. The silk most useful in the invention are those that can be woven into textiles, such as that obtained from the silkworm Bombyx Mori, however, other forms of silk that may be synthetically made or produced from other sources may also be used for this invention. Chemically, silk fiber comprises a chain of amino acids, which possesses functional groups that may be further used for binding useful moieties.
  • hydrophilic material is a material that is capable of being wet with water. Hydrophilicity of a material is generally understood by the physical phenomena of wicking, as measured by wicking rate. Hydrophilicity may also be understood by the contact angle made by the water droplet on the surface of the material.
  • the hydrophilic materials useful in the invention must also have the ability to form fibers. Useful hydrophilic materials for the diagnostic device include, but not limited to, poly(vinyl alcohol), cotton, rayon, cellulosic fibers, derivatives thereof, and blends therefrom.
  • Fig. 2 shows an alternate embodiment of a configuration of a section of the hydrophilic matrix 22.
  • the weft 24 is shown to be made of cotton 26 while the warp 28 is predominantly silk 30 with two strands of hydrophilic material 32.
  • the thread is made using at least one strand of degummed silk, at least one strand of polyester fiber, at least one strand of cotton, at least one strand of nylon and at least one strand of nylon fiber.
  • the exact properties desired for the hydrophilic matrix in terms of a defined flow path, stiffness, tensile properties, and other factors, will determine the number and the exact composition of the strands used to form the thread.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un dispositif de diagnostic comprenant : une matrice hydrophobe (60) ; une matrice hydrophile(62) constituée elle-même par une zone d'entrée d'échantillon (64), une zone d'écoulement (66), une zone de test, et une zone d'absorption d'échantillon (70). La matrice hydrophile (62), qui se trouve à l'intérieur de la matrice hydrophobe (60), est caractérisée en ce qu'elle comprend, entrelacés, au moins un fil tiré de soie souple et au moins un fil fait d'un matériau hydrophile.
PCT/IB2011/052753 2011-05-05 2011-06-23 Dispositifs de diagnostic peu coûteux Ceased WO2012150487A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1562/CHE/2011 2011-05-05
IN1562CH2011 2011-05-05

Publications (1)

Publication Number Publication Date
WO2012150487A1 true WO2012150487A1 (fr) 2012-11-08

Family

ID=44509490

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/052753 Ceased WO2012150487A1 (fr) 2011-05-05 2011-06-23 Dispositifs de diagnostic peu coûteux

Country Status (1)

Country Link
WO (1) WO2012150487A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3120927A1 (fr) 2015-07-24 2017-01-25 Centre National De La Recherche Scientifique Dispositif fluidique enchevêtré
WO2018167261A1 (fr) 2017-03-17 2018-09-20 Porcher Industries Dispositif et procédé de test rapide d'un échantillon liquide
EP3385708A1 (fr) * 2017-04-03 2018-10-10 HFT Smart Sensors, Incorporated Technologie vestimentaire comportant des capteurs électrochimiques intégrés dans les fibres des vêtements
US11344230B2 (en) 2017-04-03 2022-05-31 HFT Smart Sensors, Incorporated Wearable technology with sensors integrated into clothing fibers

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224406A1 (en) 2001-11-16 2004-11-11 Tissue Regeneration, Inc. Immunoneutral silk-fiber-based medical devices
WO2009121043A2 (fr) 2008-03-27 2009-10-01 President And Fellows Of Harvard College Fil de coton servant de plate-forme diagnostique pour analyses multiples à bas coûts

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224406A1 (en) 2001-11-16 2004-11-11 Tissue Regeneration, Inc. Immunoneutral silk-fiber-based medical devices
WO2009121043A2 (fr) 2008-03-27 2009-10-01 President And Fellows Of Harvard College Fil de coton servant de plate-forme diagnostique pour analyses multiples à bas coûts

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DAVARPANAH: "Environmentally friendly surface modification of silk fiber: Chitosan grafting and dyeing", APPLIED SURFACE SCIENCE, vol. 255, no. 7, 15 January 2009 (2009-01-15), pages 4171 - 4176, XP025860623, DOI: doi:10.1016/j.apsusc.2008.11.001
LI, X., TIAN, J., SHEN, W.: "Thread as a Versatile Material for Low-Cost Microfluidic Diagnostics", ACS APPLIED MATERIALS & INTERFACES, vol. 2, no. 1, 2009, pages 1 - 6, XP009145513, DOI: doi:10.1021/am9006148
MARTINEZ, A. W., PHILLIPS, S. T., BUTTE, M. J., WHITESIDES, G. M.: "Patterned paper as a platform for inexpensive, low-volume, portable bioassays", ANGEW CHEM INT ED ENGL, vol. 46, no. 8, 2007, pages 1318 - 20, XP008142366, DOI: doi:10.1002/anie.200603817
MEITAL RECHES ET AL: "Thread as a Matrix for Biomedical Assays", A C S APPLIED MATERIALS AND INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 2, no. 6, 1 January 2010 (2010-01-01), pages 1722 - 1728, XP009145514, ISSN: 1944-8244, [retrieved on 20100524], DOI: 10.1021/AM1002266 *
R.SAFAVIEH, M. MIRZAEI, M.A. QASAIMEH, D. JUNCKER: "Yarn based microfluidics: from basic elements to complex circuits", 13TH INTERNATIONAL CONFERENCE ON MINIATURIZED SYSTEMS FOR CHEMISTRY AND LIFE SCIENCES, MICROTAS 2009, JEJU, SOUTH KOREA, 1 November 2009 (2009-11-01) - 5 November 2009 (2009-11-05), pages 685 - 687, XP002668867, ISSN: 1556-5904, ISBN: 978-0-9798064-2-1 *
RECHES ET AL.: "ACS APPLIED MATERIALS AND INTERFACES", vol. 2, 1 January 2010, AMERICAN CHEMICAL SOCIETY, article "Thread as a Matrix for Biomedical Assays", pages: 1722 - 1728
ROOZBEH SAFAVIEH, MARYAM MIRZAEI, MOHAMMAD A. QASAIMEH, DAVID JUNCKER, YAM BASED MICROFLUIDICS: FROM BASIC ELEMENTS TO COMPLEX CIRCUITS, 1 November 2009 (2009-11-01)
XU LI ET AL: "Thread as a Versatile Material for Low-Cost Microfluidic Diagnostics", A C S APPLIED MATERIALS AND INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 2, no. 1, 1 January 2010 (2010-01-01), pages 1 - 6, XP009145513, ISSN: 1944-8244, [retrieved on 20091209], DOI: 10.1021/AM9006148 *
YAGER, P., DOMINGO, G. J., GERDES, J.: "Point-of-care diagnostics for global health", ANNU REV BIOMED ENG, vol. 10, 2008, pages 107 - 44

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3120927A1 (fr) 2015-07-24 2017-01-25 Centre National De La Recherche Scientifique Dispositif fluidique enchevêtré
WO2017017002A1 (fr) * 2015-07-24 2017-02-02 Centre National De La Recherche Scientifique Dispositif fluidique tissé composite
US10661274B2 (en) 2015-07-24 2020-05-26 Centre National De La Recherche Scientifique Composite woven fluidic device
WO2018167261A1 (fr) 2017-03-17 2018-09-20 Porcher Industries Dispositif et procédé de test rapide d'un échantillon liquide
FR3063918A1 (fr) * 2017-03-17 2018-09-21 Porcher Industries Dispositif et procede de test rapide d'un echantillon liquide
EP3385708A1 (fr) * 2017-04-03 2018-10-10 HFT Smart Sensors, Incorporated Technologie vestimentaire comportant des capteurs électrochimiques intégrés dans les fibres des vêtements
US11344230B2 (en) 2017-04-03 2022-05-31 HFT Smart Sensors, Incorporated Wearable technology with sensors integrated into clothing fibers

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