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WO2012030251A1 - Implanteur d'embryons - Google Patents

Implanteur d'embryons Download PDF

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Publication number
WO2012030251A1
WO2012030251A1 PCT/RU2011/000520 RU2011000520W WO2012030251A1 WO 2012030251 A1 WO2012030251 A1 WO 2012030251A1 RU 2011000520 W RU2011000520 W RU 2011000520W WO 2012030251 A1 WO2012030251 A1 WO 2012030251A1
Authority
WO
WIPO (PCT)
Prior art keywords
embryo
uterine
uterine cavity
endometrium
vitro fertilization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2011/000520
Other languages
English (en)
Russian (ru)
Inventor
Михаил Григорьевич ШНЕЙДЕРМАН
Лев Львович КОЛЕСНИКОВ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2012030251A1 publication Critical patent/WO2012030251A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation

Definitions

  • the device relates to auxiliary tools in medicine and can be used to increase the possibility of implantation of embryos in the uterine mucosa during the artificial insemination (IVF) procedure.
  • IVF artificial insemination
  • IVF in vitro fertilization
  • In vitro fertilization is fertilization outside the human body. After ovulation stimulation is carried out, one or several eggs are obtained by puncture, which are fertilized under laboratory conditions
  • sperm cells with subsequent transfer of the resulting embryos into the uterus of a woman.
  • the prior art method of in vitro fertilization (patent RU2181581), including ovulation stimulation, controlled by ultrasound and hormonal testing, in vitro fertilization and transfer of embryos into the uterine cavity, characterized in that the ultrasound method determines the location of the dominant ovary, percutaneous stimulation areas of the BM-147 reflex point on the same side, after which the woman is placed on the corresponding side and the embryos are transferred into the uterine cavity on side of the endometrium, ipsilateral dominant ovary.
  • the technical result of this solution is to increase the possibility of successful implantation of the embryo to the endometrium with its subsequent development.
  • the claimed technical result of improving blastocyst implantation to the endometrium is achieved by creating air pressure in the uterine body cavity, due to which close contact and fusion of the blastocyst with
  • the embryo implant is made up of a container with a compressed sterile air mixture and a disposable sterile plastic uterine
  • the tip which is made with the possibility of mounting on the cylinder head, and in the distal part of the uterine tip is a protective mesh-divider, made with the possibility of preventing the exit of a direct stream of air.
  • the composition of the air mixture is selected from a ratio of 89% oxygen and 11% nitrogen.
  • FIG. 1 shows a structural device for an embryo implant (side view) (a) a device for a disposable sterile plastic tip (b) for introducing implantable embryos into the cervix, where 1 is a balloon with a compressed sterile air mixture (composition: 89% oxygen + 11% nitrogen) designed for 1-2 injections (under a pressure of 1 atmosphere), 2 - a plastic tip for spraying an air stream, 3 - a protective mesh-divider, having the form of a cap
  • FIG. 2 shows the position of the embryo in the uterine cavity after administration through the catheter, where 9 are the mucous membranes of the uterus, 10 is the embryo.
  • FIG. 3 shows the insertion of the implant tip into the uterine cavity through the cervix and injection of the air mixture, where 11 is the cervix.
  • the embryo implant (Fig. 1) consists of a balloon (1) with compressed sterile air (composition: 89% oxygen + 11% nitrogen), designed for 1-2 air injections into the uterine cavity.
  • a special disposable sterile plastic uterine tip (2) is attached to the cylinder, which is mounted on the cylinder head with a tubular end (5).
  • On the distal part of the uterine tip is a protective mesh-divider (3), which prevents a direct stream of air from entering the uterine cavity and helps to create uniform pressure in the uterine cavity.
  • the composition of the air mixture is selected empirically from a ratio of 89% oxygen and 11% nitrogen. This composition of the mixture provides minimal harm to the embryo.
  • composition of the mixture may be different. It does not significantly affect the embryo.
  • the principle of operation of the device is as follows.
  • the implant tip (2) is inserted into the uterus through the cervix (11), pressing against
  • the air mixture is injected from the balloon (1) through the tip (2) into the uterine cavity (Fig. 3), where it is uniformly blown into the cavity through the dissecting mesh (3) and creates air pressure, which contributes to that the embryo is slightly pressed against the mucous cavity (9) of the uterus and is more successfully fixed on the mucosa.
  • the mucous membrane of the endometrium (9) of the uterine cavity, to which the blastocyst is implanted in women of the reproductive period consists of 2 layers: the basal, 1-1.5 cm thick, located on the inner layer of the myometrium and
  • the functional layer the thickness of which varies from the day of the menstrual cycle from 1 mm to 8 mm.
  • the argyrophilic fibers of the reticular fibrous structure of the endometrium move apart and are densely located around the vessels and glands.
  • branching of the glands does not occur, but in the phase of secretion in the functional layer, a deep spongy layer forms, where the glands are more closely located and the surface compact layer, in which the cytogenic stroma predominates.
  • the surface epithelium in the proliferation phase is functionally and morphologically similar to the glandular epithelium. But with the onset of the secretion phase, changes occur in it that contribute to easier adhesion of the blastocyst with the endometrium and subsequent implantation and development of the embryo.
  • IVF in vitro fertilization
  • This device solves the problem of closer adhesion of the embryo with

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Le modèle utile de la présente invention se rapporte aux instruments auxiliaires utilisés dans le domaine de la médecine, et peut être utilisé dans le processus de fécondation in vitro (FIV) afin d'améliorer la fixation de l'embryon à l'endomètre du corps de l'utérus. Le résultat technique de la présente invention peut être atteint grâce à un dispositif qui permet d'assurer une meilleure adhérence de l'embryon transféré dans la cavité de l'utérus avec l'endomètre pré-décidual, ce qui est un moment très important dans le processus de fécondation in vitro. Le résultat technique est obtenu en créant une pression minimale dans la cavité de l'utérus en y introduisant de l'air comprimé stérile (89% d'oxygène + 11% d'azote) depuis une bonbonne à l'aide d'un embout utérin plastique spécial. L'adhérence plus étroite de l'embryon contre la cavité muqueuse de l'utérus permet d'atteindre une plus grande probabilité d'implantation de l'embryon et un meilleur résultat final du processus de fécondation in vitre (FIV).
PCT/RU2011/000520 2010-09-03 2011-07-15 Implanteur d'embryons Ceased WO2012030251A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2010136691 2010-09-03
RU2010136691 2010-09-03

Publications (1)

Publication Number Publication Date
WO2012030251A1 true WO2012030251A1 (fr) 2012-03-08

Family

ID=45773113

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2011/000520 Ceased WO2012030251A1 (fr) 2010-09-03 2011-07-15 Implanteur d'embryons

Country Status (1)

Country Link
WO (1) WO2012030251A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4865589A (en) * 1987-04-22 1989-09-12 Ludwig Simmet Instrument for the transfer of materials such as sperm and embryos
RU2098030C1 (ru) * 1993-03-04 1997-12-10 Петр Анатольевич Помозов Устройство для искусственного оплодотворения женщин
US6610005B1 (en) * 1996-04-26 2003-08-26 Jun Tao Catheter system for implanting embryos
US20090299129A1 (en) * 2006-07-21 2009-12-03 Anecova Sa Recoverable intra-uterine system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4865589A (en) * 1987-04-22 1989-09-12 Ludwig Simmet Instrument for the transfer of materials such as sperm and embryos
RU2098030C1 (ru) * 1993-03-04 1997-12-10 Петр Анатольевич Помозов Устройство для искусственного оплодотворения женщин
US6610005B1 (en) * 1996-04-26 2003-08-26 Jun Tao Catheter system for implanting embryos
US20090299129A1 (en) * 2006-07-21 2009-12-03 Anecova Sa Recoverable intra-uterine system

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