[go: up one dir, main page]

WO2012016177A3 - Microbes génétiquement modifiés produisant de plus hauts niveaux de composés dérivés d'acétyl-coa - Google Patents

Microbes génétiquement modifiés produisant de plus hauts niveaux de composés dérivés d'acétyl-coa Download PDF

Info

Publication number
WO2012016177A3
WO2012016177A3 PCT/US2011/045953 US2011045953W WO2012016177A3 WO 2012016177 A3 WO2012016177 A3 WO 2012016177A3 US 2011045953 W US2011045953 W US 2011045953W WO 2012016177 A3 WO2012016177 A3 WO 2012016177A3
Authority
WO
WIPO (PCT)
Prior art keywords
acetyl
genetically modified
derived compounds
increased levels
coa derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/045953
Other languages
English (en)
Other versions
WO2012016177A2 (fr
Inventor
Darren Platt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amyris Inc
Original Assignee
Amyris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amyris Inc filed Critical Amyris Inc
Publication of WO2012016177A2 publication Critical patent/WO2012016177A2/fr
Publication of WO2012016177A3 publication Critical patent/WO2012016177A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/04—Hydrolases acting on acid anhydrides (3.6) acting on acid anhydrides; involved in cellular and subcellular movement (3.6.4)
    • C12Y306/04009—Chaperonin ATPase (3.6.4.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne des microorganismes génétiquement modifiés qui produisent de plus grandes quantités de composés dérivés de l'acétyl-CoA dans des procédés de fermentation industrielle, ainsi que leurs procédés de fabrication et d'utilisation.
PCT/US2011/045953 2010-07-30 2011-07-29 Microbes génétiquement modifiés produisant de plus hauts niveaux de composés dérivés d'acétyl-coa Ceased WO2012016177A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36955110P 2010-07-30 2010-07-30
US61/369,551 2010-07-30

Publications (2)

Publication Number Publication Date
WO2012016177A2 WO2012016177A2 (fr) 2012-02-02
WO2012016177A3 true WO2012016177A3 (fr) 2012-05-10

Family

ID=45530751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/045953 Ceased WO2012016177A2 (fr) 2010-07-30 2011-07-29 Microbes génétiquement modifiés produisant de plus hauts niveaux de composés dérivés d'acétyl-coa

Country Status (1)

Country Link
WO (1) WO2012016177A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013044475A1 (fr) * 2011-09-29 2013-04-04 私立辅仁大学 Procédé et système utilisant le genre cystofilobasidium de levure pour produire de la graisse
US20170298363A1 (en) 2014-09-18 2017-10-19 Genomatica, Inc Non-natural microbial organisms with improved energetic efficiency
JP2021505154A (ja) 2017-12-07 2021-02-18 ザイマージェン インコーポレイテッド 発酵によって（６ｅ）−８−ヒドロキシゲラニオールを生産するための設計された生合成経路
WO2019126778A1 (fr) 2017-12-21 2019-06-27 Zymergen Inc. Népétalactol oxydoréductases, népétalactol synthases et microbes capables de produire une népétalactone
CN110656056B (zh) * 2019-10-31 2021-07-27 江南大学 一种高浓度蒎烯耐受性产蒎烯工程菌的构建方法
CN110951631B (zh) * 2019-12-31 2021-03-02 江南大学 一株产香叶醇的葡萄汁有孢汉逊酵母及其发酵方法
CN111500606A (zh) * 2020-05-06 2020-08-07 浙江大学 一个参与桃芳樟醇生物合成的基因及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100159546A1 (en) * 2007-03-30 2010-06-24 Aristos Aristidou Metabolic engineering of yeasts for the production of 1-butanol

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100159546A1 (en) * 2007-03-30 2010-06-24 Aristos Aristidou Metabolic engineering of yeasts for the production of 1-butanol

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BOSL, B. ET AL.: "The molecular chaperone Hsp104-A molecular machine for protein disaggregation.", JOURNAL OF STRUCTURAL BIOLOGY., vol. 156, 6 March 2006 (2006-03-06), pages 139 - 148 *
ERIKSSON ET AL.: "The Escherichia coli heat shock protein ClpB restores acquired thermotolerance to a cyanobacterial clpB deletion mutant", CELL STRESS & CHAPERONES., vol. 5, no. 3, 2000, pages 255 - 264 *
HATTENDORF ET AL.: "Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants", EMBO J., vol. 21, no. 1, 2, 2002, pages 12 - 21 *
PARSELL ET AL.: "Saccharomyces cerevisiue Hsp104 Protein", J. BIOL. CHEM., vol. 269, no. 6, 11 February 1994 (1994-02-11), pages 4480 - 4487 *
PARSELL, D. A. ET AL., UNIPROT SUBMISSION ACCESSION P31539, 1 July 1993 (1993-07-01), pages 1, Retrieved from the Internet <URL:http://www.uniprot.org/uniproUP31539.txt?version=1> [retrieved on 20111208] *
PISZCZEK ET AL.: "The Molecular Chaperone, ClpA, Has a Single High Affinity Peptide Binding Site per Hexamer", J. BIOL CHEM., vol. 280, no. 13, 1 April 2005 (2005-04-01), pages 12221 - 12230 *
SCHIRMER ET AL.: "Subunit interactions influence the biochemical and biological properties of Hsp104", PNAS., vol. 98, no. 3, 30 January 2001 (2001-01-30), pages 914 - 919 *
SCHIRMER ET AL.: "The ATPase Activity of Hsp104, Effects of Environmental Conditions and Mutations", J. BIOL CHEM., vol. 273, no. 25, 19 June 1998 (1998-06-19), pages 15546 - 15552 *
TAKAHASHI ET AL.: "A Systematic Evaluation of the Function of the Protein-Remodeling Factor Hsp104 in [PSI+] Prion Propagation in S. cerevisiae by Comprehensive Chromosomal Mutations", PRION., vol. 1, no. 1, 2007, pages 69 - 77 *

Also Published As

Publication number Publication date
WO2012016177A2 (fr) 2012-02-02

Similar Documents

Publication Publication Date Title
WO2011006126A3 (fr) Micro-organismes modifiés ayant une activité de fermentation améliorée
WO2012058494A3 (fr) Variantes d&#39;isoprène synthase pour l&#39;augmentation de la production d&#39;isoprène
WO2008124229A3 (fr) Surfaces de bioréacteurs améliorées
MY178338A (en) Compositions and methods for biological production of lactate from c1 compounds using lactate dehydrogenase transformants
WO2012051210A3 (fr) Cellules souches mésenchymateuses et thérapies connexes
WO2012094425A3 (fr) Procédés biologiques pour préparer de l&#39;acide adipique
WO2011061032A3 (fr) Cellules, acides nucléiques, enzymes et leur utilisation, ainsi que procédé de production de sophorolipides
IL225923B (en) Cell culture material derived from a plant, methods for its preparation and uses thereof
WO2013181647A8 (fr) Compositions et procédés de production d&#39;isoprène et/ou de bioproduits industriels à l&#39;aide de microorganismes anaérobies
HK1201071A1 (en) Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
MX353579B (es) Organoide hepatico, sus usos y metodo de cultivo para obtenerlos.
EP2558582A4 (fr) Micro-organismes et procédés de production d&#39;éthylène glycol
WO2014169079A3 (fr) Productivité accrue pendant la fermentation
WO2011133504A3 (fr) Nanozymes, procédés de production de nanozymes, et procédés d&#39;utilisation de nanozymes
WO2012019002A3 (fr) Cellules souches somatiques
EP2652141A4 (fr) Microorganismes et procédés pour la production de 1,4-cyclohexanediméthanol
MX2012008738A (es) Microorganismos y metodos para la biosintesis de p-toluato y tereftalato.
WO2012016177A3 (fr) Microbes génétiquement modifiés produisant de plus hauts niveaux de composés dérivés d&#39;acétyl-coa
MY182946A (en) Production of organic acids by fermentation at low ph
WO2014206419A3 (fr) Compositions comprenant des varechs et/ou des algues fermentés
WO2012097091A3 (fr) Micro-organismes génétiquement modifiés présentant une activité de fermentation accrue
EP2590908A4 (fr) Solutions nutritives traitées par voie électrochimique
WO2012003402A3 (fr) Compositions et procédés de culture de micro-organismes
WO2012177983A3 (fr) Microorganismes capables de produire de l&#39;éthylène glycol et procédés associés
WO2012051117A3 (fr) Benzamides substitués et leurs utilisations

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11813267

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11813267

Country of ref document: EP

Kind code of ref document: A2