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WO2012077994A3 - Microbes with an improved ability to produce ornithine and method for producing ornithine using same - Google Patents

Microbes with an improved ability to produce ornithine and method for producing ornithine using same Download PDF

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Publication number
WO2012077994A3
WO2012077994A3 PCT/KR2011/009477 KR2011009477W WO2012077994A3 WO 2012077994 A3 WO2012077994 A3 WO 2012077994A3 KR 2011009477 W KR2011009477 W KR 2011009477W WO 2012077994 A3 WO2012077994 A3 WO 2012077994A3
Authority
WO
WIPO (PCT)
Prior art keywords
ornithine
microbes
improved ability
producing
produce
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2011/009477
Other languages
French (fr)
Korean (ko)
Other versions
WO2012077994A2 (en
Inventor
최향
이경민
강민선
전성후
엄혜원
최수진
이한원
신수안
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CJ CheilJedang Corp
Original Assignee
CJ CheilJedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CJ CheilJedang Corp filed Critical CJ CheilJedang Corp
Priority to EP11846603.6A priority Critical patent/EP2650358B1/en
Priority to PH1/2013/501164A priority patent/PH12013501164A1/en
Priority to ES11846603T priority patent/ES2703256T3/en
Priority to RU2013131039/10A priority patent/RU2567669C2/en
Priority to AU2011339171A priority patent/AU2011339171B2/en
Priority to JP2013543102A priority patent/JP5860476B2/en
Priority to US13/992,241 priority patent/US9303277B2/en
Priority to BR112013014441-6A priority patent/BR112013014441B1/en
Priority to PL11846603T priority patent/PL2650358T3/en
Priority to CN201180064409.4A priority patent/CN103282486B/en
Publication of WO2012077994A2 publication Critical patent/WO2012077994A2/en
Publication of WO2012077994A3 publication Critical patent/WO2012077994A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1018—Carboxy- and carbamoyl transferases (2.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01038—N-Acetyl-gamma-glutamyl-phosphate reductase (1.2.1.38)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/03—Carboxy- and carbamoyltransferases (2.1.3)
    • C12Y201/03003—Ornithine carbamoyltransferase (2.1.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01035—Glutamate N-acetyltransferase (2.3.1.35)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01013—Ornithine aminotransferase (2.6.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02008—Acetylglutamate kinase (2.7.2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to microbes with an improved ability to produce ornithine and a method for producing ornithine using the microbes by: blocking a biosynthetic pathway from ornithine to arginine; increasing the amount of glutamate within a cell; and enhancing the activity of the biosynthetic pathway which produces ornithine from glutamate.
PCT/KR2011/009477 2010-12-08 2011-12-08 Microbes with an improved ability to produce ornithine and method for producing ornithine using same Ceased WO2012077994A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP11846603.6A EP2650358B1 (en) 2010-12-08 2011-12-08 Microorganism having improved ornithine-producing ability and method for producing ornithine using the same
PH1/2013/501164A PH12013501164A1 (en) 2010-12-08 2011-12-08 Microorganisms having improved ornithine-producing ability and method for producing ornithine using the same
ES11846603T ES2703256T3 (en) 2010-12-08 2011-12-08 Microorganism that has a better ornithine production capacity and ornithine production method using the same
RU2013131039/10A RU2567669C2 (en) 2010-12-08 2011-12-08 Microorganisms having improved ornithine-producing capacity and method of producing ornithine using same
AU2011339171A AU2011339171B2 (en) 2010-12-08 2011-12-08 Microbes with an improved ability to produce ornithine and method for producing ornithine using same
JP2013543102A JP5860476B2 (en) 2010-12-08 2011-12-08 Microorganism having improved ornithine production ability and method for producing ornithine using the same
US13/992,241 US9303277B2 (en) 2010-12-08 2011-12-08 Microorganisms having improved ornithine-producing ability and method for producing ornithine using the same
BR112013014441-6A BR112013014441B1 (en) 2010-12-08 2011-12-08 MICRO-ORGANISM HAVING A BETTER CAPACITY TO PRODUCE ORNITHINE AND METHOD TO PRODUCE ORNITHINE USING THE SAME
PL11846603T PL2650358T3 (en) 2010-12-08 2011-12-08 Microorganism having improved ornithine-producing ability and method for producing ornithine using the same
CN201180064409.4A CN103282486B (en) 2010-12-08 2011-12-08 There is the microorganism of the ornithine throughput of improvement and use the method for this microorganisms producing ornithine

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20100124866 2010-12-08
KR10-2010-0124866 2010-12-08
KR10-2011-0130594 2011-12-07
KR1020110130594A KR101372635B1 (en) 2010-12-08 2011-12-07 Microorganisms for producing ornithine and process for producing ornithine using the same

Publications (2)

Publication Number Publication Date
WO2012077994A2 WO2012077994A2 (en) 2012-06-14
WO2012077994A3 true WO2012077994A3 (en) 2012-09-07

Family

ID=46684297

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/009477 Ceased WO2012077994A2 (en) 2010-12-08 2011-12-08 Microbes with an improved ability to produce ornithine and method for producing ornithine using same

Country Status (13)

Country Link
US (1) US9303277B2 (en)
EP (1) EP2650358B1 (en)
JP (1) JP5860476B2 (en)
KR (1) KR101372635B1 (en)
CN (1) CN103282486B (en)
AU (1) AU2011339171B2 (en)
BR (1) BR112013014441B1 (en)
ES (1) ES2703256T3 (en)
MY (1) MY165897A (en)
PH (1) PH12013501164A1 (en)
PL (1) PL2650358T3 (en)
RU (1) RU2567669C2 (en)
WO (1) WO2012077994A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101526047B1 (en) * 2013-04-26 2015-06-04 상지대학교산학협력단 Microorganism having improved L-ornithin production by increasing the aminotransferase activity and process for preparing the L-ornithin employing the same
KR101835164B1 (en) 2013-07-17 2018-03-06 씨제이제일제당 (주) Modified Ornithine Decarboxylase protein with an improved producing capability for Putrescine and a Use thereof
KR101835935B1 (en) 2014-10-13 2018-03-12 씨제이제일제당 (주) A microorganism of genus corynebacterium having an ability to produce L-arginine and a method for producing L-arginine using the same
US10544435B2 (en) 2015-03-12 2020-01-28 Chrysea Limited L-ornithine production in eukaryotic cells
KR101813759B1 (en) * 2015-06-24 2018-01-02 씨제이제일제당 (주) Microorganisms for producing putrescine or ornithine and process for producing putrescine or ornithine using them
KR101735935B1 (en) 2015-07-20 2017-05-16 씨제이제일제당 (주) Microorganisms for producing putrescine or ornithine and process for producing putrescine or ornithine using them
CN105950524A (en) * 2016-04-27 2016-09-21 齐鲁工业大学 Construction method of corynebacterium glutamicum engineering bacteria for high production of L-lysine
KR101941775B1 (en) 2017-06-14 2019-01-24 씨제이제일제당 (주) Novel polypeptide and a method for producing a desired product derived from ornithine using the same
KR101937569B1 (en) * 2017-06-14 2019-01-11 씨제이제일제당 (주) Novel polypeptide and a method for producing a desired product derived from ornithine using the same
CN110195088B (en) * 2018-02-26 2022-09-27 中国科学院分子植物科学卓越创新中心 Arginine hydrolase, and coding gene and application thereof
US20250197841A1 (en) * 2022-03-18 2025-06-19 Cj Cheiljedang Corporation Carbamoyl-phosphate synthetase large subunit variant and l-ornithine production method using same
KR102853096B1 (en) * 2022-03-18 2025-09-02 씨제이제일제당 주식회사 Microorganism producing L-amino acid with weakened activity of carbamoyl-phosphate synthetase and L-amino acid production method using the same

Citations (2)

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EP1801206A1 (en) * 2004-09-28 2007-06-27 Kyowa Hakko Kogyo Co., Ltd. Method for producing l-arginine, l-ornithine or l-citrulline
KR20100060909A (en) * 2008-11-28 2010-06-07 전북대학교산학협력단 Microbes enhanced ornithine productivity by suppressing of transcriptional repressor and ornithine production method using the same

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US7344874B2 (en) * 2004-03-04 2008-03-18 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing L-glutamic acid
EP1831250B1 (en) * 2004-12-28 2015-05-06 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing l-glutamic acid
WO2008033001A1 (en) * 2006-09-15 2008-03-20 Cj Cheiljedang Corporation A corynebacteria having enhanced l-lysine productivity and a method of producing l-lysine using the same
JP5675353B2 (en) * 2008-04-10 2015-02-25 コリア アドバンスド インスティチュート オブ サイエンス アンド テクノロジィ Mutant microorganism having high ability to produce putrescine and method for producing putrescine using the same

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EP1801206A1 (en) * 2004-09-28 2007-06-27 Kyowa Hakko Kogyo Co., Ltd. Method for producing l-arginine, l-ornithine or l-citrulline
KR20100060909A (en) * 2008-11-28 2010-06-07 전북대학교산학협력단 Microbes enhanced ornithine productivity by suppressing of transcriptional repressor and ornithine production method using the same

Non-Patent Citations (6)

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Title
DAISUKE MATSUI ET AL.: "Detection of D-ornithine extracellularly produced by Corynebacterium glutamicum ATCC 1302::argF", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 74, no. 12, 23 December 2010 (2010-12-23), pages 2507 - 2510, XP055126166 *
DATABASE GENBANK [online] 14 November 2006 (2006-11-14), "Ornithine carbamoyltransferase [Coryne- bacterium glutamicum ATCC 13032].", XP003030151, Database accession no. CAF21409 *
DATABASE GENBANK [online] 14 November 2006 (2006-11-14), "Small-conductance mechanosensitive channel [Corynebacterium glutamicum ATCC 13032].", XP003030150, Database accession no. CAF19973 *
JENS SCHNEIDER ET AL.: "Production of the amino acids L-glutamate, L-lysine, L-ornithine, and L-arginine from arabinose by recombinant Corynebacterium glutamicum", JOURNAL OF BIOTECHNOLOGY, vol. 154, no. 2-3, 16 July 2010 (2010-07-16), pages 191 - 198, XP055126161 *
JENS SCHNEIDER ET AL.: "Putrescine production by engineered Corynebacterium glutamicum", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 88, no. 4, 27 July 2010 (2010-07-27), pages 859 - 868, XP019841775 *
JUN NAKAMURA ET AL.: "Mutations of the Corynebacterium glutamicum NCgl1221 gene, encoding a mechanosensitive channel homolog, induce L-glutamic acid production", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 73, no. 14, July 2007 (2007-07-01), pages 4491 - 4498, XP002691368 *

Also Published As

Publication number Publication date
KR20120064045A (en) 2012-06-18
WO2012077994A2 (en) 2012-06-14
KR101372635B1 (en) 2014-03-13
PL2650358T3 (en) 2019-05-31
JP2013544532A (en) 2013-12-19
CN103282486A (en) 2013-09-04
BR112013014441B1 (en) 2021-08-17
ES2703256T3 (en) 2019-03-07
US20130344545A1 (en) 2013-12-26
MY165897A (en) 2018-05-18
PH12013501164A1 (en) 2013-07-29
EP2650358B1 (en) 2018-10-17
AU2011339171A1 (en) 2013-07-18
BR112013014441A2 (en) 2016-09-13
RU2013131039A (en) 2015-01-20
RU2567669C2 (en) 2015-11-10
AU2011339171B2 (en) 2016-02-11
JP5860476B2 (en) 2016-02-16
EP2650358A4 (en) 2015-07-01
US9303277B2 (en) 2016-04-05
EP2650358A2 (en) 2013-10-16
CN103282486B (en) 2016-02-17

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