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WO2011128911A3 - Improved process for ll-[(z)-3-(dimethylamino)propyiidenel-6-ll- dihydrodibenz[b,el oxepin-2-aceticacid - Google Patents

Improved process for ll-[(z)-3-(dimethylamino)propyiidenel-6-ll- dihydrodibenz[b,el oxepin-2-aceticacid Download PDF

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Publication number
WO2011128911A3
WO2011128911A3 PCT/IN2011/000246 IN2011000246W WO2011128911A3 WO 2011128911 A3 WO2011128911 A3 WO 2011128911A3 IN 2011000246 W IN2011000246 W IN 2011000246W WO 2011128911 A3 WO2011128911 A3 WO 2011128911A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxepin
dimethylamino
improved process
propyiidenel
dihydrodibenz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2011/000246
Other languages
French (fr)
Other versions
WO2011128911A2 (en
Inventor
Manne Satyanarayana Reddy
Sajja Eswaraiah
Komati Satyanarayana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSN Laboratories Pvt Ltd
Original Assignee
MSN Laboratories Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MSN Laboratories Pvt Ltd filed Critical MSN Laboratories Pvt Ltd
Publication of WO2011128911A2 publication Critical patent/WO2011128911A2/en
Publication of WO2011128911A3 publication Critical patent/WO2011128911A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pyrane Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

An improved process for the preparation of 11 -[(Z)-3-(dimethylamino)propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-acetic acid compound of formula-1 and pharmaceutically acceptable salts thereof are disclosed.
PCT/IN2011/000246 2010-04-12 2011-04-11 Improved process for ll-[(z)-3-(dimethylamino)propyiidenel-6-ll- dihydrodibenz[b,el oxepin-2-aceticacid Ceased WO2011128911A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1003CH2010 2010-04-12
IN1003/CHE/2010 2010-04-12

Publications (2)

Publication Number Publication Date
WO2011128911A2 WO2011128911A2 (en) 2011-10-20
WO2011128911A3 true WO2011128911A3 (en) 2011-12-08

Family

ID=44799109

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000246 Ceased WO2011128911A2 (en) 2010-04-12 2011-04-11 Improved process for ll-[(z)-3-(dimethylamino)propyiidenel-6-ll- dihydrodibenz[b,el oxepin-2-aceticacid

Country Status (1)

Country Link
WO (1) WO2011128911A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102757339A (en) * 2012-08-01 2012-10-31 北京联本医药化学技术有限公司 Improved preparation method of 4-(2-carboxybenzyloxy) phenylacetic acid
CN102838582B (en) * 2012-09-19 2014-03-26 湖州恒远生物化学技术有限公司 Preparation method of isoxepac
ITMI20131820A1 (en) * 2013-11-04 2015-05-05 Laboratorio Chimico Int Spa PROCEDURE FOR THE PREPARATION OF OLOPATADIN
CN106324111A (en) * 2015-06-24 2017-01-11 江苏吉贝尔药业股份有限公司 Olopatadine hydrochloride eye drop detection method
CN106518833A (en) * 2015-09-15 2017-03-22 江苏吉贝尔药业股份有限公司 New method for preparation of 6,11-dihydro-11-oxo dibenzo [b, e] oxepin-2-acetic acid
CN105693685B (en) * 2016-02-01 2018-05-22 山东罗欣药业集团股份有限公司 The preparation process of Olopatadine hydrochloride
CN112375060B (en) * 2020-12-07 2022-02-22 广州健康元呼吸药物工程技术有限公司 Post-treatment purification method of olopatadine hydrochloride
CN116730970A (en) * 2023-06-14 2023-09-12 内蒙古京东药业有限公司 A kind of preparation method of olopatadine hydrochloride

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0235796A2 (en) * 1986-03-03 1987-09-09 Kyowa Hakko Kogyo Co., Ltd. Dibenz [b,e] oxepin derivative and antiallergic and antiinflammatory agent
WO2007119120A2 (en) * 2005-12-22 2007-10-25 Medichem, S.A. Crystalline polymorphic forms of olopatadine hydrochloride and processes for their preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0235796A2 (en) * 1986-03-03 1987-09-09 Kyowa Hakko Kogyo Co., Ltd. Dibenz [b,e] oxepin derivative and antiallergic and antiinflammatory agent
WO2007119120A2 (en) * 2005-12-22 2007-10-25 Medichem, S.A. Crystalline polymorphic forms of olopatadine hydrochloride and processes for their preparation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIU YA-RU ET AL.: "Synthesis of a new H1, receptor antagonist olopatadine", CHINESE JOURNAL OF NEW DRUGS, vol. 15, no. 23, 2006, pages 2045 - 2046, XP008082683 *
XUE JIAN-YING ET AL.: "Study on the synthetic process of a novel anti-allergic agent olopatadine hydrochloride", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 14, no. 6, December 2004 (2004-12-01), pages 363 - 364, 367, XP008082682 *

Also Published As

Publication number Publication date
WO2011128911A2 (en) 2011-10-20

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