[go: up one dir, main page]

WO2011111027A3 - Formulation de comprimé oral dispersible à libération retardée - Google Patents

Formulation de comprimé oral dispersible à libération retardée Download PDF

Info

Publication number
WO2011111027A3
WO2011111027A3 PCT/IB2011/051031 IB2011051031W WO2011111027A3 WO 2011111027 A3 WO2011111027 A3 WO 2011111027A3 IB 2011051031 W IB2011051031 W IB 2011051031W WO 2011111027 A3 WO2011111027 A3 WO 2011111027A3
Authority
WO
WIPO (PCT)
Prior art keywords
tablet
delayed release
mini
release tablet
tablet formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2011/051031
Other languages
English (en)
Other versions
WO2011111027A2 (fr
Inventor
Adel Penhasi
Maxim Gomberg
Tal Meisler
Janina Gauchman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dexcel Pharma Technologies Ltd
Original Assignee
Dexcel Pharma Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dexcel Pharma Technologies Ltd filed Critical Dexcel Pharma Technologies Ltd
Publication of WO2011111027A2 publication Critical patent/WO2011111027A2/fr
Publication of WO2011111027A3 publication Critical patent/WO2011111027A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention a pour objet une formulation pour l'administration d'un agent thérapeutique à l'intestin grêle qui implique une combinaison d'un mini-comprimé unique à libération retardée pour l'administration au tractus gastro-intestinal, entouré par une couche de comprimé à désintégration rapide qui se dissout dans la cavité buccale. Le comprimé à désintégration orale qui subit une désintégration rapide dans la cavité buccale est facile à avaler et présente donc une facilité d'administration du mini-comprimé, ce qui est responsable de la libération retardée d'un agent thérapeutique dans l'intestin grêle. Le mini-comprimé possède de préférence un diamètre relativement petit, plus petit que celui d'un comprimé ordinaire.
PCT/IB2011/051031 2010-03-11 2011-03-11 Formulation de comprimé oral dispersible à libération retardée Ceased WO2011111027A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31272210P 2010-03-11 2010-03-11
US61/312,722 2010-03-11
US33416410P 2010-05-12 2010-05-12
US61/334,164 2010-05-12

Publications (2)

Publication Number Publication Date
WO2011111027A2 WO2011111027A2 (fr) 2011-09-15
WO2011111027A3 true WO2011111027A3 (fr) 2012-03-01

Family

ID=44483952

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/051031 Ceased WO2011111027A2 (fr) 2010-03-11 2011-03-11 Formulation de comprimé oral dispersible à libération retardée

Country Status (1)

Country Link
WO (1) WO2011111027A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8808736B2 (en) 2011-02-11 2014-08-19 Zx Pharma, Llc Enteric coated multiparticulate controlled release peppermint oil composition and related methods
TR201808978T4 (tr) 2011-02-11 2018-07-23 Zx Pharma Llc Çok partiküllü l-mentol formülasyonları ve ilgili yöntemler.
US8911780B2 (en) 2011-02-11 2014-12-16 Zx Pharma, Llc Multiparticulate L-menthol formulations and related methods
RS58325B1 (sr) 2013-04-23 2019-03-29 Zx Pharma Llc Enterosolventno obloženi višečestični preparat sa proteinskom sub-oblogom
CN103556501B (zh) * 2013-10-30 2015-06-24 齐齐哈尔大学 一种亚麻织物活性染料阳离子染色助剂的制备方法及应用
WO2016035756A1 (fr) * 2014-09-03 2016-03-10 ライオン株式会社 Préparation enrobée et son procédé de production
US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
CA3207643A1 (fr) 2015-09-23 2017-03-30 XWPharma Ltd. Promedicaments de l'acide gamma-hydroxybutyrique, compositions et utilisations de ceux-ci
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
CN110724279B (zh) * 2019-10-14 2022-04-22 浙江海洋大学 一种温度和pH敏感的瓜尔胶/淀粉复合水凝胶的制备方法
CN112156077B (zh) * 2020-10-26 2023-01-24 上海纳为生物技术有限公司 一种n-乙酰氨基葡萄糖片剂及其制备方法
JP2023549848A (ja) * 2020-11-13 2023-11-29 シーラ エスアールエル ｎ－酪酸のエステルまたは塩を含有する口腔内分散性化合物、およびその製造プロセス
EP4356904A1 (fr) * 2022-10-19 2024-04-24 Sanovel Ilac Sanayi Ve Ticaret A.S. Capsule comprenant du lansoprazole

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142034A1 (en) * 1998-05-18 2002-10-03 Toshihiro Shimizu Orally disintegrable tablets
EP1430888A1 (fr) * 2001-09-28 2004-06-23 Sanwa Kagaku Kenkyusho Co., Ltd. Double comprime a desintegration rapide
WO2007075980A2 (fr) * 2005-12-20 2007-07-05 Teva Pharmaceutical Industries Ltd. Comprimes de lansoprazole se desintegrant oralement
WO2009060064A2 (fr) * 2007-11-09 2009-05-14 Valpharma S.A. Formulations pharmaceutiques pour l'administration par voie orale de ppi

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0181966A1 (fr) 1984-11-13 1986-05-28 Gist-Brocades N.V. Comprimés dispersibles enrobés par compression
CA2262595C (fr) 1996-08-15 2005-10-18 Losan Pharma Gmbh Medicament a administration orale facile a avaler
US20040068000A1 (en) 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
US20070077300A1 (en) 2005-09-30 2007-04-05 Wynn David W Oral compositions containing a salivation inducing agent
FR2894475B1 (fr) 2005-12-14 2008-05-16 Servier Lab Composition pharmaceutique orodispersible pour administra- -tion oromucosale ou sublinguale d'agomelatine
JP2009538901A (ja) 2006-06-01 2009-11-12 デクセル ファーマ テクノロジーズ エルティーディー． 複式ユニット製薬的製剤
ITMI20062290A1 (it) 2006-11-28 2008-05-29 Monteres S R L Compresse stabili allo stoccaggio a base di derivati del benzimidazolo rivestite con film gastro-resistente

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142034A1 (en) * 1998-05-18 2002-10-03 Toshihiro Shimizu Orally disintegrable tablets
EP1430888A1 (fr) * 2001-09-28 2004-06-23 Sanwa Kagaku Kenkyusho Co., Ltd. Double comprime a desintegration rapide
WO2007075980A2 (fr) * 2005-12-20 2007-07-05 Teva Pharmaceutical Industries Ltd. Comprimes de lansoprazole se desintegrant oralement
WO2009060064A2 (fr) * 2007-11-09 2009-05-14 Valpharma S.A. Formulations pharmaceutiques pour l'administration par voie orale de ppi

Also Published As

Publication number Publication date
WO2011111027A2 (fr) 2011-09-15

Similar Documents

Publication Publication Date Title
WO2011111027A3 (fr) Formulation de comprimé oral dispersible à libération retardée
WO2011112229A3 (fr) Préparations d'agent thérapeutique pour une administration dans une lumière du tractus intestinal à l'aide d'un dispositif d'administration de médicament avalable
WO2010062688A3 (fr) Forme galénique pour insertion dans la bouche
IN2014CN00338A (fr)
MX2010007609A (es) Formulacion de capsula.
WO2011101866A3 (fr) Méthode de traitement d'une affection sensible à une thérapie par baclofène
NZ624922A (en) Orally administered corticosteroid compositions
MX2008012731A (es) Tabletas de paracetamol de liberacion rapida.
IL195931A0 (en) Pharmaceutical preparation for oral administration with controlled active ingredient release in the small intestine and methods for its production
IL215826A (en) Pharmaceutical preparation with delayed release, process of preparation of the preparation, use of the preparation for the preparation of pain medication and the pill containing it.
WO2011146876A3 (fr) Administration à travers la muqueuse buccale de sufentanil
JP2014221827A5 (fr)
BR112013006597A2 (pt) tablete para desintegração oral em múltiplas camadas, e a fabricação do mesmo
WO2012117257A8 (fr) Forme posologique de diéthylstilbestrol et son utilisation pour le traitement du cancer de la prostate ou du cancer du sein
WO2010103365A3 (fr) Composition à libération lente d'un agent thérapeutique
UA117260C2 (uk) Лікарський препарат з відстроченим вивільненням
WO2012010669A3 (fr) Médicament d'administration orale contenant un mélange de silodosine et d'un copolymère basique
NZ594311A (en) Pharmaceutical composition comprising tamsulosin and solifenacin for oral administration
WO2011037976A3 (fr) Formulations pharmaceutiques de pramipexole
PE20120647A1 (es) Composiciones y metodos para el tratamiento y prevencion de la enfermedad cardiovascular
WO2010098627A3 (fr) Préparation pharmaceutique
IL213671A (en) Pharmaceutical preparations containing alglitazar, a process for their preparation and use for the preparation of medicines
MX346316B (es) Formulacion farmaceutica o nutraceutica.
WO2011093815A3 (fr) Compositions pharmaceutiques comprenant du formotérol et du mométasone
WO2011093818A3 (fr) Compositions pharmaceutiques comprenant du salmétérol et du fluticasone

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11717748

Country of ref document: EP

Kind code of ref document: A2