[go: up one dir, main page]

WO2011107567A1 - System and method for monitoring time intervals during blood parameter monitoring - Google Patents

System and method for monitoring time intervals during blood parameter monitoring Download PDF

Info

Publication number
WO2011107567A1
WO2011107567A1 PCT/EP2011/053244 EP2011053244W WO2011107567A1 WO 2011107567 A1 WO2011107567 A1 WO 2011107567A1 EP 2011053244 W EP2011053244 W EP 2011053244W WO 2011107567 A1 WO2011107567 A1 WO 2011107567A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
patient
parameters
data
net
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2011/053244
Other languages
German (de)
French (fr)
Inventor
Hans-Otto Maier
Torsten DÖNHOFF
Horst Schmoll
Matthias Paetzold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
B Braun Melsungen AG
Original Assignee
B Braun Melsungen AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2011222943A priority Critical patent/AU2011222943B2/en
Priority to RU2012134289/08A priority patent/RU2543941C2/en
Priority to CA2789191A priority patent/CA2789191C/en
Priority to ES11707397.3T priority patent/ES2655370T3/en
Priority to JP2012553353A priority patent/JP5658767B2/en
Priority to BR112012020923A priority patent/BR112012020923A2/en
Priority to CN2011800104607A priority patent/CN102804191A/en
Priority to MX2012009596A priority patent/MX2012009596A/en
Application filed by B Braun Melsungen AG filed Critical B Braun Melsungen AG
Priority to EP11707397.3A priority patent/EP2542992B1/en
Priority to US13/579,858 priority patent/US9861745B2/en
Priority to SG2012060869A priority patent/SG183353A1/en
Publication of WO2011107567A1 publication Critical patent/WO2011107567A1/en
Priority to IL221413A priority patent/IL221413B/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/08—Sensors provided with means for identification, e.g. barcodes or memory chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150229—Pumps for assisting the blood sampling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150236—Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150244—Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150503—Single-ended needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150763—Details with identification means
    • A61B5/150786—Optical identification systems, e.g. bar codes, colour codes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/155—Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6009—General characteristics of the apparatus with identification means for matching patient with his treatment, e.g. to improve transfusion security
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/201—Glucose concentration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00871—Communications between instruments or with remote terminals
    • G01N2035/00881—Communications between instruments or with remote terminals network configurations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection

Definitions

  • the invention relates to a system and a method for monitoring in each case at least one blood parameter of the blood of different patients with a plurality of access devices for establishing in each case at least one access to the blood of each patient through the skin, a plurality of removal devices each for removal an amount of blood from each patient for obtaining at least one blood sample, at least one blood analyzer for analyzing the blood sample for predeterminable parameters of the blood, and for generating individual blood parameter data sets, a computing means commonly used for a plurality of blood parameter data sets of different patients for calculating data sets from drug parameters the drugs to be administered to the respective patient on the basis of the individual blood parameter data sets and a plurality of delivery devices for supplying the respective medicament with d en calculated drug parameters with the preamble of claims 1 and 1 1st
  • the delivery device may be an insulin delivery device or an infusion pump which adjusts the insulin value present within the bloodstream of the patient to a predeterminable level in response to a previously measured blood glucose value in the blood circulation system. keeps the patient's course.
  • feeding devices for at least one nutritional value of a food directly or indirectly supplied to the blood circulation with at least one food supply device can be administered to the patient.
  • Such delivery devices even when incorporated into a drug and / or nutritional delivery system, heretofore require entry of values by a physician or other clinician based on delivery by the delivery device. For example, quantity values, time intervals in which the supply is to take place, interval-type feeds, etc., can be entered as the basis for the subsequent delivery of, for example, insulin.
  • This delivery is preceded by a mostly hand-drawn blood collection in the patients, which requires the interposition of clinical staff. Likewise, other clinical personnel are required who have the necessary expertise in the input functions of the delivery device, such as the infusion pump, to subsequently perform this delivery.
  • the input of the dose unit is made possible with an infusion pump.
  • this requires the consideration of information on the concentration of Active ingredient of the drug to be administered and the nature of the drug. Both when specifying the concentration of the active ingredient and when entering the dose unit and the conversion of those in the delivery rate so far only the main active ingredients of the drug are taken into account. This is often sufficient if only or primarily a specific drug is to be administered.
  • Feeding or conveying devices for the supply of a drug solution mixture in a body are known several times.
  • devices / systems having a plurality of infusion and / or syringe pumps, each of which delivers a solution of at least one specific drug to a body and thereby produces a drug-solution mixture are known.
  • the infusion pumps have the properties of continuous and accurate metering of the medication in its delivery.
  • the pumps are integrated in a common order system, which usually has a central control unit, an operating unit and an alarm unit.
  • the data connection of several pumps and / or control units can also be combined in the context of a server. This possibly makes it possible, in an additional computer unit / medical computer, for even a two-digit number of different medicaments to be matched to a body and to be delivered precisely metered.
  • the data is distributed by wire or by wireless LAN to the various infusion pumps.
  • An essential point of the invention is that, in a system for monitoring at least one blood parameter of the blood from different patients having a plurality of access devices for establishing at least one access to the blood of each patient through the skin thereof, a plurality of withdrawal devices, respectively for extracting a quantity of blood from each patient to obtain at least one blood sample, at least one blood analyzer for analyzing the blood sample for predetermined blood parameters, and generating individual blood parameter data sets, one computing means commonly used for a plurality of blood parameter data sets of different patients for calculating data set drug parameters the patient to be administered drugs based on the individual blood parameter records and a plurality of feeding devices for supplying the respective drug with the be
  • An allocation device is provided for the medication parameters which is assigned to each data record of the medication parameters of a patient calculated by the calculation device for assigning in each case an identification identifier for identifying a patient and / or a time segment identifier for specifying a time interval in which the blood collection took place performs. Such an allocation device is advantageously arranged within the calculation device.
  • such an allocation device can be used for the fact that the blood parameter data sets, as obtained by the blood analysis device by the calculation device, reliably the correct identification code and / or the proper time-slot identifier to ensure that the resulting drug parameter data sets are sent to the correct delivery device, which may be an infusion pump for administration of insulin in response to a previously measured blood glucose level.
  • the correct delivery device which may be an infusion pump for administration of insulin in response to a previously measured blood glucose level.
  • each data record of the drug parameters for a patient can be transmitted in each case as a common data record or can be transmitted by the calculation device to one or more of the supply devices.
  • the wireless transmission there may be physical separation from the computing device, which may be located within a common server, and the individual delivery devices, typically located as infusion pumps in various rooms of a hospital, directly on-site to the patient.
  • At least one identification element generating device is preferably used so that each blood sample has the identification code and / or the time segment identifier in the form of a barcode, a data matrix code and / or transponder immediately after the blood quantity has been withdrawn and before being supplied to the blood analysis device the sampling device containing the blood sample can be assigned.
  • a method for monitoring in each case at least one blood parameter of the blood of different patients has the following steps:
  • an association device (1 1) in each case an identification identifier for identifying a patient and / or a time segment identifier for specifying a period of time in which the blood sampling took place, for each record of the blood analysis device (7, 9) determined parameters of the analyzed blood a patient (1 -3) are assigned (33).
  • each data set of the determined parameters of the analyzed blood, together with the identification code and the time segment identifier, is transmitted as a common data record to the one or more of the feed devices (19, 20, 21) by the blood analysis device (7, 9).
  • FIG. 2 shows a flowchart of the method according to the invention according to an embodiment of the invention.
  • Fig. 1 the system according to the invention is shown in an embodiment of the invention in a schematic representation.
  • a total of three inpatients 1, 2 and 3 are removed by means of a blood sampling system (for example a syringe
  • Each patient has on his arm a bracelet 1 c, 2 c and 3 c, are arranged on the patient-specific data, for example by means of a bar code, a data matrix code or a transponder. These can be, for example, the identifiers of the patient.
  • these sample containers e.g., syringe
  • a blood analyzer 7 in accordance with the illustrated transport paths 4, 5 and 6.
  • the identifiers on the wristband 1 c, 2 c and 3 c of the patient 1, 2, 3 are read out by means of a bar code or data matrix code reader 26 or a reading unit for transponders and by means of a bar code or data matrix code Generating means 25 or by means of a writing unit for transponders a corresponding barcode or a data matrix code printed or described a transponder.
  • This barcode or data matrix code or transponder is adhered to the outside of the respective sample containers (e.g., syringe).
  • these bar codes, data matrix codes and / or the transponder are read out by means of a reading unit 7a and at the same time the blood samples are entered into the blood analysis device.
  • the blood parameter data sets created by the analysis unit are transmitted by means of a common line 10 to a receiving unit 1 1 of a calculation device 15 without wires or conducted.
  • This receiving unit also receives - as shown by reference numeral 8a - data to the identification identifier and the time slot identifier.
  • Both the identification identification data and the time-slot identification data and the blood parameter data records are forwarded by the receiving unit 1 1 to the calculation unit 12, which calculates, from the transmitted blood parameter data sets, drug parameter data sets which are to be determined for administering the medicaments.
  • the calculation unit 12 forwards the calculated drug parameter data sets to an assignment device 13 which is suitable for associating with each calculated medication parameter data set one of the transmitted identification identifications and / or time segment identifications.
  • a transmission of the common data sets, each composed of a data set of the calculated drug parameters and an identification code and / or a time segment identifier, is then transmitted on the basis of the identification code and the associated time-dependent identifier associated feeders 19, 20 and 21 which are used as infusion pumps pen as a medicament, for example insulin, the respective associated patient 1, 2, 3 administer, this is represented by the reference numerals 22, 23 and 24.
  • step 33 After analyzing the blood sample according to step 32, a transfer of blood parameter data sets resulting from the analysis of the blood groups to the calculation device takes place in step 33.
  • data sets of the drug parameters for the respective blood parameter data sets are calculated in accordance with step 34, in order subsequently to have an assignment of the identification code and the time segment identifier to the respective data records of the medication parameters for generating common data records in step 35.
  • step 37 After transfer of the respective common data set to the associated infusion pump according to step 36, administration of the drug, step 37 takes place.
  • Reference numeral 38 shows that, after a predeterminable period of time, a blood withdrawal according to step 30 takes place and thus a closed circuit exists.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Manufacturing & Machinery (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • External Artificial Organs (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Mobile Radio Communication Systems (AREA)

Abstract

The invention relates to a system and method for monitoring in each case at least one blood parameter of the blood of different patients, comprising a plurality of access devices for establishing in each case at least one means of access to the blood of each patient through the skin thereof, a plurality of removal devices for removing a quantity of blood from each patient in order to obtain in each case at least one blood sample, at least one blood analysis device for analysing the blood sample with respect to predeterminable blood parameters and for generating individual blood parameter data sets, a calculation device which can be used jointly for a plurality of blood parameter data sets of different patients for calculating data sets of drug parameters of the drugs to be administered to the respective patient on the basis of the individual blood parameter data sets, and a plurality of supply devices for supplying the respective drug having the calculated drug parameters.

Description

System und Verfahren für eine Datenübertragung bei der Ermittlung von  System and method for data transmission in the determination of

Medikamentenparametern  medications parameters

Beschreibung description

Die Erfindung betrifft ein System und ein Verfahren zur Überwachung von jeweils mindestens einem Blutparameter des Blutes von verschiedenen Patienten mit einer Mehrzahl an Zugangseinrichtungen zum Aufbau von jeweils mindestens einem Zugang zum Blut von je- dem Patienten durch dessen Haut, einer Mehrzahl an Entnahmeeinrichtungen jeweils zum Entnehmen einer Blutmenge von jedem Patienten zum Erhalten von jeweils mindestens einer Blutprobe, mindestens einer Blutanalyseeinrichtung zum Analysieren der Blutprobe hinsichtlich vorbestimmbarer Parameter des Blutes und zur Erzeugung von einzelnen Blutparameterdatensätzen, einer für eine Mehrzahl an Blutparameterdatensätzen verschiedener Patienten gemeinsam verwendbare Berechnungseinrichtung zum Berechnen von Datensätzen an Medikamentenparametern der den jeweiligen Patienten zu verabreichenden Medikamente auf Basis der einzelnen Blutparameterdatensätze und einer Mehrzahl an Zuführeinrichtungen zum Zuführen des jeweiligen Medikamentes mit den berechneten Medikamentenparametern mit dem Oberbegriff der Patentansprüche 1 und 1 1 . The invention relates to a system and a method for monitoring in each case at least one blood parameter of the blood of different patients with a plurality of access devices for establishing in each case at least one access to the blood of each patient through the skin, a plurality of removal devices each for removal an amount of blood from each patient for obtaining at least one blood sample, at least one blood analyzer for analyzing the blood sample for predeterminable parameters of the blood, and for generating individual blood parameter data sets, a computing means commonly used for a plurality of blood parameter data sets of different patients for calculating data sets from drug parameters the drugs to be administered to the respective patient on the basis of the individual blood parameter data sets and a plurality of delivery devices for supplying the respective medicament with d en calculated drug parameters with the preamble of claims 1 and 1 1st

Herkömmlicherweise werden Patienten, die insbesondere auf der Intensivstation liegen, mit Medikamenten und gegebenenfalls künstlicher Nahrung mittels einer oder mehrerer Zuführeinrichtungen, beispielsweise intravenös oder mittels Magensonde, versorgt. Beispielsweise kann die Zuführeinrichtung eine Insulinzuführeinrichtung bzw. eine Infusionspumpe sein, die den innerhalb des Blutkreislaufes des Patienten vorhandenen Insulinwert auf ein vorbestimmbares Niveau in Reaktion auf einen zuvor gemessenen Blutglukosewert im Blutkreis- lauf des Patienten hält. Ebenso können Zuführeinrichtungen für mindestens einen Nahrungswert einer mit mindestens einer Nahrungszuführeinrichtung dem Blutkreislauf direkt oder indirekt zugeführten Nahrung dem Patienten verabreicht werden. Derartige Zuführeinrichtungen, auch wenn sie in ein System zur Verabreichung von Medikamenten und/oder Nahrungswerten integriert sind, erfordern bisher die durch einen Arzt oder ein weiteres klinisches Personal zu erfolgende Eingabe von Werten, die der Zuführung mittels der Zuführeinrichtung zugrunde liegen. Beispielsweise können hier Mengenwerte, Zeitabstände, in welchen die Zuführung erfolgen soll, intervallartige Zuführungen, etc als Basis für die anschließend zu erfolgende Zuführung von beispielsweise Insulin eingegeben werden. Conventionally, patients who are particularly in the intensive care unit, supplied with drugs and possibly artificial food by means of one or more delivery devices, such as intravenous or by gavage. For example, the delivery device may be an insulin delivery device or an infusion pump which adjusts the insulin value present within the bloodstream of the patient to a predeterminable level in response to a previously measured blood glucose value in the blood circulation system. keeps the patient's course. Likewise, feeding devices for at least one nutritional value of a food directly or indirectly supplied to the blood circulation with at least one food supply device can be administered to the patient. Such delivery devices, even when incorporated into a drug and / or nutritional delivery system, heretofore require entry of values by a physician or other clinician based on delivery by the delivery device. For example, quantity values, time intervals in which the supply is to take place, interval-type feeds, etc., can be entered as the basis for the subsequent delivery of, for example, insulin.

Dieser Zuführung vorausgehend ist eine zumeist von Hand durchgeführte Blutentnahme bei den Patienten, welche die Zwischenschaltung von klinischem Personal erfordert. Ebenso ist weiteres klinisches Personal erforderlich, welches die notwendigen Fachkenntnisse zu den Eingabefunktionen der Zuführeinrichtung, wie der Infusionspumpe hat, um anschließend diese Zuführung durchzuführen. This delivery is preceded by a mostly hand-drawn blood collection in the patients, which requires the interposition of clinical staff. Likewise, other clinical personnel are required who have the necessary expertise in the input functions of the delivery device, such as the infusion pump, to subsequently perform this delivery.

Häufig ergibt sich hieraus das Problem, dass durch die Zwischenschaltung des klinischen Personals fehlerhafte Vorgehensweisen stattfinden. Beispielsweise ist es denkbar, dass eine Blutprobe dem falschen Patienten zugeordnet wird und somit die Gefahr der Verabreichung falscher Medikamente sowohl bei der Eingabe von Daten in die Zuführeinrichtung als auch bei der Blutentnahme und auch bei der Durchführung einer Blutanalyse besteht. Hinzu kommt, dass derartige Zuführeinrichtungen, wie Infusionspumpen, eine Förderrate aufweisen, die als Volumen pro Zeiteinheit (ml/h) dargestellt ist. Dem gegenüber wird in der Medizin für eine zugeführte Medikamentenlösung die Dosiseinheit verwendet. Demzufolge ist es erforderlich, dass die Dosiseinheit in eine Förderrate der Pumpe umgerechnet wird, welches die Aufgabe des behandelnden Arztes ist. Nachteilhaft bei einer derartigen Umrech- nung können häufig Rechenfehler sein, die zu Falscheingaben der Förderrate und damit zu einer unrichtigen Verabreichung von Insulin für den Patienten führt. Often this results in the problem that take place through the interposition of clinical staff incorrect procedures. For example, it is conceivable that a blood sample is assigned to the wrong patient and thus there is the risk of the administration of wrong medicines both when entering data into the delivery device and when taking blood and also when carrying out a blood analysis. In addition, such delivery devices, such as infusion pumps, have a delivery rate represented as volume per unit time (ml / hr). On the other hand, in medicine, the dose unit is used for a supplied drug solution. Accordingly, it is necessary that the dosage unit be converted into a delivery rate of the pump, which is the task of the attending physician. A disadvantage of such a conversion can often be calculation errors, which leads to incorrect inputs of the delivery rate and thus to an incorrect administration of insulin for the patient.

Denkbar ist auch, dass bei einer Infusionspumpe die Eingabe der Dosiseinheit ermöglicht wird. Allerdings erfordert dies die Berücksichtigung von Angaben über die Konzentration des Wirkstoffes des zu verabreichenden Medikamentes und über die Art des Medikamentes. Sowohl bei der Angabe der Konzentration des Wirkstoffes als auch bei der Eingabe der Dosiseinheit und der Umrechnung derjenigen in die Förderrate werden bisher ausschließlich die Hauptwirkstoffe des Medikamentes berücksichtigt. Dies ist häufig ausreichend, sofern lediglich oder vorrangig ein spezifisches Medikament verabreicht werden soll. It is also conceivable that the input of the dose unit is made possible with an infusion pump. However, this requires the consideration of information on the concentration of Active ingredient of the drug to be administered and the nature of the drug. Both when specifying the concentration of the active ingredient and when entering the dose unit and the conversion of those in the delivery rate so far only the main active ingredients of the drug are taken into account. This is often sufficient if only or primarily a specific drug is to be administered.

Zuführeinrichtungen bzw. Fördervorrichtungen für die Zuführung eines Medikamenten- Lösungsgemisches in einem Körper sind mehrfach bekannt. Beispielsweise sind Vorrichtungen/Systeme mit einer Mehrzahl an Infusions- und/oder Spritzenpumpen, wovon jeder eine Lösung mindestens einem spezifischen Medikamentenwirkstoff einem Körper zuführt und hierdurch ein Medikamenten-Lösungsgemisch entsteht, bekannt. Feeding or conveying devices for the supply of a drug solution mixture in a body are known several times. For example, devices / systems having a plurality of infusion and / or syringe pumps, each of which delivers a solution of at least one specific drug to a body and thereby produces a drug-solution mixture, are known.

Derartige Infusionspumpen-Systeme werden häufig bei Patienten, die einer intensiven, medizinischen Behandlung bedürfen, verwendet. Hierbei weisen die Infusionspumpen die Ei- genschaften der kontinuierlichen und genauen Dosierung der Medikation in ihrer Zuführung auf. Um eine optimierte Abstimmung dieser Pumpen in ihrer Dosierung zu erreichen, werden die Pumpen in einem gemeinsamen Ordnungssystem integriert, welches üblicherweise eine zentrale Steuereinheit, eine Bedienungseinheit und eine Alarmierungseinheit aufweist. Die datentechnische Verbindung mehrerer Pumpen und/oder Steuereinheiten kann auch im Rahmen eines Servers zusammengefasst sein. Dies ermöglicht gegebenenfalls in einer zusätzlichen Recheneinheit/einem medizinischen Computer, dass sogar eine zweistellige Anzahl an verschiedenen Medikamenten auf einem Körper abgestimmt und genau dosiert zugeführt werden kann. Die Daten werden drahtgebunden oder per Wireless-LAN an die ver- schiedenen Infusionspumpen verteilt. Such infusion pump systems are often used in patients who require intensive medical treatment. Here, the infusion pumps have the properties of continuous and accurate metering of the medication in its delivery. In order to achieve an optimized tuning of these pumps in their dosage, the pumps are integrated in a common order system, which usually has a central control unit, an operating unit and an alarm unit. The data connection of several pumps and / or control units can also be combined in the context of a server. This possibly makes it possible, in an additional computer unit / medical computer, for even a two-digit number of different medicaments to be matched to a body and to be delivered precisely metered. The data is distributed by wire or by wireless LAN to the various infusion pumps.

Auch im Falle der Verwendung eines Servers ist häufig das Problem, dass eine richtige Zuordnung der ermittelten Medikamente mit den dazugehörigen Medikamentenparametern zu der richtigen Infusionspumpe oder Mehrzahl an Infusionspumpen, die zu dem Patienten mit den ermittelten Blutparameterwerten zugehörig ist, durch Zwischenschaltung von klinischem Personal nicht garantiert ist. Ebenso kann mittels des gemeinsamen Servers eine Vielzahl an Pumpen bzw. Fördervorrichtungen angesteuert werden, die bei verschiedenen Patienten angeordnet sind und zur Versorgung dieser verschiedenen Patienten dienen. Demzufolge ist es Aufgabe der Erfindung, ein System und ein Verfahren zur Überwachung von jeweils mindestens einem Blutparameter des Bluts von verschiedenen Patienten zur Verfügung zu stellen, bei dem eine fehlerfreie Zuordnung berechneter Medikamentenparameter zu den jeweiligen Zuführeinrichtungen sichergestellt ist. Diese Aufgabe wird systemseitig auf die Merkmale des Anspruches 1 und verfahrensseitig auf die Merkmale des Anspruches 1 1 gelöst. Also, in the case of using a server, there is often a problem that proper association of the detected drugs with the associated drug parameters to the proper infusion pump or plurality of infusion pumps associated with the patient having the determined blood parameter values is not guaranteed by the intervention of clinical personnel is. Likewise, by means of the common server, a plurality of pumps or conveying devices can be controlled, which are arranged in different patients and serve to supply these different patients. Accordingly, it is an object of the invention to provide a system and a method for monitoring in each case at least one blood parameter of the blood from different patients, in which an error-free allocation of calculated drug parameters to the respective delivery devices is ensured. This object is achieved on the system side on the features of claim 1 and the method side to the features of claim 1 1.

Ein wesentlicher Punkt der Erfindung ist es, dass bei einem System zur Überwachung von jeweils mindestens einem Blutparameter des Bluts von verschiedenen Patienten mit einer Mehrzahl an Zugangseinrichtungen zum Aufbau von jeweils mindestens einem Zugang zum Blut von jedem Patienten durch dessen Haut, einer Mehrzahl an Entnahmeeinrichtungen jeweils zum Entnehmen einer Blutmenge von jedem Patienten zum Erhalten von jeweils mindestens einer Blutprobe, mindestens einer Blutanalyseeinrichtung zum Analysieren der Blutprobe hinsichtlich vorbestimmter Parameter des Blutes und zur Erzeugung von einzelnen Blutparameterdatensätzen, einer für eine Mehrzahl an Blutparameterdatensätzen verschiedener Patienten gemeinsam verwendbare Berechnungseinrichtung zum Berechnen von Datensätzenmedikamentenparametern der dem Patienten zu verabreichenden Medikamente auf Basis der einzelnen Blutparameterdatensätze und einer Mehrzahl an Zuführeinrichtungen zum Zuführen des jeweiligen Medikamentes mit den berechneten Medikamentenpara- metern eine Zuordnungseinrichtung zur Verfügung gestellt wird, die zum Zuordnen jeweils einer Identifikationskennung zur Identifizierung eines Patienten und/oder eine Zeitabschnitts- kennung zur Angabe eines Zeitabschnittes, in dem die Blutentnahme stattfand, zu jedem Datensatz der von der Berechnungseinrichtung berechneten Medikamentenparameter eines Patienten durchführt. Eine derartige Zuordnungseinrichtung ist vorteilhaft innerhalb der Be- rechnungseinrichtung angeordnet. An essential point of the invention is that, in a system for monitoring at least one blood parameter of the blood from different patients having a plurality of access devices for establishing at least one access to the blood of each patient through the skin thereof, a plurality of withdrawal devices, respectively for extracting a quantity of blood from each patient to obtain at least one blood sample, at least one blood analyzer for analyzing the blood sample for predetermined blood parameters, and generating individual blood parameter data sets, one computing means commonly used for a plurality of blood parameter data sets of different patients for calculating data set drug parameters the patient to be administered drugs based on the individual blood parameter records and a plurality of feeding devices for supplying the respective drug with the be An allocation device is provided for the medication parameters which is assigned to each data record of the medication parameters of a patient calculated by the calculation device for assigning in each case an identification identifier for identifying a patient and / or a time segment identifier for specifying a time interval in which the blood collection took place performs. Such an allocation device is advantageously arranged within the calculation device.

Vorteilhaft kann eine derartige Zuordnungseinrichtung dafür verwendet werden, dass die Blutparameter Datensätze, wie sie von der Blutanalyseeinrichtung durch die Berechnungseinrichtung erhalten werden, zuverlässig der richtigen Identifikationskennung und/oder der richtigen Zeitabschnittskennung zugeordnet werden, um sicherzustellen, dass die sich daraus ergebenden Medikamentenparameterdatensätze der richtigen Zuführeinrichtung, welches eine Infusionspumpe zur Verabreichung von Insulin in Antwort auf einen zuvor gemessenen Blutglukosespiegel sein kann, zugesendet werden. Auf diese Weise ist ausgeschlos- sen, dass berechnete Medikamentenparameterdatensätze an die falschen Infusionspumpen übertragen werden und somit ein Patient eine falsche Verabreichung erhält, wie es beispielsweise bei Zwischenschaltung von medizinischem Personal für die Eingabe von Datensätzen an den Infusionspumpen der Fall sein kann. Zudem kann über die Zuordnung von einer Zeitabschnittskennung sichergestellt werden, dass bei der Entnahme mehrer Blutproben von dem gleichen Patienten gewährleistet ist, dass nicht vorausgegangene berechnete Medikamentenparameterdatensätze an die dem Patienten zugeordnete Infusionspumpe gesendet werden, sondern nur derjenige Medika- mentenparameterdatensatz, der zuletzt in Verbindung mit der Identifikationskennung zu dem ausgewählten Patienten berechnet worden ist. Advantageously, such an allocation device can be used for the fact that the blood parameter data sets, as obtained by the blood analysis device by the calculation device, reliably the correct identification code and / or the proper time-slot identifier to ensure that the resulting drug parameter data sets are sent to the correct delivery device, which may be an infusion pump for administration of insulin in response to a previously measured blood glucose level. In this way, it is ruled out that calculated drug parameter data sets are transferred to the wrong infusion pumps and thus a patient receives an incorrect administration, as may be the case, for example, when medical personnel are involved in the input of data sets to the infusion pump. In addition, it can be ensured via the association of a time segment identifier that, when multiple blood samples are taken from the same patient, it is possible to send non-predicted calculated drug parameter data records to the infusion pump assigned to the patient, but only that medication parameter data record that was last used in conjunction with the identifier for the selected patient has been calculated.

Vorteilhaft ist jeder Datensatz der Medikamentenparameter für einen Patienten zusammen mit der Identifikationskennung und der Zeitabschnittskennung jeweils als gemeinsamer Datensatz leitungsgebunden oder leitungslos von der Berechnungseinrichtung an eine oder mehrere der Zuführeinrichtungen übertragbar. Aufgrund der leitungslosen Übertragung kann eine räumliche Trennung von der Berechnungseinrichtung, die innerhalb eines gemeinsamen Servers angeordnet sein kann, und den einzelnen Zuführeinrichtungen, die in der Regel als Infusionspumpen in verschiedenen Zimmern eines Krankenhauses direkt vor Ort zu dem Patienten angeordnet sind, bestehen. Advantageously, each data record of the drug parameters for a patient, together with the identification code and the time segment identifier, can be transmitted in each case as a common data record or can be transmitted by the calculation device to one or more of the supply devices. Because of the wireless transmission, there may be physical separation from the computing device, which may be located within a common server, and the individual delivery devices, typically located as infusion pumps in various rooms of a hospital, directly on-site to the patient.

Mindestens eine Identifikationselementen-Erzeugungseinrichtung wird vorzugsweise dafür verwendet, dass jede Blutprobe unmittelbar nach dem Entnehmen der Blutmenge und vor dem Zuführen zu der Blutanalyseeinrichtung die Identifikationskennung und/oder die Zeitabschnittskennung in Form von einem Barcode, einem Datenmatrix-Code und/oder Transpon- der auf der die Blutprobe enthaltenden Entnahmeeinrichtung zuordenbar ist. Vorteilhaft weist ein Verfahren zur Überwachung von jeweils mindestens einem Blutparameter des Blutes von verschiedenen Patienten folgende Schritte auf: At least one identification element generating device is preferably used so that each blood sample has the identification code and / or the time segment identifier in the form of a barcode, a data matrix code and / or transponder immediately after the blood quantity has been withdrawn and before being supplied to the blood analysis device the sampling device containing the blood sample can be assigned. Advantageously, a method for monitoring in each case at least one blood parameter of the blood of different patients has the following steps:

Verfahren zur Überwachung von jeweils mindestens einem Blutparameter des Bluts von ver- schiedenen Patienten (1 , 2, 3), mit folgenden Schritten: Method for monitoring in each case at least one blood parameter of the blood of different patients (1, 2, 3), with the following steps:

- Aufbauen von jeweils mindestens einem Zugang zum Blut von jedem Patienten (1 , 2, 3) mittels einer Mehrzahl an Zugangseinrichtungen (1 a, 2a, 3a);  - establishing in each case at least one access to the blood of each patient (1, 2, 3) by means of a plurality of access devices (1a, 2a, 3a);

- Entnehmen (30) einer Blutmenge von jedem Patienten (1 -3) zum Erhalten von jeweils mindestens einer Blutprobe mittels einer Mehrzahl an Entnahmeeinrichtun- gen (1 b, 2b, 3b);  - withdrawing (30) a quantity of blood from each patient (1-3) for obtaining in each case at least one blood sample by means of a plurality of removal devices (1b, 2b, 3b);

- Analysieren (32) der Blutprobe hinsichtlich vorbestimmbarer Parameter des Blutes mittels einer Mehrzahl an Blutproben verschiedener Patienten (1 -3) gemeinsam  - Analyzing (32) the blood sample in terms of predeterminable parameters of the blood by means of a plurality of blood samples of different patients (1-3) together

verwendbare Blutanalyseeinrichtungen (7, 9);  usable blood analyzers (7, 9);

- Berechnen (35) von Medikamentenparametern der den jeweiligen Patienten zu  - Compute (35) of drug parameters of the respective patients

verabreichenden Medikamenten auf Basis von Datensätzen der ermittelten  administering drugs based on data sets of the determined

Parameter des analysierten Blutes mittels einer gemeinsamen Berechnungseinrichtung (15); und  Parameters of the analyzed blood by means of a common calculation device (15); and

- Zuführen (37) des jeweiligen Medikamentes mit den berechneten Medikamentenparametern mittels einer Mehrzahl an Zuführeinrichtungen (19, 20, 21 ),  - supplying (37) the respective medicament with the calculated medicament parameters by means of a plurality of supply devices (19, 20, 21),

wobei mittels einer Zuordnungseinrichtung (1 1 ) jeweils eine Identifikationskennung zur Identifizierung eines Patienten und/oder eine Zeitabschnittskennung zur Angabe eines Zeitabschnittes, in dem die Blutentnahme stattfand, zu jedem Datensatz der von der Blutanalyseeinrichtung (7, 9) ermittelten Parameter des analysierten Blutes einen Patienten (1 -3) zugeordnet (33) werden. wherein by means of an association device (1 1) in each case an identification identifier for identifying a patient and / or a time segment identifier for specifying a period of time in which the blood sampling took place, for each record of the blood analysis device (7, 9) determined parameters of the analyzed blood a patient (1 -3) are assigned (33).

In einem derartigen Verfahren wird jeder Datensatz der ermittelten Parameter des analysierten Blutes zusammen mit der Identifikationskennung und der Zeitabschnittskennung jeweils als gemeinsamer Datensatz leitungsgebunden oder leitungslos von der Blutanalyseeinrichtung (7, 9) an eine oder mehrere der Zuführeinrichtungen (19, 20, 21 ) übertragen. In such a method, each data set of the determined parameters of the analyzed blood, together with the identification code and the time segment identifier, is transmitted as a common data record to the one or more of the feed devices (19, 20, 21) by the blood analysis device (7, 9).

Weitere vorteilhafte Ausführungsformen ergeben sich aus den Unteransprüchen und der nachfolgenden Beschreibung in Verbindung mit der Zeichnung. Hierbei zeigen: Fig. 1 In einer schematischen Darstellung das erfindungsgemäße System gemäß einer Ausführungsform der Erfindung in seinem Funktionsablauf; und Further advantageous embodiments will become apparent from the dependent claims and the following description taken in conjunction with the drawings. Hereby show: 1 is a schematic representation of the system according to the invention according to an embodiment of the invention in its functional sequence; and

Fig. 2 In einem Flussdiagramm das erfindungsgemäße Verfahren gemäß einer Ausfüh- rungsform der Erfindung. 2 shows a flowchart of the method according to the invention according to an embodiment of the invention.

In Fig. 1 ist in einer schematischen Darstellung das erfindungsgemäße System in einer Ausführungsform der Erfindung gezeigt. Wie der Darstellung gemäß Fig. 1 zu entnehmen ist, wird bei insgesamt drei stationär liegenden Patienten 1 ,2 und 3 mittels eines Blutentnahmesystems (z.B. einer Spritze In Fig. 1, the system according to the invention is shown in an embodiment of the invention in a schematic representation. As can be seen from the illustration according to Fig. 1, a total of three inpatients 1, 2 and 3 are removed by means of a blood sampling system (for example a syringe

1 b, 2b und 3b, die jeweils eine Nadel 1 a, 2a und 3a aufweisen) Blut entnommen. 1 b, 2b and 3b, each having a needle 1 a, 2a and 3a) taken blood.

Jeder Patient hat an seinem Arm ein Armband 1 c, 2c und 3c, auf dem patientenspezifische Daten, beispielsweise mittels eines Barcodes, eines Datamatrix-Codes oder eines Transponders angeordnet sind. Dies können beispielsweise die Identifikationskennungen des Patienten sein. Each patient has on his arm a bracelet 1 c, 2 c and 3 c, are arranged on the patient-specific data, for example by means of a bar code, a data matrix code or a transponder. These can be, for example, the identifiers of the patient.

Sobald eine Blutprobe mittels des Blutentnahmesystems 1 b, 2b und 3b entnommen worden ist, werden diese Probenbehälter (z.B. Spritze) gemäß den dargestellten Transportwegen 4, 5 und 6 zu einer Blutanalyseeinrichtung 7 transportiert. Once a blood sample has been withdrawn by the blood collection systems 1b, 2b and 3b, these sample containers (e.g., syringe) are transported to a blood analyzer 7 in accordance with the illustrated transport paths 4, 5 and 6.

Zeitgleich oder zuvor werden mittels eines Barcode- oder Datamatrix-Code-Lesers 26 oder einer Leseeinheit für Transponder die Kennungen auf dem Armband 1 c, 2c und 3c des Pati- enten 1 , 2, 3 ausgelesen und mittels einer Barcode- oder Datamatrix-Code- Erzeugungseinrichtung 25 oder mittels einer Schreibeinheit für Transponder ein entsprechender Barcode oder ein Datamatrix-Code ausgedruckt bzw. ein Transponder beschrieben. Dieser Barcode bzw. Datamatrix-Code oder dieser Transponder werden auf die jeweiligen Probenbehälter (z.B. Spritze) außenseitig aufgeklebt. At the same time or beforehand, the identifiers on the wristband 1 c, 2 c and 3 c of the patient 1, 2, 3 are read out by means of a bar code or data matrix code reader 26 or a reading unit for transponders and by means of a bar code or data matrix code Generating means 25 or by means of a writing unit for transponders a corresponding barcode or a data matrix code printed or described a transponder. This barcode or data matrix code or transponder is adhered to the outside of the respective sample containers (e.g., syringe).

Bei Ankunft bei der Blutanalyseeinrichtung 7 werden diese Barcodes, Datamatrix-Codes und/oder der Transponder mittels einer Leseeinheit 7a ausgelesen und zugleich die Blutproben in die Blutanalyseeinrichtung eingegeben. Ein anschließender Datentransfer von der Leseeinheit 7 zu einer Analyseeinheit 9 innerhalb der Blutanalyseeinrichtung 7, wie er durch Bezugzeichen 8 wiedergegeben wird, führt dazu, dass die Identifikationskennung und die Zeitabschnittskennung an die Analyseeinheit und gemäß Bezugszeichen 10 an eine Zuordnungseinrichtung 1 1 weitergegeben werden, wobei zugleich innerhalb der Analyseeinheit 9 eine Analysierung der Blutprobe zur Feststellung vorbestimmbarer Blutparameter stattfindet. Upon arrival at the blood analysis device 7, these bar codes, data matrix codes and / or the transponder are read out by means of a reading unit 7a and at the same time the blood samples are entered into the blood analysis device. Subsequent data transfer from the reading unit 7 to an analysis unit 9 within the blood analyzer 7, as represented by reference numeral 8, results in the identifier and the time slot identifier being forwarded to the analyzer and, according to reference numeral 10, to an associate 1 1, at the same time within the analysis unit 9, an analysis of the blood sample for the determination of predeterminable blood parameters takes place.

Die von der Analyseeinheit erstellten Blutparameterdatensätze werden mittels einer gemeinsamen Leitung 10 an eine Empfangseinheit 1 1 einer Berechnungseinrichtung 15 leitungslos oder leitungsgebunden übertragen. Diese Empfangseinheit erhält ebenso - wie mit dem Bezugszeichen 8a dargestellt - Daten zu der Identifikationskennung und der Zeitabschnittskennung. Sowohl die Identifikationskennungsdaten als auch die Zeitabschnittskennungsdaten und die Blutparameterdatensätze werden von der Empfangseinheit 1 1 an die Berechnungseinheit 12 weitergegeben, welche aus den übermittelten Blutparameterdatensätzen Medika- mentenparameterdatensätze berechnet, welche zur Verabreichung der Medikamente zu ermitteln sind. The blood parameter data sets created by the analysis unit are transmitted by means of a common line 10 to a receiving unit 1 1 of a calculation device 15 without wires or conducted. This receiving unit also receives - as shown by reference numeral 8a - data to the identification identifier and the time slot identifier. Both the identification identification data and the time-slot identification data and the blood parameter data records are forwarded by the receiving unit 1 1 to the calculation unit 12, which calculates, from the transmitted blood parameter data sets, drug parameter data sets which are to be determined for administering the medicaments.

Anschließend leitet die Berechnungseinheit 12 die berechneten Medikamentenparameterda- tensätze an eine Zuordnungseinrichtung 13 weiter, welche dazu geeignet ist, jedem berech- neten Medikamentenparameterdatensatz eine der übermittelten Identifikationskennungen und/oder Zeitabschnittskennungen zuzuordnen. Subsequently, the calculation unit 12 forwards the calculated drug parameter data sets to an assignment device 13 which is suitable for associating with each calculated medication parameter data set one of the transmitted identification identifications and / or time segment identifications.

Zusätzlich kann mittels einer Tastatur 14a oder einer ähnlichen Eingabeeinrichtung weitere Parameter in eine Speichereinheit 14 eingegeben werden oder auch durch Kommunikation mit der Empfangseinheit 1 1 die entsprechenden übertragenen Identifikationskennungen und Zeitabschnittskennungen zu dem jeweiligen Blutparameterdatensatz geändert werden. Dies wird dann ebenso der Zuordnungseinrichtung 13 für eine richtige Zuordnung zu dem jeweils berechneten Medikamentenparameterdatensatz weiter übermittelt. Gemäß den Bezugszeichen 16, 17 und 18 findet anschließend eine Übertragung der gemeinsamen Datensätze, die sich jeweils aus einem Datensatz der berechneten Medikamentenparameter und einer Identifikationskennung und/oder einer Zeitabschnittskennung zusammensetzen, anhand der Identifikationskennung und der Zeitabschnittskennung ausgewählten zugehörigen Zuführeinrichtungen 19, 20 und 21 übertragen, die als Infusionspum- pen als Medikament, zum Beispiel Insulin, dem jeweils zugehörigen Patienten 1 , 2, 3 verabreichen, dies wird mittels der Bezugszeichen 22, 23 und 24 dargestellt. In addition, further parameters can be entered into a memory unit 14 by means of a keyboard 14a or a similar input device, or the corresponding transmitted identification identifications and time segment identifications for the respective blood parameter data set can also be changed by communication with the receiving unit 11. This is then also forwarded to the allocation device 13 for a correct assignment to the respectively calculated medication parameter data record. 16, 17 and 18, a transmission of the common data sets, each composed of a data set of the calculated drug parameters and an identification code and / or a time segment identifier, is then transmitted on the basis of the identification code and the associated time-dependent identifier associated feeders 19, 20 and 21 which are used as infusion pumps pen as a medicament, for example insulin, the respective associated patient 1, 2, 3 administer, this is represented by the reference numerals 22, 23 and 24.

In dem Flussdiagramm gemäß Fig. 2 wird ein Verfahren gemäß einer Ausführungsform der Erfindung gezeigt. In the flowchart of FIG. 2, a method according to an embodiment of the invention is shown.

Dieser Darstellung ist zu entnehmen, dass in einem anfänglichen Schritt 30 Blutproben von mehreren Patienten entnommen werden, die anschließend in der Blutanalyseeinrichtung eingelesen werden (Schritt 31 ). This illustration shows that, in an initial step 30, blood samples are taken from several patients, which are subsequently read in the blood analysis device (step 31).

Nach einem Analysieren der Blutprobe gemäß Schritt 32 findet in Schritt 33 eine Übertragung von Blutparameterdatensätzen, die sich aus der Analysierung der Blutgruppen ergeben, an die Berechnungseinrichtung statt. In der Berechnungseinrichtung werden Datensätze der Medikamentenparameter zu den jeweiligen Blutparameterdatensätzen gemäß Schritt 34 berechnet, um anschließend in Schritt 35 eine Zuordnung der Identifikationskennung und der Zeitabschnittskennung zu den jeweiligen Datensätzen der Medikamentenparameter zur Erzeugung von gemeinsamen Datensätzen erfolgen zu lassen. After analyzing the blood sample according to step 32, a transfer of blood parameter data sets resulting from the analysis of the blood groups to the calculation device takes place in step 33. In the calculation device, data sets of the drug parameters for the respective blood parameter data sets are calculated in accordance with step 34, in order subsequently to have an assignment of the identification code and the time segment identifier to the respective data records of the medication parameters for generating common data records in step 35.

Nach einer Übertragung des jeweils gemeinsamen Datensatzes an die zugehörige Infusionspumpe gemäß Schritt 36 findet eine Verabreichung des Medikamentes, Schritt 37 statt. After transfer of the respective common data set to the associated infusion pump according to step 36, administration of the drug, step 37 takes place.

Mit Bezugszeichen 38 wird dargestellt, dass nach einem vorbestimmbaren Zeitabschnitt wie- derum eine Blutentnahme gemäß Schritt 30 stattfindet und somit ein geschlossener Kreislauf existiert. Reference numeral 38 shows that, after a predeterminable period of time, a blood withdrawal according to step 30 takes place and thus a closed circuit exists.

Sämtliche in den Anmeldungsunterlagen offenbarten Merkmale werden als erfindungswesentlich beansprucht, sofern sie einzeln oder in Kombination gegenüber dem Stand der Technik neu sind. Bezugszeichenliste All disclosed in the application documents features are claimed as essential to the invention, provided they are new individually or in combination over the prior art. LIST OF REFERENCE NUMBERS

1 Patient 1 1 patient 1

1 a Nadel Patient 1  1 a needle patient 1

1 b Spritze Patient 1  1 b syringe patient 1

1 c Armband Patient 1  1 c patient bracelet 1

2 Patient 2  2 patient 2

2a Nadel Patient 2  2a needle patient 2

2b Spritze Patient 2  2b syringe patient 2

2c Armband Patient 2  2c bracelet patient 2

3 Patient 3  3 patient 3

3a Nadel Patient 3  3a needle patient 3

3b Spritze Patient 3  3b syringe patient 3

3c Armband Patient 3  3c bracelet patient 3

4 Transportweg  4 transport route

5 Transportweg  5 transport route

6 Transportweg  6 transport route

7 Blutanalyseeinrichtung  7 blood analysis device

7a Leseeinheit  7a reading unit

8 Datentransfer  8 data transfer

9 Analyseeinheit  9 analysis unit

10 gemeinsame Leitung  10 common line

1 1 Empfangseinheit  1 1 receiving unit

12 Berechnungseinheit  12 calculation unit

13 Zuordnungseinrichtung  13 allocation device

14 Speichereinheit  14 storage unit

14a Tastatur  14a keyboard

15 Berechnungseinrichtung  15 calculation device

16 Senden der Medikamentenparameter an die Infusionspumpe 16 Send the drug parameters to the infusion pump

17 Senden der Medikamentenparameter an die Infusionspumpe17 Send the drug parameters to the infusion pump

18 Senden der Medikamentenparameter an die Infusionspumpe18 Send the drug parameters to the infusion pump

19 Zuführeinrichtung 19 feeder

20 Zuführeinrichtung 21 Zuführeinrichtung 20 feeder 21 feeder

22 Verabreichen der richtigen Dosis des Insulins  22 Administer the right dose of insulin

23 Verabreichen der richtigen Dosis des Insulins  23 Administer the right dose of insulin

24 Verabreichen der richtigen Dosis des Insulins  24 Administer the right dose of insulin

25 Barcode- oder Datamatrix-Code-Erzeugungseinheit  25 bar code or data matrix code generation unit

26 Datamatrix-Code-Leser  26 data matrix code reader

30 Entnehmen einer Blutmenge  30 Taking a quantity of blood

31 Einlesen der Blutproben in der Blutanalyseeinrichtung  31 Reading the Blood Samples in the Blood Analyzer

32 Analysieren der Blutprobe  32 Analyzing the blood sample

33 Übertragung der Blutparameterdatensätze  33 Transmission of Blood Parameter Records

34 Berechnen der Medikamentenparameter  34 Calculating the drug parameters

35 Zuordnung der Kennungen der Medikamentenparameter  35 Assignment of the identifiers of the drug parameters

36 Übertragung der Medikamentenparameter an die Infusionspumpen 36 Transfer of the drug parameters to the infusion pumps

37 Verabreichung des Medikamentes 37 administration of the drug

38 Kreislauf des Verfahrens  38 cycle of the process

Claims

Patentansprüche claims 1. System zur Überwachung von jeweils mindestens einem Blutparameter des Blutes von verschiedenen Patienten (1,2, 3) umfassend: A system for monitoring in each case at least one blood parameter of the blood of different patients (1, 2, 3) comprising: - Eine Mehrzahl an Zugangseinrichtungen (1a, 2a, 3a) zum Aufbau von jeweils mindestens einem Zugang zum Blut von jedem Patienten (1 , 2, 3) durch dessen Haut; A plurality of access means (1a, 2a, 3a) for establishing at least one access to the blood of each patient (1, 2, 3) through the skin thereof; - eine Mehrzahl an Entnahmeeinrichtungen (1 b, 2b, 3b) zum jeweiligen Entnehmen einer Blutmenge von jedem Patienten (1-3) zum Erhalten von jeweils mindestens einer Blutprobe; - a plurality of sampling means (1b, 2b, 3b) for respectively taking a quantity of blood from each patient (1-3) for obtaining at least one blood sample each; - mindestens eine Blutanalyseeinrichtung (7, 9) zum Analysieren der Blutprobe hinsichtlich vorbestimmbarer Parameter des Blutes und zur Erzeugung von einzelnen Blutparameterdatensätzen;  - at least one blood analysis device (7, 9) for analyzing the blood sample with regard to predeterminable parameters of the blood and for generating individual blood parameter data sets; - eine für eine Mehrzahl an Blutparameterdatensätzen verschiedener Patienten gemeinsam verwendbare Berechnungseinrichtung (15) zum Berechnen von Datensätzen an Medikamentenparametern der den jeweiligen Patienten (1-3) zu verabreichenden Medikamente auf Basis der einzelnen Blutparameterdatensatze; und  a computation means (15), which can be used in common for a plurality of blood parameter data sets of different patients, for calculating data records on medicament parameters of the medicaments to be administered to the respective patients (1-3) on the basis of the individual blood parameter datasets; and - eine Mehrzahl an Zuführeinrichtungen (19-21) zum Zuführen des jeweiligen Medikamentes mit den berechneten Medikamentenparametern,  a plurality of delivery devices (19-21) for delivering the respective medicament with the calculated medicament parameters, gekennzeichnet d urch  marked by eine Zuordnungseinrichtung (13) zum Zuordnen jeweils einer Identifikationskennung zur Identifizierung eines Patienten und/oder einer Zeitabschnittserkennung zur Angabe eines Zeitabschnittes, in dem die Blutentnahme stattfand, zu jedem Datensatz der von der Berechnungseinrichtung (15) berechneten Medikamentenparameter eines Patienten (1-3).  an association device (13) for allocating in each case an identification identifier for identifying a patient and / or a time segment identification for specifying a time interval in which the blood collection took place, to each data set of the medication parameter of a patient (1-3) calculated by the calculation device (15). 2. System nach Anspruch 1 , 2. System according to claim 1, dadurch geken nzeich net, dass  characterized in that net die Zuordnungseinrichtung (13) in der Berechnungseinrichtung (15) angeordnet ist. the allocation device (13) is arranged in the calculation device (15). 3. System nach einem der vorangegangenen Ansprüche, 3. System according to one of the preceding claims, dadurch geken nzeich net, dass  characterized in that net jeder Datensatz der Medikamentenparameter für einen Patienten zusammen mit der Identifikationskennung und der Zeitabschnittkennung jeweils als gemeinsamer Datensatz leitungsgebunden oder leitungslos von der Berechnungseinrichtung (15) an eine oder mehrere der Zuführeinrichtungen (19, 20, 21 ) übertragbar ist.  each data record of the drug parameters for a patient, together with the identification code and the time segment identifier, can be transmitted as a common data record by the calculation device (15) to one or more of the supply devices (19, 20, 21). 4. System nach einem der vorangegangenen Ansprüche, 4. System according to one of the preceding claims, geken nzeich net du rch  marked by mindestens eine Identifikationselementen-Erzeugungseinrichtung (25), mittels welcher jede Blutprobe unmittelbar nach dem Entnehmen der Blutmenge und vor dem Zuführen zu der Blutanalyseeinrichtung (7, 9) die Identifikationskennung und/oder die Zeitabschnittskennung in Form von einem Barcode, einem Datamatrix-Code und/oder einem Transponder auf der die Blutprobe enthaltenen Entnahmeeinrichtung zuorden- bar ist.  at least one identification element generating device (25), by means of which each blood sample in the form of a barcode, a data matrix code and / or the time segment identification in the form of a barcode, a data matrix code and / or the time immediately after the blood quantity has been withdrawn and before being supplied to the blood analysis device (7, 9) or a transponder on which the sampling device containing the blood sample can be assigned. 5. System nach einem der vorangegangenen Ansprüche, 5. System according to one of the preceding claims, dadurch geken nzeich net, dass  characterized in that net die Blutanalyseeinrichtung (7, 9) eine Leseeinheit (7a) zum Lesen des Barcodes, des Datamatrix-Codes und/oder des Transponders aufweist.  the blood analysis device (7, 9) has a reading unit (7a) for reading the bar code, the data matrix code and / or the transponder. 6. System nach Anspruch 5, 6. System according to claim 5, dadurch geken nzeich net, dass  characterized in that net die Blutanalyseeinrichtung (7, 9) mit der Berechungseinrichtung (15) und diese mit den Zuführeinrichtungen (19-21) für einen Datentransfer verbunden ist.  the blood analysis device (7, 9) is connected to the calculation device (15) and this is connected to the feed devices (19-21) for a data transfer. 7. System nach einem der vorangegangenen Ansprüche, 7. System according to one of the preceding claims, dadurch geken nzeich net, dass  characterized in that net die Datensätze der Medikamentenparameter verschlüsselt sind.  the records of the drug parameters are encrypted. 8. System nach einem der vorangegangenen Ansprüche, 8. System according to one of the preceding claims, dadurch geken nzeich net, dass  characterized in that net die Entnahmeeinrichtung eine Spritze oder ein Blutentnahmeröhrchen ist, deren Blutaufnahmebehälter oder ein damit ein verbundener Blutaufnahmebehälter außenseitig mit dem Barcode, dem Datamatrix-Code und/oder dem Transponder verbunden ist. the sampling device is a syringe or a blood collection tube, the blood collection container or a blood collection container connected thereto on the outside is connected to the barcode, the data matrix code and / or the transponder. 9. System nach einem der Ansprüche 3-7, 9. System according to one of claims 3-7, dadurch geken nzeich net, dass  characterized in that net innerhalb des gemeinsamen Datensatzes der Datensatz der Medikamentenparameter mit den Daten der Identifikationskennung und/oder der Zeitabschnittskennung frequenz - und/oder amplitudenmoduliert ist.  within the common data set, the data set of the drug parameters is frequency and / or amplitude modulated with the data of the identification code and / or the time segment identifier. 10. System nach einem der Ansprüche 3-7, 10. System according to one of claims 3-7, dadurch geken nzeich net, dass  characterized in that net der gemeinsame Datensatz binärcodiert vorliegt.  the common data record is binary coded. 11. Verfahren zur Überwachung von jeweils mindestens einem Blutparameter des Blutes von verschiedenen Patienten (1, 2, 3) mit folgenden Schritten: 11. A method for monitoring in each case at least one blood parameter of the blood of different patients (1, 2, 3) with the following steps: - Aufbauen von jeweils mindestens einem Zugang zum Blut von jedem  - Establishing at least one access to the blood of each Patienten (1 , 2, 3) durch dessen Haut mittel einer Mehrzahl an Zugangseinrichtungen (1a, 2a, 3a);  Patients (1, 2, 3) through the skin thereof by means of a plurality of access devices (1a, 2a, 3a); - Entnehmen (30) einer Blutmenge von jedem Patienten (1-3) zum Erhalten von jeweils mindestens einer Blutprobe mittels einer Mehrzahl an Entnahmeeinrichtungen (1b, 2b, 3b);  - withdrawing (30) a quantity of blood from each patient (1-3) for obtaining at least one blood sample each time by means of a plurality of withdrawal devices (1b, 2b, 3b); - Analysieren (32) der Blutprobe hinsichtlich vorbestimmbarer Parameter des Blutes und Erzeugung von einzelnen Blutparameterdatensätzen mittels einer Blutanalyseeinrichtung (7, 9);  - analyzing (32) the blood sample with regard to predeterminable parameters of the blood and generating individual blood parameter data sets by means of a blood analysis device (7, 9); - Berechnen (34) von Datensätzen an Medikamentenparametern der den jeweiligen Patienten (1-3) zu verabreichenden Medikamenten auf Basis der einzelnen Blutparameterdatensätze mittels einer für eine Mehrzahl an Blutparameterdatensätzen verschiedener Patienten (1-3) gemeinsam verwendbaren Berechnungseinrichtung (15); und  - calculating (34) records of drug parameters of the drugs to be administered to the respective patients (1-3) on the basis of the individual blood parameter data sets by means of a calculation device (15) which can be used in common for a plurality of blood parameter data sets of different patients (1-3); and - Zuführen (36) des jeweiligen Medikamentes mit den berechneten Medikamentenparametern mittels einer Mehrzahl an Zuführeinrichtungen (19-21),  - supplying (36) the respective medicament with the calculated medicament parameters by means of a plurality of supply devices (19-21), gekennzeichnet d urch  marked by Zuordnen (35) von jeweils einer Identifikationskennung zur Identifizierung eines Patienten und/oder einer Zeitabschnittskennung zur Angabe eines Zeitabschnittes, in dem die Blutentnahme stattfand, zu jedem Datensatz der von der Berechnungsein- richtung (15) berechneten Medikamentenparameter eines Patienten (1-3) mittels einer Zuordnungseinrichtung (13). Assigning (35) in each case one identification identifier for identifying a patient and / or a time interval identifier for specifying a time period in which the blood collection took place, to each data record which was determined by the calculation unit. direction (15) calculated drug parameters of a patient (1-3) by means of an allocation device (13). 12. Verfahren nach Anspruch 11 , 12. The method according to claim 11, dadurch geken nzeich net, dass  characterized in that net jeder Datensatz der Medikamentenparameter für einen bestimmten Patienten zusammen mit der Identifikationskennung und der Zeitabschnittskennung jeweils als gemeinsamer Datensatz leitungsgebunden oder leitungslos von der Berechnungseinrichtung (15) an eine oder mehrere der Zuführeinrichtungen (19-21) übertragen wird (36).  each record of the drug parameters for a particular patient, together with the identification tag and the time slot identifier, is transmitted (36) to the one or more of the delivery devices (19-21) as a common record, wired or wireless, from the computing device (15).
PCT/EP2011/053244 2010-03-05 2011-03-03 System and method for monitoring time intervals during blood parameter monitoring Ceased WO2011107567A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN2011800104607A CN102804191A (en) 2010-03-05 2011-03-03 System and method for monitoring time intervals during blood parameter monitoring
CA2789191A CA2789191C (en) 2010-03-05 2011-03-03 System and method for monitoring time intervals during blood parameter monitoring
ES11707397.3T ES2655370T3 (en) 2010-03-05 2011-03-03 System for data transmission during the determination of medication parameters
JP2012553353A JP5658767B2 (en) 2010-03-05 2011-03-03 System for measuring blood parameters
BR112012020923A BR112012020923A2 (en) 2010-03-05 2011-03-03 system and method for monitoring time intervals during blood parameter monitoring.
MX2012009596A MX2012009596A (en) 2010-03-05 2011-03-03 System and method for monitoring time intervals during blood parameter monitoring.
EP11707397.3A EP2542992B1 (en) 2010-03-05 2011-03-03 System for data transmission in determination of medicament parameters
AU2011222943A AU2011222943B2 (en) 2010-03-05 2011-03-03 System and method for monitoring time intervals during blood parameter monitoring
RU2012134289/08A RU2543941C2 (en) 2010-03-05 2011-03-03 System for time slot tracking and method for time slot tracking during blood value tracking
US13/579,858 US9861745B2 (en) 2010-03-05 2011-03-03 System and method for monitoring time intervals during blood parameter monitoring
SG2012060869A SG183353A1 (en) 2010-03-05 2011-03-03 System and method for monitoring time intervals during blood parameter monitoring
IL221413A IL221413B (en) 2010-03-05 2012-08-12 System and method for monitoring time intervals during blood parameter monitoring

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102010010567 2010-03-05
DE102010010567.8 2010-03-05
DE102010012733 2010-03-24
DE102010012733.7 2010-03-24

Publications (1)

Publication Number Publication Date
WO2011107567A1 true WO2011107567A1 (en) 2011-09-09

Family

ID=43920342

Family Applications (6)

Application Number Title Priority Date Filing Date
PCT/EP2011/053246 Ceased WO2011107569A1 (en) 2010-03-05 2011-03-03 System and method for administering medicaments to a patient
PCT/EP2011/053248 Ceased WO2011107571A1 (en) 2010-03-05 2011-03-03 System and method for monitoring at least one blood parameter
PCT/EP2011/053243 Ceased WO2011107566A1 (en) 2010-03-05 2011-03-03 System for determining treatment-related data for the administration of drugs to patients to be treated taking into account important individual factors
PCT/EP2011/053247 Ceased WO2011107570A1 (en) 2010-03-05 2011-03-03 System and method for monitoring the time period for blood parameter monitoring processes
PCT/EP2011/053244 Ceased WO2011107567A1 (en) 2010-03-05 2011-03-03 System and method for monitoring time intervals during blood parameter monitoring
PCT/EP2011/053245 Ceased WO2011107568A1 (en) 2010-03-05 2011-03-03 System and method for administering medicaments on the basis of urine values

Family Applications Before (4)

Application Number Title Priority Date Filing Date
PCT/EP2011/053246 Ceased WO2011107569A1 (en) 2010-03-05 2011-03-03 System and method for administering medicaments to a patient
PCT/EP2011/053248 Ceased WO2011107571A1 (en) 2010-03-05 2011-03-03 System and method for monitoring at least one blood parameter
PCT/EP2011/053243 Ceased WO2011107566A1 (en) 2010-03-05 2011-03-03 System for determining treatment-related data for the administration of drugs to patients to be treated taking into account important individual factors
PCT/EP2011/053247 Ceased WO2011107570A1 (en) 2010-03-05 2011-03-03 System and method for monitoring the time period for blood parameter monitoring processes

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/053245 Ceased WO2011107568A1 (en) 2010-03-05 2011-03-03 System and method for administering medicaments on the basis of urine values

Country Status (14)

Country Link
US (6) US20120323215A1 (en)
EP (6) EP2542276A1 (en)
JP (6) JP5758409B2 (en)
CN (5) CN102713615A (en)
AU (6) AU2011222943B2 (en)
BR (6) BR112012020270B1 (en)
CA (6) CA2788603C (en)
ES (2) ES2655370T3 (en)
IL (6) IL220765B (en)
MX (6) MX2012009598A (en)
PL (1) PL2542142T3 (en)
RU (6) RU2530590C2 (en)
SG (6) SG183254A1 (en)
WO (6) WO2011107569A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10089443B2 (en) 2012-05-15 2018-10-02 Baxter International Inc. Home medical device systems and methods for therapy prescription and tracking, servicing and inventory
US10492991B2 (en) 2010-05-30 2019-12-03 Crisi Medical Systems, Inc. Medication container encoding, verification, and identification
US9514131B1 (en) * 2010-05-30 2016-12-06 Crisi Medical Systems, Inc. Medication container encoding, verification, and identification
US10262112B2 (en) 2013-02-04 2019-04-16 Precera Bioscience, Inc. Prescription decision support system and method using comprehensive multiplex drug monitoring
DE102014105058A1 (en) * 2014-04-09 2015-10-15 Stephanie Ittstein Device for production and / or administration
JP6391312B2 (en) * 2014-06-13 2018-09-19 クラリオン株式会社 Terminal connection apparatus, processing information execution system, and processing information execution method
WO2016057982A1 (en) 2014-10-10 2016-04-14 Nxstage Medical, Inc. Flow balancing devices, methods, and systems
US11714975B2 (en) 2014-10-28 2023-08-01 Avery Dennison Retail Information Services Llc High density read chambers for scanning and encoding RFID tagged items
US20160314185A1 (en) * 2015-04-27 2016-10-27 Microsoft Technology Licensing, Llc Identifying events from aggregated device sensed physical data
DE102016005131A1 (en) * 2016-04-27 2017-11-02 Justus-Liebig-Universität Giessen Device and method for preventing misinsertion of a drug
US10045725B2 (en) * 2016-05-13 2018-08-14 Hugh Califf Blood analysis method and apparatus
CN109070953B (en) * 2016-05-20 2022-06-28 麦格纳外饰公司 Active bottom panel assembly
WO2018017623A1 (en) 2016-07-18 2018-01-25 Nxstage Medical, Inc. Flow balancing devices, methods, and systems
US11865243B2 (en) 2016-08-30 2024-01-09 Nxstage Medical, Inc. Parameter monitoring in medical treatment systems
KR102632835B1 (en) * 2016-09-20 2024-02-01 브라코 다이어그노스틱스 아이엔씨. Shielding assembly for radioisotope delivery system with multiple radiation detectors
US11810685B2 (en) 2018-03-28 2023-11-07 Bracco Diagnostics Inc. Early detection of radioisotope generator end life
DK3776598T3 (en) 2018-03-28 2022-08-01 Bracco Diagnostics Inc SYSTEMS AND TECHNIQUES FOR CALIBRATION OF RADIOISOTOPE DELIVERY SYSTEMS USING A GAMMA DETECTOR
EP3669912A1 (en) * 2018-12-19 2020-06-24 Sanofi Drug delivery device and drug delivery system
AU2020277500B2 (en) 2019-05-23 2025-04-24 Nxstage Medical, Inc. Flow synchronization devices, methods and systems
JP7608437B2 (en) * 2020-03-27 2025-01-06 テルモ株式会社 Biological function estimation device
TWI811641B (en) * 2021-03-04 2023-08-11 宏碁股份有限公司 Medication risk evaluation method and medication risk evaluation device
DE102021127476A1 (en) * 2021-10-22 2023-04-27 B. Braun Melsungen Aktiengesellschaft System and method for delivering medication to a medical device
EP4440652A4 (en) * 2021-11-30 2025-12-03 Tandem Diabetes Care Inc BOLUS AUTHORIZATIONS AND PRIORIZATION SCHEME FOR AN INFUSION PUMP SYSTEM
IT202200022275A1 (en) * 2022-10-28 2024-04-28 Datamed S R L Device and method for measuring a plurality of blood parameters using artificial intelligence

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005050497A1 (en) 2003-11-21 2005-06-02 Vasogen Ireland Limited Medical treatment management systems
US20060009949A1 (en) * 2002-06-13 2006-01-12 Koninklijke Philips Electronics N.V. Aptitude test system
WO2008083313A2 (en) * 2007-01-01 2008-07-10 Medrad, Inc. Methods and systems for integrated radiopharmaceutical generation, preparation, transportation, and administration

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151845A (en) * 1977-11-25 1979-05-01 Miles Laboratories, Inc. Blood glucose control apparatus
JPS5521905A (en) * 1978-08-02 1980-02-16 Nikkiso Co Ltd Improvement of artificial pancreas
US4449538A (en) * 1982-01-25 1984-05-22 John Corbitt Medical-electronic body fluid accounting system
SU1458824A1 (en) * 1987-02-19 1989-02-15 Московский медицинский стоматологический институт им.Н.А.Семашко Method of determining disturbed activity of blood plasma fibrinogen
SU1686361A1 (en) * 1988-04-05 1991-10-23 Самарский медицинский институт им.Д.И.Ульянова Method for estimation of functional activity of donor blood cells
US5956501A (en) * 1997-01-10 1999-09-21 Health Hero Network, Inc. Disease simulation system and method
US5590648A (en) * 1992-11-30 1997-01-07 Tremont Medical Personal health care system
ATE245814T1 (en) * 1993-11-02 2003-08-15 U D Testing Inc METHOD FOR MONITORING A PATIENT'S COMPLIANCE WITH A PRESCRIBED MEDICATION
JP3243103B2 (en) * 1994-02-04 2002-01-07 吉彦 鈴木 Blood glucose control device
US5713856A (en) * 1995-03-13 1998-02-03 Alaris Medical Systems, Inc. Modular patient care system
US7384410B2 (en) * 1995-03-13 2008-06-10 Cardinal Health 303, Inc. System and method for managing patient care
JPH09329597A (en) * 1996-06-11 1997-12-22 Hitachi Ltd Urine sediment inspection system
JPH10274656A (en) * 1997-03-28 1998-10-13 Kdk Corp Measurement method of glucose concentration
US6579690B1 (en) * 1997-12-05 2003-06-17 Therasense, Inc. Blood analyte monitoring through subcutaneous measurement
US7760187B2 (en) * 2004-07-30 2010-07-20 Apple Inc. Visual expander
US8480580B2 (en) * 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6074345A (en) * 1998-10-27 2000-06-13 University Of Florida Patient data acquisition and control system
RU2148257C1 (en) * 1999-06-01 2000-04-27 Тверская государственная медицинская академия Method for examining blood
US6423035B1 (en) * 1999-06-18 2002-07-23 Animas Corporation Infusion pump with a sealed drive mechanism and improved method of occlusion detection
US6790198B1 (en) * 1999-12-01 2004-09-14 B-Braun Medical, Inc. Patient medication IV delivery pump with wireless communication to a hospital information management system
US6519569B1 (en) * 1999-12-01 2003-02-11 B. Braun Medical, Inc. Security infusion pump with bar code reader
US20030154108A1 (en) * 2000-03-01 2003-08-14 Gambro, Inc. Extracorporeal blood processing information management system
JP2001245874A (en) * 2000-03-03 2001-09-11 Sefa Technology Kk Blood collecting tube for measuring red corpuscle sedimentation speed, blood collecting tube holder, protector for carrying blood collecting tube, and method and device for measuring red corpuscle sedimentation speed
DE10011395A1 (en) * 2000-03-09 2001-09-20 Braun Melsungen Ag Fluid balancing system for use in medicine, comprises a fluid manager which controls fluid supply devices, receptacles for the fluid, and data transfer devices
US7630908B1 (en) * 2000-05-01 2009-12-08 John Amrien Wireless electronic prescription scanning and management system
GB0030809D0 (en) * 2000-12-16 2001-01-31 Schmidt Paul Sample tracking systems
WO2002049503A2 (en) * 2000-12-19 2002-06-27 University Of Rochester Method and device for administering medication and/or placebo
JP4276834B2 (en) * 2000-12-27 2009-06-10 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Biological information and blood processing apparatus information management system
US20030014093A1 (en) * 2001-05-29 2003-01-16 Makin Inder Raj. S. Excisional and ultrasound medical treatment system
EP1449331B1 (en) * 2001-11-30 2007-09-19 British Telecommunications Public Limited Company Data transmission
RU2226689C2 (en) * 2001-12-27 2004-04-10 Медицинский радиологический научный центр РАМН Method for determining organism resistibility
US20030141981A1 (en) * 2002-01-29 2003-07-31 Tuan Bui System and method for operating medical devices
US20030212379A1 (en) * 2002-02-26 2003-11-13 Bylund Adam David Systems and methods for remotely controlling medication infusion and analyte monitoring
DE20217847U1 (en) * 2002-11-19 2004-04-08 B. Braun Melsungen Ag Secretion collecting device
US20040172284A1 (en) * 2003-02-13 2004-09-02 Roche Diagnostics Corporation Information management system
JP2006524069A (en) * 2003-04-23 2006-10-26 バソジェン アイルランド リミテッド Discharge device
ZA200508816B (en) * 2003-04-23 2008-01-30 Vasogen Ireland Ltd Dispensing systems
US7258673B2 (en) * 2003-06-06 2007-08-21 Lifescan, Inc Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
WO2004112603A1 (en) * 2003-06-19 2004-12-29 Wayne State University System for identifying patient response to anesthesia infusion
US20050019943A1 (en) 2003-07-09 2005-01-27 Chaoui Sam M. Automatic blood analysis and identification system
US20050021368A1 (en) * 2003-07-25 2005-01-27 Debra Burkeen Enhanced safety medication administration system
US20050021367A1 (en) * 2003-07-25 2005-01-27 Deborah Saeger Medication administration system
JP2005102960A (en) * 2003-09-30 2005-04-21 Seiko Epson Corp Infusion support system, infusion support device, infusion device, and infusion method
US20050154368A1 (en) * 2003-11-21 2005-07-14 Vasogen Ireland Limited Medical material handling systems
TW200519382A (en) * 2003-11-21 2005-06-16 Vasogen Ireland Ltd Medical material handling systems
WO2006031255A2 (en) * 2004-04-02 2006-03-23 Riptide Systems, Inc. Biometric identification system
US8518021B2 (en) * 2004-05-27 2013-08-27 Baxter International Inc. Apparatus and method for therapeutic delivery of medication
US8359338B2 (en) * 2004-07-30 2013-01-22 Carefusion 303, Inc. System and method for managing medical databases for patient care devices
WO2006023985A2 (en) * 2004-08-23 2006-03-02 Remote Clinical Solutions, Inc. System and method for modifying a fluid for oral administration
US7970631B2 (en) * 2004-08-31 2011-06-28 Ethicon Endo-Surgery, Inc. Medical effector system
US20080027409A1 (en) * 2004-09-09 2008-01-31 Rudko Robert I Patient hydration/fluid administration system and method
US7727222B2 (en) * 2004-09-09 2010-06-01 Plc Medical Systems, Inc. Patient hydration system with taper down feature
RU2275640C1 (en) * 2004-09-20 2006-04-27 Илья Николаевич Медведев Method for selecting thrombocytopathy treatment approach in metabolic syndrome cases
EP2278511A3 (en) * 2005-02-11 2011-05-18 Cardinal Health 303 Inc. Identification system for medication management
US7785258B2 (en) * 2005-10-06 2010-08-31 Optiscan Biomedical Corporation System and method for determining a treatment dose for a patient
US8956291B2 (en) * 2005-02-22 2015-02-17 Admetsys Corporation Balanced physiological monitoring and treatment system
US7509156B2 (en) 2005-05-18 2009-03-24 Clarian Health Partners, Inc. System for managing glucose levels in patients with diabetes or hyperglycemia
KR100716015B1 (en) * 2005-06-08 2007-05-08 유재천 Lancet device and blood collection and injection method using the same
US20070088333A1 (en) * 2005-10-13 2007-04-19 G&L Consulting, Llc Method and system for infusing an osmotic solute into a patient and providing feedback control of the infusing rate
US20070100256A1 (en) * 2005-10-28 2007-05-03 Sansom Gordon G Analyte monitoring system with integrated lancing apparatus
US8543420B2 (en) * 2007-09-19 2013-09-24 Fresenius Medical Care Holdings, Inc. Patient-specific content delivery methods and systems
US8140353B2 (en) 2006-06-29 2012-03-20 The Invention Science Fund I, Llc Compliance data for health-related procedures
US9015055B2 (en) * 2006-07-13 2015-04-21 Abbott Point Of Care Inc. Medical data acquisition and patient management system and method
CN1987962A (en) * 2006-09-27 2007-06-27 上海博维康讯信息科技发展有限公司 Disposable patient wrist band and patient identity identifying system
RU2316765C1 (en) * 2006-09-28 2008-02-10 Илья Николаевич Медведев Method for detecting antithrombotic blood vessel activity weakening at early stage
RU2328000C1 (en) * 2006-11-27 2008-06-27 Илья Николаевич Медведев Method of early detection of thromboplastin-formation
JP4431629B2 (en) * 2006-12-22 2010-03-17 株式会社コナミデジタルエンタテインメント Shooting toy
JP2008224385A (en) 2007-03-12 2008-09-25 Olympus Corp Analyzer and analytical method
ES2432404T3 (en) * 2007-03-19 2013-12-03 Insuline Medical Ltd. Method and device for measuring substances
US8417311B2 (en) * 2008-09-12 2013-04-09 Optiscan Biomedical Corporation Fluid component analysis system and method for glucose monitoring and control
US8412293B2 (en) * 2007-07-16 2013-04-02 Optiscan Biomedical Corporation Systems and methods for determining physiological parameters using measured analyte values
US8562558B2 (en) 2007-06-08 2013-10-22 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US20090004317A1 (en) * 2007-06-30 2009-01-01 Xuejiao Hu High thermal conductivity molding compound for flip-chip packages
WO2009029899A1 (en) 2007-09-01 2009-03-05 Sang Hoon Woo Controlling body fluid condition using diuretics
CN102670209A (en) 2007-09-07 2012-09-19 泰尔茂株式会社 Blood sugar measuring method
DE102007047351A1 (en) * 2007-10-02 2009-04-09 B. Braun Melsungen Ag System and method for monitoring and controlling blood glucose levels
MX2010003855A (en) 2007-10-10 2010-04-27 Optiscan Biomedical Corp Fluid component analysis system and method for glucose monitoring and control.
JP5188780B2 (en) * 2007-11-08 2013-04-24 日機装株式会社 Blood purification apparatus and treatment end notification method using the same
RU2371723C1 (en) * 2008-03-03 2009-10-27 Государственное учреждение Научный центр реконструктивной и восстановительной хирургии Восточно-Сибирского научного центра Сибирского отделения Российской Академии медицинских наук Method of assessment of erythrocyte resistance to functional stress
JP2009273502A (en) 2008-05-12 2009-11-26 Jms Co Ltd Medication monitoring apparatus
US20090307008A1 (en) * 2008-06-04 2009-12-10 Cardinalhealth Blood infusion management system and method
US20100036310A1 (en) 2008-08-05 2010-02-11 Hillman Robert S Integrated patient management and control system for medication delivery
US20100160854A1 (en) * 2008-12-22 2010-06-24 Gauthier Robert T Integrated patient management and control system for medication delivery

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060009949A1 (en) * 2002-06-13 2006-01-12 Koninklijke Philips Electronics N.V. Aptitude test system
WO2005050497A1 (en) 2003-11-21 2005-06-02 Vasogen Ireland Limited Medical treatment management systems
WO2008083313A2 (en) * 2007-01-01 2008-07-10 Medrad, Inc. Methods and systems for integrated radiopharmaceutical generation, preparation, transportation, and administration

Also Published As

Publication number Publication date
BR112012021524A2 (en) 2016-07-05
CN102804191A (en) 2012-11-28
MX2012009373A (en) 2012-09-12
EP2542886A1 (en) 2013-01-09
EP2542151A1 (en) 2013-01-09
AU2011222943B2 (en) 2014-08-28
AU2011222946A1 (en) 2012-08-16
CN102762240B (en) 2017-03-08
AU2011222947B2 (en) 2014-09-18
CA2789191C (en) 2017-10-31
IL221413B (en) 2020-07-30
JP2013520217A (en) 2013-06-06
SG183118A1 (en) 2012-09-27
ES2904601T3 (en) 2022-04-05
JP2013521543A (en) 2013-06-10
CN102762240A (en) 2012-10-31
CN102713615A (en) 2012-10-03
BR112012020270A2 (en) 2016-05-03
CA2786302C (en) 2016-02-23
US20120316465A1 (en) 2012-12-13
RU2012130366A (en) 2014-01-27
AU2011222942A1 (en) 2012-08-30
IL220765A0 (en) 2012-08-30
JP2013517871A (en) 2013-05-20
IL221413A0 (en) 2012-10-31
JP2013520718A (en) 2013-06-06
CA2788057A1 (en) 2011-09-09
MX2012009598A (en) 2012-09-12
WO2011107571A1 (en) 2011-09-09
IL221373A (en) 2015-06-30
BR112012019133A2 (en) 2018-03-27
EP2542276A1 (en) 2013-01-09
CA2789191A1 (en) 2011-09-09
RU2524121C2 (en) 2014-07-27
JP5758409B2 (en) 2015-08-05
AU2011222945B2 (en) 2014-02-06
CN102762144A (en) 2012-10-31
US9861745B2 (en) 2018-01-09
RU2012134290A (en) 2014-02-20
RU2517562C2 (en) 2014-05-27
MX2012009596A (en) 2012-09-12
RU2012133280A (en) 2014-02-10
MX2012009058A (en) 2012-09-07
IL221166B (en) 2018-06-28
SG183254A1 (en) 2012-09-27
IL221009A (en) 2017-05-29
BR112012021524B1 (en) 2021-10-13
US20130023819A1 (en) 2013-01-24
RU2543941C2 (en) 2015-03-10
IL220765B (en) 2018-04-30
SG182546A1 (en) 2012-08-30
WO2011107570A1 (en) 2011-09-09
SG183352A1 (en) 2012-09-27
US20120323141A1 (en) 2012-12-20
IL221412A0 (en) 2012-10-31
AU2011222945A1 (en) 2012-09-06
CA2789188C (en) 2020-04-07
MX2012008144A (en) 2012-08-03
AU2011222943A1 (en) 2012-08-30
CA2786302A1 (en) 2011-09-09
EP2542142B1 (en) 2021-11-17
RU2522270C2 (en) 2014-07-10
IL221412A (en) 2016-07-31
RU2012132703A (en) 2014-02-10
EP2542992B1 (en) 2017-11-08
AU2011222944A1 (en) 2012-08-30
WO2011107568A1 (en) 2011-09-09
JP2013517030A (en) 2013-05-16
RU2012127707A (en) 2014-01-20
AU2011222947A1 (en) 2012-07-26
RU2530590C2 (en) 2014-10-10
IL221166A0 (en) 2012-09-24
JP2013519481A (en) 2013-05-30
EP2542142A1 (en) 2013-01-09
ES2655370T3 (en) 2018-02-19
SG183354A1 (en) 2012-09-27
WO2011107566A1 (en) 2011-09-09
RU2526141C2 (en) 2014-08-20
CN102741850A (en) 2012-10-17
EP2542992A1 (en) 2013-01-09
AU2011222946B2 (en) 2014-10-02
EP2542991A1 (en) 2013-01-09
SG183353A1 (en) 2012-09-27
CA2788603C (en) 2017-05-23
CA2787324C (en) 2018-04-17
CA2789188A1 (en) 2011-09-09
JP5658767B2 (en) 2015-01-28
PL2542142T3 (en) 2022-03-21
CA2787324A1 (en) 2011-09-09
BR112012020270B1 (en) 2022-02-15
JP5485414B2 (en) 2014-05-07
BR112012017543A2 (en) 2016-06-28
CN102834048A (en) 2012-12-19
CN102834048B (en) 2016-03-30
RU2012134289A (en) 2014-02-27
CA2788057C (en) 2014-12-02
US20130023851A1 (en) 2013-01-24
CN102762144B (en) 2015-07-08
AU2011222944B2 (en) 2013-12-19
MX2012008822A (en) 2012-09-07
CA2788603A1 (en) 2011-09-09
IL221373A0 (en) 2012-10-31
BR112012019624A2 (en) 2016-05-03
EP2542151B1 (en) 2015-05-06
AU2011222942B2 (en) 2014-05-08
WO2011107569A1 (en) 2011-09-09
BR112012020923A2 (en) 2020-01-14
JP5592506B2 (en) 2014-09-17
US20130085471A1 (en) 2013-04-04
US20120323215A1 (en) 2012-12-20

Similar Documents

Publication Publication Date Title
EP2542992B1 (en) System for data transmission in determination of medicament parameters
EP3528257A1 (en) Computer program, system and method for managing medical data related to a patient
DE102011078711A1 (en) Implantable vascular access device for creating permanent access to blood vessels of patient and administrating drug, has hollow body that is provided with penetrating membrane, where hose is attached to hollow body with container system
EP2236076B1 (en) Method and system for calculating the difference between preprandial and postprandial blood sugar values
EP2195758B1 (en) Conveyor apparatus and method for supplying a medicine-solution mixture
EP4629258A1 (en) Treatment centre for the administration of medical infusions and associated procedure
AT500492A1 (en) COMPUTER ASSISTED SYSTEM FOR PATIENT MONITORING
DE102008034736A1 (en) Method for monitoring medical condition of patient, involves continuous detecting of values of physiological parameters of patient
DE102008059901A1 (en) Method for monitoring medical status of patient in hospital, involves continuously recording physiological parameters of patient, and common and time dependent representation of category and allocated physiological parameter

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 201180010460.7

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11707397

Country of ref document: EP

Kind code of ref document: A1

REEP Request for entry into the european phase

Ref document number: 2011707397

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2011707397

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2789191

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1929/MUMNP/2012

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2011222943

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2012134289

Country of ref document: RU

WWE Wipo information: entry into national phase

Ref document number: 221413

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: MX/A/2012/009596

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2012553353

Country of ref document: JP

ENP Entry into the national phase

Ref document number: 2011222943

Country of ref document: AU

Date of ref document: 20110303

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 13579858

Country of ref document: US

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112012020923

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 112012020923

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20120821