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WO2011025977A3 - Méthodes et dispositifs de transplantation cellulaire - Google Patents

Méthodes et dispositifs de transplantation cellulaire Download PDF

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Publication number
WO2011025977A3
WO2011025977A3 PCT/US2010/047028 US2010047028W WO2011025977A3 WO 2011025977 A3 WO2011025977 A3 WO 2011025977A3 US 2010047028 W US2010047028 W US 2010047028W WO 2011025977 A3 WO2011025977 A3 WO 2011025977A3
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WO
WIPO (PCT)
Prior art keywords
porous scaffold
plug
methods
devices
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2010/047028
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English (en)
Other versions
WO2011025977A2 (fr
Inventor
Craig Hasilo
Justin Leushner
Daniel Nicholas Haworth
Simon Shohet
Philip Michael Toleikis
Delfina Maria Mazzuca Siroen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK10751750.0T priority Critical patent/DK2470228T3/en
Priority to SI201031606T priority patent/SI2470228T1/en
Priority to US13/393,038 priority patent/US9011899B2/en
Priority to SG2012013231A priority patent/SG178565A1/en
Priority to KR1020127007846A priority patent/KR101785743B1/ko
Priority to MX2015004455A priority patent/MX353390B/es
Priority to EA201270337A priority patent/EA025142B1/ru
Priority to MX2012002440A priority patent/MX2012002440A/es
Priority to SM20170609T priority patent/SMT201700609T1/it
Priority to KR1020197036588A priority patent/KR102194187B1/ko
Priority to IN2668DEN2012 priority patent/IN2012DN02668A/en
Priority to ES10751750.0T priority patent/ES2653241T3/es
Priority to MX2018000373A priority patent/MX375215B/es
Priority to HRP20171926TT priority patent/HRP20171926T1/hr
Priority to KR1020177027802A priority patent/KR101919728B1/ko
Priority to CN201080048933.8A priority patent/CN102596273B/zh
Priority to EP10751750.0A priority patent/EP2470228B1/fr
Priority to NO10751750A priority patent/NO2470228T3/no
Priority to EP17194182.6A priority patent/EP3290061B1/fr
Priority to PL17194182T priority patent/PL3290061T3/pl
Priority to BR112012004385-4A priority patent/BR112012004385B1/pt
Priority to AU2010286531A priority patent/AU2010286531B2/en
Application filed by Individual filed Critical Individual
Priority to KR1020197022807A priority patent/KR102057016B1/ko
Priority to KR1020187032731A priority patent/KR102008762B1/ko
Priority to CA2772375A priority patent/CA2772375C/fr
Priority to LTEP10751750.0T priority patent/LT2470228T/lt
Priority to PL10751750T priority patent/PL2470228T3/pl
Priority to JP2012527042A priority patent/JP5756108B2/ja
Priority to NZ598701A priority patent/NZ598701A/en
Publication of WO2011025977A2 publication Critical patent/WO2011025977A2/fr
Publication of WO2011025977A3 publication Critical patent/WO2011025977A3/fr
Priority to IL218360A priority patent/IL218360A/en
Anticipated expiration legal-status Critical
Priority to US14/625,135 priority patent/US10207026B2/en
Priority to US14/993,416 priority patent/US10034963B2/en
Priority to CY20171101306T priority patent/CY1119719T1/el
Priority to US16/241,233 priority patent/US11730860B2/en
Priority to CY20201100596T priority patent/CY1123841T1/el
Priority to US18/349,695 priority patent/US20230347018A1/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2400/00—Materials characterised by their function or physical properties
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
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    • A61M2039/0282—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body with implanted tubes connected to the port
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Virology (AREA)

Abstract

La présente invention concerne des dispositifs et des méthodes de transplantation de cellules dans un organisme hôte. Le dispositif comprend un support poreux permettant la pénétration de tissus vasculaires et conjonctifs, un tampon ou un système de tampon conçu pour être disposé à l'intérieur du support poreux et un joint conçu pour enclore une ouverture proximale du support poreux. Ledit dispositif peut comprendre, en outre, un dispositif de mise en place de cellules permettant la mise en place de cellules dans le support poreux. Ladite méthode de transplantation cellulaire implique un processus en deux étapes. Le dispositif est d'abord incubé dans l'organisme hôte pour former une matrice de collagène vascularisée autour d'un tampon positionné à l'intérieur du support poreux. Le tampon est ensuite retiré du support poreux et des cellules sont mises en place dans l'espace vascularisé créé au sein dudit support poreux.
PCT/US2010/047028 2009-08-28 2010-08-27 Méthodes et dispositifs de transplantation cellulaire Ceased WO2011025977A2 (fr)

Priority Applications (36)

Application Number Priority Date Filing Date Title
BR112012004385-4A BR112012004385B1 (pt) 2009-08-28 2010-08-27 Dispositivo para transplante celular
US13/393,038 US9011899B2 (en) 2009-08-28 2010-08-27 Methods and devices for cellular transplantation
SG2012013231A SG178565A1 (en) 2009-08-28 2010-08-27 Methods and devices for cellular transplantation
KR1020127007846A KR101785743B1 (ko) 2009-08-28 2010-08-27 세포 이식 방법 및 장치
MX2015004455A MX353390B (es) 2009-08-28 2010-08-27 Metodos y dispositivos para el trasplante de celulas.
EA201270337A EA025142B1 (ru) 2009-08-28 2010-08-27 Способ и устройство для клеточной трансплантации
MX2012002440A MX2012002440A (es) 2009-08-28 2010-08-27 Metodos y dispositivos para el transplante de celulas.
SM20170609T SMT201700609T1 (it) 2009-08-28 2010-08-27 Procedimenti e dispositivi per il trapianto di cellule
KR1020197036588A KR102194187B1 (ko) 2009-08-28 2010-08-27 세포 이식 방법 및 장치
IN2668DEN2012 IN2012DN02668A (fr) 2009-08-28 2010-08-27
ES10751750.0T ES2653241T3 (es) 2009-08-28 2010-08-27 Métodos y dispositivos para trasplante celular
MX2018000373A MX375215B (es) 2009-08-28 2010-08-27 Métodos y dispositivos para el transplante de células.
HRP20171926TT HRP20171926T1 (hr) 2009-08-28 2010-08-27 Postupci i uređaji za transplantaciju stanica
KR1020177027802A KR101919728B1 (ko) 2009-08-28 2010-08-27 세포 이식 방법 및 장치
CN201080048933.8A CN102596273B (zh) 2009-08-28 2010-08-27 用于细胞移植的方法和设备
EP10751750.0A EP2470228B1 (fr) 2009-08-28 2010-08-27 Méthodes et dispositifs de transplantation cellulaire
NO10751750A NO2470228T3 (fr) 2009-08-28 2010-08-27
EP17194182.6A EP3290061B1 (fr) 2009-08-28 2010-08-27 Procédés et dispositifs pour transplantation cellulaire
PL17194182T PL3290061T3 (pl) 2009-08-28 2010-08-27 Sposoby i urządzenia do przeszczepiania komórek
DK10751750.0T DK2470228T3 (en) 2009-08-28 2010-08-27 METHODS AND DEVICES FOR CELLULAR TRANSPLANTATION
SI201031606T SI2470228T1 (en) 2009-08-28 2010-08-27 Cell transplantation procedures and devices
AU2010286531A AU2010286531B2 (en) 2009-08-28 2010-08-27 Methods and devices for cellular transplantation
KR1020197022807A KR102057016B1 (ko) 2009-08-28 2010-08-27 세포 이식 방법 및 장치
KR1020187032731A KR102008762B1 (ko) 2009-08-28 2010-08-27 세포 이식 방법 및 장치
CA2772375A CA2772375C (fr) 2009-08-28 2010-08-27 Methodes et dispositifs de transplantation cellulaire
LTEP10751750.0T LT2470228T (lt) 2009-08-28 2010-08-27 Būdai ir įrenginiai ląstelinei transplantacijai
PL10751750T PL2470228T3 (pl) 2009-08-28 2010-08-27 Sposoby i urządzenia do przeszczepiania komórek
JP2012527042A JP5756108B2 (ja) 2009-08-28 2010-08-27 細胞移植のための方法およびデバイス
NZ598701A NZ598701A (en) 2009-08-28 2010-08-27 Methods and devices for cellular transplantation
IL218360A IL218360A (en) 2009-08-28 2012-02-28 A host cell transplant device
US14/625,135 US10207026B2 (en) 2009-08-28 2015-02-18 Methods and devices for cellular transplantation
US14/993,416 US10034963B2 (en) 2009-08-28 2016-01-12 Methods and devices for cellular transplantation
CY20171101306T CY1119719T1 (el) 2009-08-28 2017-12-13 Μεθοδοι και συσκευες για μεταμοσχευση κυτταρων
US16/241,233 US11730860B2 (en) 2009-08-28 2019-01-07 Methods and devices for cellular transplantation
CY20201100596T CY1123841T1 (el) 2009-08-28 2020-06-26 Μεθοδοι και συσκευες για μεταμοσχευση κυτταρων
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Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012508584A (ja) 2008-11-14 2012-04-12 ヴィアサイト，インコーポレイテッド ヒト多能性幹細胞由来膵臓細胞のカプセル化
SG10202001012VA (en) 2009-08-28 2020-04-29 Sernova Corp Device for cellular transplantation and uses thereof
EP2404672A1 (fr) * 2010-07-06 2012-01-11 Universiteit Twente Système multi-puits à haut rendement pour la culture de constructions tissulaires 3D in vitro ou in vivo, procédé de production dudit système multi-puits et procédés de préparation des constructions tissulaires 3D à partir de cellules à l'aide dudit système multi-puits
MX2010013135A (es) * 2010-11-30 2012-05-31 Val De Bio S De R L De C V Procedimiento y dispositivo mejorados para favorecer el trasplante de material biológico.
ES2681602T3 (es) * 2013-03-07 2018-09-14 Viacyte, Inc. Ensamblaje de dispositivo de encapsulación celular tridimensional de gran capacidad
WO2014197798A2 (fr) * 2013-06-07 2014-12-11 The Regents Of The University Of California Dispositif de greffe et procédé d'utilisation
CN104195105B (zh) * 2014-08-19 2017-10-27 杭州安体科技有限公司 一种提高人精子活力的体外培养体系试剂盒及其使用方法
US10434122B2 (en) * 2014-09-24 2019-10-08 The Governors Of The University Of Alberta Cellular transplant site
CN114344244A (zh) 2015-03-23 2022-04-15 加利福尼亚大学董事会 薄膜细胞包囊装置
CA2994934A1 (fr) * 2015-08-06 2017-02-09 Lockheed Martin Corporation Membranes de graphene implantables ayant une faible cytotoxicite
CA3005604C (fr) * 2015-11-19 2023-07-18 Tepha, Inc. Procedes de production de filets chirurgicaux enduits de collagene perfores
CA3020880A1 (fr) 2016-04-14 2017-10-19 Lockheed Martin Corporation Attenuation interfaciale selective des defauts du graphene
US10967102B2 (en) 2016-09-28 2021-04-06 Boston Scientific Limited Cell encapsulation membranes, devices and methods
AU2017344747B2 (en) * 2016-10-20 2022-03-03 Australian Foundation for Diabetes Research Cell associated scaffolds for delivery of agents
WO2018144099A1 (fr) 2016-11-03 2018-08-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona Procédés et systèmes d'évaluation en temps réel de cellules dans des dispositifs d'encapsulation avant et après la transplantation
KR20220149620A (ko) 2016-11-03 2022-11-08 아리조나 보드 오브 리전츠 온 비해프 오브 더 유니버시티 오브 아리조나 산소 전달을 수반 또는 비-수반하는 적층형 조직 캡슐화 장치 시스템
AU2017366791B2 (en) * 2016-11-03 2021-01-21 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods, systems, and implantable devices for enhancing blood glucose regulation
EP3534834A4 (fr) 2016-11-03 2020-05-13 Arizona Board of Regents on behalf of the University of Arizona Systèmes de dispositifs d'encapsulation à capteurs d'oxygène avec ou sans administration d'oxygène exogène
US11052230B2 (en) * 2016-11-08 2021-07-06 W. L. Gore & Associates, Inc. Implantable encapsulation devices
CA3042495A1 (fr) 2016-11-10 2018-05-17 Viacyte, Inc. Cellules d'endoderme pancreatique pdx1 dans des dispositifs d'administration de cellules et procedes associes
JP6557717B2 (ja) * 2016-12-23 2019-08-07 インスコビー・インコーポレイテッドＩｎｓｃｏｂｅｅ，Ｉｎｃ． 生体植立用インプラント及びその製造方法
US12016327B2 (en) 2017-03-20 2024-06-25 Boston Scientific Medical Device Limited Cell encapsulation device
KR101952762B1 (ko) * 2017-05-08 2019-02-27 강원대학교산학협력단 알긴산과 콜라겐의 조합으로 생성된 줄기세포를 캡슐화하는 미세캡슐 조성물 및 그 제조방법
RU2663470C2 (ru) * 2017-05-11 2018-08-06 Федеральное государственное бюджетное образовательное учреждение высшего образования "Казанский государственный медицинский университет" Способ стимулирования ангиогенеза с использованием генетически модифицированных клеток крови пуповины
EP3409239A1 (fr) 2017-05-29 2018-12-05 University College Dublin, National University of Ireland, Dublin Dispositif d'encapsulation d'agent actif implantable
CN107376033B (zh) * 2017-07-26 2019-03-26 湖南赛诺生物科技股份有限公司 一种细胞移植增效保护装置及其制备方法
JP7101377B2 (ja) 2017-09-15 2022-07-15 株式会社日立製作所 細胞培養基材、細胞培養容器、及び細胞培養方法
CA3116829A1 (fr) 2017-10-17 2019-04-25 The Methodist Hospital System Dispositifs d'administration
GB201717885D0 (en) * 2017-10-31 2017-12-13 Hothouse Medical Ltd Prothesis and method of manufacture
WO2019108973A2 (fr) * 2017-11-30 2019-06-06 Duke University Compositions et procédés d'ablation de cellules de niche dans des testicules et d'autres cellules épithéliales et procédés associés
IL276979B2 (en) * 2018-03-01 2024-05-01 Seraxis Inc Macro-encapsulated therapeutic cells, devices, and methods of using the same
RU2682160C2 (ru) * 2018-05-28 2019-03-15 Игорь Валерьевич Саматошенков Способ регенерации нервных волокон кровеносных сосудов
EP3829603A4 (fr) * 2018-07-27 2022-04-27 Washington University Greffon vasculaire à cellules intégrées pour transplantation
CN113286564A (zh) * 2018-08-02 2021-08-20 乔治敦大学 细胞移植物的方法和组成
WO2020041446A1 (fr) 2018-08-22 2020-02-27 Boston Scientific Scimed Inc Dispositif d'encapsulation de cellules comprenant un tube poreux
WO2020068852A1 (fr) * 2018-09-24 2020-04-02 Procyon Technologies Llc Méthodes et systèmes pour dispositifs médicaux implantables et membranes de vascularisation
WO2020138028A1 (fr) * 2018-12-25 2020-07-02 富士フイルム株式会社 Kit de transplantation de cellule, procédé de fabrication d'une structure de type poche, et agent thérapeutique pour le diabète
NZ781471A (en) * 2019-04-03 2025-08-29 Vertex Pharma Multicompartment macroencapsulation devices
US20220211770A1 (en) 2019-05-01 2022-07-07 Sernova Corporation Methods of treating diabetes using devices for cellular transplantation
CA3155905A1 (fr) 2019-09-27 2021-04-01 Isla Technologies, Inc. Pancreas bioartificiel
AU2020363978B2 (en) * 2019-10-10 2024-02-08 W. L. Gore & Associates, Inc. Cell encapsulation devices
KR20220128643A (ko) * 2020-01-13 2022-09-21 인큐브 랩스 엘엘씨 세포 전달 물품 및 투여 방법
CN115443142A (zh) * 2020-02-10 2022-12-06 优美佳生物技术有限公司 胰岛移植装置、套件和方法
US12115332B2 (en) 2020-10-30 2024-10-15 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for encapsulation devices for housing cells and agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993008850A1 (fr) * 1991-10-30 1993-05-13 Massachusetts Institute Of Technology Implants polymeres prevascularises pour la transplantation d'organes
US5733336A (en) * 1990-10-31 1998-03-31 Baxter International, Inc. Ported tissue implant systems and methods of using same

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3866609A (en) 1972-04-05 1975-02-18 Charles Howard Sparks Apparatus for growing graft tubes in place
CA1340581C (fr) 1986-11-20 1999-06-08 Joseph P. Vacanti Neomorphogenese chimerique d'organes par implatation cellulaire controlee, utilisant des matrices artificielles
US5786216A (en) * 1987-11-17 1998-07-28 Cytotherapeutics, Inc. Inner-supported, biocompatible cell capsules
WO1991000119A1 (fr) * 1989-06-30 1991-01-10 Baxter International Inc. Dispositif implantable
US5100392A (en) 1989-12-08 1992-03-31 Biosynthesis, Inc. Implantable device for administration of drugs or other liquid solutions
US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US6352707B1 (en) 1992-02-24 2002-03-05 Anton-Lewis Usala Transplant encapsulation in a hydrogel matrix to obscure immune recognition
US5425764A (en) 1992-07-30 1995-06-20 The University Of Toledo Bioartificial pancreas
US5262055A (en) 1992-10-19 1993-11-16 The University Of Utah Implantable and refillable biohybrid artificial pancreas
US6689608B1 (en) 1993-02-01 2004-02-10 Massachusetts Institute Of Technology Porous biodegradable polymeric materials for cell transplantation
AU688776B2 (en) * 1993-06-23 1998-03-19 Brown University Research Foundation Method and apparatus for sealing implantable, membrane encapsulation devices
AU1561095A (en) * 1994-01-11 1995-08-01 Baxter International Inc. Ported tissue implant systems and methods of using same
US5686091A (en) * 1994-03-28 1997-11-11 The Johns Hopkins University School Of Medicine Biodegradable foams for cell transplantation
US5620883A (en) 1994-04-01 1997-04-15 The Johns Hopkins University Living cells microencapsulated in a polymeric membrane having two layers
US5725854A (en) 1994-04-13 1998-03-10 Research Corporation Technologies, Inc. Methods of treating disease using sertoli cells an allografts or xenografts
US5958404A (en) 1994-04-13 1999-09-28 Research Corporation Technologies, Inc. Treatment methods for disease using co-localized cells and Sertoli cells obtained from a cell line
US5849285A (en) 1994-04-13 1998-12-15 Research Corporation Technologies, Inc. Autoimmune disease treatment with sertoli cells and in vitro co-culture of mammal cells with sertoli cells
US6703017B1 (en) 1994-04-28 2004-03-09 Ixion Biotechnology, Inc. Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US7018419B2 (en) 1994-05-20 2006-03-28 Spielberg Theodore E Microporous encapsulated endocrine cell disks, biconcave disks and multidimpled chambers for hormonal replacement
US20060263406A1 (en) 1994-07-01 2006-11-23 Lyles Mark B Implantable System for Cell Growth Control
US5776747A (en) * 1994-07-20 1998-07-07 Cytotherapeutics, Inc. Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer
GB9506844D0 (en) 1995-04-03 1995-05-24 Armitage Ian M Pharmaceutical microencapsulation
WO1996039993A1 (fr) * 1995-06-07 1996-12-19 Gore Hybrid Technologies, Inc. Appareil de confinement implantable destine a un dispositif therapeutque et procede permettant de charger et de recharger ledit dispositif
US5626561A (en) * 1995-06-07 1997-05-06 Gore Hybrid Technologies, Inc. Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein
US5741334A (en) 1995-06-07 1998-04-21 Circe Biomedical, Inc. Artificial pancreatic perfusion device
DE69634859D1 (de) 1995-10-26 2005-07-21 Paul P Latta Induktion von immunologischer toleranz
US5964261A (en) * 1996-05-29 1999-10-12 Baxter International Inc. Implantation assembly
US6054142A (en) * 1996-08-01 2000-04-25 Cyto Therapeutics, Inc. Biocompatible devices with foam scaffolds
US5881733A (en) 1996-09-13 1999-03-16 Depuy Orthopaedic Technology, Inc. Technique for osteocartilaginous transplantation in a mammalian joint
US6303136B1 (en) 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US7399751B2 (en) 1999-11-04 2008-07-15 Sertoli Technologies, Inc. Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
US6716246B1 (en) 1998-12-15 2004-04-06 Universidad Nacional Autonoma De Mexico Process and device for facilitating the implantation of biological material
AU4476600A (en) 1999-04-22 2000-11-10 Vanderbilt University Polymeric encapsulation system promoting angiogenesis
US7371400B2 (en) 2001-01-02 2008-05-13 The General Hospital Corporation Multilayer device for tissue engineering
US7759113B2 (en) 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US20020151055A1 (en) 1999-11-02 2002-10-17 Stegemann Jan Philip Novel artificial pancreas
US6479066B1 (en) * 1999-12-16 2002-11-12 Rst Implanted Cell Technology, Llc Device having a microporous membrane lined deformable wall for implanting cell cultures
US20030167054A1 (en) 2000-05-05 2003-09-04 Lawrence Rosenberg Device for cell implantation
ES2386505T3 (es) * 2000-10-17 2012-08-22 Diatranz Otsuka Limited Preparación y xenotrasplante de islotes de cerdo
US6517888B1 (en) 2000-11-28 2003-02-11 Scimed Life Systems, Inc. Method for manufacturing a medical device having a coated portion by laser ablation
CA2429945A1 (fr) * 2000-11-29 2002-06-06 Durect Corporation Dispositifs et procedes de liberation controlee pour instrument d'administration de medicaments
US20020155559A1 (en) * 2001-01-17 2002-10-24 Laurencin Cato T. Biocompatible, biodegradable polymer-based, lighter than or light as water scaffolds for tissue engineering and methods for preparation and use thereof
US20030068308A1 (en) 2001-10-09 2003-04-10 Jacek Rozga Intrasplenic encapsulated cell therapy
TWI222997B (en) * 2001-12-10 2004-11-01 Ind Tech Res Inst Method for tissue culture in vitro
JP2003190259A (ja) 2001-12-28 2003-07-08 Hisako Ogawara 人工臓器用チャンバー
RU2240755C2 (ru) * 2002-02-26 2004-11-27 Колганов Андрей Сергеевич Устройство для имплантации клеточной культуры
US20030181978A1 (en) 2002-03-25 2003-09-25 Brown Kelly R. Channeled biomedical foams and method for producing same
WO2004032881A2 (fr) 2002-10-11 2004-04-22 Novocell, Inc. Implantation de materiaux biologiques encapsules pour le traitement de maladies
US7044965B1 (en) 2002-12-13 2006-05-16 Spielberg Theodore E Therapeutic cellular stent
US20040156878A1 (en) * 2003-02-11 2004-08-12 Alireza Rezania Implantable medical device seeded with mammalian cells and methods of treatment
US20040197374A1 (en) * 2003-04-02 2004-10-07 Alireza Rezania Implantable pouch seeded with insulin-producing cells to treat diabetes
US7803574B2 (en) * 2003-05-05 2010-09-28 Nanosys, Inc. Medical device applications of nanostructured surfaces
AU2004266126B8 (en) 2003-07-03 2011-07-28 Sertoli Technologies, Llc Compositions containing sertoli cells and myoid cells and use thereof in cellular transplants
US8043614B2 (en) 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
WO2005072764A2 (fr) 2004-01-16 2005-08-11 Novocell, Inc. Procede d'utilisation de facteurs angiogeniques lies a la fibrine afin de stimuler la vascularisation d'un site de transplantation de cellules encapsulees
WO2005089673A1 (fr) 2004-03-24 2005-09-29 Mika Lahtinen Nouveau produit
KR20070085223A (ko) 2004-07-29 2007-08-27 유니버시티 오브 마이애미 세포 치료를 위한 하이브리드 장치
US9788978B2 (en) 2004-12-20 2017-10-17 Nicholas A. Rojo Implantable systems and stents containing cells for therapeutic uses
US20090028945A1 (en) 2005-06-04 2009-01-29 University Of Colorado Immunoisolative encapsulation system
EP2347774B1 (fr) 2005-12-13 2017-07-26 The President and Fellows of Harvard College Echafaudages pour transplantation cellulaire
WO2008008266A2 (fr) 2006-07-07 2008-01-17 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Échafaudages élastomères biohybrides et procédés d'utilisation correspondants
JP5214161B2 (ja) * 2006-07-10 2013-06-19 オリンパス株式会社 透過光学素子及びそれを用いた光学系
CA2658951A1 (fr) 2006-07-28 2008-01-31 Sertocell Biotechnology (Us) Corp. Cellules de sertoli adultes et utilisation de celles-ci
WO2008079997A2 (fr) * 2006-12-22 2008-07-03 Medtronic, Inc. Mécanisme et procédé d'angiogenèse et dispositif implantable
WO2008097498A1 (fr) 2007-02-02 2008-08-14 University Of Miami Dispositifs implantables hybrides thérapeutiques
US7875072B2 (en) 2007-03-26 2011-01-25 Spielberg Theodore E Cellular transplant stent
EP2155810A4 (fr) 2007-06-13 2013-07-03 Fmc Corp Composite de mousse de polysaccharide contenant du gel, revêtu d'alginate, procédés préparatoires, et son utilisation
US8821431B2 (en) 2007-09-07 2014-09-02 Beta O2 Technologies Ltd. Air gap for supporting cells
CA2759833A1 (fr) 2008-04-25 2009-10-29 Encapsulife, Inc. Systeme de patch d'immunoisolation pour transplantation cellulaire
WO2010032242A1 (fr) 2008-09-17 2010-03-25 Beta O2 Technologies Ltd. Optimisation de l'encapsulation dans de l'alginate d'îlots à transplanter
US9446168B2 (en) 2010-06-07 2016-09-20 Beta-O2 Technologies Ltd. Multiple-layer immune barrier for donor cells
JP2012508584A (ja) 2008-11-14 2012-04-12 ヴィアサイト，インコーポレイテッド ヒト多能性幹細胞由来膵臓細胞のカプセル化
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
EP2286822A1 (fr) 2009-08-17 2011-02-23 Universiteit Twente Traitement du diabète
SG10202001012VA (en) 2009-08-28 2020-04-29 Sernova Corp Device for cellular transplantation and uses thereof
WO2011027221A1 (fr) 2009-09-03 2011-03-10 Sernova Corporation Procédé d'évaluation de la fonction d'îlots de langerhans
US20130089594A1 (en) 2010-04-12 2013-04-11 Converge Biotech Inc. Macroporous bioengineered scaffolds for cell transplantation
EP2422823B1 (fr) 2010-07-30 2014-03-19 Institut Quimic De Sarria Implant bioactif
FR2962898B1 (fr) 2010-07-22 2012-08-17 Statice Sante Poche pour former un organe artificiel implantable
US20120083767A1 (en) 2010-10-01 2012-04-05 The Johns Hopkins University Implantable bioreactor for delivery of paracrine factors
MX2010013135A (es) 2010-11-30 2012-05-31 Val De Bio S De R L De C V Procedimiento y dispositivo mejorados para favorecer el trasplante de material biológico.
US8936650B2 (en) 2011-03-23 2015-01-20 The Regents Of The University Of California Mesh enclosed tissue constructs
US8579990B2 (en) 2011-03-30 2013-11-12 Ethicon, Inc. Tissue repair devices of rapid therapeutic absorbency
US9248013B2 (en) 2011-12-05 2016-02-02 California Institute Of Technology 3-Dimensional parylene scaffold cage
US10675138B2 (en) 2011-12-07 2020-06-09 The Trustees Of Princeton University Scaffolds for soft tissue and uses thereof
WO2013134360A1 (fr) 2012-03-06 2013-09-12 The Uab Research Foundation Technologies pour la transplantation d'îlots de langerhans
US9101707B2 (en) 2012-04-27 2015-08-11 Gregory Zeltser Implantable bioartificial perfusion system
US20140221982A1 (en) 2012-08-29 2014-08-07 Erik Gatenholm Semipermeable medical pouches and their uses
ES2681602T3 (es) 2013-03-07 2018-09-14 Viacyte, Inc. Ensamblaje de dispositivo de encapsulación celular tridimensional de gran capacidad
JP6325649B2 (ja) 2013-04-24 2018-05-16 ネステク ソシエテ アノニム カプセル化デバイス
ES2649616T3 (es) 2013-06-17 2018-01-15 Hans U. Baer Matriz e implante para ingeniería de tejidos
AU2014318846A1 (en) 2013-09-11 2016-03-10 Neurotech Usa, Inc. Encapsulated cell therapy cartridge
EP3049020B1 (fr) 2013-09-24 2022-06-15 Giner Life Sciences, Inc. Système pour le traitement gazeux d'un implant cellulaire
FR3014316B1 (fr) 2013-12-10 2017-01-20 Defymed Organe bioartificiel
WO2015187204A1 (fr) 2014-06-06 2015-12-10 Nanovault Medical, Llc Boîte de distribution d'agents biothérapeutiques et cellulaires implantables
US10434122B2 (en) 2014-09-24 2019-10-08 The Governors Of The University Of Alberta Cellular transplant site
MX2018001888A (es) 2015-08-14 2018-06-20 Massachusetts Gen Hospital Sistemas y metodos para utilizar estructuras biomimeticas que proporcionan comunicacion en tejidos vivientes.
EP3337423B1 (fr) 2015-08-17 2023-06-07 The Johns Hopkins University Treillis chirurgicaux composites fibre-hydrogel pour réparation tissulaire
US10092387B2 (en) 2015-09-24 2018-10-09 California Institute Of Technology Implantable device for retaining live cells and providing nutrients thereto
WO2017062757A1 (fr) 2015-10-08 2017-04-13 Massachusetts Institute Of Technology Croissance in situ de dispositifs issus de l'ingénierie tissulaire pour la régénération
US20170105832A1 (en) 2015-10-15 2017-04-20 Kenneth Samuel Rosenblum Porous membrane structures and related techniques
KR20190031195A (ko) 2015-11-12 2019-03-25 바이오스테이지, 인크. 위장 조직을 생성하기 위한 시스템 및 방법
EP3485001A4 (fr) 2016-05-25 2020-08-12 Salk Institute for Biological Studies Compositions et procédés pour la production d'organoïdes et la modélisation de maladies
EP3468704A4 (fr) 2016-06-14 2020-01-29 The Regents of The University of California Echafaudages polymères poreux, et leurs procédés de production et d'utilisation
WO2018055452A1 (fr) 2016-09-21 2018-03-29 Cellink Heal As Dispositif implantable et procédés de bio-impression 3d pour préparer un dispositif implantable capable d'administrer des îlots de langerhans
US10597639B2 (en) 2016-10-20 2020-03-24 Washington University 3D-printed scaffold device for cell transplantation
AU2017344747B2 (en) 2016-10-20 2022-03-03 Australian Foundation for Diabetes Research Cell associated scaffolds for delivery of agents
US10849731B2 (en) 2016-11-08 2020-12-01 W. L. Gore & Associates, Inc. Cell encapsulation devices containing structural spacers
US11338068B2 (en) 2016-11-08 2022-05-24 W. L. Gore & Associates, Inc. Two-part implantable therapy delivery device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733336A (en) * 1990-10-31 1998-03-31 Baxter International, Inc. Ported tissue implant systems and methods of using same
WO1993008850A1 (fr) * 1991-10-30 1993-05-13 Massachusetts Institute Of Technology Implants polymeres prevascularises pour la transplantation d'organes

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