[go: up one dir, main page]

WO2011011388A3 - Régénération du muscle cardiaque induite par la neuréguline - Google Patents

Régénération du muscle cardiaque induite par la neuréguline Download PDF

Info

Publication number
WO2011011388A3
WO2011011388A3 PCT/US2010/042565 US2010042565W WO2011011388A3 WO 2011011388 A3 WO2011011388 A3 WO 2011011388A3 US 2010042565 W US2010042565 W US 2010042565W WO 2011011388 A3 WO2011011388 A3 WO 2011011388A3
Authority
WO
WIPO (PCT)
Prior art keywords
muscle
heart
vivo
regeneraton
neuregulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2010/042565
Other languages
English (en)
Other versions
WO2011011388A2 (fr
Inventor
Bernhard Kuhn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
Original Assignee
Boston Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Childrens Hospital filed Critical Boston Childrens Hospital
Priority to US13/386,187 priority Critical patent/US20120121557A1/en
Publication of WO2011011388A2 publication Critical patent/WO2011011388A2/fr
Publication of WO2011011388A3 publication Critical patent/WO2011011388A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention a pour objet des méthodes permettant d'induire la division de cardiomyocytes mammifères post-mitotiques différenciés. L'invention peut être utilisée pour réparer un tissu cardiaque endommagé, par exemple, par une ischémie myocardique, une hypoxie, une attaque, un infarctus du myocarde ou une maladie cardiaque ischémique chronique in vivo. En outre, les méthodes selon l'invention peuvent être utilisées pour induire les cellules du muscle cardiaque à se diviser in vitro, in vivo et/ou ex vivo, qui peuvent ensuite être utilisées dans la réparation du tissu cardiaque.
PCT/US2010/042565 2009-07-22 2010-07-20 Régénération du muscle cardiaque induite par la neuréguline Ceased WO2011011388A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/386,187 US20120121557A1 (en) 2009-07-22 2010-07-20 Neuregulin induced proliferation of cardiomyocytes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22767709P 2009-07-22 2009-07-22
US61/227,677 2009-07-22

Publications (2)

Publication Number Publication Date
WO2011011388A2 WO2011011388A2 (fr) 2011-01-27
WO2011011388A3 true WO2011011388A3 (fr) 2011-06-16

Family

ID=43499624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/042565 Ceased WO2011011388A2 (fr) 2009-07-22 2010-07-20 Régénération du muscle cardiaque induite par la neuréguline

Country Status (2)

Country Link
US (1) US20120121557A1 (fr)
WO (1) WO2011011388A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013053076A1 (fr) 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions et procédés pour le traitement de l'insuffisance cardiaque
EP2903632A4 (fr) * 2012-10-08 2016-07-13 Zensun Shanghai Science And Technology Ltd Compositions et procédés de traitement de l'insuffisance cardiaque chez les patients diabétiques
WO2016116477A1 (fr) * 2015-01-20 2016-07-28 Universiteit Antwerpen Neuréguline dans le traitement de troubles fibrotiques
US10669596B2 (en) 2015-04-07 2020-06-02 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Methods for inducing cell division of postmitotic cells
EP3393492B1 (fr) 2015-12-22 2025-09-24 Société des Produits Nestlé S.A. Utilisation non thérapeutique de l'adénosylcobalamine pour augmenter la taille des fibres musculaires
US11820981B2 (en) 2016-09-14 2023-11-21 Agency For Science, Technology And Research Modulation of TJP1 expression to regulate regeneration of heart cells
JP2017125032A (ja) * 2017-02-20 2017-07-20 ゼンスン（シャンハイ）サイエンス アンド テクノロジー カンパニー リミテッド 糖尿病患者における心不全の治療用組成物
WO2020086667A1 (fr) 2018-10-25 2020-04-30 American University Procédé pour favoriser la différenciation des adipocytes et le traitement d'une maladie liée à l'obésité
JP2019112442A (ja) * 2019-03-13 2019-07-11 ゼンスン（シャンハイ）サイエンス アンド テクノロジー カンパニー リミテッド 糖尿病患者における心不全の治療用組成物および治療法
AR121035A1 (es) 2019-04-01 2022-04-13 Lilly Co Eli Compuestos de neuregulina-4 y métodos de uso

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444642B1 (en) * 1991-04-10 2002-09-03 Cenes Pharmaceuticals, Inc. Methods of increasing myotube formation or survival or muscle cell mitogenesis, differentiation or survival using a neuregulin
US20070264254A1 (en) * 1998-12-21 2007-11-15 Zensun (Shanghai) Science And Technology Ltd. Cardiac muscle function and manipulation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635249B1 (en) * 1999-04-23 2003-10-21 Cenes Pharmaceuticals, Inc. Methods for treating congestive heart failure
US6825333B1 (en) * 1999-08-20 2004-11-30 Chiron Corporation EGFH2 genes and gene products
AU2002304965A1 (en) * 2002-05-24 2003-12-12 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
AU2003237367A1 (en) * 2002-06-03 2003-12-19 Chiron Corporation Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer
US20070213264A1 (en) * 2005-12-02 2007-09-13 Mingdong Zhou Neuregulin variants and methods of screening and using thereof
CA2634974A1 (fr) * 2005-12-30 2007-07-12 Zensun (Shanghai) Science & Technology, Ltd. Liberation etendue de neureguline destinee a ameliorer la fonction cardiaque
US20090156488A1 (en) * 2007-09-12 2009-06-18 Zensun (Shanghai) Science & Technology Limited Use of neuregulin for organ preservation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444642B1 (en) * 1991-04-10 2002-09-03 Cenes Pharmaceuticals, Inc. Methods of increasing myotube formation or survival or muscle cell mitogenesis, differentiation or survival using a neuregulin
US20070264254A1 (en) * 1998-12-21 2007-11-15 Zensun (Shanghai) Science And Technology Ltd. Cardiac muscle function and manipulation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BERSELL, K. ET AL.: "Neuregulinl/ErbB4 signaling induces cardiomyocyte prolif eration and repair of heart injury", CELL, vol. 138, 24 July 2009 (2009-07-24), pages 257 - 270 *
ZHAO, Y.-Y. ET AL.: "Neuregulins promote survival and growth of cardiac myocy tes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventric ular myocytes", J. BIOL. CHEM., vol. 273, no. 17, 1998, pages 10261 - 10269 *

Also Published As

Publication number Publication date
US20120121557A1 (en) 2012-05-17
WO2011011388A2 (fr) 2011-01-27

Similar Documents

Publication Publication Date Title
WO2011011388A3 (fr) Régénération du muscle cardiaque induite par la neuréguline
WO2008091867A3 (fr) Périostine induisant une prolifération de cardiomyocytes et favorisant une régénération cardiaque
WO2014085830A3 (fr) Tests de dépistage pour agents thérapeutiques pour la maladie de parkinson
WO2011064669A3 (fr) Cellules adhérentes du placenta et leur utilisation dans le traitement de pathologies
WO2009134532A3 (fr) Homing dans des cellules souches mésenchymateuses
MX2012013375A (es) Peptido c pegilado.
SG178991A1 (en) Anti-gitr antibodies
CA140823S (en) Clamp for rod rotator
MX2015005797A (es) Produccion de vacuna recombinante en e.coli mediante conjugacion enzimatica.
BRPI1013771A2 (pt) "células-tronco mesenquimais projetadas e método de uso das mesmas para tratar tumores."
EP3674320A3 (fr) Production de proteines heterodimeres
EA201391154A2 (ru) Способы и композиции для нацеливания на адипоциты у млекопитающих
MX358451B (es) Métodos para purificar células derivadas de células madre pluripotenciales.
EP2155147A4 (fr) Préparation d'aloès pour l'amélioration de la peau
IL237021B (en) A pharmaceutical preparation for the treatment of pulmonary arterial hypertension with mesenchymal stem cells
WO2012068317A3 (fr) Procédés de production de protéines recombinantes
WO2011133659A3 (fr) Inhibiteurs de hif et de l'angiogenèse
GB201214580D0 (en) Benzocyanine compounds
WO2010007031A3 (fr) Procédés pour améliorer la différenciation cardiaque des cellules souches embryonnaires humaines
WO2012135868A3 (fr) Compositions et procédés pour le traitement et la prévention de lésion d'ischémie cardiaque
WO2014113704A3 (fr) Amélioration de la différenciation de cellules souches mésenchymateuses
WO2012175454A3 (fr) Méthode de dosage in vitro par technique immunologique
WO2012119103A3 (fr) Compositions et procédés permettant une mobilisation de cellules souches
WO2019004792A3 (fr) Procédé de préparation et utilisation d'un microsphéroïde de cellule souche cardiaque d'origine humaine
MX338100B (es) Celulas derivadas de tejido cardiaco.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10802762

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 13386187

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10802762

Country of ref document: EP

Kind code of ref document: A2