[go: up one dir, main page]

WO2011043590A2 - Composition pharmaceutique pour traiter le diabète ou l'hypertension à l'aide d'extraits de taxus cuspidata et de mûrier, et procédé pour sa préparation - Google Patents

Composition pharmaceutique pour traiter le diabète ou l'hypertension à l'aide d'extraits de taxus cuspidata et de mûrier, et procédé pour sa préparation Download PDF

Info

Publication number
WO2011043590A2
WO2011043590A2 PCT/KR2010/006829 KR2010006829W WO2011043590A2 WO 2011043590 A2 WO2011043590 A2 WO 2011043590A2 KR 2010006829 W KR2010006829 W KR 2010006829W WO 2011043590 A2 WO2011043590 A2 WO 2011043590A2
Authority
WO
WIPO (PCT)
Prior art keywords
mulberry
extract
hypertension
yew
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2010/006829
Other languages
English (en)
Korean (ko)
Other versions
WO2011043590A3 (fr
Inventor
오동석
박윤수
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2011043590A2 publication Critical patent/WO2011043590A2/fr
Publication of WO2011043590A3 publication Critical patent/WO2011043590A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a therapeutic agent for diabetes or hypertension using an extract mixed with yew and mulberry, or an extract mixed with yew, mulberry and pine needles and a method for producing the same.
  • Diabetes mellitus is a type of metabolic disease, such as insufficient insulin secretion or normal functioning. Diabetes mellitus is characterized by high blood sugar, which increases the concentration of glucose in the blood. Will be discharged. Diabetes is diagnosed by blood tests. If there is no symptom, the blood glucose measured after fasting for 8 hours or more is 126 mg / dL or more, or the blood sugar is 200 mg / dL or more 2 hours after the oral glucose load test. Diabetes is also diagnosed when people drink a lot of water, have more urine, lose weight, and have a blood sugar level of 200 mg / dL or more, regardless of their diet.
  • Diabetes is one of the most important adult diseases all over the world. In recent years, the prevalence of diabetes mellitus and the prevalence of diabetes has reached 7-8% in Korea, and the life expectancy of diabetic patients can be avoided due to their long life span. It became impossible. In general, almost 10 to 20 years after diabetes, almost all organs in the body are damaged, resulting in diabetic retinopathy, diabetic cataract, diabetic nephropathy, and diabetic neuropathy. diabetic neuropathy). Chronic diabetic nephropathy is the most important cause of hemodialysis treatment and end stage renal failure, and diabetic cataracts cause blindness and eventually death. Diabetes treatment is generally combined with diet, exercise therapy and drug therapy, all of which aim to prevent or delay diabetic complications by continuously maintaining normal blood sugar.
  • Hypertension refers to persistently high blood pressure beyond the normal range, with systolic blood pressure above 140 mmHg or diastolic blood pressure above 90 mmHg in adults 18 years of age and older.
  • Systolic blood pressure is the pressure exerted on blood vessels as the heart contracts and releases blood
  • diastolic blood pressure is the pressure the blood vessel receives when the heart receives blood as it expands (relaxes).
  • High blood pressure may be high only when the highest blood pressure is high, and both the highest blood pressure and the lowest blood pressure are high.
  • high blood pressure is often the latter case, when only high blood pressure is high in the amount of blood from the heart and aorta
  • the elasticity is reduced, that is, some type of heart valve disease, hyperthyroidism, aortic hardening, aortic aneurysm, etc.
  • both the highest and lowest blood pressures are high, there is a known cause of hypertension (secondary or secondary) and an unknown cause of genetic factors (primary or essential).
  • arteriosclerosis progresses little by little, blood pressure becomes higher, and thus the arteriosclerosis becomes a vicious cycle.
  • Arteriosclerosis is easy to occur in the whole body, especially the brain, heart and kidneys, and when it occurs in the kidneys, anemia occurs at night, and the face is swollen in the morning and the feet are swollen.
  • Risk factors associated with hypertension include environmental and psychological factors such as family history of high blood pressure, drinking, smoking, aging, lack of exercise, obesity, salty eating habits, and stress.
  • the yew ( ⁇ ⁇ , Taxus cuspidata ) is an evergreen tree of the attention tree of the creeper plant coniferous subfamily and is distributed in Korea, Japan, Northeast China, Siberia, etc. and mainly lives in the alpine region. It is a Japanese-made tree called var.nana, whose main stem does not stand straight and is divided into several branches from the bottom. The broader and grayer leaves are called var.latifolia, which grow on Ulleungdo and the north. The main stem grows at an angle and the roots from the branches that touch the ground are called T.caespitosa and grow like snow trees near Seoraksan Daecheongbong.
  • Mulberry (Mulberry tree or Morus alba ) is a generic name for deciduous trees or shrubs belonging to the dicotyledonous nettle mulberry family. Origin is temperate and subtropical. Small branches are greyish brown or greyish white with fine hairs but gradually disappear. Leaves are oval-shaped or long oval-shaped, divided into 3 ⁇ 5 pieces, 10cm long, with dull sawtooth at the edge, and pointed at the end. Along with petioles, fine hairs on the back veins.
  • Pine needles are one of the foods that have been used for a long time and can be easily obtained from the surroundings and can be consumed by anyone, regardless of constitution, and are excellent in treating and preventing various diseases.
  • Pine needles contain a lot of sugar and contain various nutrients such as essential amino acids, enzymes, calcium, phosphorus, iron, and chlorophyll.
  • Pine needles are known to have an amazing effect on the healing and prevention of various diseases.
  • Pine needles clear the blood and improve blood circulation, thereby expanding the peripheral nerves. This increases hormone secretion and is effective in preventing and healing strokes, hypertension, and myocardial infarction, and is well-recognized for bruises, neuralgia, and rheumatism.
  • Pine needles are also effective in preventing back pain, colds, chronic bronchitis, hypertension, stroke, neuralgia, asthma, hydrating metabolism, revitalizing the skin, and anti-inflammatory, antiseptic effect and detoxification to menstruation that comes to women as an invisible visitor. It is good for comprehensive women's diseases such as impurity, cold, uterus, and uterus.
  • tannins are combined with 'melanin pigment' to be excreted in the urine to prevent 'melanin pigment' from being deposited, which makes the skin whiter and smoother, and gives skin elasticity.
  • it is effective in stabilizing nerves and contains glycokinin, a component that lowers blood sugar. It is known to be helpful for diabetes and is rich in iron, which is known to be good for anemia.
  • the present inventors have developed a method for treating diabetes and hypertension using yew and mulberry extract.
  • Korean Patent No. 826672 discloses a technique for health drinks for reducing hypertension, including pine needles and some pine needles as main ingredients, and Korean Patent Laid-Open No. 2001-49156 for pine needle extracts that can treat hypertension. Techniques are known.
  • Korean Patent No. 529793 discloses a technology for mulberry extract for treating diabetes
  • Korean Patent Publication No. 2005-80501 discloses a technology for health supplements containing mulberry leaf powder and pine needle powder for patients with hypertension and diabetes. This is known.
  • the prior art is different from the yew and mulberry extract or yew, mulberry and pine needle extract of the present invention as an extract or a mixture state of not containing attention.
  • Attention is widely known as a material that can mass-produce taxol, an anticancer drug, and it is used as a material for some cosmetics because it is known to inhibit aging, but there are no cases of treating it as a treatment for diabetes or hypertension.
  • An object of the present invention to provide a yew and mulberry extract or yew, mulberry and pine needle extract for treating diabetes and hypertension.
  • Still another object of the present invention is to provide a pharmaceutical preparation and health functional food including yeast and mulberry extract or yeast, mulberry and pine needle extract.
  • Step 1 washing and drying leaves and stems of yew and mulberry
  • Extracts added pine needles are especially effective for high blood pressure.
  • the extract heated in step 4 may be cooled to room temperature and then reheated under the same conditions without removing solids.
  • the extraction solvent of step 4 may be purified water, alcohol (methanol, ethanol, isopropanol, butanol), an organic solvent or a mixed solvent thereof, but preferably purified water, the heating step is 1 to 10 hours at 70 ⁇ 125 °C Can be heated during. The heating is preferably performed by heating the bath using a conventional water bath to prepare the extract rather than direct heating.
  • the filtration process of the fifth step is to sink the solids of the extract after the heating process can remove the solids using a cotton, filter paper, non-woven fabric, filter paper, fine sieve, etc. commonly used to filter the extract.
  • Filtrate filtrate of the attention and mulberry extract (possibly pine needle extract) of the 5 step can be used as it is sterilized and sealed packaging without any additional processing or included in pharmaceutical preparations or health functional food for the treatment of diabetes and hypertension.
  • the filtrate of the yew and mulberry extract (can include pine needles extract) is preferably taken 1 to 3 times a day 100 ⁇ 150ml by 60kg adult.
  • the filtrate of the yeast and mulberry extract (possibly including pine needle extract) of the 5 step may be used as a pharmaceutical preparation or health functional food by powdering by lyophilization, hot air drying or spray drying.
  • the yeast and mulberry extract are oral forms of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, etc. according to conventional methods, respectively.
  • Formulations, external preparations, suppositories, and sterile injectable solutions can be formulated and used.
  • Carriers, excipients and diluents that may be included in the composition containing the yeast and mulberry extract (including pine needle extract) powdered using lyophilization, hot air drying or spray drying may be lactose, dextrose, sucrose, etc.
  • diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents and surfactants are usually used.
  • Solid preparations for oral administration include tablets, pills, powders, granules, capsules and the like, and such solid preparations may contain at least one excipient such as starch, calcium carbonate, sucrose or lactose, gelatin, or the like. Mix is prepared. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Oral liquid preparations include suspensions, solvents, emulsions, and syrups, and may include various excipients, such as wetting agents, sweeteners, fragrances, and preservatives, in addition to commonly used simple diluents such as water and liquid paraffin. .
  • Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories.
  • non-aqueous solvent and suspending agent propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate and the like can be used.
  • base of the suppository witepsol, macrogol, tween 61, cacao butter, laurin butter, glycerogelatin and the like can be used.
  • the dosage of the active ingredient will vary depending on the age, sex and weight of the subject to be treated, the particular disease or pathology to be treated, the severity of the disease or pathology, the route of administration and the judgment of the prescriber. Dosage determination based on these factors is within the level of skill in the art and generally dosages range from 0.001 mg / kg / day to approximately 2000 mg / kg / day. More preferred dosage is 1 mg / kg / day to 300 mg / kg / day. Administration may be administered once a day or may be divided several times. The dosage does not limit the scope of the invention in any aspect.
  • the extract of the present invention can be administered to mammals such as mice, livestock, humans, etc. by various routes.
  • the extract of the present invention is a drug that can be used with confidence even for a long period of time because there is little toxicity and side effects.
  • the attention of the present invention and mulberry extract provides a dietary supplement for improving the treatment of diabetes and hypertension, including a food supplement acceptable food supplement.
  • the health functional food of the present invention includes the form of frozen, hot air or spray-dried powder, tablets, capsules, pills or liquids of the filtrate of yew and mulberry extract (can include pine needle extract), and the compound of the present invention is added. Examples of foods that can be used include various foods, beverages, gums, teas, vitamin complexes, and health functional foods.
  • the present invention provides a dietary supplement for diabetes and hypertension prevention and treatment comprising yeast mulberry extract (can include pine needle extract) food additives food acceptable.
  • Example 1 is a flow chart showing a method for producing yew and mulberry extract according to Example 1 of the present invention.
  • Figure 2 is a flow chart showing a method for producing yew, mulberry and pine needle extract according to Example 2 of the present invention.
  • the extract was prepared in the same manner as in Preparation Example 1, but the extract was prepared using only 8 kg of yeast.
  • the extract was prepared in the same manner as in Preparation Example 1, but the extract was prepared using only 8 kg of mulberry.
  • the extract was prepared in the same manner as in Preparation Example 1, but the extract was prepared using only 8 kg of pine needles instead of yew and mulberry.
  • the extract was prepared in the same manner as in Preparation Example 1, but the extract was prepared using 4 kg of pine needles instead of mulberry.
  • the extract was prepared in the same manner as in Preparation Example 1, but the extract was prepared using 4 kg of pine needles instead of attention.
  • mice ICR male mice (body weight 24 ⁇ 1 g) fasted from the evening before the experiment were taken as a group, and the powders obtained by lyophilizing the extracts of Examples 1 and 2 were orally administered, and abnormal behavior was observed. .
  • the results were calculated LD 50 value according to the method of Richfield J. T. and Wilcoxon F. and are shown in Table 1 below.
  • the extracts of Examples 1 and 2 according to the present invention were found to be as stable as Rosiglitazone (antidiabetic drug) upon oral administration.
  • Example 1 In order to measure the hypoglycemic activity of the extract prepared in Example 1, the hypoglycemic effect was tested in db / db diabetic mice, which are spontaneous diabetic experimental animals. First, the extracts of Examples 1 to 2 and Comparative Examples 1 to 5 were lyophilized to be orally administered to the animals.
  • 10-week-old male db / db mice with diabetes mellitus were adapted to a breeding environment for 2 weeks, and diabetic mice with a blood glucose level of about 600 mg / dL were selected as the test animals.
  • the experimental group was divided into a control group not administering the extract and the sample administration groups of Examples 1 to 2 and Comparative Examples 1 to 5, and the number of experimental animals per group was 5.
  • the lyophilized extracts were prepared as a suspension using 0.5% CMC (Carboxymethyl-cellulose) solution, and each extract was orally administered at 500 mg / kg (body weight).
  • Blood glucose was measured in the tail every morning in the non-fasted state, and blood glucose was measured by the glucose oxidase method. The results are shown in Table 2 below.
  • the group treated with the extracts of Examples 1 to 2 according to the present invention was confirmed to have an excellent blood sugar lowering effect compared to the extracts of Comparative Examples 1 to 5 and the control group. No difference in the effects of the extracts of Example 1 and Example 2 was observed.
  • the surgical site was applied with sulfadiazine powder, and heparin solution was applied twice a day to prevent blood coagulation in the catheter. 0.5 ml each was injected. Observation of blood pressure and heart rate was performed 24 hours after insertion of the catheter. Systolic and diastolic blood pressures were measured by connecting the catheter inserted into the carotid artery directly to a Statham pressure transducer (P23 ID), and the average arterial pressure was simultaneously recorded in different channels. The position of the pressure transducer was kept parallel to the position of the rat heart. Heart rate was measured in other channels via cardio-tachograph (7P44C) of arterial wave.
  • Rats carried to measure blood pressure and heart rate were left for 2 hours for stability and sedation, and then blood pressure and heart rate were measured.
  • the blood pressure and heart rate obtained as a result of the experiment were obtained by averaging 10 values read for 5 minutes every 30 seconds.
  • As a result of measuring blood pressure in the systolic blood pressure in the state having the same heart rate, it was confirmed that the excellent systolic blood pressure drop effect in the extract of Example 2 compared to the control group, the same was observed in the diastolic blood pressure and the average blood pressure (see Table 3). .
  • the extract of Example 1 had a slight effect, but the effect was not higher than the extract of Example 2 and Comparative Examples 1 to 5 did not show a significant effect.
  • Filtrate filtrates of the extracts of Examples 1 to 2 and Comparative Examples 1 to 5 were each ingested by 120 ml twice daily for 30 days in the morning and evening for 30 days, and then blood glucose was measured at 5 day intervals. It was. Blood glucose was measured using a self glucose meter after fasting for at least 8 hours. As a control group, diabetic patients who did not consume the extract were compared. Blood glucose levels lowered to 126 mg / dL or less blood glucose were the basis for recovery to normal blood glucose.
  • Table 4 is a table showing the number of people whose blood sugar recovered to normal blood glucose among 15 patients of diabetic patients who took each extract on the date of measuring each blood glucose.
  • Example 2 the extract of Example 1 and Example 2 was found to have the effect of restoring the blood sugar of the diabetic patients to normal.
  • the pine needle extract added in Example 2 did not seem to have any effect on lowering blood sugar, and each single extract, yew and pine needle extract and mulberry and yew extract showed little effect.
  • the filtrates of the extracts of Examples 1 to 2 and Comparative Examples 1 to 5 were each ingested by 120ml twice daily for 120 days twice a day in the morning and evening for 15 hypertension patients, and then manual medical sphygmomanometer at 5-day intervals. Blood pressure was measured using. The blood pressure was based on the fact that the systolic blood pressure was lowered to 140 mmHg or less and the diastolic blood pressure was lowered to 90 mmHg or less.
  • Table 5 is a table showing the number of persons whose blood pressure of each hypertension patient returned to normal out of 15 at each measurement date.
  • Example 2 Checking the results of Table 5, the extract added pine needles to yeast and mulberry extract in Example 2 was the most effective in recovering high blood pressure to normal blood pressure, and extracts using only yew and mulberry trees were less effective than the extract added pine needles It was. Also, each single extract, yew and pine needle extract, and mulberry and pine needle extract had little effect.
  • Yew and mulberry extract or yeast, mulberry and pine needle extract produced using the present invention can be added to medicines or foods and prepared and used to treat diabetes or hypertension.
  • the present invention provides a pharmaceutical and functional food for treating diabetes and hypertension using yeast and mulberry extract or yeast, mulberry and pine needle extract.
  • the above ingredients are mixed and filled in an airtight cloth to prepare a powder.
  • the above ingredients are mixed and filled in an airtight cloth to prepare a powder.
  • tablets are prepared by tableting according to a conventional method for preparing tablets.
  • tablets are prepared by tableting according to a conventional method for preparing tablets.
  • the above ingredients are mixed and filled into gelatin capsules to prepare capsules.
  • the above ingredients are mixed and filled into gelatin capsules to prepare capsules.
  • Vitamin Blend ... ..
  • Nicotinic Acid Amide ... 1.7mg
  • Vitamin Blend ... ..
  • composition ratio of the above-mentioned vitamin and mineral mixtures is composed of relatively suitable ingredients suitable for health foods in a preferred formulation example, but the compounding ratios may be arbitrarily modified, and the above ingredients are mixed according to a conventional health food manufacturing method.
  • the granules may be prepared and used for preparing a health food composition according to a conventional method.
  • the compounding ratio may be arbitrarily modified according to regional and ethnic preferences such as demand hierarchy, demand country, and use purpose.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Botany (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne des extraits de mélange de Taxus cuspidata et de mûrier ou des extraits de mélange de Taxus cuspidata, de mûrier et d'épines de pin, qui peuvent être utilisés en tant qu'agents thérapeutiques pour le diabète ou l'hypertension. Les épines de pin, l'écorce de Morus, qui est l'écorce de la racine du mûrier, ou des feuilles et des tiges de mûrier sont connues pour leur efficacité contre le diabète ou l'hypertension. Cependant, la première utilisation de Taxus cuspidata en tant qu'agent thérapeutique pour le diabète ou l'hypertension est décrite dans la présente invention. Les extraits de mélange de Taxus cuspidata et de mûrier ou les extraits de mélange de Taxus cuspidata, de mûrier et d'épines de pin selon la présente invention présentent des effets supérieurs remarquables contre le diabète ou l'hypertension chez les animaux ou les humains par comparaison à l'extrait pur de mûrier ou d'épine de pin.
PCT/KR2010/006829 2009-10-08 2010-10-06 Composition pharmaceutique pour traiter le diabète ou l'hypertension à l'aide d'extraits de taxus cuspidata et de mûrier, et procédé pour sa préparation Ceased WO2011043590A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0095563 2009-10-08
KR1020090095563A KR100949482B1 (ko) 2009-10-08 2009-10-08 주목과 뽕나무 추출물을 이용한 당뇨 또는 고혈압 치료용 약학 조성물 및 이의 제조 방법

Publications (2)

Publication Number Publication Date
WO2011043590A2 true WO2011043590A2 (fr) 2011-04-14
WO2011043590A3 WO2011043590A3 (fr) 2011-08-18

Family

ID=42183782

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/006829 Ceased WO2011043590A2 (fr) 2009-10-08 2010-10-06 Composition pharmaceutique pour traiter le diabète ou l'hypertension à l'aide d'extraits de taxus cuspidata et de mûrier, et procédé pour sa préparation

Country Status (2)

Country Link
KR (1) KR100949482B1 (fr)
WO (1) WO2011043590A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101310539B1 (ko) * 2013-01-18 2013-09-23 김석근 주목 나무 잎의 성분이 포함된 액상 추출물의 제조방법 및 그 액상 추출물
KR20170096030A (ko) * 2014-11-10 2017-08-23 농업회사법인 주식회사 미라클바이오 뽕나무 추출물을 함유하는 호흡기 질환 치료용 약학 조성물 및 항균 조성물
KR101736036B1 (ko) * 2015-06-15 2017-05-16 오동석 주목, 뽕나무 및 여주 추출물을 포함하는 당뇨병의 예방 또는 치료용 조성물 및 이의 제조 방법
KR101791802B1 (ko) * 2016-12-29 2017-10-30 최동림 뽕나무와 측백나무를 이용한 건강 증진용 환 및 농축액 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800817A (en) * 1996-03-11 1998-09-01 Verge; Andre J. Plant extracts and therapy for insulin deficiencies
KR100529793B1 (ko) * 1997-01-27 2005-11-23 링 지 솔잎 추출물 및 이것의 용도
US6551627B1 (en) * 2001-05-03 2003-04-22 Holomed Pharmaceuticals, Ltd. Medicinal herbal compounds for the prevention and treatment of diabetes
KR100468429B1 (ko) * 2001-09-07 2005-01-27 주식회사 엔바이오테크놀러지 알파-글루코시다제 저해활성이 있는 소나무 추출물 및 그추출방법
KR20050031251A (ko) * 2003-09-29 2005-04-06 최진우 당뇨병 치료 및 예방제
KR20060120321A (ko) * 2005-05-19 2006-11-27 한상민 혈당강하 효능이 있는 건강식품 조성물

Also Published As

Publication number Publication date
WO2011043590A3 (fr) 2011-08-18
KR100949482B1 (ko) 2010-03-24

Similar Documents

Publication Publication Date Title
WO2011043590A2 (fr) Composition pharmaceutique pour traiter le diabète ou l'hypertension à l'aide d'extraits de taxus cuspidata et de mûrier, et procédé pour sa préparation
WO2013100340A1 (fr) Composition comprenant un extrait de dendropanax morbiferus pour améliorer la fonction sexuelle masculine
WO2011115416A2 (fr) Fraction de sedum sarmentosum pour décomposer l'alcool et soulager la gueule de bois
KR100601390B1 (ko) 혼합 생약재를 이용한 비만 억제용 조성물
KR100964603B1 (ko) 주목과 뽕나무 추출물을 이용한 당뇨 치료용 약학 조성물 및 이의 제조 방법
JP6980791B2 (ja) 胃炎または消化性潰瘍予防または治療用組成物
WO2009091121A2 (fr) Composition renfermant des extraits de lysimachia clethroides pour la prévention et le traitement de maladies cardio-vasculaires
US8455014B2 (en) Composition comprising Trachelospermi caulis and Pyrola japonica extracts for the treatment and prevention of inflammatory diseases
WO2024147689A1 (fr) Composition pour inhiber le coronavirus, comprenant un extrait complexe double de mélange contenant du phellodendri cortex, de l'aulne et du fenouil
KR101131719B1 (ko) 백두옹 추출물을 유효성분으로 포함하는 염증성 질환 치료 및 예방용 조성물
WO2012105816A2 (fr) Composition destinée à prévenir et traiter le diabète et les complications du diabète comprenant une poudre d'amphicarpaea edgeworthii var. trisperma ou un extrait de celle-ci
WO2011019153A2 (fr) Composition pour la prévention ou le traitement de l’arthrite, contenant un extrait d’un mélange médicinal à base de plantes de schisandra chinensis baillon, scutellaria baicalensis et kalopanax pictus nakai en tant qu’ingrédient actif
WO2012138076A2 (fr) Composition contenant un mélange d'extraits végétaux pour la prévention ou le traitement de maladies gastro-intestinales
KR20120092444A (ko) 심혈관계 질환 치료 및 예방을 위한 복합생약 추출물을 유효성분으로 함유하는 조성물 및 이의 제조 방법
KR20050116007A (ko) 생약추출물이 함유된 간질환 예방 또는 치료용 약학 조성물
WO2021246703A1 (fr) Composition anti-obésité
WO2017030419A1 (fr) Composition incluant un extrait ou une fraction raf. d'euphorbia supina comme ingrédient actif pour la prévention ou le traitement de l'obésité
JP7553216B2 (ja) Ｈｇｆ産生促進剤及びその製造方法
CN101152355A (zh) 大叶蛇葡萄提取物在制备治疗高血压药物中的应用
JP2022519330A (ja) セリシンを含む脂肪肝の治療、予防、又は緩和用組成物及び該組成物の製造方法
WO2018226038A1 (fr) Composition pour le traitement, la prévention ou le soulagement d'une maladie cardiovasculaire comprenant un composant de médicament brut de variant de saule
US20220233623A1 (en) Composition, comprising aucklandia lappa decne. extract, for preventing hair loss or promoting hair regrowth
KR100787174B1 (ko) 반하, 백출, 천마, 진피, 복령, 산사, 희렴 및 황련을포함하는 한약제제 혼합물의 동맥경화 및 관련 질환의 예방및 치료용 추출물과, 이를 유효성분으로 함유하는동맥경화 및 관련 질환의 예방 및 치료용 약학 조성물
WO2019245245A1 (fr) Composition pharmaceutique pour la prévention et le traitement d'une lésion hépatique comprenant un extrait de curcuma
EP1925312B1 (fr) Racine de réglisse fermentée pour le traitement des complications des diabètes mellitus

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10822235

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10822235

Country of ref document: EP

Kind code of ref document: A2