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WO2010143879A2 - Composition cosmétique destinée à éliminer les rides, contenant un extrait d'ormeau en tant que principe actif - Google Patents

Composition cosmétique destinée à éliminer les rides, contenant un extrait d'ormeau en tant que principe actif Download PDF

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Publication number
WO2010143879A2
WO2010143879A2 PCT/KR2010/003690 KR2010003690W WO2010143879A2 WO 2010143879 A2 WO2010143879 A2 WO 2010143879A2 KR 2010003690 W KR2010003690 W KR 2010003690W WO 2010143879 A2 WO2010143879 A2 WO 2010143879A2
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WIPO (PCT)
Prior art keywords
extract
abalone
cosmetic composition
skin
active ingredient
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2010/003690
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English (en)
Korean (ko)
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WO2010143879A3 (fr
Inventor
정원철
김지은
박은지
강성국
박난희
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MEDIPLAN CO Ltd
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MEDIPLAN CO Ltd
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Publication date
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Publication of WO2010143879A2 publication Critical patent/WO2010143879A2/fr
Publication of WO2010143879A3 publication Critical patent/WO2010143879A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds

Definitions

  • the present invention relates to a cosmetic composition for improving skin wrinkles containing the abalone extract as an active ingredient.
  • Abalone belongs to the abalone and abalone genus of Archaeogastropoda, which is a taxonomy useful for molluscs. It is known as a highly valuable functional marine product in Korea, China, and Japan. Abalone has a high moisture content, a low fat content among shellfish, and is rich in vitamin B1, vitamin B12, calcium and phosphorus. In addition, it contains collagen, which forms most of organic substances such as skin and bone, and chondroitin sulfate, a functional material having an effect of inhibiting skin aging, inflammation, and analgesic effects. According to the Oriental Medicine, abalone is effective for skin beauty, such as treating skin swelling, and has been used for medicinal purposes as well as food.
  • ECM dermal extracellular matrix
  • the collagen fibers are cross-linked with the maturation to become a large linear straight, imparted proper elasticity, elastin fibers are rich in elasticity to impart moderate flexibility to the skin.
  • fibroblast activity decreases, quantitative decrease in dermal extracellular matrix and qualitative changes occur, and collagen fibers are stiffened by the formation of abnormal aging crosslinks, which inherently loses their original elasticity.
  • elastin fibers are denatured and collapsed by photoaging, and elastins with different amino acid resistances are formed to cause functional disorders. As such, the natural and photo-aged skin loses its flexibility and wrinkles are generated.
  • Active oxygen one of the causes of skin aging, causes acute and chronic inflammation, degeneration of extracellular matrix, and wrinkle and elasticity deterioration along with photooxidation disorders such as lipid peroxidation, DNA disorder, protein degeneration and metabolic abnormalities. Active oxygen and free radicals directly attack the matrix components to decompose or polymerize to generate denaturation and fragmentation, and to initiate Maillard reactions to form aging pigments in collagen fibers.
  • elastin causes wrinkles and loss of elasticity of the skin, and various studies are being conducted on the recovery of wrinkles and the improvement of the distortion of elastin fibers.
  • MMP-1 Collagen degrading enzyme
  • the present invention is to determine whether there is a possibility as a functional cosmetic material for improving skin aging from the abalone gut among marine natural resources material, and to manufacture a wrinkle improvement cosmetics using the same.
  • the present invention relates to a cosmetic composition for improving skin wrinkles, containing an abalone extract as an active ingredient, and more particularly, for improving skin wrinkles containing methanol, ethanol, hot water or 4 ° C. extract of abalone intestine as an active ingredient. It relates to a cosmetic composition.
  • the present invention provides a cosmetic composition for improving skin wrinkles containing abalone extract as an active ingredient.
  • the present invention also provides a cosmetic composition for improving skin wrinkles containing an extract of abalone viscera as an active ingredient.
  • the abalone viscera extract may be any one selected from methanol, ethanol, hot water and 4 °C extract, the extract by ethanol is most preferred.
  • the content of the abalone extract is 1 to 3.5% by weight based on the total weight of the cosmetic composition.
  • the total weight of the abalone viscera extract is less than 0.0001%, the effect is less likely to appear, when more than 20% is likely to cause irritation to the skin, it can also have a significant effect on the stabilization of the formulation.
  • the present invention was prepared wrinkle improvement cream containing 1 ⁇ 3.5% by weight of abalone viscera extract, it was confirmed that the effect of improving the skin wrinkles by applying it directly to the skin.
  • the cosmetic composition of the present invention contains ingredients commonly used in cosmetic compositions in addition to the abalone extract as an active ingredient, and include, for example, conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings, and Carrier.
  • conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings, and Carrier.
  • the cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing , Oils, powder foundations, emulsion foundations, wax foundations and sprays, and the like, but are not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.
  • the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components.
  • animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components.
  • animal oils vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide
  • cellulose derivatives polyethylene glycols
  • silicones bentonites
  • silicas talc or zinc oxide
  • lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.
  • a solvent, solubilizing agent or emulsifying agent is used as the carrier component, for example water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol , Fatty acid esters of 1,3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.
  • liquid carrier diluents such as water, ethanol or propylene glycol
  • suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.
  • the carrier component is aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide.
  • Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.
  • the abalone viscera extract of the present invention is excellent in synthesizing the collagen which is a component of skin dermis, and excellent in inhibiting the production of MMP-1, a collagen degrading enzyme. In addition, it is also excellent in inhibiting melanin synthesis, and also has a feature of restoring skin barrier damage.
  • the cosmetic composition prepared by containing the abalone viscera extract having such an effect as an active ingredient has excellent skin wrinkle improvement effect in both subjective evaluation and objective skin wrinkle measurement when applied directly to the skin, and does not cause skin irritation.
  • the present invention provides a cosmetic method comprising applying a cosmetic composition containing the abalone viscera extract as an active ingredient to human skin.
  • a cosmetic composition containing the abalone viscera extract as an active ingredient to human skin.
  • the cosmetic composition of the present invention may be used alone or in duplicate, or may be used in combination with other cosmetic compositions other than the present invention.
  • the cosmetic composition excellent in improving the skin wrinkles according to the present invention can be used according to a conventional method of use, the number of times of use can be varied according to the user's skin condition or taste.
  • the cosmetic composition of the present invention is a flexible lotion, nourishing lotion, nutrition cream, essence, eye cream, spray or powder formulation, it can be applied to the skin an appropriate amount once, twice or three times a day.
  • the cosmetic composition of the present invention is a massage cream, a surfactant-containing cleansing formulation or a surfactant-free cleansing formulation, a soap, a pack formulation, it may be wiped off, peeled off or washed with water after application to the skin.
  • the soap is liquid soap, powdered soap, solid soap and oil soap
  • the surfactant-containing cleansing formulation is a cleansing foam, cleansing water, cleansing towels and cleansing pack
  • the surfactant-free cleansing formulation is a cleansing cream , Cleansing lotion, cleansing water and cleansing gel, but are not limited thereto.
  • the cosmetic composition containing the abalone viscera extract of high protein is excellent in antioxidant activity and the production of collagen, and the inhibitory effect of collagen, elastase degrading enzyme (MMP-1) Excellent for wrinkle improvement of skin.
  • Figure 1 shows the DPPH antioxidant activity of the abalone extract (methanol, ethanol, hot water and 4 °C).
  • Figure 2 shows the elastase inhibitory activity of the abalone viscera extract (methanol, ethanol, hot water and 4 °C).
  • Figure 3 shows the cell growth rate according to the concentration of abalone viscera extract (methanol, ethanol, hot water and 4 °C).
  • Figure 4 shows the procollagen production according to the concentration of ethanol extract of abalone intestine.
  • Figure 5 shows the evaluation of MMP-1 inhibition according to the concentration of ethanol extract of abalone intestine.
  • Figure 6 shows the elastase inhibitory activity of the anti-wrinkle cream according to the present invention.
  • Figure 7 shows the degree of collagen biosynthesis of the wrinkle improvement cream according to the present invention.
  • Figure 8 shows the degree of inhibition of MMP-1 activity of the wrinkle improvement cream according to the present invention.
  • Abalone was purchased raw abalone from Wando-gun, Jeollanam-do, and washed by separating meat and intestine, and rapidly frozen and stored at -20 ° C. Analysis of the general components of the prepared lyophilized abalone and viscera were measured according to the A.O.A.C. method (AOAC 2000). In other words, moisture is the atmospheric pressure drying method, crude protein is the Kjeldahl method using automatic nitrogen distillation unit (KJELTEC 2200 SYSTEM, Foss, Sweden), crude fat is the automatic fat extraction unit (SOXTEC AVANTI 2055 SYSTEM, Foss, Sweden) The crude fat was determined by Soxhlet extraction, and dry ash was measured by dry ash method.
  • the protein was highest in the abalone meat powder 58.5% and abalone viscera powder 53.3%. Therefore, the abalone powder contained more than 50% protein in both meat and intestine, it can be seen that it can be utilized as a high protein material.
  • the organic solvent was used a grade 1 and special grade
  • the reagents used for the evaluation of the extract was all biochemical grade (Biochemical grade).
  • Each solvent methanol, ethanol, distilled water was added 20 times per 50 g of lyophilized abalone viscera powder, and extracted repeatedly at 60 ° C. for 6 hours, 3 times, and filtered under reduced pressure using 5 ⁇ m paper filter paper (Advantec, No. 2). It was. Subsequently, the resultant was concentrated using a reduced pressure concentrator (Eyela, Japan) and then completely dried, and the yield thereof was measured.
  • Example 2 The sample prepared in Example 2 was taken, mixed with a 0.2 mM DPPH solution, the reaction mixture was left at room temperature for 10 minutes, and the absorbance was measured at 517 nm. At this time, the control group was BHT.
  • the synthetic antioxidant BHT showed the highest activity as 60.9%
  • 4 °C extract of abalone viscera extract showed a similar high activity of 58.6%
  • methanol, ethanol and hot water extract showed about 30% activity.
  • Ursolic acid an inhibitory activity of elastase showed a high activity of 77.7%, but the abalone viscera extract extracted at methanol, ethanol, hot water and 4 °C (sample concentration 100 ⁇ g / ml ) Showed somewhat lower elastase inhibitory activity.
  • the abalone ethanol extract was found to be 36.2%, methanol extract 18.5% and 4 °C extract 24.4%, and ethanol extract showed the highest elastase inhibitory activity.
  • hot water extract it can be seen that almost 1% of the elastase inhibitory activity.
  • Human dermal fibroblasts were CCD-1064SK (Momal human dermal fibroblasts, ATCC CRL-2076, USA), and 10% FBS (fetal bovine serum) was added to IMDM (Iscove's Modified Dulbecco's Midium) medium. Subcultured at 3 ° C., 5% CO 2 conditions with medium replacement every three days. At this time, the cell line is subcultured within 3 to 7 times after thawing.
  • Cytotoxicity was purchased from 3- (4,5-dimethylthiazol-2-yl) -2-5-diphenyltetrazolium bromide (MTT, Sigma, USA). 200 ⁇ l / well of CCD-1064SK (Momal human dermal fibroblast, ATCC CRL-2076, USA) was placed in a 96-well plate at a concentration of 1 ⁇ 10 5 cells / well, and the final concentration of each extract was 50, 100 and The solution was treated to a concentration of 200 ⁇ g / ml and incubated at 37 ° C. and 5% CO 2 conditions for 24 hours.
  • CCD-1064SK Momal human dermal fibroblast, ATCC CRL-2076, USA
  • the methanol extract showed a growth rate of 125-131%, the EtOH extract 137-146% and the hydrothermal extract 134-139%, and the positive control retinoic acid was 117-125%. By showing the growth rate it can be seen that there is no cytotoxicity without the difference between the samples (see Figure 3).
  • the culture solution was removed, washed four times with PBS, 100 ⁇ l of the color developing reagent was injected, incubated for 15 minutes at room temperature, 100 ⁇ l of stop solution, and then placed into a 450 nm enzyme immunoassay device (ELISA reader). Measured.
  • Figure 4 shows the results of examining the amount of collagen biosynthesis by taking a culture solution after incubation by treating the ethanol extract in human fibroblasts by the above concentration.
  • retinoic acid was treated at a concentration of 0.02 ⁇ g / ml
  • the amount of collagen biosynthesis was 453.9 ng / ml.
  • the ethanol extracts treated in the cells at concentrations of 3.125, 6.25, 10, 12.5 and 25 ⁇ g / ml resulted in 686.6 ng / ml, 697.6 ng / ml, 706.9 ng / ml, 718 ng / ml and 677.1 ng / ml. Indicated.
  • the ethanol extract was treated at a lower concentration than the high concentration, it was found that the amount of collagen production increased specifically.
  • the MMP-1 activity of the TNF- ⁇ -treated control group was 39.4 ng / ml, and the sample treated with 3.125 ⁇ g / ml was 47.0 ng / ml and 10 ⁇ g / ml was 45.3 ng / ml. ml, 25 ⁇ g / ml was 47.3ng / ml MMP-1 activity inhibitory effect was higher than the control group. As such, it was found that the inhibition of MMP-1 activity was higher at low concentrations than at high concentrations, which showed similar results to collagen biosynthesis experiments.
  • the antiwrinkle effect of the cosmetic composition containing the abalone viscera extract according to the present invention as an active ingredient was evaluated.
  • the wrinkle improvement cream according to the present invention was found that elastase inhibitory activity was 65.2%, 42.1% increased compared to the control.
  • Collagen biosynthesis evaluation was performed in the same manner as in Example ⁇ 3-3>.
  • the antiwrinkle cream according to the present invention was found to have high collagen biosynthesis.
  • MMP-1 inhibition evaluation was carried out in the same manner as in Example ⁇ 4-4>.
  • control group was 36.391 ng / ml at a concentration of 3.125 ⁇ g / ml, 40.378 ng / ml at 6.25 ⁇ g / ml, 49.262 ng / ml at 10 ⁇ g / ml, and 44.048 ng / ml at 12.5 ⁇ g / ml. And 46.123 ng / ml at 25 ⁇ g / ml.
  • the anti-wrinkle cream according to the present invention is 37.544 ng / ml at 3.125 ⁇ g / ml, 41.568 ng / ml at 6.25 ⁇ g / ml, 46.276 ng / ml at 10 ⁇ g / ml, and 45.235 ng / ml at 12.5 ⁇ g / ml And 47.936 ng / ml at 25 ⁇ g / ml.
  • the MMP-1 inhibitory ability increased as the treatment concentration increased.
  • Carboxyl vinyl polymer ......... 1.0 wt%

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
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  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition cosmétique destinée à éliminer les rides, contenant un extrait d'ormeau en tant que principe actif, et plus particulièrement, une composition cosmétique destinée à éliminer les rides, contenant du méthanol et de l'éthanol des viscères de l'ormeau et un extrait de celles-ci extraites au moyen d'eau chaude ou d'eau à une température de 4°C, en tant que principes actifs. La composition cosmétique contenant un extrait des viscères de l'ormeau à forte teneur en protéines est excellente dans la stimulation de l'activité antioxydante et dans la production de collagène, et présentent d'excellents effets dans l'inhibition des enzymes de rupture de la collagénase ou de l'élastase (MMP-1), et peut donc être utile dans l'élimination des rides.
PCT/KR2010/003690 2009-06-09 2010-06-09 Composition cosmétique destinée à éliminer les rides, contenant un extrait d'ormeau en tant que principe actif Ceased WO2010143879A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090050969A KR20100132245A (ko) 2009-06-09 2009-06-09 전복 추출물을 유효성분으로 함유하는 피부 주름 개선용 화장료 조성물
KR10-2009-0050969 2009-06-09

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WO2010143879A2 true WO2010143879A2 (fr) 2010-12-16
WO2010143879A3 WO2010143879A3 (fr) 2011-05-19

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US20140106001A1 (en) * 2012-10-15 2014-04-17 Commercial Marine Biology Institute, Llc Marine extract compositions and methods of use

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KR101322477B1 (ko) * 2011-09-15 2013-10-29 조선대학교산학협력단 항산화 및 안지오텐신전환효소 억제 효과를 갖는 전복 추출물 및 이를 함유하는 기능성 조성물
KR101336804B1 (ko) * 2013-07-23 2013-12-03 주식회사 유로코스텍 버섯을 이용한 전복 버섯 발효물, 이의 제조방법 및 이를 포함하는 화장품 조성물
US20190290574A1 (en) * 2015-12-08 2019-09-26 University Of Pretoria Topical skin care compositions comprising myrsine africana extracts
KR102094073B1 (ko) * 2018-05-11 2020-03-26 대구한의대학교산학협력단 흑설 추출물의 포함하는 피부 주름 개선용 화장료 조성물
KR102148703B1 (ko) * 2019-02-20 2020-08-31 군산대학교 산학협력단 전복에서 유래한 펩타이드를 유효성분으로 포함하는 피부주름 개선용 조성물
KR102754564B1 (ko) * 2024-08-21 2025-01-14 한국해양과학기술원 전복 내장 추출물을 유효성분으로 함유하는 피부 개선용 조성물
WO2025048379A1 (fr) * 2023-08-28 2025-03-06 한국해양과학기술원 Composition pour améliorer la peau, contenant un hydrolysat de viscères d'abalone ou un extrait de viscères d'abalone en tant que principe actif

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JPH07285873A (ja) * 1994-04-14 1995-10-31 Kunio Tsuji 代謝活性化剤及びこれを含有する皮膚外用剤並びに浴用剤
US20060018867A1 (en) * 2004-05-12 2006-01-26 Ichimaru Pharcos Co., Ltd Cosmetic composition and production thereof
KR100852864B1 (ko) * 2007-04-13 2008-08-18 보령메디앙스 주식회사 초록입 홍합(Ｐｅｒｎａ Ｃａｎａｌｉｃｕｌｕｓ.)추출물을 함유하는 화장료 조성물

Cited By (4)

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US20140106001A1 (en) * 2012-10-15 2014-04-17 Commercial Marine Biology Institute, Llc Marine extract compositions and methods of use
WO2014062607A1 (fr) * 2012-10-15 2014-04-24 Commercial Marine Biology Institute, Llc Compositions d'extrait marin et procédés d'utilisation
US20160228352A1 (en) * 2012-10-15 2016-08-11 I Commercial Marine Biology Institute, LLC Marine extract compositions and methods of use
US10772825B2 (en) * 2012-10-15 2020-09-15 Marine Biology % Environmental Technologies, LLC Marine extract compositions and methods of use

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WO2010143879A3 (fr) 2011-05-19
KR20100132245A (ko) 2010-12-17

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