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WO2016024753A1 - Composition cosmétique pour améliorer les rides de la peau - Google Patents

Composition cosmétique pour améliorer les rides de la peau Download PDF

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Publication number
WO2016024753A1
WO2016024753A1 PCT/KR2015/008197 KR2015008197W WO2016024753A1 WO 2016024753 A1 WO2016024753 A1 WO 2016024753A1 KR 2015008197 W KR2015008197 W KR 2015008197W WO 2016024753 A1 WO2016024753 A1 WO 2016024753A1
Authority
WO
WIPO (PCT)
Prior art keywords
rhubarb
baekryeom
pogongyoung
leaflets
mixed extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2015/008197
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English (en)
Korean (ko)
Inventor
장영표
정세영
김동일
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyung Hee University
Industry Academic Cooperation Foundation of Dongguk University
Original Assignee
Kyung Hee University
Industry Academic Cooperation Foundation of Dongguk University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyung Hee University, Industry Academic Cooperation Foundation of Dongguk University filed Critical Kyung Hee University
Priority to CN201580052455.0A priority Critical patent/CN106714779A/zh
Publication of WO2016024753A1 publication Critical patent/WO2016024753A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/591—Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Definitions

  • the present invention relates to a cosmetic composition for improving skin wrinkles comprising a herbal extract mixture.
  • the causes of wrinkles can be broadly divided into the generation of wrinkles by natural aging and the generation of wrinkles by UV exposure (photoaging), and the mechanism of wrinkle formation by two causes is not known yet.
  • Common phenomena found in relation to skin changes due to natural aging and photoaging are the reduction and modification of collagen and elastin, the major constituent proteins in the dermis, and the reduction of skin elasticity due to the reduction of the hyaluronic acid, the substrate of the dermis.
  • collagen and elastin the major constituent proteins in the dermis
  • the reduction of skin elasticity due to the reduction of the hyaluronic acid, the substrate of the dermis the reduction and modification of the main proteins in the dermis, collagen and elastin, are directly involved in the formation of wrinkles and the deterioration of skin elasticity.
  • Collagen the major constituent of the extracellular matrix, is the major matrix protein produced by the fibroblasts of the skin. It is also an important protein, accounting for about 30% of the total weight of biological proteins, and has a solid triple helix structure. Collagen forms most of the organic material in the skin, tendons, bones and teeth, especially in bones and skin.
  • Collagen is reduced by age and photoaging by ultraviolet irradiation, which is known to be closely associated with wrinkle formation of the skin. Collagen also plays an important role in wound healing and promotes the synthesis of collagen in the damaged epithelium, allowing the wound to recover quickly and without scars.
  • collagen synthesis promoting substances include vitamin C, retinoic acid, protein from animal placenta, betulinic acid, and chlorella extract.
  • An object of the present invention to provide a cosmetic composition having a wrinkle improvement and elasticity enhancing effect.
  • It is another object of the present invention to provide a method for improving wrinkles comprising applying an effective amount of pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract.
  • Still another object of the present invention is to provide a use of pogongyoung, rhubarb, non-leafed and white spirit mixed extract in the preparation of cosmetics for wrinkle improvement.
  • the present inventors earnestly researched to develop a cosmetic composition having the effect of improving wrinkles and elasticity, and confirmed that the mixed extract of pogongyoung, rhubarb, non-leaflets and baekryeom has excellent wrinkle improvement and elasticity enhancing effect, and completed the present invention. .
  • the present invention provides pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract.
  • Pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract of the present invention according to the synergistic effect of the four kinds of medicinal herbs, has a lower cytotoxicity than when using each medicinal herbs and has excellent wrinkle improvement and elasticity enhancing effect.
  • pogongyoung is the Asteraceae (Compositae) is a sentinel of dandelion (Taraxacum platycarpum H.) or other dongsok plant, it is widely distributed in Korea, China and elsewhere.
  • Rhei Rhizoma is dried root stem of Rheum palmatum L., Rheum tanguticum M., Medicinal rhubarb Rheum officinale B. of Polygonaceae. It is widely distributed in China and Korea.
  • Eriobotryae Folium is dried leaves of Rosaceae Eriobotrya japonica L., widely distributed in Korea, China, Japan and the like.
  • Ampelopsis Radix is dried root of Ampelopsis japonica Makino, which is a deciduous vine stem plant belonging to the Vitaceae, and is widely distributed in China and Korea.
  • the medicinal herbs can be easily obtained at low cost at home and abroad, and purchased or directly collected.
  • pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract may be an extract after first mixing these extracts, or may be a mixed extract after each of these extracts, preferably the mixed extract of the present invention poongyoung, rhubarb, The extract extracted after mixing non-lobe and pneumonia is used.
  • the mixed extract may be a concentrated liquid or may be in the form of a lyophilized powder.
  • Mixed extract of the present invention is poongyoung 30% to 50% by weight, rhubarb 15% to 30% by weight, 15% to 30% by weight of non-leaflets and 10% to 100% by weight relative to the total weight of poongyoung, rhubarb, non-leaf and baekryeom mixed extract 20 wt%, preferably 35 wt% to 50 wt% of poongongyoung, 17 wt% to 30 wt% of rhubarb, 17 wt% to 30 wt% of non-leaflets, and 15 wt% to 20 wt% of baekryeom. It may include.
  • the pogongyoung, rhubarb, non-leaflets and baekryeom of the mixed extract of the present invention may have a ratio of poongyoung: rhubarb: non-leaflets: baekryeom 4: 2: 2: 1.5 based on the weight ratio.
  • the mixed extract of the present invention exhibits a remarkably superior effect on improving skin wrinkles or enhancing skin elasticity, as compared to the individual extracts or combination combinations of two or more by including the weight% described above for the four medicinal herbs, in particular MMP-1 expression inhibition At the same time, it has a remarkable effect on Type-1 pro collagen enhancement, thereby showing excellent activity in improving skin wrinkles and enhancing skin elasticity.
  • pogongyoung, rhubarb, non-leaflet and baekryeom mixed extract can be prepared using an extraction method such as hot water extraction, immersion extraction, reflux cooling extraction and ultrasonic extraction, the number of extraction is 1 to 5 times desirable.
  • the extraction solvent is preferably water, an alcohol having 1 to 4 carbon atoms or a mixture thereof, preferably water, an aqueous ethanol solution, but is not limited thereto.
  • the amount of the extraction solvent is 2 to 15 times the total weight of pogongyoung, rhubarb, non-leaflets and baekryeom.
  • hot water (water) extract may be repeated 1 to 4 times the extraction of the water bath reflux for 2 to 24 hours at 100 ⁇ 110 °C preferably 2 to 10 hours.
  • the present invention provides a fraction of pogongyoung, rhubarb, non-leaflet and baekryeom mixed extract obtained by further separating the pogongyoung, rhubarb, non-leaflet and baekryeom mixed extract. Fractionation is carried out by separation methods known in the art.
  • the pogongyoung, rhubarb, non-leaflets and baekryeom suspending in water, and then extracted using a solvent such as hexane, chloroform, ethyl acetate, butanol to obtain a soluble extract of poongyoung, rhubarb, non-leaflets and baekryeom.
  • the present invention also provides a cosmetic composition for improving skin wrinkles including pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract.
  • Pogongyoung, rhubarb, non-leaflet and baekryeom mixed extract of the present invention using a safe natural formulation has no side effects when applied to the skin, and at the same time inhibit the MMP-1 expression and at the same time improve the type-1 procollagen to improve skin elasticity and wrinkle improvement It has an excellent effect and shows an excellent effect as a cosmetic composition for improving skin wrinkles.
  • the cosmetic composition for improving skin wrinkles including pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract of the present invention when compared to each of these extracts alone or two or more combination extracts, medicinal herbs liver of pogongyoung, rhubarb, non-leaflet and baekryeom Due to the synergistic effect of the combination has a better skin wrinkle improvement.
  • cosmetic composition for improving skin wrinkles including poongyoung, rhubarb, non-leaflets and baekryeom mixed extract of the present invention is individual It has a significant synergistic effect by the combination of medicines, and shows a significant effect on both the inhibition of the expression of collagen degrading enzyme MMP-1 and the enhancement of the biosynthesis amount of the collagen precursor type-1 pro collagen.
  • pogongyoung is a high cytotoxic substance has a problem that can only be used at low concentrations in the treatment of the human body
  • the extract of the present invention solves the cytotoxicity problem by the combination of medicinal herbs and inhibits MMP-1 expression and Type-1 In contrast to the individual extract in that it showed a significant effect on the procollagen enhancement.
  • pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract may be added to the cosmetic in an amount of 0.001% to 10% by weight in powder form or liquid form relative to the total weight of the cosmetic composition, preferably to the total weight of the cosmetic composition It may be added to the cosmetic in an amount of 0.01 to 5% by weight in powder form or liquid form.
  • the components included in the cosmetic composition include components commonly used in cosmetic compositions in addition to pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract as an active ingredient, for example, antioxidants, stabilizers, solubilizers, vitamins, pigments, pigments And conventional adjuvants such as perfumes, and carriers.
  • the cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing , Oils, powder foundations, emulsion foundations, wax foundations and sprays, and the like, but are not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, pack, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.
  • the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, trakant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide, etc. may be used as carrier components.
  • animal oil vegetable oil, wax, paraffin, starch, trakant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide, etc.
  • trakant cellulose derivative
  • polyethylene glycol silicone
  • bentonite silica
  • talc or zinc oxide etc.
  • lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.
  • a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, butyl Ethylene glycol, 1,3-butylglycol oil, polyoxyethylene hardened castor oil, glycerol, glycerin, aliphatic ester, phenoxyethanol, triethanolamine, polyethylene glycol, beeswax, polysorbate 60, sorbitan sesquiolade, paraffin, Sorbitan stearate, lipophilic monostearic acid glycerine, stearic acid, glyceryl stearate / fiji-400 stearate, carboxypolymer, cytososterol, polyglyceryl 2-oleate, ceramide, cholesterol,
  • a solvent, solubilizer or emulsifier
  • suspensions such as liquid diluents such as water, ethanol, butylene glycol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters as carrier components
  • microcrystalline cellulose, hydroxyethyl cellulose, sodium hyaluronate, phenoxyethanol, aluminum meta hydroxide, bentonite, agar or tracant and the like can be used.
  • the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide.
  • Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.
  • the present invention provides a method for improving wrinkles, comprising applying an effective amount of pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract.
  • the term "effective amount” refers to the amount of pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract exhibiting a preventive or alleviating effect on the skin wrinkles.
  • the anti-wrinkle method of the present invention comprises contacting the skin with a composition comprising a pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract.
  • the skin includes, but is not limited to, skin of the face, skin of the neck, skin of the hands and arms, and skin of the feet and legs.
  • the dose of pogongyoung, rhubarb, non-lobe and pneumoniae mixed extract will vary depending on the age of the subject, the progression of the wrinkles, or the site of application. Appropriate doses can be readily selected by those skilled in the art, which, of course, consider such factors.
  • pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract may be applied with an effective amount of additional active agent to help improve skin wrinkles.
  • Wrinkle improvement method of the present invention may further comprise the step of identifying a portion that needs to be improved wrinkles.
  • the verification may be performed by a user or a third party, such as a dermatologist, beauty specialist, or other individual.
  • the present invention provides the use of pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract in the preparation of cosmetics for wrinkle improvement.
  • the pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract for cosmetic preparation may be mixed with acceptable adjuvants, diluents, etc., may be mixed with other active agents and have a synergistic effect.
  • Such other active agents can be, for example, sunscreens, moisturizers, exfoliants, emollients, whitening agents and the like.
  • Pogongyoung, rhubarb, non-leaflet and baekryeom mixed extract of the present invention using a safe natural formulation has no side effects, wrinkles improvement, elasticity by promoting collagen production, inhibition of collagenase (MMP-1) expression and type-1 procollagen expression, etc. Has a promoting effect.
  • 1 is a diagram confirming the change of Type-1 Procollagen according to the treatment of pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract.
  • Figure 2 is a diagram confirming the expression change of MMP-1 according to the treatment of pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract.
  • poongyoung pogongyoung, rhubarb, non-leaflet and baekryeom mixed extract
  • poongyoung poongyoung (origin: Korea), rhubarb (origin: China), non-leafy (origin: China), baekryum (origin: China) purchased from OmniHerb Used after washing with water and drying.
  • pogongyoung, rhubarb, non-leaflets and baekryeom individual extract 100g each individual medicinal herbs in 1 L of distilled water, fitted with a reflux tube and reflux extracted at 100 °C for 4 hours, concentrated under reduced pressure to poongyoung 20 g, rhubarb 28 g, 12 g of non-leaflets and 16 g of pneumonia were prepared.
  • Human fibroblasts were aliquoted into 24-wells at 10 4 cells / well per well using DMEM culture (10% fetal bovine serum, 1% antibiotics). After confirming the adherence of the cells, the culture medium was removed, and then 0.5 mL of each extract of pogongyoung, rhubarb, non-leaflets, and baekryeom prepared at concentrations (50, 100, and 200 ⁇ g / mL) showed no toxicity as a result of toxicity. . After incubation for 48 hours in an incubator at 37 ° C., 5% CO 2 condition, wrinkle formation factors (type-I procollagen, matrix metalloproteinase-1) in the culture were measured.
  • wrinkle formation factors type-I procollagen, matrix metalloproteinase-1
  • the type-1 procollagen increase effect of the present invention overcomes the limitation of treatment capacity due to cytotoxicity of pogongyoung, rhubarb, non-leaflets or baekryeom individual extracts depending on the type of medicinal herbs, type-1 significantly increased compared to the individual medicinal herbs It was confirmed that the procollagen increase effect.
  • Human fibroblasts were aliquoted into 24-well at 10 4 cells per well using DMEM culture (10% fetal bovine serum, 1% antibiotics). After confirming the adhesion of the cells, the culture solution was removed, and then treated with poglucose, rhubarb, non-leaflets, and baekryeom mixed extract prepared for each concentration 0.5 mL each well. After incubation for 48 hours in an incubator at 37 ° C., 5% CO 2 conditions, MMP-1 in the culture was measured.
  • the concentration of the collagen degrading enzyme MMP-1 was 50. 100 and 200 ⁇ g / mL in the experimental group treated with pogongyoung, rhubarb, non-leaflet and baekryeom mixed extract at 45.0, 52.8 and 58.7%, respectively. It was confirmed that the decrease ( p ⁇ 0.001).
  • the MMP-1 inhibitory effect of the present invention overcomes the limitation of treatment capacity due to cytotoxicity of pogongyoung, rhubarb, non-leaflets or baekryeom individual extracts depending on the type of medicinal herbs, significantly increased MMP-1 inhibition compared to the individual medicinal herbs It confirmed that it showed an effect.
  • MMP-1 inhibition and Type-1 procollagen biosynthesis enhancement should be performed at the same time.
  • Pogongyoung, rhubarb, non-leaflet and baekryeom mixed extract of the present invention solves the cytotoxic problems of each individual medicinal herbs harmless to the human body, while having high MMP-1 inhibition and Type-1 procollagen biosynthesis When the effect was shown, it was confirmed that the cosmetic composition for improving wrinkles showed a remarkable effect.
  • Table 1 Composition of the lotion containing pogongyoung, rhubarb, non-leaflets and baekryeom
  • the nutrition lotion containing pogongyoung, rhubarb, non-leaflets and baekryeom mixed extract was prepared in the content of 1kg to the following Table 2.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne un mélange d'extraits de Taraxicum officinalis, Eisenia bicyclis, feuille d'Eriobotrya japonica et Ampelopsis japonica Makino. La présente invention comprend des agents naturels sûrs, de manière à ne pas causer des effets secondaires, et présente les avantage d'amélioration des rides et d'augmentation de l'élasticité par stimulation de la production de collagène, d'inhibition de l'expression de collagénase (MMP-1), et d'augmentation de l'expression de procollagène de type-1.
PCT/KR2015/008197 2014-08-11 2015-08-05 Composition cosmétique pour améliorer les rides de la peau Ceased WO2016024753A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201580052455.0A CN106714779A (zh) 2014-08-11 2015-08-05 用于改善皮肤皱纹的化妆品组合物

Applications Claiming Priority (2)

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KR1020140104013A KR101753306B1 (ko) 2014-08-11 2014-08-11 피부 주름 개선용 화장료 조성물
KR10-2014-0104013 2014-08-11

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WO2016024753A1 true WO2016024753A1 (fr) 2016-02-18

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KR102121006B1 (ko) * 2019-11-11 2020-06-09 주식회사 래디안 서양민들레잎 추출물을 포함하는 피부 개선용 화장료 조성물
CN110840807B (zh) * 2019-12-14 2022-06-07 广州尚妆优品生物科技有限公司 祛皱组合物
CN112501216B (zh) * 2020-12-17 2023-04-11 中国热带农业科学院热带生物技术研究所 绿藻高效生产维a酸的方法

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KR20060044298A (ko) * 2004-03-09 2006-05-16 주식회사 한생화장품 비파엽 추출물을 유효성분으로 하는 주름 개선용 화장료 조성물
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KR20110112231A (ko) * 2010-04-06 2011-10-12 (주)아모레퍼시픽 약용 잎을 활용한 쌈 발효법 및 이를 활용한 피부 외용제 조성물

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CN106714779A (zh) 2017-05-24
KR101753306B1 (ko) 2017-07-04
KR20160019631A (ko) 2016-02-22

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