[go: up one dir, main page]

WO2010089764A3 - Improved process for preparation of nebivolol hydrochloride - Google Patents

Improved process for preparation of nebivolol hydrochloride Download PDF

Info

Publication number
WO2010089764A3
WO2010089764A3 PCT/IN2010/000004 IN2010000004W WO2010089764A3 WO 2010089764 A3 WO2010089764 A3 WO 2010089764A3 IN 2010000004 W IN2010000004 W IN 2010000004W WO 2010089764 A3 WO2010089764 A3 WO 2010089764A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzopyran
dihydro
fluoro
nebivolol
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2010/000004
Other languages
French (fr)
Other versions
WO2010089764A2 (en
Inventor
Manne Satyanarayana Reddy
Sajja Eswaraiah
Maramreddy Sahadeva Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSN Laboratories Pvt Ltd
Original Assignee
MSN Laboratories Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MSN Laboratories Pvt Ltd filed Critical MSN Laboratories Pvt Ltd
Publication of WO2010089764A2 publication Critical patent/WO2010089764A2/en
Publication of WO2010089764A3 publication Critical patent/WO2010089764A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

An improved process for the preparation of nebivolol and its pharmaceutically acceptable salts is disclosed Concretely, the process involves a) esterifying 6-fluoro-3,4-dihydro-2H-l-benzopyran-2-carboxylic acid to provide alkyl 6-fluoro-3,4-dihydro-2H-l-benzopyran-2-carboxylate, b) reducing the alkyl 6-fluoro-3,4-dihydro-2H-l-benzopyran-2-carboxylate to provide 6-fluoro-3,4-dihydro-2H-l-benzopyran-2-carboxaldehyde, which is subsequently converted to 6-fluoro-3,4-dihydro-2-oxiranyl-2H-l-benzopyran, c) reacting 6-fluoro-3,4-dihydro-2-oxiranyl-2H-l-benzopyran with benzyl amine in a suitable solvent followed by treatment with suitable organic acid, and recrystalhzing the obtained compound to provide the corresponding organic acid salt of benzyl protected nebivolol, d) debenzylating the benzyl protected nebivolol salt, followed by treatment with hydrochloric acid to provide nebivolol hydrochloride
PCT/IN2010/000004 2009-01-05 2010-01-05 Improved process for the preparation of nebivolol hydrochloride Ceased WO2010089764A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN19/CHE/2009 2009-01-05
IN19CH2009 2009-01-05

Publications (2)

Publication Number Publication Date
WO2010089764A2 WO2010089764A2 (en) 2010-08-12
WO2010089764A3 true WO2010089764A3 (en) 2010-11-04

Family

ID=42542465

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000004 Ceased WO2010089764A2 (en) 2009-01-05 2010-01-05 Improved process for the preparation of nebivolol hydrochloride

Country Status (1)

Country Link
WO (1) WO2010089764A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102329291A (en) * 2011-07-27 2012-01-25 上海现代制药股份有限公司 Method for preparing 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-formaldehyde
ITRM20110418A1 (en) 2011-08-02 2013-02-03 Menarini Int Operations Lu Sa PROCESS FOR THE PREPARATION OF EPOXY WHICH INTERMEDIATES FOR THE SYNTHESIS OF NEBIVOLOL.
ES2700973T3 (en) 2014-02-14 2019-02-20 Corden Pharma Int Gmbh Process without base for the preparation of intermediate ketone compounds that can be used to manufacture nebivolol
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
DE102014107132A1 (en) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Process for the preparation of epoxides which can be used in the preparation of nebivolol and its derivatives
WO2016185492A1 (en) * 2015-05-19 2016-11-24 Ipca Laboratories Limited Process for preparation of nebivolol and it's salts

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654362A (en) * 1983-12-05 1987-03-31 Janssen Pharmaceutica, N.V. Derivatives of 2,2'-iminobisethanol
WO2004041805A1 (en) * 2002-11-06 2004-05-21 EGIS Gyógyszergyár Rt. NEW PROCESS FOR THE PREPARATION OF RACEMIC ([2S[2R*[R[R*]]]] and ([2R[2S*[S[S*]]]]-(±)- α,α' -[imino-bis(methylene)]bis[6-fluoro­chroman-2-methanol] AND ITS PURE [2S[2R*[R[R*]&
WO2006016376A1 (en) * 2004-08-11 2006-02-16 Hetero Drugs Limited A novel process for preparation of nebivolol intermediates
WO2006025070A2 (en) * 2004-07-30 2006-03-09 Torrent Pharmaceuticals Limited Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654362A (en) * 1983-12-05 1987-03-31 Janssen Pharmaceutica, N.V. Derivatives of 2,2'-iminobisethanol
WO2004041805A1 (en) * 2002-11-06 2004-05-21 EGIS Gyógyszergyár Rt. NEW PROCESS FOR THE PREPARATION OF RACEMIC ([2S[2R*[R[R*]]]] and ([2R[2S*[S[S*]]]]-(±)- α,α' -[imino-bis(methylene)]bis[6-fluoro­chroman-2-methanol] AND ITS PURE [2S[2R*[R[R*]&
WO2006025070A2 (en) * 2004-07-30 2006-03-09 Torrent Pharmaceuticals Limited Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol
WO2006016376A1 (en) * 2004-08-11 2006-02-16 Hetero Drugs Limited A novel process for preparation of nebivolol intermediates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CASREACT 6 November 2009 (2009-11-06), Database accession no. 152:525671 *

Also Published As

Publication number Publication date
WO2010089764A2 (en) 2010-08-12

Similar Documents

Publication Publication Date Title
NZ602450A (en) Agomelatine hydrochloride hydrate and preparation thereof
WO2010089764A3 (en) Improved process for preparation of nebivolol hydrochloride
AU2015221439B2 (en) Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same
TN2011000590A1 (en) Preparation of nalmefene hydrochloride from naltrexone
WO2012098461A8 (en) Fused aminodihydrothiazine derivatives
JO2967B1 (en) Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
WO2012042534A3 (en) Preparation of r-sitagliptin and intermediates thereof
MX2011011245A (en) Processes for the preparation of morphinane and morphinone compounds.
NZ601805A (en) Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
WO2010064109A3 (en) An improved process for the preparation of montelukast sodium and its intermediates
PT2462098E (en) Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
WO2011102640A3 (en) Method for preparing sitagliptin and amine salt intermediates used therein
MX2010009876A (en) New process for the preparation of cyclohexanecarboxylic acid derivatives via the corresponding cyclohexanecarboxamide derivative.
WO2009139002A3 (en) An improved process for the preparation of solifenacin and its pharmaceutically acceptable salts thereof
WO2012018791A3 (en) Preparation of prasugrel hydrochloride
WO2011108009A3 (en) Process for the preparation of fampridine
UA106208C2 (en) Process for synthesis of ivabradine and pharmaceutically acceptable acid addition salts thereof
WO2011048612A3 (en) Process for preparation of propargylated aminoindans or pharmaceutically acceptable salts thereof
WO2008059518A3 (en) Process for preparing crystalline aripiprazole
WO2008093205A3 (en) A method for the purification of rosuvastatin intermediate
EP2679580A4 (en) THIOAMIDE COMPOUND, PROCESS FOR PRODUCING THIOAMIDE COMPOUND, PROCESS FOR PRODUCING [(4R, 6R) -6-AMINOETHYL-1,3-DIOXAN-4-YLE) ACETATE DERIVATIVE, AND METHOD FOR PRODUCING THIOAMIDE COMPOUND ATORVASTATIN PRODUCTION
PH12012502478A1 (en) Isoquinoline derivative
WO2009034582A3 (en) Process for the preparation of amorphous fexofenadine hydrochloride
EP2189450A4 (en) Method for producing quinazoline derivative
WO2011157670A3 (en) Process for the preparation of benzamide derivatives

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10738282

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 10738282

Country of ref document: EP

Kind code of ref document: A2