[go: up one dir, main page]

WO2010064109A3 - An improved process for the preparation of montelukast sodium and its intermediates - Google Patents

An improved process for the preparation of montelukast sodium and its intermediates Download PDF

Info

Publication number
WO2010064109A3
WO2010064109A3 PCT/IB2009/007594 IB2009007594W WO2010064109A3 WO 2010064109 A3 WO2010064109 A3 WO 2010064109A3 IB 2009007594 W IB2009007594 W IB 2009007594W WO 2010064109 A3 WO2010064109 A3 WO 2010064109A3
Authority
WO
WIPO (PCT)
Prior art keywords
intermediates
preparation
formula
montelukast
improved process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2009/007594
Other languages
French (fr)
Other versions
WO2010064109A2 (en
Inventor
Chandra Sekhar Nakka Krishnamurthy
Tapan Kashyap
Jagat Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MAYUKA LABS PRIVATE Ltd
Original Assignee
MAYUKA LABS PRIVATE Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MAYUKA LABS PRIVATE Ltd filed Critical MAYUKA LABS PRIVATE Ltd
Publication of WO2010064109A2 publication Critical patent/WO2010064109A2/en
Publication of WO2010064109A3 publication Critical patent/WO2010064109A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a process for the preparation of montelukast sodium (formula I) and formula.4. The invention concerns the coupling of thiol derivative, Methyl I - (mercaptomethyl)cyclopropane acetate with mesylate of formula 4 compound using alkyl substituted ammonium hydroxide base, alkali amides and purification of Montelukast acid by crystallization in suitable organic solvents. The invention further concerns to provide an improved process of montelukast intermediates having good yield and quality.
PCT/IB2009/007594 2008-12-02 2009-12-01 An improved process for the preparation of montelukast sodium and its intermediates Ceased WO2010064109A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2732/DEL/2008 2008-12-02
IN2732DE2008 2008-12-02

Publications (2)

Publication Number Publication Date
WO2010064109A2 WO2010064109A2 (en) 2010-06-10
WO2010064109A3 true WO2010064109A3 (en) 2010-08-26

Family

ID=41818874

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/007594 Ceased WO2010064109A2 (en) 2008-12-02 2009-12-01 An improved process for the preparation of montelukast sodium and its intermediates

Country Status (1)

Country Link
WO (1) WO2010064109A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012077133A1 (en) * 2010-12-07 2012-06-14 Ind-Swift Laboratories Limited Processes for preparation of montelukast sodium and purification of diol intermediate
CN102702097A (en) * 2012-05-16 2012-10-03 浙江大学 Preparation method of montelukast sodium intermediate
JP5553096B2 (en) * 2012-08-29 2014-07-16 大日本印刷株式会社 Manufacturing method of high purity montelukast
WO2014081616A1 (en) * 2012-11-21 2014-05-30 Merck Sharp & Dohme Corp. Preparation of precursors for leukotriene antagonists
CN103012261B (en) * 2013-01-14 2016-02-03 鲁南制药集团股份有限公司 The preparation method of a kind of Menglusitena and intermediate thereof
CN104496899B (en) * 2015-01-15 2017-05-31 安润医药科技（苏州）有限公司 The synthetic method of the intermediate of Menglusitena
CN104592110A (en) * 2015-01-26 2015-05-06 中山奕安泰医药科技有限公司 A kind of technique for synthesizing 2-[3-(S)-[3-[2-(7-chloro-2-quinolyl) vinyl] phenyl]-3-hydroxypropyl] methyl benzoate
CN105294545A (en) * 2015-11-23 2016-02-03 中山奕安泰医药科技有限公司 Method for preparing montelukast nano chiral alcohol intermediate
CN105585525B (en) * 2016-02-29 2018-08-14 山东新时代药业有限公司 A kind of synthetic method of Montelukast Sodium
CN116969999A (en) * 2022-04-22 2023-10-31 台州爱申特科技有限公司 Synthesis and application of novel bidentate nitrogen ligand palladium complex
CN115710221A (en) * 2022-11-29 2023-02-24 宿迁盛基医药科技有限公司 Synthesis method of montelukast sodium intermediate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0480717A1 (en) * 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5614632A (en) * 1993-12-28 1997-03-25 Merck & Co., Inc. Process for the preparation of leukotriene anatgonists
WO2008001213A1 (en) * 2006-06-26 2008-01-03 Aurobindo Pharma Limited An improved process for the preparation of leukotriene receptor antagonist (montelukast sodium)

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0480717A1 (en) * 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5614632A (en) * 1993-12-28 1997-03-25 Merck & Co., Inc. Process for the preparation of leukotriene anatgonists
WO2008001213A1 (en) * 2006-06-26 2008-01-03 Aurobindo Pharma Limited An improved process for the preparation of leukotriene receptor antagonist (montelukast sodium)

Also Published As

Publication number Publication date
WO2010064109A2 (en) 2010-06-10

Similar Documents

Publication Publication Date Title
WO2010064109A3 (en) An improved process for the preparation of montelukast sodium and its intermediates
NZ600119A (en) Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives
WO2009095933A3 (en) Improved and novel process for the preparation of bosentan
WO2008062478A3 (en) Improved process for pure montelukast sodium through pure intermediates as well as novel amine salts
ZA201007977B (en) Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
WO2008096372A3 (en) Process for preparing highly pure ezetimibe using novel intermediates
MX2009003823A (en) Novel diphenylazetidinone substituted by piperazine-1-sulfonic acid having improved pharmacological properties.
WO2009154754A3 (en) Synthesis of deuterated morpholine derivatives
MX2011009898A (en) Process for the preparation of propionic acid derivatives.
PT2462098E (en) Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
WO2010004578A3 (en) Novel and improved processes for the preparation of paliperidone
UA111868C2 (en) METHOD OF PREPARING ETHERS (5-FLUOR-2-METHYL-3-QUINOLIN-2-ILMETHYLINDOL-1-IL) -ACETIC ACID
MX2010009876A (en) New process for the preparation of cyclohexanecarboxylic acid derivatives via the corresponding cyclohexanecarboxamide derivative.
MX2010009926A (en) New process for the preparatiion of cyclohexanecarboxylic acid dericatives.
WO2009060297A3 (en) An improved process for the preparation of paliperidone and its intermediates
WO2011024056A3 (en) An improved process for the preparation of bosentan
MX2013004193A (en) Process for the preparation of 3-(6-amino-pyridin-3yl)-2-acrylic acid derivatives.
WO2015022702A3 (en) Process for preparation of 4,5-dimethoxybenzene derivatives and use in the synthesis of ivabradine and salts thereof
WO2007143014A3 (en) Methods for preparing glutamic acid derivatives and intermediates thereof
NZ598278A (en) Process for preparing biphenyl imidazole compounds
WO2011107076A8 (en) Use of halogenated cyanocinnamic acid derivatives as matrices in maldi mass spectrometry
WO2011070179A8 (en) Process for the preparation of propionic acid derivatives
WO2012070896A3 (en) Synthetic method of enantiomerically pure 2,2'-dihydroxy-1,1'-binaphthyl-3-carboxylic acid
WO2009027811A3 (en) Polymorphs of 3- ( ( (4-tert-butyl-benzyl) - (pyridine-3-sulfonyl) -amino) -methyl) -phenoxy) -acetic acid sodium salt or a hydrate thereof and methods for making the same
WO2012052939A3 (en) Preparation of bicyclo[2.2.2]octan-2-one compounds

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09793574

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09793574

Country of ref document: EP

Kind code of ref document: A2