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WO2010067980A3 - Histone deacetylase inhibitor that reactivates hiv-1 proviruses from latently hiv-infected cells - Google Patents

Histone deacetylase inhibitor that reactivates hiv-1 proviruses from latently hiv-infected cells Download PDF

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Publication number
WO2010067980A3
WO2010067980A3 PCT/KR2009/007162 KR2009007162W WO2010067980A3 WO 2010067980 A3 WO2010067980 A3 WO 2010067980A3 KR 2009007162 W KR2009007162 W KR 2009007162W WO 2010067980 A3 WO2010067980 A3 WO 2010067980A3
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
proviruses
inhibitor
infected cells
latently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/007162
Other languages
French (fr)
Korean (ko)
Other versions
WO2010067980A2 (en
Inventor
홍기종
최병선
김성순
이학성
노성구
현영란
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Centers for Disease Control and Prevention
Original Assignee
Korea Centers for Disease Control and Prevention
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Centers for Disease Control and Prevention filed Critical Korea Centers for Disease Control and Prevention
Priority to KR1020117012184A priority Critical patent/KR101388596B1/en
Publication of WO2010067980A2 publication Critical patent/WO2010067980A2/en
Publication of WO2010067980A3 publication Critical patent/WO2010067980A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a histone deacetylase (HDAC) inhibitor represented by chemical formula 1 that enables reactivation of HIV-1 proviruses from latently HIV-infected cells, and a method for reactivating HIV-1 provirus from latently HIV-infected cells using the inhibitor. The HDAC inhibitor exhibits low cytotoxicity and high stability, and thus can effectively reactivate latent HIV-1 proviruses from a CD4+ T cell reservoir. Accordingly, the HDAC inhibitor is processed together with an HAART cocktail therapeutic drug such as a reverse transcriptase inhibitor AZT, thereby efficiently reducing or removing the latent HIV reservoir.
PCT/KR2009/007162 2008-12-11 2009-12-02 Histone deacetylase inhibitor that reactivates hiv-1 proviruses from latently hiv-infected cells Ceased WO2010067980A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020117012184A KR101388596B1 (en) 2008-12-11 2009-12-02 Histone deacetylase inhibitor that reactivates hiv-1 proviruses from latently hiv-infected cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12190108P 2008-12-11 2008-12-11
US61/121,901 2008-12-11

Publications (2)

Publication Number Publication Date
WO2010067980A2 WO2010067980A2 (en) 2010-06-17
WO2010067980A3 true WO2010067980A3 (en) 2010-09-23

Family

ID=42243170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/007162 Ceased WO2010067980A2 (en) 2008-12-11 2009-12-02 Histone deacetylase inhibitor that reactivates hiv-1 proviruses from latently hiv-infected cells

Country Status (2)

Country Link
KR (1) KR101388596B1 (en)
WO (1) WO2010067980A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016074580A1 (en) * 2014-11-14 2016-05-19 中国科学院上海生命科学研究院 Reagent for improving survival rate and activity of cd4 positive t-lymphocytes and application thereof
KR101978364B1 (en) * 2017-06-15 2019-05-14 크리스탈지노믹스(주) Pharmaceutically acceptable salts of alkylcarbamoyl naphthalenyloxy octenoylhydroxyamide or derivatives thereof and preparing method thereof
US11311603B2 (en) 2018-06-19 2022-04-26 Nantcell, Inc. HIV treatment compositions and methods
KR102678356B1 (en) * 2018-10-29 2024-06-26 씨지인바이츠 주식회사 Alkylcarbamoyl naphthalenyloxy octenoyl hydroxyamide phosphate, alkylcarbamoyl naphthalenyloxy octenoyl hydroxyamide tartrate or combination thereof and preparing method thereof
KR20220118747A (en) * 2021-02-19 2022-08-26 크리스탈지노믹스(주) PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING SARS-CoV-2 INFECTIOUS DISEASE

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004076386A2 (en) * 2003-02-25 2004-09-10 Topotarget Uk Limited Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
WO2007052938A1 (en) * 2005-11-01 2007-05-10 Korea Research Institute Of Chemical Technology Alkylcarbamoyl naphthalenyloxy- octenoylhydroxyamide derivatives having inhibitory activity against histone deacetylase and preparation thereof
WO2008068170A1 (en) * 2006-12-04 2008-06-12 William Paul Jackson Hdac inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004076386A2 (en) * 2003-02-25 2004-09-10 Topotarget Uk Limited Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
WO2007052938A1 (en) * 2005-11-01 2007-05-10 Korea Research Institute Of Chemical Technology Alkylcarbamoyl naphthalenyloxy- octenoylhydroxyamide derivatives having inhibitory activity against histone deacetylase and preparation thereof
WO2008068170A1 (en) * 2006-12-04 2008-06-12 William Paul Jackson Hdac inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YLISASTIGUI, LOYDA ET AL.: "Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression", AIDS, vol. 18, no. ISSUE, 21 May 2004 (2004-05-21), pages 1101 - 1108 *

Also Published As

Publication number Publication date
KR101388596B1 (en) 2014-04-24
WO2010067980A2 (en) 2010-06-17
KR20110096028A (en) 2011-08-26

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