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WO2010059001A3 - 내성암 치료용 고분자 미셀 조성물 및 그 제조방법 - Google Patents

내성암 치료용 고분자 미셀 조성물 및 그 제조방법 Download PDF

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Publication number
WO2010059001A3
WO2010059001A3 PCT/KR2009/006882 KR2009006882W WO2010059001A3 WO 2010059001 A3 WO2010059001 A3 WO 2010059001A3 KR 2009006882 W KR2009006882 W KR 2009006882W WO 2010059001 A3 WO2010059001 A3 WO 2010059001A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
treatment
polymer micelle
micelle composition
cancer cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/006882
Other languages
English (en)
French (fr)
Other versions
WO2010059001A2 (ko
Inventor
강혜원
서민효
김봉오
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Samyang Corp
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Priority to JP2011537369A priority Critical patent/JP5449388B2/ja
Priority to US13/130,259 priority patent/US20110224151A1/en
Priority to EP09827766.8A priority patent/EP2359860B1/en
Priority to CN2009801550218A priority patent/CN102292109A/zh
Publication of WO2010059001A2 publication Critical patent/WO2010059001A2/ko
Publication of WO2010059001A3 publication Critical patent/WO2010059001A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

양친성 이중블록 공중합체 및 유효성분으로서 탁산 및 P-당단백 억제제인 싸이클로스포린을 함유하는 내성암 치료용 고분자 미셀 조성물 및 그 제조방법이 개시된다. 상기 내성암 치료용 고분자 미셀 조성물은, 암조직에 고농도로 축적되고, 상기 암조직에서 탁산계 항암제에 의한 P-당단백의 과다발현으로 내성이 발현된 암세포에 대하여 우수한 항암효과를 나타내며, 가용화제의 사용으로 인한 과민반응이 일어나지 않는다는 장점이 있다.
PCT/KR2009/006882 2008-11-21 2009-11-23 내성암 치료용 고분자 미셀 조성물 및 그 제조방법 Ceased WO2010059001A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2011537369A JP5449388B2 (ja) 2008-11-21 2009-11-23 耐性がん治療用高分子ミセル組成物及びその製造方法
US13/130,259 US20110224151A1 (en) 2008-11-21 2009-11-23 Polymeric Micelle Composition for Treatment of Resistant Cancer and Preparation Method of the Same
EP09827766.8A EP2359860B1 (en) 2008-11-21 2009-11-23 Polymer micelle composition for treatment of resistant cancer cells
CN2009801550218A CN102292109A (zh) 2008-11-21 2009-11-23 用于治疗耐受性癌症的聚合物胶束组合物及其制备方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0116141 2008-11-21
KR20080116141 2008-11-21

Publications (2)

Publication Number Publication Date
WO2010059001A2 WO2010059001A2 (ko) 2010-05-27
WO2010059001A3 true WO2010059001A3 (ko) 2010-09-10

Family

ID=42198692

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/006882 Ceased WO2010059001A2 (ko) 2008-11-21 2009-11-23 내성암 치료용 고분자 미셀 조성물 및 그 제조방법

Country Status (6)

Country Link
US (1) US20110224151A1 (ko)
EP (1) EP2359860B1 (ko)
JP (1) JP5449388B2 (ko)
KR (1) KR20110091515A (ko)
CN (1) CN102292109A (ko)
WO (1) WO2010059001A2 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2938586T3 (es) * 2012-06-27 2023-04-12 Medincell S A Liberación de fármacos biodegradables para composiciones hidrófobas
CN102920649B (zh) * 2012-08-24 2014-07-02 中国科学院深圳先进技术研究院 载药纳米胶束及其制备方法和应用
PL405241A1 (pl) 2013-09-04 2015-03-16 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Micela polimerowa, sposób jej wytwarzania i zastosowanie
CN104761710B (zh) * 2014-02-14 2016-06-29 苏州海特比奥生物技术有限公司 一种聚乙二醇单甲醚-聚乳酸嵌段共聚物及其制备方法
EP3241546B1 (en) * 2014-12-30 2021-02-17 Samyang Biopharmaceuticals Corporation Polymer nanoparticle freeze-dried product, and preparation method therefor
AU2016355236C1 (en) 2015-11-16 2022-09-22 Medincell A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
CN110538328A (zh) * 2018-05-28 2019-12-06 中国科学院宁波材料技术与工程研究所 多肽复合物和载药纳米粒子及其制法和药物组合物及应用
CN112999151B (zh) * 2019-12-19 2024-03-19 鲁南制药集团股份有限公司 一种口服用紫杉醇复合胶束
CN114246840B (zh) * 2020-09-22 2024-10-11 鲁南制药集团股份有限公司 一种口服用紫杉醇胶囊
WO2025160108A1 (en) * 2024-01-22 2025-07-31 Sapu Nano Limited Compositions for cancer therapeutics

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040253195A1 (en) * 2001-10-18 2004-12-16 Min-Hyo Seo Polymeric michelle composition with improved stability

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0180334B1 (ko) * 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040253195A1 (en) * 2001-10-18 2004-12-16 Min-Hyo Seo Polymeric michelle composition with improved stability

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALIABADI, H.M. ET AL.: "Micelles of methoxy poly (ethylene oxide)-b-poly (epsilone- caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine A", J JOURNAL OF CONTROLLED RELEASE, vol. 104, 2005, pages 301 - 311, XP027664273 *
LETCHFORD, K. ET AL.: "A review of the formulation and classification of amphiphilic block copolymer nanoparticulate structures:micelles, nanospheres, nanocapsules and polymersomes", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2007, pages 259 - 269, XP005914364 *
MALINGRE, M.M. ET AL.: "Coadministration of Cyclosporine Strongly Enhances the Oral Bioavailability of Docetaxel", JOURNAL OF CLINICAL ONCOLOGY, 2001, pages 1160 - 1166, XP008149347 *
SHUAI , X. ET AL.: "Core-Cross-Linked Polymeric Micelles as Paclitaxel Carriers", BIOCONJUGATE CHEMISTRY, vol. 15, 2004, pages 441 - 448, XP001195317 *

Also Published As

Publication number Publication date
EP2359860B1 (en) 2014-08-06
CN102292109A (zh) 2011-12-21
US20110224151A1 (en) 2011-09-15
EP2359860A2 (en) 2011-08-24
JP2012509318A (ja) 2012-04-19
EP2359860A4 (en) 2012-04-25
KR20110091515A (ko) 2011-08-11
WO2010059001A2 (ko) 2010-05-27
JP5449388B2 (ja) 2014-03-19

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