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WO2010058982A2 - Composition cosmétique anti-oxydante contenant un extrait traité de pivoine, de polygonati rhizoma ou de lys - Google Patents

Composition cosmétique anti-oxydante contenant un extrait traité de pivoine, de polygonati rhizoma ou de lys Download PDF

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Publication number
WO2010058982A2
WO2010058982A2 PCT/KR2009/006834 KR2009006834W WO2010058982A2 WO 2010058982 A2 WO2010058982 A2 WO 2010058982A2 KR 2009006834 W KR2009006834 W KR 2009006834W WO 2010058982 A2 WO2010058982 A2 WO 2010058982A2
Authority
WO
WIPO (PCT)
Prior art keywords
lily
extract
peony
polygonati rhizoma
unprocessed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/006834
Other languages
English (en)
Other versions
WO2010058982A3 (fr
Inventor
Dong Hyun Kim
Jun Seong Park
Jae Kyoung Lee
Hye Yoon Park
Soo Mi Ahn
Duck Hee Kim
Han Kon Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amorepacific Corp
Original Assignee
Amorepacific Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amorepacific Corp filed Critical Amorepacific Corp
Priority to US13/129,957 priority Critical patent/US8445039B2/en
Priority to JP2011536263A priority patent/JP5597641B2/ja
Priority to CN2009801450987A priority patent/CN102209527B/zh
Publication of WO2010058982A2 publication Critical patent/WO2010058982A2/fr
Publication of WO2010058982A3 publication Critical patent/WO2010058982A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212—Face masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Definitions

  • the present invention relates to an antioxidant cosmetic composition, and more particularly to an antioxidant cosmetic composition containing, as an active ingredient, either an extract of at least one of peony, Polygonati rhizoma and lily, processed using a medicinal herb processing technique, or a mixture of said extract and an extract of at least one of unprocessed peony, Polygonati rhizoma and lily.
  • a medicinal herb processing technique that is a traditional Chinese medicine manufacturing technique is called “Po-je”, “Hap-hwa”, “Hap-yak”, “Su-chi”, “Po-ja”, “Bub- je” and “Su-sa” in Korean.
  • This technique can be defined as a medicine manufacturing technique of changing the inherent properties of medicinal herbs by processing the medicinal herbs on the basis of the Chinese medicine theory.
  • the objects of processing medicinal herbs are to clarify medicines, facilitate the storage of medicines, reduce or remove the toxicity or side effects of medicines, change the properties of medicines to make the medicines more effective, enhance the therapeutic effects of medicines, and the offensive odor and taste of medicines to facilitate the intake of the medicines.
  • the present inventors have conducted studies on natural materials having excellent antioxidant effects and, as a result, have found that, when a cosmetic composition is prepared using an extract of processed peony, Polygonati rhizoma or lily alone or in a mixture said extract and an extract of unprocessed peony, Polygonati rhizoma or lily, the prepared composition shows a very excellent antioxidant effect, thereby completing the present invention.
  • the present invention provides an antioxidant cosmetic composition containing, as an active ingredient, an extract of at least one of processed peony, Polygonati rhizoma and lily.
  • the present invention provides an antioxidant cosmetic composition containing a mixture of an extract of at least one of processed peony, Polygonati rhizoma and lily and an extract of at least one of unprocessed peony, Polygonati rhizoma and lily.
  • the cosmetic composition according to the present invention contains an extract of at least one of processed peony, Polygonati rhizome and lily alone or in a mixture said extract and an extract of at least one of unprocessed peony, Polygonati rhizoma and lily, and thus has an excellent antioxidant effect of inhibiting DPPH oxidation.
  • the present invention relates to an antioxidant cosmetic composition containing, as an active ingredient, an extract of at least one of processed peony, Polygonati rhizoma and lily.
  • the present invention also relates to an antioxidant cosmetic composition containing a mixture of an extract of at least one of processed peony, Polygonati rhizoma and lily and an extract of at least one of unprocessed peony, Polygonati rhizoma and lily.
  • the extract of the unprocessed plant which is mixed with the extract of the processed plant, is prepared from a plant different from a plant used to prepare the extract of the processed plant.
  • a cosmetic composition according to a preferred embodiment of the present invention may contain, as active ingredients, an extract of unprocessed peony and extracts of processed Polygonati rhizoma and lily, but the scope of the present invention is not limited thereto.
  • extract of the unprocessed plant refers to an extract obtained by extracting peony, Polygonati rhizoma or lily with water or an organic solvent, which are conventionally used, without processing the plant.
  • Peony which is used in the present invention is a perennial plant belonging to the family Ranunculaceae. It has a single flower blooming at the end of the stem.
  • the flower is large and beautiful and is about 10 cm in diameter in cultivated forms.
  • the flower has various colors, including red and white, and is cultivated in many horticultural varieties.
  • the flower has about 10 petals, particularly 8-13 petals in the case of basic types.
  • the flower petals are about 5 cm in diameter.
  • the stamens are very numerous and yellow, and the pistils are 3-5 in number, with the stigmas turned back.
  • the peony root is used in a dried form, but the scope of the present invention is not limited thereto.
  • Polygonati rhizoma which is used in the present invention is the dried root of
  • Polygonatum odoratum perennial plant belonging to the family Veneridae.
  • the plant is called "Hwang-jung", “Wi-yu” or “Ok-jook” in Korean.
  • the stem of the plant emerges from the ground and grows to a height of about 30-80 cm.
  • the leaves are alternate on the stem and have an acute tip and a slender edge.
  • the plant is sweet and plain in taste and cold and nontoxic in nature. It acts mainly in the spleen, lungs, stomach and intestines, and the typical components thereof include conva- llamarin, convallarin, kaempferolglucoside, quercitol, vitamin A, starch and mucus.
  • Lily which is used in the present invention is a perennial plant belonging to the family family Veneridae and grows to a height of 1 m, and the bulb looks like a slightly flattened ball.
  • the leaves are alternate around the stem without a petiole.
  • the flowers bloom sideward or downward in a cluster of 2-3 flowers at the end of the stem in May to June.
  • the flowers usually have fragrance, but some varieties may also have fragrance.
  • the lily stem is used in a dried form, but the scope of the present invention is not limited thereto.
  • the cosmetic composition according to the present invention is characterized in that it contains extracts prepared by processing each of peony, Polygonati rhizoma and lily and extracting each of the processed plants with an organic solvent.
  • Extracts of processed peony, Polygonati rhizoma and lily can be prepared through a method comprising the steps of:
  • step b) roasting the plant of step a) at 100-180 0 C for 10 minutes to 1 hour;
  • the honey in step a) is added in an amount of 20-30 wt% based on the weight of peony, Polygonati rhizoma or lily used.
  • the extraction in step c) can be carried out according to any conventional method known in the art.
  • an extract of each of the processed peony, Polygonati rhizoma or lily can be obtained by adding water or an organic solvent to each of the processed peony, Polygonati rhizoma or lily, extracting the plant under reflux in the solvent, dipping the extract in the solvent, filtering the extract through filter cloth, cen- trifuging the filtered extract to separate it into the residue and the filtrate, and concentrating the separated filtrate under reduced pressure.
  • the organic solvent which is used in the present invention can be selected from the group consisting of ethanol, methanol, butanol, ether, ethyl acetate, chloroform, and mixtures of these solvents with water. Preferably, 80% ethanol is used.
  • the extraction temperature is preferably 10-80 0 C, and the extraction time is preferably 6-24 hours. If the extraction temperature and time are out of the above- specified ranges, the extraction efficiency can be reduced or the changes in the components of the extract can occur.
  • the extract may be macerated at room temperature according to a conventional method known in the art, and the macerated extract may be heated and filtered, thus obtaining a liquid- phase material.
  • the extract may additionally be evaporated to remove the solvent or be spray-dried or freeze-dried.
  • the cosmetic composition according to the present invention contains one or a mixture of two or more selected from the extracts of the processed peony, Polygonati rhizoma and lily in an amount of 0.0001-30 wt% based on the total weight of the composition. If the content of the extract in the cosmetic composition is less than 0.0001 wt%, the antioxidant effect of the extract cannot be obtained, and if the content exceeds 30 wt%, the increase in the content will not lead to a significant increase in the effect of the extract and it will be difficult to maintain stability or prepare a formulation.
  • the mixture of the extracts of the processed peony, Polygonati rhizoma and lily is used, the mixture is preferably contained in an amount of 0.0001-30 wt% based on the total weight of the composition, and each of the components of the mixture may be used in an amount suitably selected from the range of 0.0001 to 30 wt% based on total weight of the composition.
  • the extracts of the processed peony, Polygonati rhizoma and lily are used at a weight ratio of 1 : 1 : 1.
  • the cosmetic composition according to the present invention may contain, in addition to the extract of at least one of the processed peony, Polygonati rhizoma and lily, an extract of at least one of unprocessed peony, Polygonati rhizoma and lily.
  • the extract of unprocessed peony, Polygonati rhizoma or lily is prepared by extracting peony, Polygonati rhizoma or lily with water or an organic solvent without processing the plant, and the preparation process thereof is the same as the above- described extraction process of step c).
  • the extract of the unprocessed plant, which is mixed with the extract of the processed plant is prepared from a plant different from a plant used to prepare the extract of the processed plant.
  • the cosmetic composition according to the present invention contains an extract of at least one of processed peony, Polygonati rhizoma and lily and an extract of at least one of unprocessed peony, Polygonati rhizoma and lily in an amount of 0.0001-30 wt% based on the total weight of the composition. If the content of the extracts in the composition is less than 0.0001 wt%, the antioxidant effect of the extract cannot be obtained, and if the content exceeds 30 wt%, the increase in the content will not lead to a significant increase in the effects of the extracts and it will be difficult to maintain stability or prepare a formulation.
  • the mixture of the extract of the processed peony, Polygonati rhizoma or lily with the extract of the unprocessed peony, Polygonati rhizoma or lily is used, the mixture is preferably contained in an amount of 0.0001-30 wt% based on the total weight of the composition, and each of the components of the mixture may be used in an amount suitably selected from the range of 0.0001 to 30 wt% based on the total weight of the composition.
  • the extracts of the mixture are used in equal amounts.
  • the cosmetic composition of the present invention can be formulated as a skin lotion, an astringent lotion, a milk lotion, a nourishing cream, a massage cream, an essence, a pack, a foundation, a lipstick or a powder foundation, but the scope of the present invention is not limited thereto.
  • components other than the extract in the cosmetic composition can be suitably selected by a skilled in the art depending on the formulation or intended use of the cosmetic composition.
  • honey was sufficiently absorbed into 1 kg of dried peony.
  • the honeyed plant was roasted at 15O 0 C for 15 minutes, and then dried in the shade.
  • the honey- roasted plant was added to 5 I of 80% ethanol aqueous solution, extracted three times under reflux, and then dipped at 15 0 C for 1 day.
  • the extract was filtered through filter cloth and centrifuged to separate it into the residue and the filtrate.
  • the separated filtrate was concentrated under reduced pressure, thus obtaining 430 g of an extract of honey-roasted peony.
  • Example 4 Preparation of mixture of extracts of unprocessed peony, un- processed Polvgonati rhizoma and honev-roasted lily
  • Example 6 Preparation of mixture of extracts of honey-roasted peony, un- processed Polygonati rhizoma and unprocessed lily
  • Polygon ⁇ ti rhizom ⁇ extract of Comparative Example 2 and 50 g of the unprocessed lily extract of Comparative Example 3 were mixed with each other, dissolved completely in 800 ml of 80% ethanol aqueous solution, and then dipped at 15 0 C for 1 day. Then, the mixture solution was filtered through filer cloth and centrifuged to separate it into the residue and the filtrate. The separated filtrate was concentrated under reduced pressure, thus obtaining 115 g of a mixture of extracts of honey-roasted peony, unprocessed Polygon ⁇ ti rhizom ⁇ and unprocessed lily.
  • Example 7 Preparation of mixture of extracts of honev-roasted peony, honey- roasted Polvgonati rhizoma and unprocessed lily
  • Polygon ⁇ ti rhizom ⁇ extract of Example 2 and 50 g of the unprocessed lily extract of Comparative Example 3 were mixed with each other, dissolved completely in 800 ml of 80% ethanol aqueous solution, and then dipped at 15 0 C for 1 day. Then, the mixture solution was filtered through filer cloth and centrifuged to separate it into the residue and the filtrate. The separated filtrate was concentrated under reduced pressure, thus obtaining 128 g of a mixture of extracts of honey-roasted peony, honey -roasted Polygon ⁇ ti rhizom ⁇ and unprocessed lily.
  • Example 8 Preparation of mixture of extracts of unprocessed peony, honey- roasted Polygonati rhizoma and honey-roasted lily
  • Example 9 Preparation of mixture of extracts of honev-roasted peony, un- processed Polvgonati rhizoma and honev-roasted lily
  • Polygonati rhizoma extract of Comparative Example 2 and 50 g of the honey-roasted lily extract of Example 3 were mixed with each other, dissolved completely in 800 ml of 80% ethanol aqueous solution, and then dipped at 15 0 C for 1 day. Then, the mixture solution was filtered through filer cloth and centrifuged to separate it into the residue and the filtrate. The separated filtrate was concentrated under reduced pressure, thus obtaining 108 g of a mixture of extracts of honey-roasted peony, unprocessed Polygonati rhizoma and honey-roasted lily.
  • Example 10 Preparation of mixture of extracts of honey-roasted peony.
  • Polygonati rhizoma extract of Example 2 and 50 g of the honey-roasted lily extract of Example 3 were mixed with each other, dissolved completely in 800 ml of 80% ethanol aqueous solution, and then dipped at 15 0 C for 1 day. Then, the mixture solution was filtered through filer cloth and centrifuged to separate it into the residue and the filtrate. The separated filtrate was concentrated under reduced pressure, thus obtaining 134 g of a mixture of extracts of honey-roasted peony, honey-roasted Polygonati rhizoma and honey-roasted lily.
  • Test Example 1 Test of antioxidant effect (DPPH test)
  • a nourishing cream containing a mixture of extracts of unprocessed peony, honey- roasted Polygonati rhizoma and honey-roasted lily was prepared to have the composition shown in Table 4 below (unit: wt%).

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Abstract

L'invention concerne une composition cosmétique anti-oxydante, et en particulier une composition cosmétique anti-oxydante contenant, en tant que principe actif, soit un extrait de pivoine et/ou de Polygonati rhizoma et/ou de lys, traité à l'aide d'une technique de traitement de plantes médicinales, soit un mélange dudit extrait et d'un extrait non traité de pivoine et/ou de Polygonati rhizoma et/ou de lys.
PCT/KR2009/006834 2008-11-19 2009-11-19 Composition cosmétique anti-oxydante contenant un extrait traité de pivoine, de polygonati rhizoma ou de lys Ceased WO2010058982A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/129,957 US8445039B2 (en) 2008-11-19 2009-11-19 Antioxidant cosmetic composition containing extract of processed peony, polygonati rhizoma or lily
JP2011536263A JP5597641B2 (ja) 2008-11-19 2009-11-19 炮製処理されたシャクヤク、玉竹または百合の抽出物を含有する抗酸化用化粧料組成物
CN2009801450987A CN102209527B (zh) 2008-11-19 2009-11-19 含有经加工的牡丹、黄精或百合的提取物的抗氧化化妆品组合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0115368 2008-11-19
KR1020080115368A KR101537292B1 (ko) 2008-11-19 2008-11-19 포제 처리된 작약, 옥죽 또는 백합 추출물을 함유하는 항산화용 화장료 조성물

Publications (2)

Publication Number Publication Date
WO2010058982A2 true WO2010058982A2 (fr) 2010-05-27
WO2010058982A3 WO2010058982A3 (fr) 2010-08-19

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PCT/KR2009/006834 Ceased WO2010058982A2 (fr) 2008-11-19 2009-11-19 Composition cosmétique anti-oxydante contenant un extrait traité de pivoine, de polygonati rhizoma ou de lys

Country Status (5)

Country Link
US (1) US8445039B2 (fr)
JP (1) JP5597641B2 (fr)
KR (1) KR101537292B1 (fr)
CN (1) CN102209527B (fr)
WO (1) WO2010058982A2 (fr)

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CN110051593A (zh) * 2019-05-28 2019-07-26 西安量木生态科技有限公司 一种牡丹精华露及其制备方法
CN111685207A (zh) * 2020-05-27 2020-09-22 包头金氏中医肾病医院有限责任公司 黑苦荞黄精茶及其制备方法

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CN105218692B (zh) * 2014-06-05 2018-01-30 上海家化联合股份有限公司 一种黄精β‑半乳聚糖及其制备方法和抑制细胞凋亡的应用
KR102043644B1 (ko) * 2017-07-28 2019-11-12 대구한의대학교산학협력단 최종당화산물 생성 저해 효과를 나타내는 주초 작약 추출물 및 이를 유효성분으로 포함하는 항산화 및 주름 개선용 조성물
KR102271886B1 (ko) 2019-05-24 2021-06-30 이승호 한방복합조성물을 유효성분으로 함유하는 기능성 화장료 조성물
JP7557963B2 (ja) * 2019-05-30 2024-09-30 第一三共ヘルスケア株式会社 月経困難症の予防及び／又は治療のための組合せ医薬
CN111849642A (zh) * 2020-07-16 2020-10-30 菏泽瑞璞牡丹产业科技发展有限公司 一种牡丹鲜花水及其制备方法
EP4267090A1 (fr) * 2020-12-23 2023-11-01 L V M H Recherche Composition cosmétique comprenant un extrait aqueux ou hydroalcoolique de pivoine
CN117243880A (zh) * 2023-10-13 2023-12-19 现代百朗德生物科技(江苏)有限公司 一种具有美白抗衰老功效的化妆品组合物及其制备方法

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CN110051593A (zh) * 2019-05-28 2019-07-26 西安量木生态科技有限公司 一种牡丹精华露及其制备方法
CN111685207A (zh) * 2020-05-27 2020-09-22 包头金氏中医肾病医院有限责任公司 黑苦荞黄精茶及其制备方法

Also Published As

Publication number Publication date
US20110223263A1 (en) 2011-09-15
CN102209527A (zh) 2011-10-05
JP5597641B2 (ja) 2014-10-01
JP2012509255A (ja) 2012-04-19
KR20100056281A (ko) 2010-05-27
US8445039B2 (en) 2013-05-21
KR101537292B1 (ko) 2015-07-16
CN102209527B (zh) 2013-02-13
WO2010058982A3 (fr) 2010-08-19

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