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WO2010057861A2 - Dispositif d'analyse automatisé comportant un dispositif automatique de prélèvement par pipette et un dispositif de mesure pour déterminer la position de la pointe de l'aiguille de prélèvement par pipette - Google Patents

Dispositif d'analyse automatisé comportant un dispositif automatique de prélèvement par pipette et un dispositif de mesure pour déterminer la position de la pointe de l'aiguille de prélèvement par pipette Download PDF

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Publication number
WO2010057861A2
WO2010057861A2 PCT/EP2009/065252 EP2009065252W WO2010057861A2 WO 2010057861 A2 WO2010057861 A2 WO 2010057861A2 EP 2009065252 W EP2009065252 W EP 2009065252W WO 2010057861 A2 WO2010057861 A2 WO 2010057861A2
Authority
WO
WIPO (PCT)
Prior art keywords
pipetting
measuring
electrically conductive
needle
rinsing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2009/065252
Other languages
German (de)
English (en)
Other versions
WO2010057861A3 (fr
Inventor
Roland Schenk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diasys Technologies SARL
Original Assignee
Diasys Technologies SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42105227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2010057861(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Diasys Technologies SARL filed Critical Diasys Technologies SARL
Priority to CN200980146759.8A priority Critical patent/CN102216785B/zh
Priority to ES09756468.6T priority patent/ES2628211T3/es
Priority to EP09756468.6A priority patent/EP2350675B1/fr
Publication of WO2010057861A2 publication Critical patent/WO2010057861A2/fr
Publication of WO2010057861A3 publication Critical patent/WO2010057861A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011—Control of the position or alignment of the transfer device
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B7/00—Measuring arrangements characterised by the use of electric or magnetic techniques
    • G01B7/003—Measuring arrangements characterised by the use of electric or magnetic techniques for measuring position, not involving coordinate determination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes
    • G01N2035/0491—Position sensing, encoding; closed-loop control
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B2219/00—Program-control systems
    • G05B2219/30—Nc systems
    • G05B2219/37—Measurements
    • G05B2219/37418—By capacitive means

Definitions

  • An automated analyzer having an automatic pipetting device and a measuring device for determining the position of the pipetting needle tip
  • the present invention relates to an automatic pipetting device with a pipetting needle of electrically conductive material, which is movable in a three-dimensional working area on at least one horizontal working plane and arranged substantially perpendicular to the horizontal working plane, and with a measuring device for determining the exact position of the pipetting needle tip on the at least a horizontal work plane.
  • the present invention relates to an automated analysis device with such an automatic pipetting device and a method for rinsing a pipette needle of such an automatic pipetting device.
  • analyzers designed to take the various reagents required for carrying out an analysis from reagent containers and combine them with a sample for the purpose of carrying out the analysis in a reaction vessel.
  • the analyzers often have a carousel in which either receiving areas for reagent containers or receiving areas for sample containers are provided.
  • receiving areas for reagent containers and receiving areas for sample containers are provided.
  • Such carousels are usually driven by a drive device provided in the analyzer for performing a rotary movement of the carousel.
  • an automatic pipetting device generally comprises a pipetting arm, on which a pipetting needle is arranged vertically, which is connected to a pumping unit, with which a liquid can be drawn into the pipetting needle and ejected again from the pipetting needle.
  • a pipetting arm is generally designed in such a way that the pipetting needle can be moved in a working area with the pipetting arm, in which working area the reagent containers, sample containers and / or reaction vessels (eg cuvettes) are stationarily arranged or by e.g. B. a carousel are temporarily provided and in which the pipette needle can be immersed.
  • Pipetting can be arranged on lifting columns, with which they are adjustable perpendicular to the base of the work area in the working height, for example, to move the pipette needle on the arranged in the work area liquid container and to be able to insert the pipetting needle into selected liquid container from above.
  • a pipetting arm can also be designed in such a way that the pipetting needle is arranged to be height-adjustable even on the pipetting arm.
  • the pipette needle is usually immersed in a rinsing liquid, wherein a certain amount of rinsing liquid is drawn into the pipette needle. Subsequently, the pipette needle is pulled out of the rinsing liquid and emptied through a waste container or a drain and drained or stripped.
  • analyzers also include a measuring device for determining a physical or chemical quantity of a reaction mixture prepared in a reaction vessel.
  • the reaction vessel may, for. Example, be a cuvette, which is arranged in the beam path of a arranged in the analyzer photometer or can be introduced.
  • analyzers usually include at least one control unit for controlling the movements of the pipetting arm, the pumping unit, the pipetting needle, the lifting column and / or the carousel, and a data processing device for setting up and executing an analysis program and for processing and outputting a measured physical or chemical Size.
  • the openings of the reagent container or sample container and the openings of reaction vessels, but also the opening of an optionally provided Pipettiemadel Nursingstation are sometimes designed very small, so that it may happen that in case of malfunction of the controller, the pipette needle is not as intended introduced into the opening of a container but hits the edge of the container, or possibly even next to the container and thus may impact a part of the analyzer. In these cases, the pipette needle or the object may be damaged, which may hit the pipette needle. Such Damage can be so severe that it is no longer possible to continue the analysis run.
  • an automatic pipetting device with a measuring device of the type mentioned, wherein the M ess device a) comprises at least one electrically conductive measuring body, which is arranged on at least one NEN horizontal working plane, and b) connected to a capacitor Capacitance measuring device for measuring the electrical capacitance of the capacitor, wherein the pipette needle tip forms a first electrode of the capacitor and the at least one electrically conductive measuring body forms a second electrode of the capacitor.
  • the electrical capacity is a physical quantity that defines the ability of a capacitor to store electrical energy.
  • a capacitor consists of two electrically conductive surfaces (electrodes) with electrical connections and an insulating dielectric between them, e.g. Air.
  • the capacitance of a capacitor changes with the distance of the electrodes.
  • capacitors can be used for measuring distance and thickness if the electrode spacing changes as a function of a measured variable.
  • the position can be determined based on the predetermined position of the measuring body. Does the measuring body on the at least one horizontal working plane has a circular surface with a diameter which substantially corresponds to the diameter of the Pipettiemadelspitze on. If the pipette needle tip can be precisely aligned with this measuring body, it will measured a certain capacity, which indicates the achieved exact alignment of the pipette needle tip on the measuring body and thus the exact position of the pipette needle tip on the corresponding working plane. If the measured capacity deviates from the value expected for this case, the position of the pipette needle tip is also different than expected.
  • the plurality of measuring bodies may be in a field of measuring bodies on the at least one horizontal working plane, all of which have a circular area with a diameter substantially equal to the diameter of the pipette needle tip and which are all separately connected to a respective associated capacitance measuring device.
  • the position of the pipette needle tip is.
  • the position determination can be based on the shape of a measuring body with a larger surface over which the pipetting needle is movable, and on the speed of movement of the pipetting needle over the measuring body and the time over which a certain capacity can be measured, or based take place in the movement over the measuring body set back route.
  • the measuring device as the second electrode next to the pipette needle exactly on an electrically conductive measuring body having a extending on at least one horizontal working plane surface (F), wherein the surface (F) is a triangle, a trapezoid, a rhombus or a Semicircle is.
  • the position can also be determined based on the predetermined position and shape of the measuring body and the distance traveled by the pipetting needle during the movement in the direction of the measuring body or the time required for reaching the measuring body at a given speed.
  • the measuring body may be an electrically conductive wire extending on at least one horizontal working plane at a predetermined angle to a path projected onto the horizontal working plane on which the pipetting needle moves through the working area.
  • a second measuring wire is additionally provided which extends on the same plane as the first wire at an angle to the first wire, that is not parallel to the first wire.
  • the measuring device comprises at least one electrically conductive measuring body, which is arranged in a recess in an area extending on the at least one horizontal working plane in the working area.
  • the recess has a triangular, trapezoidal or semi-circular circumference in plan view from above, wherein the at least one measuring body extends along the circumference of the recess, thereby spanning a space having the same peripheral shape as the recess.
  • the measuring body forms a measuring edge towards the interior of the depression, to which a pipetting needle introduced into the depression can be guided.
  • the pipetting needle tip forms a first contact of the switch and the at least one electrically conductive measuring body forms a second contact of the switch.
  • this must be applied to the pipette needle a voltage, which can be associated with a number of disadvantages.
  • the determination of the position of the pipette needle tip can also take place via a resistance measurement.
  • a resistance measuring device for measuring the resistance is preferably connected to the pipetting needle and to the measuring body. At a large distance between pipette needle tip and measuring body, the resistance is correspondingly large. If the pipette needle moves towards the measuring body, the resistance decreases. If the pipette needle is even moved to contact with the measuring body, the resistance correspondingly approaches zero.
  • a voltage must also be applied to the pipette needle, which can be associated with a number of disadvantages.
  • the capacitance measurement described above is preferred over the capacitance measuring device.
  • the capacity measuring device is expediently connected to a data processing unit for calculating the exact position of the pipette needle tip on the basis of the predetermined or measured data discussed above.
  • this data processing unit is integrated in the analyzer.
  • the electrically conductive measuring body and the pipette needle are electrically insulated from the automatic pipetting device.
  • the pipetting needle is connected to ground to avoid parasitic capacitances.
  • the measuring body is connected to ground in order to avoid interference capacitances.
  • both the pipette needle and the measuring body have a ground connection.
  • the electrically conductive measuring body can consist of any electrically conductive material.
  • the at least one electrically conductive measuring body preferably consists of metal.
  • the automatic pipetting device additionally comprises a rinsing station for rinsing the pipetting needle.
  • a rinsing station preferably comprises at least one upwardly open rinsing bowl having a height (H) corresponding to at least a predetermined maximum depth of immersion (T) of the pipetting needle (27) into a sample or reagent liquid during an automatic pipetting operation, and the Inner circumference (UW) is greater than the outer circumference (UP) of the pipetting needle, wherein the inner circumference (UW) of the Spülnapf at most 3 times, 2.5 times, 2 times or 1, 5 times the outer circumference (UP ) corresponds to the area of the pipetting needle to be inserted into the rinsing bowl.
  • the hydraulic drain resistance of the Spülnapfablaufs is selected so that the delivery rate of Rinse liquid is greater than the drain rate (volume per time) of the rinse liquid through the Spülnapfablauf.
  • the hydraulic drainage resistance is determined by the nature of the inner surface and the geometry, cross-section and length of the Spülnapfablaufs.
  • the ratio of the inner circumference (UW) of the rinsing bowl to the outer circumference (UP) of the pipette needle is selected such that, given a sufficient total amount of rinsing liquid, the rinsing liquid rises into the area between the outer wall of the pipette needle and the inner wall of the rinsing bowl. If a corresponding amount of rinsing liquid is ejected through the pipetting needle into the rinsing bowl, this not only cleans the pipetting needle from the inside, but also cleans the pipetting needle from the outside.
  • the ratio UW / UP and Q are chosen so that at a given delivery rate of a particular liquid through the pipetting needle into the rinsing bowl and with sufficient velvet delivery of flushing fluid in the region between the outer wall of the pipette needle and the inner wall of the Spülnapfs in the rinsing fluid turbulent flow occurs.
  • the ratios are selected so that the turbulent flow along the pipetting needle over the entire predetermined maximum immersion depth (T) is achieved.
  • the turbulent flow has the advantage that hereby a greater cleaning effect is achieved than with only laminar flow.
  • UW / UP and Q are therefore chosen so that in the area between the outer wall of the pipette needle and the inner wall of the Spülnapfs in the rinsing liquid a Reynolds number of at least 2 500 is reached. More preferably, a Reynolds number of at least 100,000, at least 200,000 or even at least 250,000 is achieved.
  • the adjustment device for determining the exact position of the pipetting needle tip in the working region of the pipette needle, it can be determined whether the pipette needle tip can be aligned precisely enough over the at least one rinsing bowl to introduce the pipetting needle into the narrow rinsing cup opening.
  • the rinsing station preferably has at least 2 rinsing bowls arranged next to one another, preferably at least three rinsing bowls arranged in a row.
  • a data processing device may decide, based on the data obtained from the auto-adjusting device, in which of the rinsing cups the pipetting needle may (best) be inserted to achieve the desired rinsing action.
  • rinsing stations in which at least three rinsing cups arranged in a row are provided, the rinsing bowl openings lying on a horizontal plane.
  • more than three rinsing bowls can be arranged on a straight line running through their central longitudinal axis, the rinsing bowl openings lying on a horizontal plane.
  • the two are or more dishwashers having their Spülnapfö réelleen in the workspace of Pipettierarms on a common horizontal plane, preferably arranged on a line passing through the central longitudinal axis straight that this straight line at an angle to a projected onto the plane of the Spülnapfö réelleen web on which the Pipette needle moved through the work area, runs.
  • the inner circumference UW of the rinsing cups and the circumference of the rinsing cup openings and the angle at which the straight line on which the circle centers of the rinsing bowls lie are a trajectory projected onto the plane of the rinsing nozzle openings , on which the pipetting needle moves through the working area, cuts, so chosen, that a pipetting needle, the tip of which does not move on the assumed ideal trajectory, can nevertheless be inserted into one of the rinsing heads, provided that the actual trajectory on which the Pipette needle moves in the area between the outermost points of the two outermost Spülnapfötechnisch.
  • the present invention also includes a method for determining the exact position of the pipette needle tip on at least one horizontal working plane of the pipetting needle of an automatic pipetting device. In this procedure, one carries out the steps in which one
  • the present invention also includes a method of rinsing the pipette needle tip of an automatic pipetting apparatus, comprising: a) determining the path on which the pipette needle tip (41) moves in accordance with the method described in the preceding paragraph; a) determines certain path, whether, as and which Spülnapf (30, 30 ', 30 ") can be controlled so that the Pipettiemadelspitze (41) in the Spülnapf (30, 30', 30”) can be introduced.
  • the measuring body and / or the rinsing station of the automatic pipetting device according to the invention are arranged interchangeably in the analyzer.
  • a certain rinsing liquid is pumped through the pipetting needle into the rinsing bowl at a given hydraulic outlet resistance of the rinsing bowl, such that the delivery rate is greater than the rinsing rate of the rinsing liquid the Spülnapfablauf is.
  • the rinsing liquid preferably rises so far that a height is reached which corresponds at least to the predetermined maximum immersion depth (T) of the pipetting needle into a sample or reagent liquid during an automatic pipetting operation. More preferably, the rinse liquid rises above the top of the rinse cup.
  • the present invention includes automated analyzers having a pipetting device with the described adjustment device and optionally additionally with the described rinsing station.
  • the automated analyzer may additionally include one or more Comprise elements under an analyzer rotor, a heat generating device, a cold generating device, an optical measuring device and an optoelectronic reading device for reading an opto-electronically readable code.
  • FIG. 1 shows an apparatus for the automated analysis of liquids (analyzer) with an automatic pipetting device with a rinsing station according to the present invention
  • Figure 2 is a schematic representation of the adjustment device for a pipette needle in the context of the present invention.
  • FIG. 3 is a detailed view of the adjustment device according to the invention in conjunction with a Pipettiemadel Series.
  • FIG. 1 shows an apparatus for the automated analysis of liquids (analyzer), which has a carousel 1 for liquid containers and a pipetting apparatus 2 with a pipetting arm 5.
  • the carousel 1 is arranged so that it can move the liquid container into the working area of the pipetting arm 5.
  • a rinsing station 3 and a measuring device 4 for determining the exact position of the pipette needle tip are provided in the working area of the pipetting arm 5.
  • FIG. 2 shows a schematic representation of the capacitance measuring device 4 according to the invention with adjustment function.
  • the capacitance measuring device 4 comprises the measuring body 42 arranged on a working plane and the pipette needle tip 41 aligned above it.
  • the measuring body 42 and the pipette needle tip 41 are connected via the terminals 46, 47 to a capacitance measuring device 43 for measuring the capacitance of the capacitor formed by the measuring body 42 and the pipette needle tip 41.
  • the capacity measuring device 43 is connected via a connecting line 45 to a data processing unit 44, which determines the exact position of the pipette needle tip 41 from the given data (eg shape and / or position of the measuring body 42) and the measured data (eg electrical capacity, time) can determine the horizontal work plane.
  • FIG. 3 shows an automatic pipetting device 2 according to the invention with a pipetting arm 5 pivotably arranged about the rotation axis 59, at the distal end of which a receiving device 50 for the pipette needle is arranged.
  • a rinsing station with three rinsing cups 30, 30 ', 30 "arranged in a row and in a collecting trough 31 is provided on a circular path that can be controlled by a pipette needle about the rotation axis 59.
  • the rinsing heads 30, 30', 30 are arranged on a straight line that intersects the circular path on which moves the pipette needle tip. This straight line runs parallel to a tangent of the circular path on which the pipette needle tip moves.
  • the rinsing cups are arranged so that the center of the central rinsing bowl 30 'lies on an imaginary ideal circular path on which the pipetting needle is to move.
  • the center of the rinsing bowl 30 "lies on a circular path which has a larger radius deviating from the ideal circular path
  • the center of the rinsing bowl 30 lies on a circular path which has a smaller radius deviating from the ideal circular path Movement along the imaginary ideal circular path of the pipette needle arranged one behind the other.
  • a measuring body 42 of a measuring device for determining the horizontal position of the pipette needle tip is likewise provided on a circular path around the rotation axis 59, which can be controlled with the pipetting needle.
  • the measuring body 42 is provided in a triangular depression in the working surface 40.
  • the measuring body 42 also has the circumference of a triangle, as it extends along the circumference of the recess and thereby a space with the same peripheral shape, as having the recess um- stressed. In this case, the measuring body 42 forms a measuring edge to which a pipetting needle introduced into the depression can be introduced.
  • the measuring body 42 and the electrically conductive pipette needle when aligned with one another, form a capacitor which is connected to a capacitance measuring device.
  • the pipette needle is inserted into the area spanned by the measuring body 42 and moved in one direction until a capacity of a certain size is detected.
  • the pipetting needle can also be moved to contact, that is, until it hits the edge of the measuring body.
  • the pipetting needle is moved in the opposite direction until a capacity of a certain size is determined or until it touches the edge of the measuring body. From the signals and from the distance traveled between the two end points, a data processing unit provided in the analyzer can determine the exact horizontal position of the pipette needle tip.

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un dispositif automatique de prélèvement par pipette présentant une aiguille de prélèvement par pipette à base de matériau électroconducteur, déplaçable dans une zone de travail tridimensionnelle sur au moins un plan de travail horizontal et disposée sensiblement perpendiculairement au plan de travail horizontal. Pour pouvoir éviter qu'en cas de défaillance de la commande des mouvements une aiguille de prélèvement par pipette vienne de manière intempestive en contact avec un objet disposé dans l'analyseur, il est nécessaire de prévoir un dispositif servant à déterminer la position exacte de la pointe de l'aiguille de prélèvement par pipette (fonction d'ajustement). L'invention vise à mettre au point un dispositif de prélèvement par pipette présentant une fonction d'ajustement précise, fiable et aisée à utiliser. A cet effet, ledit dispositif de prélèvement par pipette comprend un dispositif de mesure qui présente a) au moins un corps de mesure électroconducteur, monté sur la zone de travail horizontale et b), un capacimètre relié à un condensateur, qui sert à mesurer la capacité électrique du condensateur. La pointe de l'aiguille de prélèvement par pipette constitue une première électrode du condensateur et le corps de mesure électroconducteur constitue quant à lui une seconde électrode du condensateur.
PCT/EP2009/065252 2008-11-18 2009-11-16 Dispositif d'analyse automatisé comportant un dispositif automatique de prélèvement par pipette et un dispositif de mesure pour déterminer la position de la pointe de l'aiguille de prélèvement par pipette Ceased WO2010057861A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN200980146759.8A CN102216785B (zh) 2008-11-18 2009-11-16 具有自动吸液装置和用于确定吸液针末梢位置的测量装置的自动分析装置
ES09756468.6T ES2628211T3 (es) 2008-11-18 2009-11-16 Dispositivo de análisis automatizado con un dispositivo pipeteador automático y con un dispositivo de medición para la determinación de la posición de la punta de la aguja pipeteadora
EP09756468.6A EP2350675B1 (fr) 2008-11-18 2009-11-16 Dispositif d'analyse automatisé comportant un dispositif automatique de prélèvement par pipette et un dispositif de mesure pour déterminer la position de la pointe de l'aiguille de prélèvement par pipette

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008058065.1 2008-11-18
DE200810058065 DE102008058065A1 (de) 2008-11-18 2008-11-18 Automatisierte Analysevorrichtung mit einer automatischen Pipettiervorrichtung und mit einer Messvorrichtung zum Bestimmen der Position der Pipettiernadelspitze

Publications (2)

Publication Number Publication Date
WO2010057861A2 true WO2010057861A2 (fr) 2010-05-27
WO2010057861A3 WO2010057861A3 (fr) 2011-01-27

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PCT/EP2009/065252 Ceased WO2010057861A2 (fr) 2008-11-18 2009-11-16 Dispositif d'analyse automatisé comportant un dispositif automatique de prélèvement par pipette et un dispositif de mesure pour déterminer la position de la pointe de l'aiguille de prélèvement par pipette

Country Status (5)

Country Link
EP (1) EP2350675B1 (fr)
CN (1) CN102216785B (fr)
DE (1) DE102008058065A1 (fr)
ES (1) ES2628211T3 (fr)
WO (1) WO2010057861A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9108191B2 (en) 2010-06-02 2015-08-18 Perkinelmer Chemagen Technologie Gmbh Device and method for the complete uptake of liquids from vessels
US9335336B2 (en) 2011-09-09 2016-05-10 Gen-Probe Incorporated Automated sample handling instrumentation, systems, processes, and methods
CN105606837A (zh) * 2015-12-17 2016-05-25 苏州长光华医生物医学工程有限公司 一种自适应液面探测采样系统及其控制方法
US9476895B2 (en) 2007-04-06 2016-10-25 Becton, Dickinson And Company Open platform automated sample processing system
US9953141B2 (en) 2009-11-18 2018-04-24 Becton, Dickinson And Company Laboratory central control unit method and system

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011118612B4 (de) * 2011-11-16 2013-08-14 Euroimmun Medizinische Labordiagnostika Ag Vorrichtung zur Steuerung einer Pipettiervorrichtung
JP2015087329A (ja) * 2013-10-31 2015-05-07 シスメックス株式会社 吸引部の位置調整方法及び検体処理装置
EP2955526A1 (fr) 2014-06-10 2015-12-16 Siemens Healthcare Diagnostics Products GmbH Dispositif de détermination de la position d'une jauge et procédé de détermination de la position
EP2977767B1 (fr) * 2014-07-21 2021-08-25 Siemens Healthcare Diagnostics Products GmbH Dispositif de détermination de position d'une jauge mobile automatique
CH712735A1 (de) * 2016-07-22 2018-01-31 Tecan Trading Ag Pipettiervorrichtung mit einem Flüssigkeitsvolumensensor und Flüssigkeitsbearbeitungssystem.
JP2021515201A (ja) * 2018-02-27 2021-06-17 エッペンドルフ アクチェンゲゼルシャフト 対象を測定するための実験室自動機用の測定器具、この測定器具用の対象及び測定方法
CN109115258B (zh) * 2018-06-21 2020-10-23 迈克医疗电子有限公司 一种检测装置的校准方法、装置和终端设备
WO2020232605A1 (fr) * 2019-05-20 2020-11-26 深圳迈瑞生物医疗电子股份有限公司 Appareil d'analyse d'échantillons et procédé de commande de sortie de liquide
CN111610336B (zh) * 2020-06-22 2025-01-03 中电建十一局工程有限公司 一种用于血凝分析仪上的样本针防撞装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317351A (en) * 1990-12-21 1994-05-31 Canon Kabushiki Kaisha Position detecting device
US5270210A (en) 1992-07-16 1993-12-14 Schiapparelli Biosystems, Inc. Capacitive sensing system and wash/alignment station for a chemical analyzer
US5529754A (en) * 1994-05-02 1996-06-25 Hoffmann-La Roche Inc. Apparatus for capacitatively determining the position of a pipetting needle within an automated analyzer
JP3295551B2 (ja) * 1994-09-16 2002-06-24 富士写真フイルム株式会社 検査用素子およびこの素子収容用のカートリッジ
DE69836736T2 (de) * 1997-05-01 2007-10-04 Sophion Bioscience A/S Vorrichtung zur automatischen elektrodenpositionierung
AU3271600A (en) * 1999-02-19 2000-09-04 Gesim Gesellschaft Fur Silizium-Mikrosysteme Mbh Sensor-measuring field for controlling functioning of a micropipette
WO2008012882A1 (fr) * 2006-07-26 2008-01-31 Pioneer Corporation Dispositif de sortie vocale et dispositif contenant un appareil sonore
JP5137436B2 (ja) * 2007-03-29 2013-02-06 シスメックス株式会社 試料分析装置
ES2843373T3 (es) * 2007-04-06 2021-07-16 Becton Dickinson Co Sistema de preparación de muestras para procesamiento de especímenes clínicos

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9476895B2 (en) 2007-04-06 2016-10-25 Becton, Dickinson And Company Open platform automated sample processing system
US9953141B2 (en) 2009-11-18 2018-04-24 Becton, Dickinson And Company Laboratory central control unit method and system
US11355220B2 (en) 2009-11-18 2022-06-07 Becton, Dickinson And Company Laboratory central control unit method and system
US9108191B2 (en) 2010-06-02 2015-08-18 Perkinelmer Chemagen Technologie Gmbh Device and method for the complete uptake of liquids from vessels
US9335336B2 (en) 2011-09-09 2016-05-10 Gen-Probe Incorporated Automated sample handling instrumentation, systems, processes, and methods
US10132821B2 (en) 2011-09-09 2018-11-20 Gen-Probe Incorporated Automated method for determining the presence of a mucoid strand
US10877057B2 (en) 2011-09-09 2020-12-29 Gen-Probe Incorporated Thermal printing on wall of tubular vessel
US10921338B2 (en) 2011-09-09 2021-02-16 Gen-Probe Incorporated Sample container handling with automated cap removal/replacement and drip control
US11614454B2 (en) 2011-09-09 2023-03-28 Gen-Probe Incorporated Automated container capping/decapping mechanism
US11815522B2 (en) 2011-09-09 2023-11-14 Gen-Probe Incorporated Automated sample handing instrumentation, systems, processes, and methods
CN105606837A (zh) * 2015-12-17 2016-05-25 苏州长光华医生物医学工程有限公司 一种自适应液面探测采样系统及其控制方法

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WO2010057861A3 (fr) 2011-01-27
CN102216785A (zh) 2011-10-12
DE102008058065A1 (de) 2010-05-20
EP2350675B1 (fr) 2017-04-19
ES2628211T3 (es) 2017-08-02
EP2350675A2 (fr) 2011-08-03

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