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WO2009132313A3 - Morphinan derivatives of organic and inorganic acids - Google Patents

Morphinan derivatives of organic and inorganic acids Download PDF

Info

Publication number
WO2009132313A3
WO2009132313A3 PCT/US2009/041722 US2009041722W WO2009132313A3 WO 2009132313 A3 WO2009132313 A3 WO 2009132313A3 US 2009041722 W US2009041722 W US 2009041722W WO 2009132313 A3 WO2009132313 A3 WO 2009132313A3
Authority
WO
WIPO (PCT)
Prior art keywords
organic
inorganic acids
morphinan derivatives
disclosed
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/041722
Other languages
French (fr)
Other versions
WO2009132313A2 (en
Inventor
Amy Qi Han
Yakov Rotshteyn
Virendra Kumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Progenics Pharmaceuticals Inc
Original Assignee
Progenics Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Progenics Pharmaceuticals Inc filed Critical Progenics Pharmaceuticals Inc
Publication of WO2009132313A2 publication Critical patent/WO2009132313A2/en
Publication of WO2009132313A3 publication Critical patent/WO2009132313A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Novel 4,5-epoxy-14-substituted morphinan derivatives of organic and inorganic acids are disclosed. Pharmaceutical compositions containing the compounds and methods of their pharmaceutical uses and syntheses are also disclosed. The compounds disclosed are useful, inter alia, as modulators of opioid receptors.
PCT/US2009/041722 2008-04-25 2009-04-24 Morphinan derivatives of organic and inorganic acids Ceased WO2009132313A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4799608P 2008-04-25 2008-04-25
US61/047,996 2008-04-25
US5511508P 2008-05-21 2008-05-21
US61/055,115 2008-05-21

Publications (2)

Publication Number Publication Date
WO2009132313A2 WO2009132313A2 (en) 2009-10-29
WO2009132313A3 true WO2009132313A3 (en) 2010-02-18

Family

ID=41217443

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/041722 Ceased WO2009132313A2 (en) 2008-04-25 2009-04-24 Morphinan derivatives of organic and inorganic acids

Country Status (1)

Country Link
WO (1) WO2009132313A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2340832A1 (en) * 2009-12-23 2011-07-06 Universität Innsbruck Morphinan-6-one compounds for the treatment or prevention of neurodegenerative diseases
MX362830B (en) * 2010-01-29 2019-02-14 Toray Industries Therapeutic or prophylactic agent for biliary diseases.
US20140037729A1 (en) * 2010-12-28 2014-02-06 Euro-Celtique, S.A. Combination of an opioid agonist and an opioid antagonist in the treatment of parkinson's disease
GB2560284B (en) * 2011-10-03 2019-01-09 Johnson Matthey Plc Process for the 3-O-demethylation of morphinan compounds
US8637538B1 (en) 2012-12-14 2014-01-28 Trevi Therapeutics, Inc. Methods for treatment of pruritis
US20140179727A1 (en) 2012-12-14 2014-06-26 Trevi Therapeutics, Inc. Methods for treating pruritus
US8987289B2 (en) 2012-12-14 2015-03-24 Trevi Therapeutics, Inc. Methods for treating pruritus
ES2784690T3 (en) 2013-12-05 2020-09-29 Univ Bath New opioid compounds and their uses
CN105985348B (en) * 2015-02-12 2019-02-01 正大天晴药业集团股份有限公司 A kind of preparation method of methylnaltrexone bromide
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
CN112703000B (en) 2018-07-23 2024-05-31 特雷维治疗股份有限公司 Treatment of chronic cough, shortness of breath, and difficulty breathing
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
AU2021206252A1 (en) 2020-01-10 2022-07-28 Trevi Therapeutics, Inc. Methods of administering nalbuphine
CN114702510B (en) * 2022-05-05 2023-06-30 重庆华邦胜凯制药有限公司 Preparation method of rifabutin oxidation impurity
WO2024211482A2 (en) * 2023-04-04 2024-10-10 Board Of Regents, The University Of Texas System METHODS OF SYNTHESIZING 14-β-AMINOMORPHANS AND SALTS THEREOF

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031463A1 (en) * 1994-05-18 1995-11-23 Astra Aktiebolag New antagonist compounds
WO2004005294A2 (en) * 2002-07-03 2004-01-15 Alcasynn Pharmaceuticals Gmbh Morphinan derivatives the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof
EP1595541A1 (en) * 2004-05-12 2005-11-16 Alcasynn Pharmaceuticals Gmbh Use of opioid receptor antagonist compounds for the prevention and/or treatment of diseases associated with the target calcineurin
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031463A1 (en) * 1994-05-18 1995-11-23 Astra Aktiebolag New antagonist compounds
WO2004005294A2 (en) * 2002-07-03 2004-01-15 Alcasynn Pharmaceuticals Gmbh Morphinan derivatives the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof
EP1595541A1 (en) * 2004-05-12 2005-11-16 Alcasynn Pharmaceuticals Gmbh Use of opioid receptor antagonist compounds for the prevention and/or treatment of diseases associated with the target calcineurin
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALICE S. ET AL.: "14-beta-[(p-nitrocinnamoyl)amino]morphinones, 14-beta-[(p- nitrocinnamoyl)amino]-7,8-dihydromorphinones, and their codeinone analogs:synthesis and receptor activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, no. 21, 1993, pages 3154 - 3160 *
DAVID R. ET AL.: "Structural Determinants of Opioid Activity in Derivatives of 14- Aminomorphinones: Effects of Changes to the Chain Linking of the C14-Amino Group to the Aryl Ring", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 20, 2006, pages 6104 - 6110 *
GUILLERMO R. ET AL.: "OSAR study on the antinociceptive activity of some morphinans", CHEMICAL BIOLOGY & DRUG DESIGN, vol. 70, no. 1, 2007, pages 53 - 64 *

Also Published As

Publication number Publication date
WO2009132313A2 (en) 2009-10-29

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