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WO2008065282A3 - Substituted pyrazoles, compositions containing these, method of production and use - Google Patents

Substituted pyrazoles, compositions containing these, method of production and use Download PDF

Info

Publication number
WO2008065282A3
WO2008065282A3 PCT/FR2007/001851 FR2007001851W WO2008065282A3 WO 2008065282 A3 WO2008065282 A3 WO 2008065282A3 FR 2007001851 W FR2007001851 W FR 2007001851W WO 2008065282 A3 WO2008065282 A3 WO 2008065282A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions containing
production
substituted pyrazoles
pyrazoles
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2007/001851
Other languages
French (fr)
Other versions
WO2008065282A2 (en
Inventor
Kirsten Bjergarde
Mark Dodson
Jacques Mauger
Anil Nair
Marcel Patek
Michel Tabart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SI200731592T priority Critical patent/SI2091920T1/en
Priority to EP07870263.6A priority patent/EP2091920B1/en
Priority to NZ576709A priority patent/NZ576709A/en
Priority to EA200970472A priority patent/EA019454B1/en
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to HRP20150070TT priority patent/HRP20150070T1/en
Priority to CA002667846A priority patent/CA2667846A1/en
Priority to MX2009004983A priority patent/MX2009004983A/en
Priority to DK07870263.6T priority patent/DK2091920T3/en
Priority to ES07870263.6T priority patent/ES2528385T3/en
Priority to AU2007327423A priority patent/AU2007327423B2/en
Priority to JP2009535773A priority patent/JP5538893B2/en
Priority to CN200780045533XA priority patent/CN101553473B/en
Priority to HK10103174.0A priority patent/HK1137988B/en
Priority to UAA200905930A priority patent/UA97965C2/en
Priority to PL07870263T priority patent/PL2091920T3/en
Priority to BRPI0718999-0A2A priority patent/BRPI0718999A2/en
Publication of WO2008065282A2 publication Critical patent/WO2008065282A2/en
Publication of WO2008065282A3 publication Critical patent/WO2008065282A3/en
Priority to IL198328A priority patent/IL198328A0/en
Priority to TNP2009000155A priority patent/TN2009000155A1/en
Priority to EC2009009312A priority patent/ECSP099312A/en
Priority to US12/437,618 priority patent/US7989439B2/en
Anticipated expiration legal-status Critical
Priority to NO20091990A priority patent/NO20091990L/en
Priority to US13/156,947 priority patent/US8420824B2/en
Priority to US13/156,915 priority patent/US8410286B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention relates to new chemical compounds, particularly to substituted pyrazoles, compositions containing these, and their use as drugs.
PCT/FR2007/001851 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing these, method of production and use Ceased WO2008065282A2 (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
CN200780045533XA CN101553473B (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions comprising them, methods of production and uses
NZ576709A NZ576709A (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing these, method of production and use
EA200970472A EA019454B1 (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing these, method of production and use
UAA200905930A UA97965C2 (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing these, method of production and use thereof
HRP20150070TT HRP20150070T1 (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing these, method of production and use
CA002667846A CA2667846A1 (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing these, method of production and use
MX2009004983A MX2009004983A (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing these, method of production and use.
DK07870263.6T DK2091920T3 (en) 2006-11-10 2007-11-09 SUBSTITUTED PYRAZOLES, PREPARATIONS CONTAINING THEM, METHOD AND METHOD OF USE
ES07870263.6T ES2528385T3 (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing them, manufacturing and use procedure
AU2007327423A AU2007327423B2 (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing these, method of production and use
EP07870263.6A EP2091920B1 (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing these, method of production and use
HK10103174.0A HK1137988B (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing these, method of production and use
JP2009535773A JP5538893B2 (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing them, production methods and uses
SI200731592T SI2091920T1 (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing these, method of production and use
PL07870263T PL2091920T3 (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing these, method of production and use
BRPI0718999-0A2A BRPI0718999A2 (en) 2006-11-10 2007-11-09 REPLACED PIRAZOIS, COMPOSITIONS CONTAINING THEM, PRODUCTION AND USE PROCESS
IL198328A IL198328A0 (en) 2006-11-10 2009-04-23 Substituted pyrazoles, compositions containing these, method of production and use
TNP2009000155A TN2009000155A1 (en) 2006-11-10 2009-04-24 SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SAME, PROCESS FOR PRODUCTION AND USE
EC2009009312A ECSP099312A (en) 2006-11-10 2009-05-05 REPLACED PIRAZOLS, COMPOSITIONS CONTAINING THEM, MANUFACTURING PROCEDURE AND USE
US12/437,618 US7989439B2 (en) 2006-11-10 2009-05-08 Substituted pyrazoles, compositions containing these, method of production and use
NO20091990A NO20091990L (en) 2006-11-10 2009-05-22 Substituted pyrazoles, compositions containing them, methods of preparation and use
US13/156,947 US8420824B2 (en) 2006-11-10 2011-06-09 Substituted pyrazoles, compositions containing these, method of production and use
US13/156,915 US8410286B2 (en) 2006-11-10 2011-06-09 Substituted pyrazoles, compositions containing these, method of production and use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0609812 2006-11-10
FR0609812A FR2908409B1 (en) 2006-11-10 2006-11-10 SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SAME, PROCESS FOR PRODUCTION AND USE

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/437,618 Continuation US7989439B2 (en) 2006-11-10 2009-05-08 Substituted pyrazoles, compositions containing these, method of production and use

Publications (2)

Publication Number Publication Date
WO2008065282A2 WO2008065282A2 (en) 2008-06-05
WO2008065282A3 true WO2008065282A3 (en) 2008-07-31

Family

ID=38169388

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/001851 Ceased WO2008065282A2 (en) 2006-11-10 2007-11-09 Substituted pyrazoles, compositions containing these, method of production and use

Country Status (39)

Country Link
US (3) US7989439B2 (en)
EP (1) EP2091920B1 (en)
JP (1) JP5538893B2 (en)
KR (1) KR20090083456A (en)
CN (1) CN101553473B (en)
AR (1) AR063638A1 (en)
AU (1) AU2007327423B2 (en)
BR (1) BRPI0718999A2 (en)
CA (1) CA2667846A1 (en)
CL (1) CL2007003251A1 (en)
CO (1) CO6190516A2 (en)
CR (1) CR10749A (en)
CY (1) CY1116000T1 (en)
DK (1) DK2091920T3 (en)
DO (1) DOP2009000088A (en)
EA (1) EA019454B1 (en)
EC (1) ECSP099312A (en)
ES (1) ES2528385T3 (en)
FR (1) FR2908409B1 (en)
HN (1) HN2009000856A (en)
HR (1) HRP20150070T1 (en)
IL (1) IL198328A0 (en)
MA (1) MA30972B1 (en)
MX (1) MX2009004983A (en)
MY (1) MY147502A (en)
NI (1) NI200900078A (en)
NO (1) NO20091990L (en)
NZ (1) NZ576709A (en)
PE (2) PE20081162A1 (en)
PL (1) PL2091920T3 (en)
PT (1) PT2091920E (en)
SI (1) SI2091920T1 (en)
SV (1) SV2009003253A (en)
TN (1) TN2009000155A1 (en)
TW (1) TW200829556A (en)
UA (1) UA97965C2 (en)
UY (1) UY30707A1 (en)
WO (1) WO2008065282A2 (en)
ZA (1) ZA200903560B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858323B2 (en) * 2004-06-09 2010-12-28 The Regents Of The University Of Michigan Phage microarray profiling of the humoral response to disease
FR2947546B1 (en) * 2009-07-03 2011-07-01 Sanofi Aventis PYRAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
AR079967A1 (en) * 2010-01-26 2012-02-29 Sanofi Aventis 3-HETEROAROILAMINE-PROPIONIC ACID DERIVATIVES REPLACED WITH OXYGEN AND ITS USE AS PHARMACEUTICAL PRODUCTS
TWI523844B (en) * 2011-01-26 2016-03-01 賽諾菲公司 Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
CN102432639B (en) * 2011-09-30 2013-11-06 山东大学 1-(2-hydroxy-3-(phenylamino)propyl)-3-ferrocenyl-1H-pyrazole-5-ethyl formate compound and medicinal use thereof
WO2014068527A1 (en) 2012-11-02 2014-05-08 Pfizer Inc. Bruton's tyrosine kinase inhibitors
RU2017134379A (en) 2015-03-25 2019-04-03 Новартис Аг FORMED N-HETEROCYCLIC DERIVATIVES AS FGFR4 INHIBITORS
CN107619388A (en) * 2016-07-13 2018-01-23 南京天印健华医药科技有限公司 Heterocyclic compound as FGFR inhibitor
CN107840842A (en) 2016-09-19 2018-03-27 北京天诚医药科技有限公司 Alkynes is for heterocyclic compound, its preparation method and its in application pharmaceutically

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088090A2 (en) * 2001-04-27 2002-11-07 Vertex Pharmaceuticals Incorporated Pyrazole derived kinase inhibitors
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
WO2004094410A1 (en) * 2003-04-16 2004-11-04 Astrazeneca Ab Chemical compounds
WO2005012256A1 (en) * 2003-07-22 2005-02-10 Astex Therapeutics Limited 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
WO2006003440A1 (en) * 2004-07-05 2006-01-12 Astex Therapeutics Limited 3,4-disubstituted pyrazoles as cyclin dependent kinases (cdk) or aurora kinase or glycogen synthase 3 (gsk-3) inhibitors
WO2006018662A2 (en) * 2004-08-16 2006-02-23 Prosidion Limited Aryl urea derivatives for treating obesity
WO2006070198A1 (en) * 2004-12-30 2006-07-06 Astex Therapeutics Limited Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases
EP1683796A1 (en) * 2005-01-24 2006-07-26 Schering Aktiengesellschaft Pyrazolopyridines, their preparation and their medical use
WO2006077425A1 (en) * 2005-01-21 2006-07-27 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors and further antitumor agents
WO2006077414A1 (en) * 2005-01-21 2006-07-27 Astex Therapeutics Limited Pyrazole derivatives for the inhibition of cdk' s and gsk' s

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
FR2947546B1 (en) * 2009-07-03 2011-07-01 Sanofi Aventis PYRAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088090A2 (en) * 2001-04-27 2002-11-07 Vertex Pharmaceuticals Incorporated Pyrazole derived kinase inhibitors
WO2004094410A1 (en) * 2003-04-16 2004-11-04 Astrazeneca Ab Chemical compounds
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
WO2005012256A1 (en) * 2003-07-22 2005-02-10 Astex Therapeutics Limited 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
WO2006003440A1 (en) * 2004-07-05 2006-01-12 Astex Therapeutics Limited 3,4-disubstituted pyrazoles as cyclin dependent kinases (cdk) or aurora kinase or glycogen synthase 3 (gsk-3) inhibitors
WO2006018662A2 (en) * 2004-08-16 2006-02-23 Prosidion Limited Aryl urea derivatives for treating obesity
WO2006070198A1 (en) * 2004-12-30 2006-07-06 Astex Therapeutics Limited Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases
WO2006077425A1 (en) * 2005-01-21 2006-07-27 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors and further antitumor agents
WO2006077414A1 (en) * 2005-01-21 2006-07-27 Astex Therapeutics Limited Pyrazole derivatives for the inhibition of cdk' s and gsk' s
EP1683796A1 (en) * 2005-01-24 2006-07-26 Schering Aktiengesellschaft Pyrazolopyridines, their preparation and their medical use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.L LARS AND CO: "Studies on carbanilic acidesters of cyclic amino alcohols.4-esters of pyrrolidinols and piperidinols as local anesthetics", JOURNAL OF MEDICINAL CHEMISTRY, vol. 14, no. 8, 1971, pages 710 - 714, XP002479633 *

Also Published As

Publication number Publication date
SV2009003253A (en) 2009-10-27
SI2091920T1 (en) 2015-02-27
AR063638A1 (en) 2009-02-04
UA97965C2 (en) 2012-04-10
PT2091920E (en) 2015-02-05
CA2667846A1 (en) 2008-06-05
US20110237801A1 (en) 2011-09-29
EA019454B1 (en) 2014-03-31
JP5538893B2 (en) 2014-07-02
PE20081162A1 (en) 2008-10-02
IL198328A0 (en) 2010-02-17
MY147502A (en) 2012-12-14
AU2007327423B2 (en) 2012-09-06
TN2009000155A1 (en) 2010-10-18
ES2528385T3 (en) 2015-02-09
HK1137988A1 (en) 2010-08-13
PE20121152A1 (en) 2012-09-07
EP2091920A2 (en) 2009-08-26
AU2007327423A1 (en) 2008-06-05
US20110237641A1 (en) 2011-09-29
FR2908409B1 (en) 2009-01-09
EP2091920B1 (en) 2014-10-22
WO2008065282A2 (en) 2008-06-05
CY1116000T1 (en) 2017-01-25
ECSP099312A (en) 2009-06-30
CR10749A (en) 2009-07-23
MA30972B1 (en) 2009-12-01
CN101553473B (en) 2013-06-05
HRP20150070T1 (en) 2015-02-27
CN101553473A (en) 2009-10-07
US7989439B2 (en) 2011-08-02
JP2010509297A (en) 2010-03-25
FR2908409A1 (en) 2008-05-16
US8420824B2 (en) 2013-04-16
BRPI0718999A2 (en) 2014-02-25
US20090291984A1 (en) 2009-11-26
CO6190516A2 (en) 2010-08-19
TW200829556A (en) 2008-07-16
ZA200903560B (en) 2010-08-25
DK2091920T3 (en) 2015-01-26
NI200900078A (en) 2010-01-27
CL2007003251A1 (en) 2009-08-07
MX2009004983A (en) 2009-05-22
PL2091920T3 (en) 2015-04-30
NZ576709A (en) 2011-08-26
DOP2009000088A (en) 2013-06-15
HN2009000856A (en) 2011-10-19
UY30707A1 (en) 2008-07-03
NO20091990L (en) 2009-06-02
KR20090083456A (en) 2009-08-03
EA200970472A1 (en) 2009-10-30
US8410286B2 (en) 2013-04-02

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