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WO2009130926A1 - Procédé endermique, organisateur d'aiguille et dispositif d'injecteur endermique - Google Patents

Procédé endermique, organisateur d'aiguille et dispositif d'injecteur endermique Download PDF

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Publication number
WO2009130926A1
WO2009130926A1 PCT/JP2009/051186 JP2009051186W WO2009130926A1 WO 2009130926 A1 WO2009130926 A1 WO 2009130926A1 JP 2009051186 W JP2009051186 W JP 2009051186W WO 2009130926 A1 WO2009130926 A1 WO 2009130926A1
Authority
WO
WIPO (PCT)
Prior art keywords
needle
skin
microneedle
forming body
microneedles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2009/051186
Other languages
English (en)
Japanese (ja)
Inventor
昭典 稲生
雅浩 瀧川
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanbu Plastics Co Ltd
Hamamatsu University School of Medicine NUC
Original Assignee
Nanbu Plastics Co Ltd
Hamamatsu University School of Medicine NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanbu Plastics Co Ltd, Hamamatsu University School of Medicine NUC filed Critical Nanbu Plastics Co Ltd
Publication of WO2009130926A1 publication Critical patent/WO2009130926A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles

Definitions

  • the present invention relates to a percutaneous administration method for transdermally administering a drug solution / drug, a needle forming body having an assembly of medical microneedles used in the drug solution / drug administration method, and the needle forming body.
  • the present invention relates to a percutaneous administration device that is worn and transdermally administered.
  • microneedles and microblades have been developed recently.
  • the purpose of the microneedle is to shorten the effective time by directly administering a drug solution / drug to the living cell layer of the epidermis (the epidermis layer below the spinous cell layer).
  • a drug solution / drug to the living cell layer of the epidermis (the epidermis layer below the spinous cell layer).
  • it may be used for the purpose of shortening the time of drug efficacy expression of drugs such as insulin and anesthetics, and physiologically active substances such as DNA, RNA, protein, and peptides based on the same principle.
  • a microneedle is generally a fine needle having a tip diameter of 10 ⁇ m, a height of 100 ⁇ m, and a skirt diameter of 100 ⁇ m, and is a micro structure having a large aspect ratio.
  • Such a microneedle penetrates the stratum corneum of the skin, but does not reach the pain point, and therefore has an advantage that it does not feel pain when inserted into the human body.
  • the technology related to microneedles so far has focused on the invasion of the body by a syringe, in particular, alleviation of pain due to needle piercing. JP 2006-149818 A
  • microneedles are extremely small as described above, in order to administer a drug solution / drug, it must first penetrate the stratum corneum in the surface layer of the epidermis. Microneedles need to have a length (or height) sufficient to penetrate the stratum corneum. In addition, since the stratum corneum is relatively hard and has elasticity, the microneedles need to be thin enough to penetrate the stratum corneum in order to penetrate the stratum corneum. However, if the length and the thinness are required at the same time, the strength is insufficient, and the microneedle must be broken or broken in the living body at the time of drug solution / drug administration so that the microneedle does not remain in the body. Thus, it is not easy to manufacture a microneedle that is long, thin, and has sufficient strength.
  • the first object of the present invention is a transdermal administration method that can solve the above-mentioned problems and that can reliably transdermally administer a drug solution / drug even if the microneedle is short.
  • the second object of the present invention is to provide a needle forming body that is used in the above transdermal administration method.
  • transdermal administration device for transdermal administration by attaching a needle forming body provided for the above transdermal administration method.
  • the invention according to claim 1 is directed to a portion where the stratum corneum layer of the skin is peeled off from a needle forming body provided with a microneedle assembly portion formed by collecting and arranging a plurality of microneedles.
  • the drug solution / drug is administered into the epidermis from the microneedles of the microneedle assembly by pressing.
  • the invention according to claim 2 is characterized in that the surface is formed in a convex shape and a microneedle assembly part formed by arranging and arranging a plurality of microneedles is formed on the top part of the surface. It is characterized in that one or more chemical / drug dropping holes are formed penetrating from the back surface to the front surface.
  • the microneedle is made of a thermoplastic resin
  • the base diameter is ⁇ 10 to 1000 ⁇ m (preferably 50 to 200 ⁇ m)
  • the tip diameter is ⁇ 10 to 100 ⁇ m
  • the height is 10 to 1000 ⁇ m. (Preferably 50 to 100 ⁇ m).
  • the microneedle assembling portion has a microneedle pitch of 0.1 to 20 mm (preferably 0.5 to 1 mm) at a pitch of 1 to 1000 (preferably 100 to 650). Book) is provided.
  • a needle forming body provided on the surface with a microneedle assembly formed by arranging and arranging a plurality of microneedles is provided in a certain range at the inner lower portion of the cylindrical body.
  • the tip of the syringe inserted inside the cylindrical body is fixed to the needle forming body integrally, and the syringe is pumped so that the microneedles below the needle forming body are inserted into the skin.
  • the drug solution / drug that has reached the microneedle from the syringe through the needle-forming body is administered to the living cell layer of the epidermis (the epidermis layer below the spinous cell layer).
  • the needle forming body is integrally fixed to a pedestal provided on the inner lower portion of the cylindrical body so as to be movable up and down within a certain range, and the tip of the syringe is It is fixed to the pedestal, and the pedestal is formed with a communication hole for communicating the tip of the syringe with the needle forming body.
  • an opening having an engagement piece left in the middle is formed, and the engaging portion formed to protrude from the pedestal or cylindrical body is The engaging piece is engaged, and the base is biased upward by the elasticity of the engaging piece.
  • the invention according to claim 8 is the invention according to any one of claims 5 to 7, wherein a skin expanding means is provided at a lower end opening of the cylindrical body to expand the skin when the cylindrical body is pressed against the skin. It is characterized by that.
  • the invention according to claim 1 is provided with a microneedle assembly on the surface where a plurality of microneedles having a height of 10 to 1000 ⁇ m (preferably 50 to 100 ⁇ m) are gathered and arranged on a portion of the skin where the stratum corneum is peeled off.
  • This is a method to administer a drug solution / medicine from the microneedle to the living cell layer of the epidermis (the epidermis layer below the spinous cell layer) from the microneedle. Since there is no need to penetrate, the height of the microneedle can be reduced, and sufficient strength can be ensured even if it is thin. As a result, it is possible to shorten the time of drug efficacy expression of drugs such as insulin and anesthetics, and physiologically active substances such as DNA, RNA, protein, and peptides.
  • stratum corneum is always peeled and reborn to a new one in a certain cycle, so it is easy to peel off this part artificially and without pain. Therefore, the burden on the patient is very light.
  • the surface provided with the microneedle assembly portion is formed with a convex curvature radius R10 to 100 mm (preferably 30 to 40 mm), all of them are pressed against the human skin. Alternatively, some of the microneedles are evenly inserted without any unevenness, so that the efficiency is good.
  • one or more liquid passage holes are formed through the back surface to the front surface, when the chemical solution / medicine is supplied from the back side, the chemical solution / medicine moves to the front side and flows along the convex surface, and the base of the microneedle Move to. Therefore, the drug solution / drug can be administered along the microneedle to the living cell layer of the epidermis (the epidermis layer below the spinous cell layer).
  • the microneedle is made of a thermoplastic resin
  • the base diameter is ⁇ 10 to 1000 ⁇ m (preferably 50 to 200 ⁇ m)
  • the tip diameter is ⁇ 10 to 100 ⁇ m
  • the height is 10 to 1000 ⁇ m (preferably 50 100 ⁇ m)
  • the microneedle assembly is provided with 1 to 1000 (preferably 100 to 650) microneedles at a pitch of 0.1 to 20 mm (preferably 0.5 to 1 mm). Therefore, the chemical solution / drug can be efficiently supplied to the living cell layer of the epidermis (the epidermis layer below the spinous cell layer).
  • a needle forming body provided on the surface with a microneedle assembly part formed by collecting and arranging a plurality of microneedles is provided on the inner lower part of the cylindrical body so as to be movable vertically.
  • the tip of the syringe inserted inside the cylindrical body is integrally fixed to the needle forming body, the syringe is pumped, and the microneedles below the needle forming body are pierced into the skin, so that the needle is removed from the syringe.
  • the drug solution / drug that reaches the microneedle via the formed body is administered to the living cell layer of the epidermis (the epidermis layer below the spinous cell layer), a commercially available syringe can be used, so the cost It can be kept low and the administration operation is easy.
  • the said needle formation body is integrally fixed to the base provided in the inner lower part of the said cylindrical body so that a vertical movement is possible, and the front-end
  • the opening part which left the engagement piece in the middle is formed in the said cylindrical body or a base,
  • the engagement part which protruded and formed in the said base or a cylindrical body is said engagement piece Since the pedestal is urged upward by the elasticity of the engagement piece, it is not necessary to provide a means for urging the pedestal upward, and the structure can be simplified.
  • the skin corresponding to the microneedle is thinly drawn at the lower end opening of the cylindrical body by the skin expanding means when the cylindrical body is pressed against the skin. Since the length of the microneedles is extended, the microneedle can enter the living cell layer of the epidermis (the epidermis layer below the spinous cell layer) more reliably and administer the drug solution / drug.
  • (A) and (b) are a side view and a plan view of the needle forming body, respectively.
  • Side view showing a part of the microneedle assembly Expanded sectional view of microneedle Perspective view of transdermal administration device
  • Cross-sectional view of transdermal administration device Partial cross-sectional view of a transdermal administration device
  • FIG. 1 (a) and 1 (b) show the principle diagram of the transdermal administration method according to the present invention, in which the reference numeral 1 is a needle forming body.
  • the reference numeral 1 is a needle forming body.
  • a microneedle assembly portion 3 formed by collecting and arranging a plurality of microneedles 2 having a height of 10 to 1000 ⁇ m (preferably 50 to 100 ⁇ m).
  • the stratum corneum has a thickness of 10 to 20 ⁇ m, but varies slightly depending on age and sex. The same applies to the elasticity of the stratum corneum.
  • the needle forming body 1 is a disk-shaped member having a convex surface and a diameter of 10 to 50 mm (preferably 20 to 40 mm).
  • a microneedle assembly portion 3 is provided in which a plurality of microneedles 2 are collectively arranged.
  • the microneedle assembly 3 has a convex surface with a radius of curvature R of 10 to 100 mm (preferably 30 to 40 mm).
  • the microneedle 2 is formed in a truncated cone shape, the base diameter L1 is 10 to 1000 ⁇ m (preferably 50 to 200 ⁇ m), the needle tip diameter L2 is 10 to 100 ⁇ m, and the length (height) H is 10 to 1000 ⁇ m (preferably 50 to 100 ⁇ m).
  • the microneedle assembly 3 has 1 to 1000 (preferably, 1 to 1000) microneedles 2 at a pitch of 0.1 to 20 mm (preferably 0.5 to 1 mm). About 100 to 650).
  • one or more liquid passage holes 4 are formed through the central portion of the needle forming body 1 from the back surface to the front surface.
  • the diameter of the hole may be ⁇ 5 mm or less, and the size should be such that the drug solution / medicine from above does not spill down and oozes out.
  • the position of the liquid passage hole 4 is not limited to the central portion. It may be provided around the microneedle assembly 3. Two or more may be provided.
  • the needle forming body 1 may be manufactured by injection molding or imprint molding using a thermoplastic resin such as polycarbonate, polypropylene, ABS resin, or polystyrene.
  • die is manufactured by the forging process or electric discharge process or etching process or electroforming process etc. by a cutting tool by a micron bite or a punching tool.
  • the needle forming body 1 is used by being attached to the transdermal administration device 5 shown in FIGS.
  • the syringe 7 is inserted from the upper part of the cylindrical body 6, screwed and fixed to the pedestal 8, the drug solution / drug is soaked into the microneedle assembly 3, and then the syringe 7 is pumped to pedestal.
  • the microneedle 2 of the needle forming body 1 welded at the welded portion is pierced into the skin, and the above-described chemical solution / medicine is supplied to the living cell layer of the epidermis (the epidermal layer below the spinous cell layer). Is.
  • the needle forming body 1 is integrally fixed to a pedestal 8 that is movably provided at the inner lower portion of the cylindrical body 6.
  • the pedestal 8 is formed in a short cylindrical shape having a cylindrical portion 10 at the center, and a male screw 11 a is formed on the outer end of the cylindrical portion 10.
  • the male screw 11a is formed in such a size that it can be screwed into the female screw 11b inside the outer peripheral edge 12a formed on the outer periphery of the injection needle mounting portion 12 at the tip of the syringe 7.
  • the needle forming body 1 is welded and fixed to the lower surface of the base 8.
  • the pedestal-equipped needle-forming body 1 is fitted into a cylindrical body 6.
  • the cylindrical body 6 is formed with an opening 14 having an engagement piece 13 in the middle, and a rod-like or round engagement portion 15 is formed on the outer side of the pedestal 8 so as to protrude.
  • the engaging portion 15 is engaged on the engaging piece 13.
  • the needle-forming body 1 with a pedestal is biased upward by the elasticity of the engagement piece 13 and is provided so as to be movable up and down within a certain range.
  • the cylindrical body 6 is formed with an accommodating portion 16 that accommodates the pedestal-equipped needle forming body 1 so as to be movable up and down, and the upper portion of the accommodating portion 16 is sized so that the cylinder 17 of the syringe 7 can be inserted. Is formed.
  • an annular edge 20 is formed at the lower end opening of the cylindrical body 6 as a skin expansion means for expanding the skin when the cylindrical body 6 is pressed against the skin 18.
  • the piston 19 of the syringe 7 is pulled out, and the drug solution / drug 21 is injected and filled into the cylinder 17. Then, the syringe 7 is inserted into the cylindrical body 6 with the syringe 7 facing upward, the syringe needle mounting portion 12 at the tip of the syringe 7, the male screw 11 a of the tube portion 10 of the base 8, and the female screw 11 b of the tip outer peripheral edge 12 a of the syringe 7. Screw in and fix. Thereby, the said injection needle attachment part 12 and the cylinder part 10 of the base 8 are connected.
  • the direction of the dosing device is returned, and its tip is applied to the part where the stratum corneum 18a of the skin 18 is peeled off, and the piston 19 of the syringe 7 is pushed, so that the medicinal solution / drug 21 passes from the cylinder 17 through the liquid passage hole. And ooze on the skin.
  • the drug solution / drug 21 is supplied along the microneedle 2 to the living cell layer of the epidermis (the epidermis layer below the spinous cell layer).
  • the annular edge 20 of the lower end opening of the cylindrical body 6 is pressed against the skin 18 by pumping, the skin 18 is spread and thinly stretched, and the microneedles 2 are more reliably living cells of the epidermis.
  • the medicinal solution / drug 21 can be administered by entering the layer (the epidermis layer below the spinous cell layer), and the medicinal solution / drug 21 flows out during administration because the annular edge 20 is in close contact with the skin 18. Can be prevented.
  • the cylindrical body 6 When the syringe 7 is pushed, the cylindrical body 6 is pressed against the skin 18 by the pressing force, and the engaging portion 15 of the base 8 deflects the engaging piece 13 of the cylindrical body 6 downward to form a cylindrical shape. Since it moves downward relative to the body 6, the microneedle 2 pierces the skin 18. When the pressing force is released, the engagement piece 13 returns to its original position due to its inherent elasticity, so that the base 8 also moves upward relative to the cylindrical body 6.
  • the pedestal and the needle forming body may be formed integrally instead of separately and the tip of the syringe may be fixed to the needle forming body.
  • the needle-forming body with a pedestal may be urged upward by a spring.
  • the skin 18 is thinned by the thickness of the peeled stratum corneum, and the skin 18 is pushed and spread at the time of administration, so that the skin 18 is further thinned. Therefore, by setting the height of the microneedles 2 to 10 to 1000 ⁇ m (preferably 50 to 100 ⁇ m), all or most of the microneedles 2 are living cell layers of the epidermis (epidermal layers below the spinous cell layer). It was confirmed that it reached the state reached.
  • the microneedle assembly 3 is provided with 1 to 1000 (preferably 100 to 650) microneedles 2 at a pitch of 0.1 to 20 mm (preferably 0.5 to 1 mm). The drug can be efficiently supplied to the living cell layer of the epidermis (the epidermis layer below the spinous cell layer).
  • the skirt diameter is ⁇ 10 to 1000 ⁇ m (preferably 50 to 200 ⁇ m), and the tip diameter is 10 to 100 ⁇ m. Sufficient strength can be ensured, and it is possible to prevent the microneedles 2 from remaining in the body due to breakage or breakage of the microneedles 2 in the living body at the time of drug solution / drug administration.
  • the microneedle assembly 3 is intensively pressed strongly when pressed against the skin, and the pressure is not dispersed. Therefore, most of the microneedles 2 are inserted into the skin, and the drug solution / medicine 21 can be efficiently supplied into the skin 18.
  • the needle forming body 1 may not be a circle but may be a square, an oval, an ellipse, or the like, and the needle assembly portion that is a skin contact surface is not limited to a convex surface. It may be formed in a planar shape.
  • the shape of the microneedle 2 is not limited to the above.
  • the needle portion may not be in the shape of a truncated cone, but may be a triangular frustum, a quadrangular pyramid, or the like, and a groove for passing a drug solution / medicine may be cut in the height direction. Furthermore, there may be a through hole from the vicinity of the tip of the needle part to the back surface of the needle forming body 1.
  • Polycarbonate microneedles 2 in which 121 needles of a truncated cone having an outer diameter of ⁇ 20 mm and a thickness of 100 ⁇ m, a base diameter of ⁇ 200 ⁇ m, and a tip diameter of 20 ⁇ m are arranged at a pitch of 1 mm on a base having a diameter of 20 mm and histamine (made of sigma) ) Urticaria erupted when 1, 10, and 20 mg containing the substance was applied to the skin and then applied transdermally. Thereby, it was verified that the needle of the microneedle 2 surely passed through the stratum corneum and reached the living cell layer (skin layer below the spinous cell layer) of the epidermis.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention porte sur un procédé endermique pour effectuer une administration par voie endermique de médicaments et de produits chimiques de façon sûre même si une micro-aiguille est courte, sur un organisateur d'aiguille pour une utilisation dans le procédé et sur un dispositif d'injecteur endermique. Un organisateur d'aiguille (1) comportant, sur sa surface, une partie (3) dans laquelle une pluralité de micro-aiguilles (2) sont agencées collectivement, est appliqué à une partie d'une peau (18) à partir de laquelle une couche cornée est enlevée par stripping, puis des médicaments et des produits chimiques sont injectés dans la peau à partir des micro-aiguilles (2) dans la partie (3) où une pluralité de micro-aiguilles sont agencées collectivement. La partie (3) où une pluralité de micro-aiguilles (2) sont agencées collectivement et une surface convexe est formée sur la surface de celle-ci est formée sur le dessus de la surface, et un ou plusieurs trous de passage de liquide (4) sont formés pour faire pénétrer l'organisateur d'aiguille (1) de la surface arrière à la surface avant.
PCT/JP2009/051186 2008-04-22 2009-01-26 Procédé endermique, organisateur d'aiguille et dispositif d'injecteur endermique Ceased WO2009130926A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2008-111862 2008-04-22
JP2008111862 2008-04-22
JP2008-142397 2008-05-30
JP2008142397 2008-05-30
JP2009005906 2009-01-14
JP2009-005906 2009-01-14

Publications (1)

Publication Number Publication Date
WO2009130926A1 true WO2009130926A1 (fr) 2009-10-29

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Application Number Title Priority Date Filing Date
PCT/JP2009/051186 Ceased WO2009130926A1 (fr) 2008-04-22 2009-01-26 Procédé endermique, organisateur d'aiguille et dispositif d'injecteur endermique

Country Status (2)

Country Link
JP (1) JP5486211B2 (fr)
WO (1) WO2009130926A1 (fr)

Cited By (12)

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WO2010126174A1 (fr) 2009-05-01 2010-11-04 Nanbu Plastics Co., Ltd. Dispositif d'administration transdermique
JP2012100784A (ja) * 2010-11-08 2012-05-31 Nanbu Plastics Co Ltd 経皮投薬装置に使用するニードル形成体
WO2012126784A1 (fr) 2011-03-18 2012-09-27 Universite Libre De Bruxelles Dispositifs pour la perforation d'une membrane du corps humain ou animal
WO2014017561A1 (fr) * 2012-07-25 2014-01-30 凸版印刷株式会社 Outil de manipulation pour injecteur de fluide utilisant un dispositif à multi-microaiguilles
WO2015009530A1 (fr) * 2013-07-16 2015-01-22 3M Innovative Properties Company Article à réseau de micro-aiguilles creuses
CN104684610A (zh) * 2012-10-17 2015-06-03 凸版印刷株式会社 使用多微针构件的流体注入器操作器具
CN106422046A (zh) * 2016-10-27 2017-02-22 游学秋 射流微针注射系统
US10201691B2 (en) 2013-07-16 2019-02-12 3M Innovative Properties Article comprising a microneedle
US10232157B2 (en) 2013-07-16 2019-03-19 3M Innovative Properties Company Hollow microneedle with beveled tip
US10384047B2 (en) 2013-07-16 2019-08-20 3M Innovative Properties Company Hollow microneedle with bevel opening
WO2022071322A1 (fr) * 2020-09-30 2022-04-07 株式会社資生堂 Pièce avec des saillies en forme d'aiguille
CN118662773A (zh) * 2024-08-20 2024-09-20 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） 一种用于卵巢保养的便捷给药装置

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JP6074889B2 (ja) * 2012-02-08 2017-02-08 凸版印刷株式会社 マイクロニードルチップ
JP5954011B2 (ja) * 2012-07-18 2016-07-20 凸版印刷株式会社 マイクロニードル刺し込み量規制器具
JP5954014B2 (ja) * 2012-07-20 2016-07-20 凸版印刷株式会社 マイクロニードル刺し込み量規制器具
JP6579099B2 (ja) * 2014-04-03 2019-09-25 凸版印刷株式会社 穿刺注入器具
JP6001043B2 (ja) 2014-12-15 2016-10-05 日本写真印刷株式会社 マイクロニードルアレイ製造装置及びマイクロニードルアレイの製造方法並びにマイクロニードルアレイを有する製品
EP3466478B1 (fr) * 2016-06-07 2020-08-26 FUJIFILM Corporation Réseau de micro-aiguilles
KR101862679B1 (ko) * 2018-05-03 2018-05-31 박영오 켈로이드 치료용 주사키트
JP7394576B2 (ja) * 2018-12-13 2023-12-08 花王株式会社 微細突起具
KR102297883B1 (ko) * 2021-02-17 2021-09-03 주식회사 지엘캄퍼니 마이크로 니들조립체
JP7757109B2 (ja) * 2021-09-27 2025-10-21 タクセル株式会社 マイクロニードルアレイ穿刺用デバイス
JPWO2023190584A1 (fr) * 2022-03-30 2023-10-05

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