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WO2009148281A3 - 신규 디아릴 헤파토노이드계 화합물 및 그 용도 - Google Patents

신규 디아릴 헤파토노이드계 화합물 및 그 용도 Download PDF

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Publication number
WO2009148281A3
WO2009148281A3 PCT/KR2009/002996 KR2009002996W WO2009148281A3 WO 2009148281 A3 WO2009148281 A3 WO 2009148281A3 KR 2009002996 W KR2009002996 W KR 2009002996W WO 2009148281 A3 WO2009148281 A3 WO 2009148281A3
Authority
WO
WIPO (PCT)
Prior art keywords
based compound
virus
diaryl hepatonoid
hepatonoid
therapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/002996
Other languages
English (en)
French (fr)
Other versions
WO2009148281A2 (ko
Inventor
라정찬
김영호
권혁준
윈후퉁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RNL Bio Co Ltd
Original Assignee
RNL Bio Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RNL Bio Co Ltd filed Critical RNL Bio Co Ltd
Priority to CN2009801298674A priority Critical patent/CN102112427B/zh
Priority to JP2011512385A priority patent/JP2011523660A/ja
Priority to US12/996,314 priority patent/US20110124740A1/en
Publication of WO2009148281A2 publication Critical patent/WO2009148281A2/ko
Publication of WO2009148281A3 publication Critical patent/WO2009148281A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 바이러스 억제활성을 갖는 하기 화학식(1)의 디아릴 헤파토노이드계(diaryl hepatonoid) 화합물; 약제학적으로 허용 가능한 그의 염; 그의 수화물, 그의 용매화물 또는 프로드럭, 그리고, 이를 함유하는 약제학적 조성물 및 치료제로서의 용도에 관한 것이다. 본 발명에 따른 상기 디아릴 헤파토노이드계(diaryl hepatonoid) 화합물은 바이러스 활성 억제 효능이 우수하므로 바이러스와 관련된 질환에 대한 치료제로서 유용하게 사용될 수 있다.
PCT/KR2009/002996 2008-06-05 2009-06-04 신규 디아릴 헤파토노이드계 화합물 및 그 용도 Ceased WO2009148281A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN2009801298674A CN102112427B (zh) 2008-06-05 2009-06-04 新型二芳基庚酮类化合物及其使用
JP2011512385A JP2011523660A (ja) 2008-06-05 2009-06-04 新規ジアリールヘパトノイド系化合物及びその用途
US12/996,314 US20110124740A1 (en) 2008-06-05 2009-06-04 Novel diaryl hepatonoid-based compounds and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0052843 2008-06-05
KR20080052843 2008-06-05

Publications (2)

Publication Number Publication Date
WO2009148281A2 WO2009148281A2 (ko) 2009-12-10
WO2009148281A3 true WO2009148281A3 (ko) 2010-03-11

Family

ID=41398687

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/002996 Ceased WO2009148281A2 (ko) 2008-06-05 2009-06-04 신규 디아릴 헤파토노이드계 화합물 및 그 용도

Country Status (5)

Country Link
US (1) US20110124740A1 (ko)
JP (1) JP2011523660A (ko)
KR (1) KR100930480B1 (ko)
CN (1) CN102112427B (ko)
WO (1) WO2009148281A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024228949A1 (en) * 2023-04-29 2024-11-07 Anju Majeed Compositions for modulating the expression of aquaporins in diabetes and associated conditions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3550475B2 (ja) * 1997-02-27 2004-08-04 サンスター株式会社 化粧料
KR100629314B1 (ko) * 2004-03-03 2006-09-29 한국생명공학연구원 오리나무 추출물 또는 그로부터 분리된 디아릴헵타노이드계 화합물을 유효성분으로 하는 심장순환계질환의 예방 및 치료용 조성물
US20050215635A1 (en) * 2004-03-08 2005-09-29 Rafi M Mohamed Diarylheptanoid compounds and uses thereof
KR100721703B1 (ko) * 2006-06-29 2007-05-25 주식회사 알앤엘바이오 오리나무 추출물을 함유하는 항바이러스 조성물
KR100769050B1 (ko) * 2007-02-06 2007-10-22 주식회사 알앤엘바이오 오리나무 추출물을 함유하는 항바이러스 조성물

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CASTELLAN A. ET AL: "Photophysics and photochemistry of tetrahydrocurcuminoids", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A: CHEMISTRY, vol. 190, 2007, pages 110 - 120, XP022107957 *
JIN W.Y. ET AL: "Triterpenoids and Diarylheptanoids from Alnus hirsuta Inhibit HIF-1 in AGS Cells", ARCH.PHARM.RES., vol. 30, 2007, pages 412 - 418 *

Also Published As

Publication number Publication date
US20110124740A1 (en) 2011-05-26
KR100930480B1 (ko) 2009-12-09
CN102112427B (zh) 2013-11-13
CN102112427A (zh) 2011-06-29
JP2011523660A (ja) 2011-08-18
WO2009148281A2 (ko) 2009-12-10

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