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MX2010008690A - Farmacoforos duales - antagonistas muscarinicos de pde4. - Google Patents

Farmacoforos duales - antagonistas muscarinicos de pde4.

Info

Publication number
MX2010008690A
MX2010008690A MX2010008690A MX2010008690A MX2010008690A MX 2010008690 A MX2010008690 A MX 2010008690A MX 2010008690 A MX2010008690 A MX 2010008690A MX 2010008690 A MX2010008690 A MX 2010008690A MX 2010008690 A MX2010008690 A MX 2010008690A
Authority
MX
Mexico
Prior art keywords
pde4
dual
muscarinic
antagonistics
pharmacophores
Prior art date
Application number
MX2010008690A
Other languages
English (en)
Inventor
Zehong Wan
Hongxing Yan
James Francis Callahan
Guoliang Lin
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40935342&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010008690(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MX2010008690A publication Critical patent/MX2010008690A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a nuevos compuestos de la fórmula (I) y a sus sales farmacéuticamente aceptables, (ver fórmula) a composiciones farmacéuticas y a su uso como cromóforos duales que tienen actividad inhibitoria contra receptores de PDE4 y receptores muscarinicos de acetilcolina (mAChRs), siendo así de utilidad para tratar enfermedades respiratorias.
MX2010008690A 2008-02-06 2009-02-05 Farmacoforos duales - antagonistas muscarinicos de pde4. MX2010008690A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2656308P 2008-02-06 2008-02-06
PCT/US2009/033128 WO2009100166A1 (en) 2008-02-06 2009-02-05 Dual pharmacophores-pde4-muscarinic antagonistics

Publications (1)

Publication Number Publication Date
MX2010008690A true MX2010008690A (es) 2010-08-30

Family

ID=40935342

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010008690A MX2010008690A (es) 2008-02-06 2009-02-05 Farmacoforos duales - antagonistas muscarinicos de pde4.

Country Status (19)

Country Link
US (1) US8084449B2 (es)
EP (1) EP2259681A4 (es)
JP (1) JP2011511082A (es)
KR (1) KR20100113155A (es)
CN (1) CN101990401A (es)
AR (1) AR070562A1 (es)
AU (1) AU2009212408A1 (es)
BR (1) BRPI0908008A2 (es)
CA (1) CA2714352A1 (es)
CL (1) CL2009000250A1 (es)
CR (1) CR11665A (es)
DO (1) DOP2010000235A (es)
EA (1) EA201070916A1 (es)
IL (1) IL207352A0 (es)
MX (1) MX2010008690A (es)
PE (1) PE20091552A1 (es)
TW (1) TW201000476A (es)
UY (1) UY31637A1 (es)
WO (1) WO2009100166A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011240070A1 (en) 2010-04-16 2012-11-08 Bayer Intellectual Property Gmbh Heterocyclic compounds as pest control agents
WO2011143106A1 (en) 2010-05-10 2011-11-17 Gilead Sciences, Inc. Bi - functional pyrazolopyridine compounds
PH12012502551A1 (en) 2010-06-28 2017-08-23 Bayer Ip Gmbh Heterocyclic compounds as agents for pest control
US9763924B2 (en) 2014-06-05 2017-09-19 Chiesi Farmaceutici S.P.A. Aminoester derivatives
US9975847B2 (en) 2014-11-11 2018-05-22 Johnson & Johnson Consumer Inc. Amino acid derivatives and their uses
US9321744B1 (en) 2015-06-26 2016-04-26 Industrial Technology Research Institute Method for preparing 2,5-furan dicarboxylic acid
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas

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BE787249A (fr) * 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
US3856799A (en) * 1971-08-05 1974-12-24 Squibb & Sons Inc Intermediates for production of amino derivatives of pyrazolopyridine carboxylic acids and esters
US3925388A (en) * 1971-08-05 1975-12-09 Squibb & Sons Inc 4-Piperazino-{8 3,4-b{9 pyridine-5-carboxylic acids and esters
US3833594A (en) * 1971-08-05 1974-09-03 Squibb & Sons Inc Amino derivatives of pyrazolopyridine carboxylic acids and esters
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US4364948A (en) 1981-09-28 1982-12-21 Ici Americas Inc. Pyrazolo[3,4-b]pyridine compounds
US6326379B1 (en) 1998-09-16 2001-12-04 Bristol-Myers Squibb Co. Fused pyridine inhibitors of cGMP phosphodiesterase
US6670364B2 (en) 2001-01-31 2003-12-30 Telik, Inc. Antagonists of MCP-1 function and methods of use thereof
TWI236474B (en) 2001-04-03 2005-07-21 Telik Inc Antagonists of MCP-1 function and methods of use thereof
US6825184B2 (en) * 2001-10-18 2004-11-30 Boehringer Ingelheim Pharmaceuticals, Inc. 1,4-Disubstituted benzo-fused urea compounds
EP1499598A1 (en) 2002-04-18 2005-01-26 Ucb, S.A. Chemical compounds with dual activity, processes for their preparation and pharmaceutical compositions
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EP1613307A4 (en) 2003-04-07 2008-03-12 Glaxo Group Ltd M SB 3 / SB MUSCARIN ACETYLCHOLINE RECEPTOR ANTAGONISTS
TW200519108A (en) 2003-07-17 2005-06-16 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
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Also Published As

Publication number Publication date
EP2259681A1 (en) 2010-12-15
AR070562A1 (es) 2010-04-21
CR11665A (es) 2011-01-11
BRPI0908008A2 (pt) 2015-08-18
US20090203657A1 (en) 2009-08-13
KR20100113155A (ko) 2010-10-20
CA2714352A1 (en) 2009-08-13
CL2009000250A1 (es) 2009-09-11
CN101990401A (zh) 2011-03-23
TW201000476A (en) 2010-01-01
AU2009212408A1 (en) 2009-08-13
EA201070916A1 (ru) 2011-02-28
JP2011511082A (ja) 2011-04-07
IL207352A0 (en) 2010-12-30
DOP2010000235A (es) 2011-01-15
WO2009100166A1 (en) 2009-08-13
US8084449B2 (en) 2011-12-27
EP2259681A4 (en) 2012-04-04
UY31637A1 (es) 2009-08-03
PE20091552A1 (es) 2009-10-25

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal