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WO2009145456A3 - 헤테로사이클 유도체 - Google Patents

헤테로사이클 유도체 Download PDF

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Publication number
WO2009145456A3
WO2009145456A3 PCT/KR2009/001659 KR2009001659W WO2009145456A3 WO 2009145456 A3 WO2009145456 A3 WO 2009145456A3 KR 2009001659 W KR2009001659 W KR 2009001659W WO 2009145456 A3 WO2009145456 A3 WO 2009145456A3
Authority
WO
WIPO (PCT)
Prior art keywords
heterocyclic derivatives
medicaments
preparation
uric acid
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/001659
Other languages
English (en)
French (fr)
Other versions
WO2009145456A2 (ko
Inventor
안성오
박찬희
임준환
이순옥
이경준
조성욱
고광석
한선영
이원일
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
C&C Research Laboratories
Original Assignee
C&C Research Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HRP20151098TT priority Critical patent/HRP20151098T1/hr
Priority to PL09754921T priority patent/PL2266989T3/pl
Priority to US12/935,478 priority patent/US8394792B2/en
Priority to HK11102459.7A priority patent/HK1148283B/en
Priority to BRPI0909691-4A priority patent/BRPI0909691B1/pt
Priority to EA201071144A priority patent/EA018521B1/ru
Priority to CA2718709A priority patent/CA2718709C/en
Priority to KR1020107021818A priority patent/KR101250297B1/ko
Priority to MX2010010366A priority patent/MX2010010366A/es
Priority to JP2011502853A priority patent/JP5314123B2/ja
Priority to AU2009252166A priority patent/AU2009252166B9/en
Priority to ES09754921.6T priority patent/ES2552311T3/es
Priority to EP09754921.6A priority patent/EP2266989B1/en
Priority to CN200980113926.9A priority patent/CN102015726B/zh
Priority to DK09754921.6T priority patent/DK2266989T3/en
Priority to SI200931323T priority patent/SI2266989T1/sl
Application filed by C&C Research Laboratories filed Critical C&C Research Laboratories
Priority to NZ587880A priority patent/NZ587880A/en
Publication of WO2009145456A2 publication Critical patent/WO2009145456A2/ko
Publication of WO2009145456A3 publication Critical patent/WO2009145456A3/ko
Priority to ZA2010/06475A priority patent/ZA201006475B/en
Priority to IL208203A priority patent/IL208203A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

본 발명은 헤테로사이클 유도체에 관한 것으로, 보다 상세하게는, 뇨산과 관련된 질병을 치료하는 의약의 제조에 유용한 신규한 헤테로사이클 유도체에 관한 것이다.
PCT/KR2009/001659 2008-03-31 2009-03-31 헤테로사이클 유도체 Ceased WO2009145456A2 (ko)

Priority Applications (19)

Application Number Priority Date Filing Date Title
AU2009252166A AU2009252166B9 (en) 2008-03-31 2009-03-31 Heterocyclic derivatives
US12/935,478 US8394792B2 (en) 2008-03-31 2009-03-31 Heterocyclic derivatives
HK11102459.7A HK1148283B (en) 2008-03-31 2009-03-31 Heterocyclic derivatives
BRPI0909691-4A BRPI0909691B1 (pt) 2008-03-31 2009-03-31 Composto derivado de heterociclo, método para preparar um composto, e, composição farmacêutica
EA201071144A EA018521B1 (ru) 2008-03-31 2009-03-31 Гетероциклические производные
PL09754921T PL2266989T3 (pl) 2008-03-31 2009-03-31 Pochodne heterocykliczne
KR1020107021818A KR101250297B1 (ko) 2008-03-31 2009-03-31 헤테로사이클 유도체
MX2010010366A MX2010010366A (es) 2008-03-31 2009-03-31 Derivados heterociclicos.
JP2011502853A JP5314123B2 (ja) 2008-03-31 2009-03-31 複素環誘導体
ES09754921.6T ES2552311T3 (es) 2008-03-31 2009-03-31 Derivados heterocíclicos
CA2718709A CA2718709C (en) 2008-03-31 2009-03-31 Heterocyclic derivatives
HRP20151098TT HRP20151098T1 (hr) 2008-03-31 2009-03-31 Heterocikliäśki derivati
CN200980113926.9A CN102015726B (zh) 2008-03-31 2009-03-31 杂环衍生物
DK09754921.6T DK2266989T3 (en) 2008-03-31 2009-03-31 Heterocyclic derivatives
SI200931323T SI2266989T1 (sl) 2008-03-31 2009-03-31 Heterociklični derivati
EP09754921.6A EP2266989B1 (en) 2008-03-31 2009-03-31 Heterocyclic derivatives
NZ587880A NZ587880A (en) 2008-03-31 2009-03-31 Fused morpholine derivatives
ZA2010/06475A ZA201006475B (en) 2008-03-31 2010-09-09 Heterocyclic derivatives
IL208203A IL208203A (en) 2008-03-31 2010-09-16 Annotations of 3,2-Dihydro-Pyrido-4,1-Exazine and 3,2-Dihydro-4-Oxa-9,1-Diazapananthrene, Preparation Processes and Pharmaceutical Preparations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20080030067 2008-03-31
KR10-2008-0030067 2008-03-31

Publications (2)

Publication Number Publication Date
WO2009145456A2 WO2009145456A2 (ko) 2009-12-03
WO2009145456A3 true WO2009145456A3 (ko) 2010-01-21

Family

ID=41377713

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/001659 Ceased WO2009145456A2 (ko) 2008-03-31 2009-03-31 헤테로사이클 유도체

Country Status (23)

Country Link
US (1) US8394792B2 (ko)
EP (1) EP2266989B1 (ko)
JP (1) JP5314123B2 (ko)
KR (1) KR101250297B1 (ko)
CN (1) CN102015726B (ko)
AU (1) AU2009252166B9 (ko)
BR (1) BRPI0909691B1 (ko)
CA (1) CA2718709C (ko)
DK (1) DK2266989T3 (ko)
EA (1) EA018521B1 (ko)
ES (1) ES2552311T3 (ko)
HR (1) HRP20151098T1 (ko)
HU (1) HUE026261T2 (ko)
IL (1) IL208203A (ko)
MX (1) MX2010010366A (ko)
MY (1) MY155517A (ko)
NZ (1) NZ587880A (ko)
PL (1) PL2266989T3 (ko)
PT (1) PT2266989E (ko)
SI (1) SI2266989T1 (ko)
TW (2) TWI613203B (ko)
WO (1) WO2009145456A2 (ko)
ZA (1) ZA201006475B (ko)

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GB201106814D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compounds
US20130090334A1 (en) * 2011-10-05 2013-04-11 Hoffmann-La Roche Inc Azabenzoxazine derivatives as crac modulators
HK1201209A1 (en) * 2012-01-27 2015-08-28 帝人制药株式会社 Therapeutic agent for diabetes
US20140034475A1 (en) * 2012-04-06 2014-02-06 Deka Products Limited Partnership Water Vapor Distillation Apparatus, Method and System
JP5805613B2 (ja) * 2012-11-16 2015-11-04 株式会社神戸製鋼所 改質石炭の製造方法及び改質石炭製造装置
CN103936762B (zh) * 2013-01-17 2016-02-24 上海汇伦生命科技有限公司 吗啉并喹啉类化合物，其制备方法和用途
CN103664764A (zh) * 2013-12-06 2014-03-26 常熟市联创化学有限公司 一种3-氨基-2-羟基吡啶的制备方法
CA2935944A1 (en) 2014-01-09 2015-07-16 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Substituted benzoxazine and related compounds
EP3144304A4 (en) * 2014-05-13 2017-10-25 Teijin Pharma Limited Novel crystalline polymorph of pyridine derivative, and method for producing same
KR102556608B1 (ko) 2014-12-29 2023-07-17 닛뽕 케미파 가부시키가이샤 Urat1 저해제
WO2017040963A1 (en) 2015-09-03 2017-03-09 Forma Therapeutics, Inc. [6,6] fused bicyclic hdac8 inhibitors
US10894038B2 (en) 2015-12-28 2021-01-19 Shanghai Fochon Pharmaceutical Co. Ltd. Indolizine derivatives, composition and methods of use
CN108084186B (zh) 2016-11-16 2021-06-25 江苏新元素医药科技有限公司 Urat1抑制剂及其应用
WO2018090921A1 (zh) 2016-11-16 2018-05-24 江苏新元素医药科技有限公司 Urat1抑制剂及其应用
HRP20250183T1 (hr) 2017-05-25 2025-04-11 Jw Pharmaceutical Corporation Hidrokloridna sol 1,5 hidrata heterocikličkog spoja kao derivata
CN109111464B (zh) * 2017-06-23 2021-02-26 爱科诺生物医药股份有限公司 一种具有细胞坏死抑制活性的杂环化合物
WO2018237370A1 (en) 2017-06-23 2018-12-27 Accro Bioscience Inc. Heteroaryl compounds as inhibitors of necrosis, composition and method using the same
CN111615515B (zh) 2018-01-19 2023-11-24 苏州信诺维医药科技股份有限公司 杂环化合物、制备方法及其在医药上的应用
CN108558906A (zh) * 2018-05-21 2018-09-21 日照市普达医药科技有限公司 一种治疗白内障药物苯并吩噁嗪类化合物及其制备方法
HUE067912T2 (hu) 2018-08-13 2024-11-28 Hoffmann La Roche Új heterociklusos vegyületek, mint monoacil-glicerin-lipáz inhibitorok
AU2020297771A1 (en) * 2019-06-17 2021-12-02 Fochon Pharmaceuticals, Ltd. Heterocyclic derivatives and use thereof
WO2021244608A1 (en) * 2020-06-04 2021-12-09 Beigene, Ltd. Pyrido[2,3-b] [1,4] oxazines or tetrahydropyrido[2,3-b][1,4] oxazepines as iap antagonists
CN113880774B (zh) * 2020-07-02 2023-12-08 沈阳中化农药化工研发有限公司 一种苯基异恶唑啉类化合物的制备方法
CN111841896B (zh) * 2020-08-06 2022-10-18 武汉工程大学 一种苯并杂环羟肟酸类捕收剂及其制备方法和应用
WO2022169974A1 (en) 2021-02-05 2022-08-11 Nexys Therapeutics, Inc. Inhibitors of urat1 and pharmaceutical uses thereof
CN119059989A (zh) * 2023-05-31 2024-12-03 中国药科大学 Urat1抑制剂及其制备方法和用途

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US20070010670A1 (en) * 2004-11-29 2007-01-11 Japan Tobacco Inc. Nitrogen-containing fused ring compounds and use thereof
WO2007089034A1 (en) * 2006-02-02 2007-08-09 Mitsubishi Tanabe Pharma Corporation Benzoxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents
US20070197512A1 (en) * 2006-01-27 2007-08-23 Japan Tobacco Inc. Carboxylic Acid Compounds and Use Thereof
US20080064871A1 (en) * 2006-05-26 2008-03-13 Japan Tobacco Inc. Production Method of Nitrogen-Containing Fused Ring Compounds

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JP2002220389A (ja) * 2001-01-26 2002-08-09 Hokko Chem Ind Co Ltd ピリジルベンズオキサジン誘導体、除草剤および中間体
JP3988832B2 (ja) 2004-11-29 2007-10-10 日本たばこ産業株式会社 窒素含有縮合環化合物及びその用途
US20060177646A1 (en) * 2005-02-09 2006-08-10 Detlef Burgard Method for producing shatterproof glass panels and casting resin molding
ATE550329T1 (de) * 2006-02-13 2012-04-15 Hoffmann La Roche Heterobicyclische sulfonamidderivate zur behandlung von diabetes
US7960377B2 (en) 2008-03-28 2011-06-14 Cara Therapeutics, Inc. Substituted pyridoxazines

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Publication number Priority date Publication date Assignee Title
US20070010670A1 (en) * 2004-11-29 2007-01-11 Japan Tobacco Inc. Nitrogen-containing fused ring compounds and use thereof
US20070197512A1 (en) * 2006-01-27 2007-08-23 Japan Tobacco Inc. Carboxylic Acid Compounds and Use Thereof
WO2007089034A1 (en) * 2006-02-02 2007-08-09 Mitsubishi Tanabe Pharma Corporation Benzoxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents
US20080064871A1 (en) * 2006-05-26 2008-03-13 Japan Tobacco Inc. Production Method of Nitrogen-Containing Fused Ring Compounds

Also Published As

Publication number Publication date
TW201522347A (zh) 2015-06-16
TWI613203B (zh) 2018-02-01
CA2718709A1 (en) 2009-12-03
DK2266989T3 (en) 2015-11-23
US8394792B2 (en) 2013-03-12
ES2552311T3 (es) 2015-11-27
AU2009252166B2 (en) 2013-10-10
WO2009145456A2 (ko) 2009-12-03
NZ587880A (en) 2012-06-29
KR101250297B1 (ko) 2013-04-03
HK1148283A1 (en) 2011-09-02
JP5314123B2 (ja) 2013-10-16
EP2266989A2 (en) 2010-12-29
TW201000488A (en) 2010-01-01
TWI500622B (zh) 2015-09-21
MY155517A (en) 2015-10-30
PL2266989T3 (pl) 2016-04-29
PT2266989E (pt) 2015-11-23
BRPI0909691A2 (pt) 2015-08-04
EA018521B1 (ru) 2013-08-30
HUE026261T2 (en) 2016-06-28
EP2266989A4 (en) 2011-10-12
BRPI0909691B1 (pt) 2021-07-20
MX2010010366A (es) 2010-11-30
EA201071144A1 (ru) 2011-06-30
IL208203A (en) 2016-06-30
CA2718709C (en) 2016-08-09
AU2009252166B9 (en) 2014-02-13
CN102015726B (zh) 2014-07-23
IL208203A0 (en) 2010-12-30
AU2009252166A1 (en) 2009-12-03
ZA201006475B (en) 2011-10-26
JP2011516468A (ja) 2011-05-26
US20110028467A1 (en) 2011-02-03
BRPI0909691A8 (pt) 2018-01-02
KR20110005688A (ko) 2011-01-18
CN102015726A (zh) 2011-04-13
HRP20151098T1 (hr) 2016-01-01
EP2266989B1 (en) 2015-09-02
SI2266989T1 (sl) 2015-12-31

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