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WO2009038021A1 - ４－スルホニルピペリジン誘導体 - Google Patents

４－スルホニルピペリジン誘導体 Download PDF

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Publication number
WO2009038021A1
WO2009038021A1 PCT/JP2008/066525 JP2008066525W WO2009038021A1 WO 2009038021 A1 WO2009038021 A1 WO 2009038021A1 JP 2008066525 W JP2008066525 W JP 2008066525W WO 2009038021 A1 WO2009038021 A1 WO 2009038021A1
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
alkyl
forms
sulfonylpiperidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/066525
Other languages
English (en)
French (fr)
Inventor
Tsuyoshi Nagase
Takahide Sasaki
Toshiyuki Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Priority to AU2008301718A priority Critical patent/AU2008301718B2/en
Priority to CA2699275A priority patent/CA2699275C/en
Priority to US12/674,999 priority patent/US8163898B2/en
Priority to JP2009533122A priority patent/JP5319536B2/ja
Priority to EP08831915.7A priority patent/EP2204368B1/en
Publication of WO2009038021A1 publication Critical patent/WO2009038021A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

【課題】　循環器系疾患、神経系疾患、代謝性疾患、生殖系疾患、消化管系疾患の予防剤又は治療剤として有用な化合物を提供する。 【解決手段】　式（Ｉ） ［式中、Ｒ１は、Ｃ１－６アルキル基、Ｃ３－８シクロアルキル基等を表し、Ｒ２は、フェニル基又はヘテロアリール基等を表し、Ｑは、Ｎ又はＣＨを表し、Ｍ１、Ｍ２、Ｍ３及びＭ４は、それぞれ独立して、水素原子若しくはＣ１－６アルキル基を表すか、又は、Ｍ１は、Ｍ２又はＭ３と一緒になって、－ＣＨ２－ＣＨ２－等を形成するか、若しくはＭ４は、Ｍ２又はＭ３と一緒になって、－ＣＨ２－ＣＨ２－等を形成し、但し、Ｍ１、Ｍ２、Ｍ３及びＭ４は、それらのなかで１つの－ＣＨ２－又は－ＣＨ２－ＣＨ２－を形成するものとする］で表される化合物又は薬学的に許容されるその塩。
PCT/JP2008/066525 2007-09-21 2008-09-12 ４－スルホニルピペリジン誘導体 Ceased WO2009038021A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2008301718A AU2008301718B2 (en) 2007-09-21 2008-09-12 4-sulfonylpiperidine derivatives
CA2699275A CA2699275C (en) 2007-09-21 2008-09-12 4-sulfonylpiperidine derivative
US12/674,999 US8163898B2 (en) 2007-09-21 2008-09-12 4-sulfonylpiperidine derivatives
JP2009533122A JP5319536B2 (ja) 2007-09-21 2008-09-12 ４−スルホニルピペリジン誘導体
EP08831915.7A EP2204368B1 (en) 2007-09-21 2008-09-12 4-sulfonylpiperidine derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-244731 2007-09-21
JP2007244731 2007-09-21

Publications (1)

Publication Number Publication Date
WO2009038021A1 true WO2009038021A1 (ja) 2009-03-26

Family

ID=40467837

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/066525 Ceased WO2009038021A1 (ja) 2007-09-21 2008-09-12 ４－スルホニルピペリジン誘導体

Country Status (6)

Country Link
US (1) US8163898B2 (ja)
EP (1) EP2204368B1 (ja)
JP (1) JP5319536B2 (ja)
AU (1) AU2008301718B2 (ja)
CA (1) CA2699275C (ja)
WO (1) WO2009038021A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8314094B2 (en) 2007-10-05 2012-11-20 Msd K.K Benzoxazinone derivative
JP5377329B2 (ja) * 2007-12-26 2013-12-25 Ｍｓｄ株式会社 スルホニル置換六員環誘導体

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004024720A1 (en) * 2002-09-11 2004-03-25 Merck & Co., Inc. Piperazine urea derivatives as melanocortin-4 receptor agonists
WO2005005665A1 (ja) 2003-07-11 2005-01-20 Banyu Pharmaceutical Co., Ltd. Lceによる肥満治療に有効な化合物の評価方法
WO2007007069A1 (en) * 2005-07-07 2007-01-18 Vernalis (R & D) Limited Azacyclic compounds as inhibitors of sensory neurone specific sodium channels

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA000828B1 (ru) 1995-12-14 2000-04-24 Мерк Энд Ко., Инк. Антагонисты гонадотропин-высвобождающего фактора
FR2744449B1 (fr) * 1996-02-02 1998-04-24 Pf Medicament Nouvelles piperazines aromatiques derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
JP5207382B2 (ja) 2006-08-30 2013-06-12 塩野義製薬株式会社 ウレア誘導体
WO2008120653A1 (ja) * 2007-04-02 2008-10-09 Banyu Pharmaceutical Co., Ltd. インドールジオン誘導体
CA2701406C (en) 2007-10-05 2016-01-26 Banyu Pharmaceutical Co., Ltd. Benzoxazinone derivative
US8124807B2 (en) 2007-12-26 2012-02-28 Msd K.K. Sulfonyl-substituted 6-membered ring derivative
AU2009211724B2 (en) 2008-02-06 2013-05-16 Msd K.K. 3-substituted sulfonyl piperazine derivative
EP2280001B1 (en) 2008-04-24 2014-10-15 Msd K.K. Long-chain fatty acid elongation enzyme inhibitor comprising arylsulfonyl derivative as active ingredient

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004024720A1 (en) * 2002-09-11 2004-03-25 Merck & Co., Inc. Piperazine urea derivatives as melanocortin-4 receptor agonists
WO2005005665A1 (ja) 2003-07-11 2005-01-20 Banyu Pharmaceutical Co., Ltd. Lceによる肥満治療に有効な化合物の評価方法
WO2007007069A1 (en) * 2005-07-07 2007-01-18 Vernalis (R & D) Limited Azacyclic compounds as inhibitors of sensory neurone specific sodium channels

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
"Design of Prodrugs", 1985, ELSEVIER
"The Merck Manual of Medical Information", 2003, MERCK & CO
CELL, vol. 126, 2006, pages 691 - 699
EIJI ITAGAKI: "STEP TaishaINaibunpitsu", 1998, KAIBASHOBO
J. BIOL. CHEM., vol. 276, no. 48, 2001, pages 45358 - 45366
J. LIPID RES., vol. 43, no. 6, 2002, pages 911 - 920
LEE S. H. ET AL., CELL, vol. 126, 2006, pages 691 - 699
MATSUZAKA T. ET AL., J, LIPID RES., vol. 43, no. 6, 2002, pages 911 - 920
MOON, J. BIOL .CHEM., vol. 276, 2001, pages 45358 - 45366
See also references of EP2204368A4
T. W. GREENE: "Protective Groups in Organic Synthesis", 1981, JOHN WILEY & SONS

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8314094B2 (en) 2007-10-05 2012-11-20 Msd K.K Benzoxazinone derivative
JP5377329B2 (ja) * 2007-12-26 2013-12-25 Ｍｓｄ株式会社 スルホニル置換六員環誘導体

Also Published As

Publication number Publication date
AU2008301718A1 (en) 2009-03-26
EP2204368A4 (en) 2012-02-15
EP2204368B1 (en) 2014-05-21
CA2699275C (en) 2015-08-25
US8163898B2 (en) 2012-04-24
JP5319536B2 (ja) 2013-10-16
US20100234392A1 (en) 2010-09-16
EP2204368A1 (en) 2010-07-07
AU2008301718B2 (en) 2013-01-10
CA2699275A1 (en) 2009-03-26
JPWO2009038021A1 (ja) 2011-01-06

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