WO2009036924A1 - Method for reducing wrinkles - Google Patents
Method for reducing wrinkles Download PDFInfo
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- WO2009036924A1 WO2009036924A1 PCT/EP2008/007482 EP2008007482W WO2009036924A1 WO 2009036924 A1 WO2009036924 A1 WO 2009036924A1 EP 2008007482 W EP2008007482 W EP 2008007482W WO 2009036924 A1 WO2009036924 A1 WO 2009036924A1
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- Prior art keywords
- skin
- product applicator
- filler
- product
- spray head
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/442—Evaluating skin mechanical properties, e.g. elasticity, hardness, texture, wrinkle assessment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
- A61M15/025—Bubble jet droplet ejection devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
Definitions
- the present invention relates to a method for the selective application of cosmetic or pharmaceutical formulations to the skin and to a selective product applicator for cosmetic or pharmaceutical formulations.
- US 2006/0016999 A1 discloses a device which indicates to the user the type of cosmetic sunscreen preparation required. The intensity of the
- UVA and UVB radiation of sunlight detected by corresponding sensors By means of a data processing unit, the preparation needed to protect the skin is calculated on the basis of appropriately preselected data on the individual skin properties and displayed to the user via optical or acoustic signals. However, automatic application of the corresponding preparation does not take place.
- WO 04/039255 A1 discloses methods for the noninvasive analysis of the skin structure by means of optical methods. In particular, the methods shown are used to determine the melanin density.
- WO 02/087681 a method for the administration of therapeutic agents is known, in which a device implanted to the patient generates a signal which controls the delivery of an active ingredient from an adhesive plaster applied to the skin of the patient.
- a device implanted to the patient generates a signal which controls the delivery of an active ingredient from an adhesive plaster applied to the skin of the patient.
- no substances acting on or only in the upper layers of the skin can be used, since they do not or only in very small, ineffective amounts enter the body of a patient.
- the method of skin care or skin treatment is not suitable because only relatively small areas of skin can be covered with a patch. It is therefore an object of the present invention to provide a method and a suitable device which enable a selective application of cosmetic or pharmaceutical preparations for skin care or skin treatment, in particular for the treatment of wrinkles.
- the object is achieved in a first aspect by a method in which first the coloration of the skin, the skin relief or both over the entire surface of a selected skin surface is optically detected, the areas are determined within which the data deviate from target values, and then the cosmetic or pharmaceutical preparations are released on these surfaces.
- Preferred embodiments of the method are the subject of the subclaims.
- Measurements of the skin roughness on the measurement of shadows of an obliquely illuminated skin area are known. The higher the elevations or deeper the grooves in the considered skin section, the longer shadows they cast. Also known are methods for determining skin color, in which light rays reflected at the skin surface are detected. It uses the phenomenon that a light beam incident on the skin is reflected with changed wavelength distribution depending on the color of the skin. These measurements can be performed with both white light and narrowband (colored) light.
- the light reflected on the skin surface is detected via corresponding sensors.
- the change in intensity, the change in the wavelength of the reflected light or both in comparison to the incident light are detected.
- the values obtained are compared with setpoints or setpoint ranges.
- the setpoint values can be determined in advance, for example, by appropriate measurements on wrinkle-free skin areas with a lower relief depth or uniformly pigmented skin areas.
- Another method for determining the desired values is, for example, to determine average values during the measurement itself from the measured values. which are used as setpoints or setpoint range. It is important to be able to record the structure of the skin surface either line-wise (line scanner) or areal (CCD camera).
- Preparations which contain active ingredients are preferably used according to the invention.
- the choice of active ingredients depends on the type of skin change and the desired effect. Thus, for example, to smooth the skin roughness moisturizing or wrinkle-reducing agents are suitable.
- the inventive method is preferably used for targeted wrinkle reduction. Furthermore, the method according to the invention can be used for targeted treatment of acne, inflammation, redness and irritation as well as insect bites.
- the pharmaceutical or cosmetic preparations used in the process according to the invention have active substances, individually or in combination, which are suitable for the particular application.
- Suitable active ingredients are, for example, the following active ingredients selected from the group of biochinones, in particular ubiquinone (Q10), ubiquinol, folic acid and its derivatives, in particular tetrahydrofolic acid and dihydrofolic acid, niacin and its derivatives, in particular niacinamide, creatine and creatinine, carnitine, biotin, isoflavone, cardiolipin , Lipoic acid, anti-freezing proteins, Pimpinella anis fruit extract, hop and hop malt extracts, active ingredients that promote the restructuring of connective tissue, such as natural and synthetic isoflavonoids and isoflavonoid-containing plant extracts such as soy and clover extracts , Active ingredients to support the skin functions in dry skin such as vitamin C, biotin, carnitine, propionic acid, green tea extracts, eucalyptus oil, urea and mineral salts such as NaCl, marine minerals and osmolytes eg in
- Active substances in encapsulated form can also be used in the process according to the invention, in particular alpha-, beta-, HP-beta, random-Me-beta, gamma-cyclodextrin, cellulose, gelatin, wax or liposomes being used as encapsulation materials serve.
- Hyaluronic acid, Q10, folic acid, creatine, vitamin C are preferably used to treat wrinkles.
- Wrinkles can also be laminated by application of fillers, in particular by PMMA, silica or siloxane elastomers.
- the present object is achieved by a selective product applicator which has at least one optoelectronic sensor, at least one product reservoir, a data processing unit and at least one electrically triggered device for releasing liquids.
- a selective product applicator which has at least one optoelectronic sensor, at least one product reservoir, a data processing unit and at least one electrically triggered device for releasing liquids.
- Preferred embodiments of the product applicator are the subject of the subclaims.
- the optoelectronic sensors and those associated with the product reservoirs are Liquid release devices connected to the data processing unit.
- the product applicator according to the invention in the form of a pin, which can be operated or applied with one hand. All components are chosen so that they can be arranged in a housing which can be held in one hand.
- the electrically triggered device for releasing liquids has a spray head.
- the spray head can have a micropump, wherein, for example, diaphragm pumps or piston pumps are used.
- Micro diaphragm pumps often use the piezo effect (piezo diaphragm micropumps) mentioned below.
- a preferred embodiment of the present invention is the use of overpressure containers and microvalves (corresponding to the technique used in the airbrush method).
- the spray head comprises a bubble jet spray head or a piezo spray head.
- a spray head according to the bubble jet method which is referred to below as a bubble jet spray head
- tiny drops of liquid are produced by means of a heating element.
- a vapor bubble forms explosively, which presses a drop of liquid out of a nozzle by its pressure.
- a piezo spray head the property of piezocrystals is used to deform under electrical tension to force fluid through a nozzle. The drop formation of the liquid occurs, whereby the drop volume can be controlled via the applied electrical pulse.
- the operating frequency of a piezocrystal reaches up to 23 kHz.
- the active ingredients and / or preparations by microinjections directly into the folds.
- the preparation to be released must not be too hot, so that the active ingredients are not destroyed.
- the viscosity, the maximum particle size and the agglomeration behavior of the particles of the preparation to be released must also be matched to the pumping power and the nozzle geometry of the device used in order to enable a targeted release.
- CCD Charge Coupled Device
- the measured value acquisition according to the present invention is an evaluation of the light intensity distribution.
- a special optical arrangement e.g. Angle between the optical axes of the light source and the recording unit to better determine the wrinkle expression is to pay attention to the exact location assignment between the intensity signal and the application target area.
- the light intensity can be recorded as a sum signal or spectrally differentiating via optical or electronic filters.
- the trigger signal for the application can be obtained via a threshold value of the intensity or from threshold value combinations of different spectral intensities.
- the threshold value or the threshold value combinations must be determined individually for each skin in a "training mode.”
- optical iris may be required in order to focus the training particularly selectively on specific skin characteristics.
- the present object is achieved by the use of the product applicator according to the invention for the selective application of cosmetic or pharmaceutical preparations on the skin.
- the applicator according to the invention is preferred for the application of pharmaceutical and cosmetic preparations for the treatment of acne, wrinkles and other signs of aging as well as pigmentation disorders.
- Preparations suitable according to the invention are solutions, for example aqueous and / or alcoholic solutions (concentrates), emulsions, gels, melts, serums and make-up.
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- Bioinformatics & Cheminformatics (AREA)
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Abstract
Description
Verfahren zur Faltenreduktion Procedure for wrinkle reduction
Beschreibungdescription
Die vorliegende Erfindung betrifft ein Verfahren zur selektiven Applikation von kosmetischen oder pharmazeutischen Formulierungen auf die Haut sowie einen selektiven Produktapplikator für kosmetische oder pharmazeutische Formulierungen.The present invention relates to a method for the selective application of cosmetic or pharmaceutical formulations to the skin and to a selective product applicator for cosmetic or pharmaceutical formulations.
Aus US 2006/0016999 A1 ist eine Vorrichtung bekannt, welche dem Verwender die Art der benötigten kosmetischen Sonnenschutz-Zubereitung anzeigt. Dabei wird die Intensität derUS 2006/0016999 A1 discloses a device which indicates to the user the type of cosmetic sunscreen preparation required. The intensity of the
UVA- und UVB-Strahlung des Sonnenlichts über entsprechende Sensoren erfasst. Über eine Datenverarbeitungseinheit wird anhand entsprechend vorgewählter Daten zu den individuellen Hauteigenschaften die zum Schutz der Haut benötigte Zubereitung berechnet und dem Verwender über optische oder akustische Signale angezeigt. Eine automatische Applikation der entsprechenden Zubereitung erfolgt jedoch nicht.UVA and UVB radiation of sunlight detected by corresponding sensors. By means of a data processing unit, the preparation needed to protect the skin is calculated on the basis of appropriately preselected data on the individual skin properties and displayed to the user via optical or acoustic signals. However, automatic application of the corresponding preparation does not take place.
Die WO 04/039255 A1 offenbart Methoden zur nichtinvasiven Analyse der Hautstruktur mittels optischer Methoden. Insbesondere dienen die aufgezeigten Methoden zur Bestimmung der Melanindichte.WO 04/039255 A1 discloses methods for the noninvasive analysis of the skin structure by means of optical methods. In particular, the methods shown are used to determine the melanin density.
Aus WO 02/087681 ist ein Verfahren zur Verabreichung therapeutischer Wirkstoffe bekannt, in dem eine dem Patienten implantierte Vorrichtung ein Signal erzeugt, welches die Abgabe eines Wirkstoffes aus einem auf die Haut des Patienten geklebten Wirkstoff- Pflasters steuert. Jedoch können in diesem Verfahren keine auf bzw. nur in den oberen Schichten der Haut wirkenden Substanzen eingesetzt werden, da diese nicht oder nur in sehr geringen, unwirksamen Mengen in den Körper eines Patienten gelangen. Auch ist das Verfahren zur Hautpflege oder Hautbehandlung nicht geeignet, da nur verhältnismäßig kleine Hautareale mit einem Pflaster abgedeckt werden können. Aufgabe der vorliegenden Erfindung ist es daher ein Verfahren sowie eine geeignete Vorrichtung zur Verfügung zu stellen, welche eine selektive Applikation von kosmetischen oder pharmazeutischen Zubereitungen zur Hautpflege oder Hautbehandlung ermöglichen, insbesondere zur Behandlung von Falten.From WO 02/087681 a method for the administration of therapeutic agents is known, in which a device implanted to the patient generates a signal which controls the delivery of an active ingredient from an adhesive plaster applied to the skin of the patient. However, in this method, no substances acting on or only in the upper layers of the skin can be used, since they do not or only in very small, ineffective amounts enter the body of a patient. Also, the method of skin care or skin treatment is not suitable because only relatively small areas of skin can be covered with a patch. It is therefore an object of the present invention to provide a method and a suitable device which enable a selective application of cosmetic or pharmaceutical preparations for skin care or skin treatment, in particular for the treatment of wrinkles.
Die Aufgabe wird in einem ersten Aspekt durch ein Verfahren gelöst, in welchem zunächst die Färbung der Haut, das Hautrelief oder beides über die gesamte Fläche einer ausgewählten Hautoberfläche optisch erfasst wird, die Flächen bestimmt werden, innerhalb derer die Daten von Sollwerten abweichen, und dann die kosmetischen oder pharmazeutischen Zubereitungen auf diesen Flächen freigesetzt werden. Bevorzugte Ausführungsformen des Verfahrens sind Gegenstand der Unteransprüche.The object is achieved in a first aspect by a method in which first the coloration of the skin, the skin relief or both over the entire surface of a selected skin surface is optically detected, the areas are determined within which the data deviate from target values, and then the cosmetic or pharmaceutical preparations are released on these surfaces. Preferred embodiments of the method are the subject of the subclaims.
Erfindungsgemäß vorteilhaft ist es, die Wirkstoffapplikation so zu steuern, das die Bedeckung mit Wirkstoffen über den Randbereich der Falte hinaus geht.According to the invention, it is advantageous to control the application of the active ingredient in such a way that the covering with active ingredients extends beyond the edge region of the fold.
((
Messungen der Hautrauhigkeit über das Ausmessen von Schatten eines schräg angeleuchteten Hautareals sind bekannt. Je höher die Erhebungen bzw. tiefer die Rillen in dem betrachteten Hautabschnitt sind, desto längere Schatten werfen sie. Ebenso sind Verfahren zur Bestimmung der Hautfarbe bekannt, in denen an der Hautoberfläche reflektierte Lichtstrahlen erfasst werden. Dabei wird das Phänomen genutzt, dass ein auf die Haut auftreffender Lichtstrahl in Abhängigkeit von der Farbe der Haut mit veränderter Wellenlängenverteilung reflektiert wird. Diese Messungen können sowohl mit Weißlicht als auch mit engerbandigem (farbigem) Licht durchgeführt werden.Measurements of the skin roughness on the measurement of shadows of an obliquely illuminated skin area are known. The higher the elevations or deeper the grooves in the considered skin section, the longer shadows they cast. Also known are methods for determining skin color, in which light rays reflected at the skin surface are detected. It uses the phenomenon that a light beam incident on the skin is reflected with changed wavelength distribution depending on the color of the skin. These measurements can be performed with both white light and narrowband (colored) light.
In dem erfindungsgemäßen Verfahren wird das an der Hautoberfläche reflektierte Licht über entsprechende Sensoren erfasst. In einer bevorzugten Ausführungsform der Erfindung werden die Änderung der Intensität, die Änderung der Wellenlänge des reflektierten Lichts oder beides im Vergleich zum eingestrahlten Licht erfasst.In the method according to the invention, the light reflected on the skin surface is detected via corresponding sensors. In a preferred embodiment of the invention, the change in intensity, the change in the wavelength of the reflected light or both in comparison to the incident light are detected.
Die erhaltenen Werte werden mit Sollwerten bzw. Sollwertbereichen verglichen. Die Sollwerte können beispielsweise vorab durch entsprechende Messungen an faltenfreien Hautarealen mit geringerer Relieftiefe oder gleichmäßig pigmentierten Hautarealen ermittelt werden. Ein anderes Verfahren zur Bestimmung der Sollwerte ist beispielsweise während der Messung selbst aus den gemessenen Werten Mittelwerte zu bestimmen, welche als Sollwerte oder Sollwertbereich eingesetzt werden. Wichtig dabei ist die Möglichkeit, die Struktur der Hautoberfläche entweder zeilenförmig (Linienscanner) oder flächig (CCD-Kamera) zu erfassen.The values obtained are compared with setpoints or setpoint ranges. The setpoint values can be determined in advance, for example, by appropriate measurements on wrinkle-free skin areas with a lower relief depth or uniformly pigmented skin areas. Another method for determining the desired values is, for example, to determine average values during the measurement itself from the measured values. which are used as setpoints or setpoint range. It is important to be able to record the structure of the skin surface either line-wise (line scanner) or areal (CCD camera).
Liegen die gemessenen Daten einer Hautfläche außerhalb der vorgegebenen Bereiche, wird gezielt auf dieser Fläche eine kosmetische oder pharmazeutische Zubereitung freigesetzt.If the measured data of a skin area lie outside the predetermined areas, a cosmetic or pharmaceutical preparation is deliberately released on this area.
Erfindungsgemäß bevorzugt werden Zubereitungen eingesetzt, welche Wirkstoffe enthalten. Die Wahl der Wirkstoffe hängt dabei von der Art der Hautveränderung und der gewünschten Wirkung ab. So sind beispielsweise zur Glättung der Hautrauhigkeit feuchtigkeitsspendende oder faltenmindernde Wirkstoffe geeignet.Preparations which contain active ingredients are preferably used according to the invention. The choice of active ingredients depends on the type of skin change and the desired effect. Thus, for example, to smooth the skin roughness moisturizing or wrinkle-reducing agents are suitable.
Das erfindungsgemäße Verfahren wird bevorzugt zur gezielten Faltenminderung eingesetzt. Des Weiteren kann das erfindungsgemäße Verfahren zur gezielten Behandlung bei Akne, Entzündungen, Rötungen und Irritationen sowie Insektenstichen eingesetzt werden.The inventive method is preferably used for targeted wrinkle reduction. Furthermore, the method according to the invention can be used for targeted treatment of acne, inflammation, redness and irritation as well as insect bites.
Es ist besonders vorteilhaft, wenn die im erfindungsgemäßen Verfahren eingesetzten pharmazeutischen oder kosmetischen Zubereitungen Wirkstoffe, einzeln oder in Kombination, aufweisen, die für die jeweilige Anwendung geeignet sind.It is particularly advantageous if the pharmaceutical or cosmetic preparations used in the process according to the invention have active substances, individually or in combination, which are suitable for the particular application.
Geeignete Wirkstoffe sind beispielsweise die folgenden Wirkstoffe, gewählt aus der Gruppe der Biochinone, insbesondere Ubichinon (Q10), Ubichinol, Folsäure und ihre Derivate insbesondere Tetrahydrofolsäure und Dihydrofolsäure, Niacin und seine Derivate insbesondere Niacinamid, Kreatin und Kreatinin, Carnitin, Biotin, Isoflavon, Cardiolipin, Liponsäure, Anti-Freezing-Proteine, Pimpinella-anis-fruit-extract, Hopfen- und Hopfen- Malz-Extrakte, Wirkstoffe, welche die Restrukturierung des Bindegewebes fördern wie natürliche und synthetische Isoflavonoide und isoflavonoidhaltige Pflanzenextrakte wie z.B. Soja- und Klee-Extrakte, Wirkstoffe zur Unterstützung der Hautfunktionen bei trockener Haut wie beispielsweise Vitamin C, Biotin, Carnitin, Propionsäure, Grüntee- Extrakte, Eucalyptusöl, Harnstoff und Mineralsalze wie z.B. NaCI, Meeresmineralien sowie Osmolyte z.B. Inositol, Betain und quartäre Ammoniumverbindungen, Wirkstoffe zur Linderung bzw. positiven Beeinflussung von irritativen Hautzuständen bei empfindlicher Haut im allgemeinen oder bei durch Noxen wie beispielsweise UV-Strahlung oder Chemikalien gereizter Haut wie Sericoside, verschiedene Extrakte des Süßholzes, Licochalcone insbesondere Licochalcon A1 Silymarin, Silyphos, Dexpanthenol, Inhibitoren des Prostaglandinstoffwechsels insbesondere der Cyclooxygenase und des Leukotrien- Stoffwechsels insbesondere der 5-Lipoxygenase und des 5-Lipoxygenase-lnhibitor- Proteins, FLAP, Modulatoren der Pigmentierung, welche die Pigmentierung der Haut vermindern, wie beispielsweise Tyrosinsulfat, Dioic acid (8-Hexadecen-1 ,16- dicarbonsäure) sowie Liponsäure und Liponamid, verschiedene Extrakte des Süßholzes, Kojisäure, Hydrochinon, Arbutin, Alpha-Arbutin, Deoxyarbutin, Fruchtsäuren insbesondere Alpha-Hydroxy-Säuren (AHAs), Bärentrauben-Extrakte (Bearberry oder Uvae ursi), Ursolsäure, Ascorbinsäure, Grüntee-Extrakte, Aminoguanidin, Pyridoxamin, Niacinamid, Inhibitoren des Proteinase Activated Receptors 2 (PAR-2), Wirkstoffe, die eine verstärkte oder schnellere Bräunung der Haut mit oder ohne Einfluss von UV-Licht herbeiführen, beispielsweise Advanced Glycation Endproducts (AGE), Lipofuscine, Nukleinsäure- Oligonukleotide, Purine und Pyrimidine, NO-freisetzende Substanzen, Tyrosin und seine Derivate insbesondere N-Acetyl-Tyrosin, Phenylalanin und seine Derivate insbesondere N- Acetyl-Phenylalanin sowie Aktivatoren des Proteinase Activated Receptors 2 (PAR-2), Antifaltenwirkstoffe wie Flavonglycoside insbesondere α-Glycosyl rutin, Coenzym Q10, Vitamin E und seine Derivate. In dem erfindungsgemäßen Verfahren können auch Wirkstoffe in verkapselter Form eingesetzt werden, wobei als Verkapselungsmaterialien z.B. Kollagenmatrices, cyclische Oligosaccharide insbesondere alpha-, beta-, HP-beta-, random-Me-beta, gamma-Cyclodextrin, Cellulose, Gelatine, Wachs oder Liposomen dienen. Zur Behandlung von Falten werden bevorzugt Hyaluronsäure, Q10, Folsäure, Creatin, Vitamin C eingesetzt. Falten können auch durch Applikation von Füllstoffen kaschiert werden, insbesondere durch PMMA, Silica oder Siloxanelastomere. In einem weiteren Aspekt wird die vorliegende Aufgabe durch selektiven Produktapplikator gelöst, welcher mindestens einen optoelektronischen Sensor, mindestens ein Produktreservoir, eine Datenverarbeitungseinheit und mindestens eine elektrisch ausgelöste Vorrichtung zur Freisetzung von Flüssigkeiten aufweist. Bevorzugte Ausführungsformen des Produktapplikators sind Gegenstand der Unteransprüche.Suitable active ingredients are, for example, the following active ingredients selected from the group of biochinones, in particular ubiquinone (Q10), ubiquinol, folic acid and its derivatives, in particular tetrahydrofolic acid and dihydrofolic acid, niacin and its derivatives, in particular niacinamide, creatine and creatinine, carnitine, biotin, isoflavone, cardiolipin , Lipoic acid, anti-freezing proteins, Pimpinella anis fruit extract, hop and hop malt extracts, active ingredients that promote the restructuring of connective tissue, such as natural and synthetic isoflavonoids and isoflavonoid-containing plant extracts such as soy and clover extracts , Active ingredients to support the skin functions in dry skin such as vitamin C, biotin, carnitine, propionic acid, green tea extracts, eucalyptus oil, urea and mineral salts such as NaCl, marine minerals and osmolytes eg inositol, betaine and quaternary ammonium compounds, active ingredients for relief or positive Influence of irritative Skin conditions at sensitive Skin in general or in skin irritated by noxious substances such as, for example, UV radiation or chemicals such as sericosides, various extracts of licorice, licochalcones, in particular licochalcone A 1 silymarin, silyphos, dexpanthenol, inhibitors of prostaglandin metabolism, in particular cyclooxygenase and leukotriene metabolism, in particular 5- Lipoxygenase and the 5-lipoxygenase inhibitor protein, FLAP, modulators of pigmentation that reduce pigmentation of the skin, such as tyrosine sulfate, dioic acid (8-hexadecene-1, 16-dicarboxylic acid) as well as lipoic acid and lipoamide, various extracts of licorice , Kojic acid, hydroquinone, arbutin, alpha-arbutin, deoxyarbutin, fruit acids especially alpha-hydroxy acids (AHAs), bearberry extracts (Bearberry or Uvae ursi), ursolic acid, ascorbic acid, green tea extracts, aminoguanidine, pyridoxamine, niacinamide, inhibitors of Proteinase Activated Receptors 2 (PAR-2), agents containing a vers markets or faster tanning of the skin with or without UV light, for example advanced glycation endproducts (AGE), lipofuscins, nucleic acid oligonucleotides, purines and pyrimidines, NO-releasing substances, tyrosine and its derivatives especially N-acetyl-tyrosine, Phenylalanine and its derivatives, in particular N-acetyl-phenylalanine and activators of the Proteinase Activated Receptor 2 (PAR-2), anti-wrinkle agents such as flavone glycosides in particular α-glycosyl rutin, coenzyme Q10, vitamin E and its derivatives. Active substances in encapsulated form can also be used in the process according to the invention, in particular alpha-, beta-, HP-beta, random-Me-beta, gamma-cyclodextrin, cellulose, gelatin, wax or liposomes being used as encapsulation materials serve. Hyaluronic acid, Q10, folic acid, creatine, vitamin C are preferably used to treat wrinkles. Wrinkles can also be laminated by application of fillers, in particular by PMMA, silica or siloxane elastomers. In a further aspect, the present object is achieved by a selective product applicator which has at least one optoelectronic sensor, at least one product reservoir, a data processing unit and at least one electrically triggered device for releasing liquids. Preferred embodiments of the product applicator are the subject of the subclaims.
In einer bevorzugten Ausführungsform der vorliegenden Erfindung sind die optoelektronischen Sensoren und die mit den Produktreservoiren verbundenen Vorrichtungen zur Freisetzung von Flüssigkeiten mit der Datenverarbeitungseinheit verbunden.In a preferred embodiment of the present invention, the optoelectronic sensors and those associated with the product reservoirs are Liquid release devices connected to the data processing unit.
In einer weiteren bevorzugten Ausführungsform der Erfindung weist der erfindungsgemäße Produktapplikator die Form eines Stifts auf, der mit einer Hand betätigt bzw. angewendet werden kann. Alle Bauelemente sind dabei so gewählt, dass sie in einem Gehäuse angeordnet werden können, welches in einer Hand gehalten werden kann.In a further preferred embodiment of the invention, the product applicator according to the invention in the form of a pin, which can be operated or applied with one hand. All components are chosen so that they can be arranged in a housing which can be held in one hand.
Es ist erfindungsgemäß bevorzugt, dass die elektrisch ausgelöste Vorrichtung zur Freisetzung von Flüssigkeiten einen Sprühkopf aufweist. Der Sprühkopf kann dabei eine Mikropumpe aufweisen, wobei beispielsweise Membranpumpen oder Kolbenpumpen eingesetzt werden. Mikromembranpumpen nutzen häufig den unten angeführten Piezoeffekt (Piezomembran-Mikropumpen). Eine bevorzugte Ausführungsform der vorliegenden Erfindung ist die Verwendung von Überdruckbehältern und Mikroventilen (entsprechend der beim Airbrush-Verfahren eingesetzten Technik).It is inventively preferred that the electrically triggered device for releasing liquids has a spray head. The spray head can have a micropump, wherein, for example, diaphragm pumps or piston pumps are used. Micro diaphragm pumps often use the piezo effect (piezo diaphragm micropumps) mentioned below. A preferred embodiment of the present invention is the use of overpressure containers and microvalves (corresponding to the technique used in the airbrush method).
Es ist weiterhin erfindungsgemäß bevorzugt, dass der Sprühkopf einen Bubble-Jet- Sprühkopf oder einen Piezo-Sprühkopf aufweist. In einem Sprühkopf nach dem Bubble- Jet-Verfahren, der im Folgenden als Bubble-Jet-Sprühkopf bezeichnet wird, werden winzige Flüssigkeitstropfen mit Hilfe eines Heizelements erzeugt. Dabei bildet sich explosionsartig eine Dampfblase, die durch ihren Druck einen Flüssigkeitstropfen aus einer Düse presst. In einem Piezo-Sprühkopf wird die Eigenschaft von Piezokristallen genutzt, sich unter elektrischer Spannung zu verformen, um Flüssigkeit durch eine Düse zu pressen. Es erfolgt die Tropfenbildung der Flüssigkeit, wobei sich das Tropfenvolumen über den angelegten elektrischen Impuls steuern lässt. Die Arbeitsfrequenz eines Piezokristalls reicht bis zu 23 kHz.It is further preferred according to the invention that the spray head comprises a bubble jet spray head or a piezo spray head. In a spray head according to the bubble jet method, which is referred to below as a bubble jet spray head, tiny drops of liquid are produced by means of a heating element. As a result, a vapor bubble forms explosively, which presses a drop of liquid out of a nozzle by its pressure. In a piezo spray head, the property of piezocrystals is used to deform under electrical tension to force fluid through a nozzle. The drop formation of the liquid occurs, whereby the drop volume can be controlled via the applied electrical pulse. The operating frequency of a piezocrystal reaches up to 23 kHz.
In einer besondere Ausführungsform werde die Wirkstoffe und/oder Zubereitungen durch Mikroinjektionen (Mikronadelsystem) direkt in die Falten.In a particular embodiment, the active ingredients and / or preparations by microinjections (microneedle system) directly into the folds.
Erfindungsgemäß sind auch Auftragungsarten wie Thermal InkJet, Mirkoventil und Sprühvervahren unter Verwendung einer Venturi-Düse (Airbrush Prinzip) Wichtig ist dabei, dass die freizusetzende Zubereitung nicht zu heiß werden darf, damit die Wirkstoffe nicht zerstört werden. Darüber hinaus müssen auch die Viskosität, die maximale Partikelgröße und das Agglomerationsverhalten der Partikel der freizusetzenden Zubereitung auf die Pumpleistung und die Düsengeometrie der eingesetzten Vorrichtung abgestimmt sein, um eine gezielte Freisetzung zu ermöglichen.According to the application types such as thermal inkjet, Mirkoventil and Sprühvervahren using a Venturi nozzle (airbrush principle) are also It is important that the preparation to be released must not be too hot, so that the active ingredients are not destroyed. In addition, the viscosity, the maximum particle size and the agglomeration behavior of the particles of the preparation to be released must also be matched to the pumping power and the nozzle geometry of the device used in order to enable a targeted release.
In einer weiteren bevorzugten Ausführungsform der vorliegenden Erfindung werden als optoelektronische Sensoren Photodioden, Phototransistoren oder CCD-Elemente bzw. CCD-Sensoren (CCD: Charge coupled device) einzeln oder in Kombination eingesetzt. Erfindungsgemäß bevorzugt ist der Einsatz von CCD-Sensoren wie sie beispielsweise in Scannern verwendet werden. CCD-Sensoren erlauben durch ihre hohe Empfindlichkeit die Erfassung von sehr schwachen Lichtstrahlen. Sie besitzen darüber hinaus eine breite spektrale Empfindlichkeit und einen hohen Dynamikumfang, d.h. sie können gleichzeitig sehr lichtschwache und sehr helle Bereiche eines Bildes erfassen.In a further preferred embodiment of the present invention, photodiodes, phototransistors or CCD elements or CCD sensors (CCD: Charge Coupled Device) are used individually or in combination as optoelectronic sensors. According to the invention, the use of CCD sensors, as used for example in scanners, is preferred. Due to their high sensitivity CCD sensors allow the detection of very weak light rays. They also have broad spectral sensitivity and high dynamic range, i. they can simultaneously capture very faint and very bright areas of an image.
Die Messwerterfassung gemäß der vorliegenden Erfindung ist eine Auswertung der Lichtintensitätsverteilung. Bei spezieller optischer Anordnung z.B. Winkel zwischen den optischen Achsen der Lichtquelle und der Aufnahmeeinheit zur besseren Bestimmung der Faltenausprägung ist auf die exakte Ortszuordnung zwischen Intensitätssignal und Applikationszielgebiet zu achten. Die Lichtintensität kann als Summensignal oder spektral differenzierend über optische oder elektronische Filter aufgenommen werden. Das Triggersignal zur Applikation kann über einen Schwellwert der Intensität oder aus Schwellwertkombinationen verschiedener spektraler Intensitäten gewonnen werden. Der Schwellwert bzw. die Schwellwertkombinationen müssen hautindividuell in einem „Trainingsmode" bestimmt werden. Eventuell sind hier optische Blenden erforderlich, um das Training besonders selektiv auf spezifische Hautmerkmale zu fokussieren.The measured value acquisition according to the present invention is an evaluation of the light intensity distribution. For a special optical arrangement, e.g. Angle between the optical axes of the light source and the recording unit to better determine the wrinkle expression is to pay attention to the exact location assignment between the intensity signal and the application target area. The light intensity can be recorded as a sum signal or spectrally differentiating via optical or electronic filters. The trigger signal for the application can be obtained via a threshold value of the intensity or from threshold value combinations of different spectral intensities. The threshold value or the threshold value combinations must be determined individually for each skin in a "training mode." Optionally, optical iris may be required in order to focus the training particularly selectively on specific skin characteristics.
In einem weiteren Aspekt wird die vorliegende Aufgabe gelöst durch die Verwendung des erfindungsgemäßen Produktapplikators zur selektiven Applikation von kosmetischen oder pharmazeutischen Zubereitungen auf der Haut.In a further aspect, the present object is achieved by the use of the product applicator according to the invention for the selective application of cosmetic or pharmaceutical preparations on the skin.
Bevorzugt wird der erfindungsgemäße Applikator zur Applikation von pharmazeutischen und kosmetischen Zubereitungen zur Behandlung von Akne, Falten und anderen Alterserscheinungen sowie Pigmentstörungen. Erfindungsgemäß geeignete Zubereitungen sind Lösungen, beispielsweise wässrige und/oder alkoholische Lösungen (Konzentrate), Emulsionen, Gele, Schmelzen, Seren und Make-up. The applicator according to the invention is preferred for the application of pharmaceutical and cosmetic preparations for the treatment of acne, wrinkles and other signs of aging as well as pigmentation disorders. Preparations suitable according to the invention are solutions, for example aqueous and / or alcoholic solutions (concentrates), emulsions, gels, melts, serums and make-up.
Claims
Applications Claiming Priority (4)
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|---|---|---|---|
| DE102007043698.1 | 2007-09-13 | ||
| DE200710043698 DE102007043698A1 (en) | 2007-09-13 | 2007-09-13 | Selective product applicator |
| DE102008041972A DE102008041972A1 (en) | 2007-09-13 | 2008-09-10 | Procedure for wrinkle reduction |
| DE102008041972.9 | 2008-09-10 |
Publications (2)
| Publication Number | Publication Date |
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| WO2009036924A1 true WO2009036924A1 (en) | 2009-03-26 |
| WO2009036924A8 WO2009036924A8 (en) | 2009-07-09 |
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| PCT/EP2008/007482 Ceased WO2009036924A1 (en) | 2007-09-13 | 2008-09-11 | Method for reducing wrinkles |
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| DE (1) | DE102008041972A1 (en) |
| WO (1) | WO2009036924A1 (en) |
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| US10933156B2 (en) | 2018-02-01 | 2021-03-02 | The Procter & Gamble Company | System and method for dispensing material |
| US10945515B2 (en) | 2017-06-16 | 2021-03-16 | The Procter & Gamble Company | Personal care device with audible feedback |
| US11077689B2 (en) | 2015-12-07 | 2021-08-03 | The Procter & Gamble Company | Systems and methods for providing a service station routine |
| US11076675B2 (en) | 2017-06-16 | 2021-08-03 | The Procter & Gamble Company | Method for camouflaging tonal imperfections |
| US11083672B2 (en) | 2018-02-01 | 2021-08-10 | The Procter & Gamble Company | Cosmetic ink composition comprising a surface tension modifier |
| US11090238B2 (en) | 2017-06-16 | 2021-08-17 | The Procter & Gamble Company | Array of cosmetic compositions for camouflaging tonal imperfections |
| US11116302B2 (en) | 2015-06-11 | 2021-09-14 | The Procter & Gamble Company | Apparatus and methods for modifying keratinous surfaces |
| USRE49230E1 (en) | 2015-06-11 | 2022-10-04 | The Procter & Gamble Company | Cartridges for use in an apparatus for modifying keratinous surfaces |
| US11590782B2 (en) | 2015-12-07 | 2023-02-28 | The Procter & Gamble Company | Systems and methods for providing a service station routine |
| US11833236B2 (en) | 2018-02-01 | 2023-12-05 | The Procter And Gamble Company | Heterogenous cosmetic ink composition for inkjet printing applications |
| US11857665B2 (en) | 2018-02-01 | 2024-01-02 | The Procter And Gamble Company | Stable cosmetic ink composition |
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| JP2021095353A (en) * | 2019-12-16 | 2021-06-24 | ロレアル | Cosmetic method using hyaluronic acid droplets |
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| US20030065294A1 (en) * | 2001-09-28 | 2003-04-03 | Pickup Ray L. | Cutaneous administration system |
| EP1459782A2 (en) * | 2003-03-21 | 2004-09-22 | Hewlett-Packard Development Company, L.P. | Method and device for targeted epithelial delivery of medicinal and related agents |
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| US11116302B2 (en) | 2015-06-11 | 2021-09-14 | The Procter & Gamble Company | Apparatus and methods for modifying keratinous surfaces |
| USRE49230E1 (en) | 2015-06-11 | 2022-10-04 | The Procter & Gamble Company | Cartridges for use in an apparatus for modifying keratinous surfaces |
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| US11590782B2 (en) | 2015-12-07 | 2023-02-28 | The Procter & Gamble Company | Systems and methods for providing a service station routine |
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| US11090238B2 (en) | 2017-06-16 | 2021-08-17 | The Procter & Gamble Company | Array of cosmetic compositions for camouflaging tonal imperfections |
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| US11083672B2 (en) | 2018-02-01 | 2021-08-10 | The Procter & Gamble Company | Cosmetic ink composition comprising a surface tension modifier |
| US11090239B2 (en) | 2018-02-01 | 2021-08-17 | The Procter & Gamble Company | Cosmetic ink composition comprising a surface tension modifier |
| US11833236B2 (en) | 2018-02-01 | 2023-12-05 | The Procter And Gamble Company | Heterogenous cosmetic ink composition for inkjet printing applications |
| US11857665B2 (en) | 2018-02-01 | 2024-01-02 | The Procter And Gamble Company | Stable cosmetic ink composition |
Also Published As
| Publication number | Publication date |
|---|---|
| DE102008041972A1 (en) | 2010-03-11 |
| WO2009036924A8 (en) | 2009-07-09 |
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