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WO2009035333A1 - Acides aminés bioactifs en tant que nutraceutiques stimulant la croissance chez le saumon - Google Patents

Acides aminés bioactifs en tant que nutraceutiques stimulant la croissance chez le saumon Download PDF

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Publication number
WO2009035333A1
WO2009035333A1 PCT/NO2008/000305 NO2008000305W WO2009035333A1 WO 2009035333 A1 WO2009035333 A1 WO 2009035333A1 NO 2008000305 W NO2008000305 W NO 2008000305W WO 2009035333 A1 WO2009035333 A1 WO 2009035333A1
Authority
WO
WIPO (PCT)
Prior art keywords
fish
amino acids
arginine
growth
nutraceutica
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/NO2008/000305
Other languages
English (en)
Inventor
Bendik Fyhn Terjesen
Ståle REFSTIE
Kjell-Arne RØRVIK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOFIMA AKVAFORSK-FISKERIFORSKNING AS
Original Assignee
NOFIMA AKVAFORSK-FISKERIFORSKNING AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NOFIMA AKVAFORSK-FISKERIFORSKNING AS filed Critical NOFIMA AKVAFORSK-FISKERIFORSKNING AS
Publication of WO2009035333A1 publication Critical patent/WO2009035333A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof

Definitions

  • Smoltification transfer from freshwater to sea water, and the first period in seawater is physiologically and metabolically a very stressful period for salmonid fishes.
  • the physiology of the fish is switched from freshwater to saltwater adaptation, but sub-optimal osmoregulation often result in depressed appetite, stunted growth, and increased susceptibility to disease. Other stress situations may also have a negative impact on the growth rate of fish species.
  • Arginine is one of the most versatile amino acids in addition to its function as a protein component (Walsh & Mommsen, 2001). Among several roles, arginine is an oxidative energy substrate, it is necessary for nitric oxide synthesis, elevates growth hormone, IGF 1, and insulin levels, and is a substrate for polyamine synthesis, which are vital for growth (Mommsen, 2001). Arginine is currently termed an indispensable amino acid necessary for optimal growth for young fish (Wilson, 2002), unlike in mammals, where this amino acid has a conditionally indispensable status (Flynn, et al., 2002).
  • Glutamate is a dispensable amino acid of the same structural group (glutamate family) as arginine.
  • Glutamine which is glutamate plus one ammonia molecule, is an important energy substrate for intestinal tissues in mammals, and is the precursor for proline and arginine synthesis in mammals (Young & Ajami, 2001). Whether the same biochemical pathways for intestinal glutamate/glutamine handling exist in fishes is unknown, although the final step in proline biosynthesis was recently described for rainbow trout (Dabrowski, et al., 2005; Terjesen and Dabrowski, unpublished).
  • dietary glutamate supplementation has been shown to reduce arginine requirements in channel catfish, suggesting the pathway between glutamate and arginine exists in fish (Buentello & Gatlin, 2000). Further, dietary glutamine supplementation to juvenile carp was recently demonstrated to improve growth, feed conversion, and intestinal parameters such as total gut weight, fold height and enzyme activities (Yan & Qiu-Zhou, 2006).
  • Figure 1 shows the feed intake in 1+ smolts given diet A (control) and diet F (fortified).
  • Figure 2 shows the estimated body weight of 1+ smolts given diet A (control) and diet F (fortified).
  • arginine supplementation in a rapidly absorbed molecular from e.g. free or dipeptide, (Tesser, et al., 2005)
  • glutamate supplementation is used to provide the intestinal tissues in salmon with an easily available energy substrate during periods of rapid growth.
  • purified bioactive amino acids are added to the diets of Atlantic salmon smolts following transfer to seawater in the early summer.
  • the amino acids are preferably arginine and/or glutamine.
  • a fish feed product comprising purified bioactive amino acids.
  • the amino acids are preferably arginine and/or glutamine.
  • the present invention comprises a method for the use of purified bioactive amino acids as nutraceutica to boost the capacity for nutrient absorption and conversion of absorbed nutrients to muscle growth in Atlantic salmon during stressful periods.
  • purified amino acids are added to the diet of fish, preferably salmonid fish such as Atlantic Salmon.
  • the purified amino acids are believed to be absorbed in advance of amino acids and other nutrients resulting from digestion, priming the anabolic machinery prior to absorption and assimilation of the main feed components.
  • Two diets were produced by high-pressure moist extrusion: A standard salmon diet (diet A), and a diet fortified with 5 g arginine (Arg HCl) and 7.5 g glutamate per kg (diet F). The total content of arginine was 27 g and 32 g per kg diet, respectively.
  • Each diet is fed to triplicate groups of Atlantic salmon for a period of 100 g following transfer to seawater in May 2007.
  • These Atlantic salmon 1+ smolts are raised in 125 m 3 pens with 400 fish/pen at AKVAFORSK's model sea farm at Aver ⁇ y (Norway).
  • the feeding is appetite driven, and feed intake is recorded daily. The experiment will be terminated in the last week of September 2007.
  • diet F has stimulated a higher feed intake than diet A. This has resulted in faster estimated growth and higher body weight, as shown in Figure 2.
  • the experiment verifies that a combination of arginine and glutamate may be used as nutraceutica to boost growth in Atlantic salmon 1+ smolts following transfer to seawater.
  • Biol. 208, 2885-2894 Flynn, N.E., Meininger, CJ., Haynes, T.E., Wu, G., 2002. The metabolic basis of arginine nutrition and pharmacotherapy. Biomed Pharmacother 56, 427-238.

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  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Insects & Arthropods (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)

Abstract

La présente invention concerne un procédé permettant de stimuler la croissance du poisson pendant des périodes de stress particulières, consistant à ajouter des acides aminés bioactifs purifiés seuls ou en mélange en tant que nutraceutiques aux régimes alimentaires du poisson afin de stimuler sa capacité d'absorption des nutriments et de conversion des nutriments absorbés en croissance musculaire.
PCT/NO2008/000305 2007-09-11 2008-08-29 Acides aminés bioactifs en tant que nutraceutiques stimulant la croissance chez le saumon Ceased WO2009035333A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97127007P 2007-09-11 2007-09-11
US60/971,270 2007-09-11

Publications (1)

Publication Number Publication Date
WO2009035333A1 true WO2009035333A1 (fr) 2009-03-19

Family

ID=40227201

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NO2008/000305 Ceased WO2009035333A1 (fr) 2007-09-11 2008-08-29 Acides aminés bioactifs en tant que nutraceutiques stimulant la croissance chez le saumon

Country Status (1)

Country Link
WO (1) WO2009035333A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010082832A1 (fr) * 2009-01-14 2010-07-22 Nofima Marin As Amélioration de la qualité des filets de poissons d'élevage au moyen d'acides aminés bioactifs
US20110308474A1 (en) * 2009-01-28 2011-12-22 Trouw International B.V. Feed additive
CN104304685A (zh) * 2014-11-14 2015-01-28 中国水产科学研究院黑龙江水产研究所 一种提高鲟鱼饲料蛋白质利用率的饲料添加剂及其添加方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551495A (en) * 1967-12-04 1970-12-29 Monsanto Co Polymeric amines
US5171587A (en) * 1990-08-31 1992-12-15 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Amino acid modified food for ictalurid catfish and fish with similar feeding behavior
WO2006034570A1 (fr) * 2004-09-28 2006-04-06 Chemaphor Inc. Compositions et procedes pour favoriser le gain de poids et la conversion d'aliments

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551495A (en) * 1967-12-04 1970-12-29 Monsanto Co Polymeric amines
US5171587A (en) * 1990-08-31 1992-12-15 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Amino acid modified food for ictalurid catfish and fish with similar feeding behavior
WO2006034570A1 (fr) * 2004-09-28 2006-04-06 Chemaphor Inc. Compositions et procedes pour favoriser le gain de poids et la conversion d'aliments

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JUXING CHEN ET AL: "Growth and metabolism of marine fish Chinook salmon embryo cells: response to lack of glucose and glutamine", BIOTECHNOLOGY LETTERS, KLUWER ACADEMIC PUBLISHERS, DO, vol. 27, no. 6, 1 March 2005 (2005-03-01), pages 395 - 401, XP019231119, ISSN: 1573-6776 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010082832A1 (fr) * 2009-01-14 2010-07-22 Nofima Marin As Amélioration de la qualité des filets de poissons d'élevage au moyen d'acides aminés bioactifs
US20110308474A1 (en) * 2009-01-28 2011-12-22 Trouw International B.V. Feed additive
CN104304685A (zh) * 2014-11-14 2015-01-28 中国水产科学研究院黑龙江水产研究所 一种提高鲟鱼饲料蛋白质利用率的饲料添加剂及其添加方法

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