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WO2009034433A3 - 3-azabicyclo [3.1.0] hexane derivatives as vanilloid receptor ligands - Google Patents

3-azabicyclo [3.1.0] hexane derivatives as vanilloid receptor ligands Download PDF

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Publication number
WO2009034433A3
WO2009034433A3 PCT/IB2008/002321 IB2008002321W WO2009034433A3 WO 2009034433 A3 WO2009034433 A3 WO 2009034433A3 IB 2008002321 W IB2008002321 W IB 2008002321W WO 2009034433 A3 WO2009034433 A3 WO 2009034433A3
Authority
WO
WIPO (PCT)
Prior art keywords
azabicyclo
receptor ligands
vanilloid receptor
hexane derivatives
vanilloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2008/002321
Other languages
French (fr)
Other versions
WO2009034433A2 (en
Inventor
Laxmikant Atmaram Gharat
Lakshminarayana Narayana
Neelima Khairatkar-Joshi
Vidya G. Kattige
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ichnos Sciences SA
Original Assignee
Glenmark Pharmaceuticals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals SA filed Critical Glenmark Pharmaceuticals SA
Publication of WO2009034433A2 publication Critical patent/WO2009034433A2/en
Publication of WO2009034433A3 publication Critical patent/WO2009034433A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to 3-azabicyclo [3.1.0] hexane derivatives, which can be used as vanilloid receptor ligands, methods of treating diseases, conditions and/or disorders modulated by vanilloid receptors with them, and processes for preparing them.
PCT/IB2008/002321 2007-09-10 2008-09-08 3-azabicyclo [3.1.0] hexane derivatives as vanilloid receptor ligands Ceased WO2009034433A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1727/MUM/2007 2007-09-10
IN1727MU2007 2007-09-10

Publications (2)

Publication Number Publication Date
WO2009034433A2 WO2009034433A2 (en) 2009-03-19
WO2009034433A3 true WO2009034433A3 (en) 2009-11-05

Family

ID=40452616

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/002321 Ceased WO2009034433A2 (en) 2007-09-10 2008-09-08 3-azabicyclo [3.1.0] hexane derivatives as vanilloid receptor ligands

Country Status (1)

Country Link
WO (1) WO2009034433A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017216726A1 (en) 2016-06-13 2017-12-21 Glaxosmithkline Intellectual Property Development Limited Substituted pyridines as inhibitors of dnmt1
JOP20190024A1 (en) 2016-08-26 2019-02-19 Gilead Sciences Inc Substituted pyrrolizine compounds and uses thereof
US11242332B2 (en) 2017-03-15 2022-02-08 Sumitomo Dainippon Pharma Co., Ltd. Method for producing benzimidazole derivative
WO2019165374A1 (en) 2018-02-26 2019-08-29 Gilead Sciences, Inc. Substituted pyrrolizine compounds as hbv replication inhibitors
RU2755206C1 (en) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Agent with prolonged analgesic action and medicinal product based thereon

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002090326A1 (en) * 2001-05-02 2002-11-14 Smithkline Beecham P.L.C. Heterocyclic ureas, their preparation and their use as vanilloid receptor antagonists
WO2004078749A1 (en) * 2003-03-06 2004-09-16 Glaxo Group Limited Heterocyclic urea derivatives for the treatment of pain
WO2008010061A2 (en) * 2006-07-17 2008-01-24 Glenmark Pharmaceuticals S.A. 3-azabicyclo [3.1.0] hexane vanilloid receptor ligands, pharmaceutical compositions containing them, and processes for their preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002090326A1 (en) * 2001-05-02 2002-11-14 Smithkline Beecham P.L.C. Heterocyclic ureas, their preparation and their use as vanilloid receptor antagonists
WO2004078749A1 (en) * 2003-03-06 2004-09-16 Glaxo Group Limited Heterocyclic urea derivatives for the treatment of pain
WO2008010061A2 (en) * 2006-07-17 2008-01-24 Glenmark Pharmaceuticals S.A. 3-azabicyclo [3.1.0] hexane vanilloid receptor ligands, pharmaceutical compositions containing them, and processes for their preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RENSLO, ADAM R. ET AL: "Conformational Constraint in Oxazolidinone Antibacterials. Synthesis and Structure-Activity Studies of (Azabicyclo[3.1.0]hexylphenyl)oxazolidinones", JOURNAL OF MEDICINAL CHEMISTRY , 48(15), 5009-5024 CODEN: JMCMAR; ISSN: 0022-2623, vol. 48, no. 15, 2005, pages 5009 - 5024, XP002544540 *

Also Published As

Publication number Publication date
WO2009034433A2 (en) 2009-03-19

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