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WO2009031606A1 - 関節炎治療及び予防剤 - Google Patents

関節炎治療及び予防剤 Download PDF

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Publication number
WO2009031606A1
WO2009031606A1 PCT/JP2008/065943 JP2008065943W WO2009031606A1 WO 2009031606 A1 WO2009031606 A1 WO 2009031606A1 JP 2008065943 W JP2008065943 W JP 2008065943W WO 2009031606 A1 WO2009031606 A1 WO 2009031606A1
Authority
WO
WIPO (PCT)
Prior art keywords
arthritis
therapeutic
prophylactic agents
stem cell
mesenchymal stem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/065943
Other languages
English (en)
French (fr)
Inventor
Masahiko Kuroda
Masakatsu Takanashi
Katsuko Sudo
Shigeki Yamauchi
Hiroyuki Shirono
Toru Hirado
Kenichi Maeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JCR Pharmaceuticals Co Ltd
MIRACURE Inc
Original Assignee
JCR Pharmaceuticals Co Ltd
MIRACURE Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JCR Pharmaceuticals Co Ltd, MIRACURE Inc filed Critical JCR Pharmaceuticals Co Ltd
Priority to US12/676,638 priority Critical patent/US20110262402A1/en
Priority to JP2009531268A priority patent/JPWO2009031606A1/ja
Priority to EP08829164A priority patent/EP2191835A4/en
Publication of WO2009031606A1 publication Critical patent/WO2009031606A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

　関節炎，特に関節リウマチを治療及び／又は予防するための薬剤及び方法が提供されている。当該薬剤は，ヒト間葉系幹細胞を含んでなり，当該方法は，ヒト間葉系幹細胞の有効量を患者に投与することを含んでなる。
PCT/JP2008/065943 2007-09-07 2008-09-04 関節炎治療及び予防剤 Ceased WO2009031606A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/676,638 US20110262402A1 (en) 2007-09-07 2008-09-04 Therapeutic and prophylactic agents for arthritis
JP2009531268A JPWO2009031606A1 (ja) 2007-09-07 2008-09-04 関節炎治療及び予防剤
EP08829164A EP2191835A4 (en) 2007-09-07 2008-09-04 THERAPEUTIC AND PROPHYLACTIC AGENTS FOR ARTHRITIS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-233094 2007-09-07
JP2007233094 2007-09-07

Publications (1)

Publication Number Publication Date
WO2009031606A1 true WO2009031606A1 (ja) 2009-03-12

Family

ID=40428919

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065943 Ceased WO2009031606A1 (ja) 2007-09-07 2008-09-04 関節炎治療及び予防剤

Country Status (4)

Country Link
US (1) US20110262402A1 (ja)
EP (1) EP2191835A4 (ja)
JP (1) JPWO2009031606A1 (ja)
WO (1) WO2009031606A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015180199A (ja) * 2009-11-27 2015-10-15 ステムピューティクス リサーチ ピーブイティー．リミテッドＳｔｅｍｐｅｕｔｉｃｓ Ｒｅｓｅａｒｃｈ Ｐｖｔ． Ｌｔｄ． 間葉系幹細胞を調製する方法、その組成物及びキット
JP2016185972A (ja) * 2010-08-31 2016-10-27 クック・ジェネラル・バイオテクノロジー・エルエルシー 動物の疾病の治療のための全身的、同種間幹細胞治療
US10104880B2 (en) 2008-08-20 2018-10-23 Celularity, Inc. Cell composition and methods of making the same
WO2018225673A1 (ja) * 2017-06-06 2018-12-13 Ｄｓファーマアニマルヘルス株式会社 細胞凝集低減方法および細胞凝集が低減された治療用組成物

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
WO2007039150A2 (en) 2005-09-23 2007-04-12 Cellerix, S.L. Cell populations having immunoregulatory activity, method for isolation and uses
EP2210608B1 (en) * 2007-11-02 2016-08-31 JCR Pharmaceuticals CO., LTD. Pharmaceutical composition containing human mesenchymal stem cell
EP3124601A1 (en) 2008-08-14 2017-02-01 Mesoblast International Sàrl Purified mesenchymal stem cell compositions and methods of purifying mesenchymal stem cell compositions
JP5892931B2 (ja) * 2009-07-09 2016-03-23 タイジェニックス，エス．アー． 細胞治療において使用するための方法および組成物
CN103961373A (zh) * 2013-02-04 2014-08-06 西比曼生物科技（上海）有限公司 异体间质血管层细胞和异体间充质祖细胞在预防或治疗骨性关节炎中的应用
US20140276359A1 (en) * 2013-03-15 2014-09-18 Plum Systems Co. Apparatus and method for tissue rejuvenation
GB201604304D0 (en) 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
US10987381B2 (en) * 2017-01-27 2021-04-27 Neil Riordan Mesenchymal stem cells with enhanced efficacy in treatment of autoimmunity particularly rheumatoid arthritis
CN117915925A (zh) * 2021-07-08 2024-04-19 勃林格殷格翰比利时兽医公司 用于在动物中治疗骨关节炎的间充质干细胞

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
WO1999047163A2 (en) 1998-03-18 1999-09-23 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
JP2004129549A (ja) 2002-10-09 2004-04-30 Yasuo Kitagawa 脂肪由来細胞群からの間葉系幹細胞の選択的増殖方法
JP2004201612A (ja) 2002-12-26 2004-07-22 Minoru Ueda 未分化多能性細胞並びに、それを用いた関連組織又は歯作製方法
JP2004210713A (ja) 2002-12-27 2004-07-29 Asahi Kasei Corp 医療用胎盤由来細胞製剤
WO2005093044A1 (en) 2004-03-22 2005-10-06 Osiris Therapeutics, Inc. Mesenchymal stem cells and uses therefor
JP2006204200A (ja) * 2004-12-27 2006-08-10 Two Cells Co Ltd 間葉系幹細胞の骨化及び／又は軟骨化促進剤と骨化及び／又は軟骨化促進方法
JP2006346420A (ja) * 2005-06-13 2006-12-28 Univ Nagoya 移植材料及び骨質改善剤

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
WO1999047163A2 (en) 1998-03-18 1999-09-23 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US6328960B1 (en) 1998-03-18 2001-12-11 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
JP2002506831A (ja) 1998-03-18 2002-03-05 オシリス セラピューティクス，インコーポレイテッド 移植で免疫応答の予防と処置のための間葉幹細胞を利用する方法とその組成物
JP2004129549A (ja) 2002-10-09 2004-04-30 Yasuo Kitagawa 脂肪由来細胞群からの間葉系幹細胞の選択的増殖方法
JP2004201612A (ja) 2002-12-26 2004-07-22 Minoru Ueda 未分化多能性細胞並びに、それを用いた関連組織又は歯作製方法
JP2004210713A (ja) 2002-12-27 2004-07-29 Asahi Kasei Corp 医療用胎盤由来細胞製剤
WO2005093044A1 (en) 2004-03-22 2005-10-06 Osiris Therapeutics, Inc. Mesenchymal stem cells and uses therefor
JP2006204200A (ja) * 2004-12-27 2006-08-10 Two Cells Co Ltd 間葉系幹細胞の骨化及び／又は軟骨化促進剤と骨化及び／又は軟骨化促進方法
JP2006346420A (ja) * 2005-06-13 2006-12-28 Univ Nagoya 移植材料及び骨質改善剤

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ARTHRITIS & RHEUMATISM, vol. 52, no. 5, 2005, pages 1595 - 1603
ARTHRITIS & RHEUMATISM, vol. 56, no. 4, 2007, pages 1175 - 1186
ARTHRITIS RHEUM., vol. 56, no. 2, 2007, pages 521 - 530
AUGELLO, A. ET AL.: "Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collage-induced arthritis", ARTHRITIS & RHEUMATISM, vol. 56, no. 4, April 2007 (2007-04-01), pages 1175 - 1186, XP002517050 *
BLOOD, vol. 105, no. 4, 2005, pages 1815 - 22
J EXP MED., vol. 191, 2000, pages 313 - 320
See also references of EP2191835A4 *
TRANSPLANTATION, vol. 81, no. 10, 2006, pages 1390 - 1397

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10104880B2 (en) 2008-08-20 2018-10-23 Celularity, Inc. Cell composition and methods of making the same
JP2015180199A (ja) * 2009-11-27 2015-10-15 ステムピューティクス リサーチ ピーブイティー．リミテッドＳｔｅｍｐｅｕｔｉｃｓ Ｒｅｓｅａｒｃｈ Ｐｖｔ． Ｌｔｄ． 間葉系幹細胞を調製する方法、その組成物及びキット
JP2016185972A (ja) * 2010-08-31 2016-10-27 クック・ジェネラル・バイオテクノロジー・エルエルシー 動物の疾病の治療のための全身的、同種間幹細胞治療
WO2018225673A1 (ja) * 2017-06-06 2018-12-13 Ｄｓファーマアニマルヘルス株式会社 細胞凝集低減方法および細胞凝集が低減された治療用組成物
JPWO2018225673A1 (ja) * 2017-06-06 2020-04-09 Ｄｓファーマアニマルヘルス株式会社 細胞凝集低減方法および細胞凝集が低減された治療用組成物
JP7133549B2 (ja) 2017-06-06 2022-09-08 住友ファーマアニマルヘルス株式会社 細胞凝集低減方法および細胞凝集が低減された治療用組成物

Also Published As

Publication number Publication date
JPWO2009031606A1 (ja) 2010-12-16
US20110262402A1 (en) 2011-10-27
EP2191835A4 (en) 2011-12-14
EP2191835A1 (en) 2010-06-02

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