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WO2009031477A1 - オートフォーカス装置および顕微鏡 - Google Patents

オートフォーカス装置および顕微鏡 Download PDF

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Publication number
WO2009031477A1
WO2009031477A1 PCT/JP2008/065585 JP2008065585W WO2009031477A1 WO 2009031477 A1 WO2009031477 A1 WO 2009031477A1 JP 2008065585 W JP2008065585 W JP 2008065585W WO 2009031477 A1 WO2009031477 A1 WO 2009031477A1
Authority
WO
WIPO (PCT)
Prior art keywords
incident
microscope
reference light
automatic focusing
dichroic mirror
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/065585
Other languages
English (en)
French (fr)
Inventor
Ichiro Sase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nikon Corp
Original Assignee
Nikon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nikon Corp filed Critical Nikon Corp
Priority to JP2009531214A priority Critical patent/JP5621259B2/ja
Priority to EP16153962.2A priority patent/EP3067729B1/en
Priority to EP08829327.9A priority patent/EP2196836B1/en
Priority to US12/676,095 priority patent/US8629382B2/en
Publication of WO2009031477A1 publication Critical patent/WO2009031477A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/245—Devices for focusing using auxiliary sources, detectors

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Microscoopes, Condenser (AREA)
  • Automatic Focus Adjustment (AREA)

Abstract

本発明は、顕微鏡における観察環境を向上させることができるオートフォーカス装置および顕微鏡に関する。 オートフォーカス用のLED６１から射出された参照光は、ハーフミラー１３４乃至対物レンズ２３を介して標本が接着されたガラスカバーに入射する。ガラスカバーに入射した参照光は、その境界面Ｓにおいて反射して反射光となり、対物レンズ２３を介してダイクロイックミラー６３に入射する。反射光の一部は、ダイクロイックミラー６３において透過されてフィルタ６５に入射し、フィルタ６５は反射光を透過させてダイクロイックミラー１９１乃至レンズ６９を介してカメラ２７に入射させる。ユーザは、カメラ２７により撮像された参照光の像を見ながら電動操作ミラー１３５を回動させ、境界面Ｓ上における参照光の像の位置を移動させる。本発明は、顕微鏡に適用することができる。
PCT/JP2008/065585 2007-09-03 2008-08-29 オートフォーカス装置および顕微鏡 Ceased WO2009031477A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009531214A JP5621259B2 (ja) 2007-09-03 2008-08-29 顕微鏡装置
EP16153962.2A EP3067729B1 (en) 2007-09-03 2008-08-29 Automatic focusing device and microscope
EP08829327.9A EP2196836B1 (en) 2007-09-03 2008-08-29 Automatic focusing device and microscope
US12/676,095 US8629382B2 (en) 2007-09-03 2008-08-29 Auto focus apparatus for detecting a focal point with a setting section for shifting an irradiation position outside an observation field of an imaging section

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-227651 2007-09-03
JP2007227651 2007-09-03

Publications (1)

Publication Number Publication Date
WO2009031477A1 true WO2009031477A1 (ja) 2009-03-12

Family

ID=40428796

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065585 Ceased WO2009031477A1 (ja) 2007-09-03 2008-08-29 オートフォーカス装置および顕微鏡

Country Status (4)

Country Link
US (1) US8629382B2 (ja)
EP (2) EP3067729B1 (ja)
JP (1) JP5621259B2 (ja)
WO (1) WO2009031477A1 (ja)

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JP2013533513A (ja) * 2010-07-28 2013-08-22 ライカ マイクロシステムス ツェーエムエス ゲーエムベーハー 試料構造の顕微鏡像を取得する方法及び装置
EP2491452A4 (en) * 2009-10-19 2015-03-11 Ventana Med Syst Inc IMAGING SYSTEM AND TECHNIQUES
EP2495592A4 (en) * 2009-07-13 2018-04-18 Nikon Corporation Three-dimensional directional drift control device and microscope device
CN119270491A (zh) * 2024-11-22 2025-01-07 南京波长光电科技股份有限公司 一种适用于荧光显微镜的快速自动对焦模组及方法

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HU0800686D0 (en) * 2008-11-17 2009-01-28 Femtonics Kft Laser scanning microscope
US9229207B2 (en) * 2008-11-17 2016-01-05 Femtonics Kft Laser scanning microscope with focus-detecting unit
EP2498113B1 (de) * 2011-03-10 2013-03-06 Sick AG Fokusverstellvorrichtung für einen Codeleser
GB201113071D0 (en) * 2011-07-29 2011-09-14 Ffei Ltd Method and apparatus for image scanning
US9594230B2 (en) 2011-12-23 2017-03-14 Rudolph Technologies, Inc. On-axis focus sensor and method
WO2015181951A1 (ja) 2014-05-30 2015-12-03 株式会社ニコン 焦点調節装置、顕微鏡装置、焦点調節方法、及び制御プログラム
JP6590366B2 (ja) * 2015-09-25 2019-10-16 オリンパス株式会社 顕微鏡装置、オートフォーカス装置、及び、オートフォーカス方法
US10496156B2 (en) * 2016-05-17 2019-12-03 Google Llc Techniques to change location of objects in a virtual/augmented reality system
EP3287829A1 (en) * 2016-08-25 2018-02-28 Deutsches Krebsforschungszentrum Method of and microscope with installation for focus stabilization
JP6680653B2 (ja) * 2016-09-12 2020-04-15 シスメックス株式会社 顕微鏡装置、顕微鏡システムおよび撮像方法
GB201704770D0 (en) * 2017-01-05 2017-05-10 Illumina Inc Predictive focus tracking apparatus and methods
US10165170B2 (en) * 2017-03-06 2018-12-25 Semiconductor Components Industries, Llc Methods and apparatus for autofocus
CN107656364B (zh) * 2017-11-16 2020-10-23 宁波舜宇仪器有限公司 一种显微成像系统及其实时对焦方法
CN108195804A (zh) * 2017-12-12 2018-06-22 濮阳光电产业技术研究院 一种荧光探测器
US11567293B2 (en) * 2018-02-14 2023-01-31 Riken Autofocus device, and optical apparatus and microscope including the same
DE102019113975B4 (de) * 2019-05-24 2023-10-19 Abberior Instruments Gmbh Verfahren und Vorrichtung zum Überwachen des Fokuszustands eines Mikroskops sowie Mikroskop
CN110691153B (zh) * 2019-08-27 2020-09-22 珠海格力电器股份有限公司 一种显示模组及终端
CN114415325B (zh) * 2022-02-22 2023-11-03 北京半导体专用设备研究所（中国电子科技集团公司第四十五研究所） 调焦光学成像系统
KR20230139684A (ko) * 2022-03-28 2023-10-05 주식회사 스타노스 광학현미경을 위한 자동 초점 장치 및 자동 초점 유지 방법
WO2024208601A1 (en) * 2023-04-03 2024-10-10 Nanolive Sa Microscope with autofocus system

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JPH10133117A (ja) * 1996-10-31 1998-05-22 Nikon Corp 焦点検出装置を備えた顕微鏡
JP2002328297A (ja) * 2001-05-01 2002-11-15 Olympus Optical Co Ltd 焦点検出装置及びそれを備えた光学顕微鏡又は光学検査装置
JP2004070276A (ja) * 2002-06-14 2004-03-04 Nikon Corp オートフォーカス装置
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US7345814B2 (en) * 2003-09-29 2008-03-18 Olympus Corporation Microscope system and microscope focus maintaining device for the same
US7369308B2 (en) * 2004-02-09 2008-05-06 Olympus Corporation Total internal reflection fluorescence microscope
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JP4910382B2 (ja) * 2005-12-15 2012-04-04 株式会社ニコン 顕微鏡

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10133117A (ja) * 1996-10-31 1998-05-22 Nikon Corp 焦点検出装置を備えた顕微鏡
JP2002328297A (ja) * 2001-05-01 2002-11-15 Olympus Optical Co Ltd 焦点検出装置及びそれを備えた光学顕微鏡又は光学検査装置
JP2004070276A (ja) * 2002-06-14 2004-03-04 Nikon Corp オートフォーカス装置
JP2005316070A (ja) * 2004-04-28 2005-11-10 Olympus Corp レーザ集光光学系
JP2008116900A (ja) * 2006-10-11 2008-05-22 Olympus Corp 干渉対物レンズと、その干渉対物レンズを備える干渉顕微鏡装置

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2495592A4 (en) * 2009-07-13 2018-04-18 Nikon Corporation Three-dimensional directional drift control device and microscope device
US10613311B2 (en) 2009-07-13 2020-04-07 Nikon Corporation Three-dimensional drift control apparatus and microscope apparatus
EP2491452A4 (en) * 2009-10-19 2015-03-11 Ventana Med Syst Inc IMAGING SYSTEM AND TECHNIQUES
US9575301B2 (en) 2009-10-19 2017-02-21 Ventana Medical Systems, Inc. Device for a microscope stage
US10061107B2 (en) 2009-10-19 2018-08-28 Ventana Medical Systems, Inc. Method and device for slide scanning
JP2013533513A (ja) * 2010-07-28 2013-08-22 ライカ マイクロシステムス ツェーエムエス ゲーエムベーハー 試料構造の顕微鏡像を取得する方法及び装置
US9720221B2 (en) 2010-07-28 2017-08-01 Leica Microsystems Cms Gmbh Device and method for acquiring a microscopic image of a sample structure
CN119270491A (zh) * 2024-11-22 2025-01-07 南京波长光电科技股份有限公司 一种适用于荧光显微镜的快速自动对焦模组及方法

Also Published As

Publication number Publication date
EP3067729A1 (en) 2016-09-14
EP2196836A1 (en) 2010-06-16
JP5621259B2 (ja) 2014-11-12
US8629382B2 (en) 2014-01-14
JPWO2009031477A1 (ja) 2010-12-16
US20110127406A1 (en) 2011-06-02
EP2196836B1 (en) 2016-03-30
EP3067729B1 (en) 2020-09-23
EP2196836A4 (en) 2012-08-08

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