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WO2009030705A2 - Dispositif permettant l'administration d'un médicament sous blister - Google Patents

Dispositif permettant l'administration d'un médicament sous blister Download PDF

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Publication number
WO2009030705A2
WO2009030705A2 PCT/EP2008/061621 EP2008061621W WO2009030705A2 WO 2009030705 A2 WO2009030705 A2 WO 2009030705A2 EP 2008061621 W EP2008061621 W EP 2008061621W WO 2009030705 A2 WO2009030705 A2 WO 2009030705A2
Authority
WO
WIPO (PCT)
Prior art keywords
section
pipe section
connecting pipe
bag
pump
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/061621
Other languages
German (de)
English (en)
Other versions
WO2009030705A3 (fr
Inventor
Alfred Von Schuckmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2009030705A2 publication Critical patent/WO2009030705A2/fr
Publication of WO2009030705A3 publication Critical patent/WO2009030705A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type

Definitions

  • the invention relates to a device for administering a blister packaged medicament.
  • Such devices are known. These are mainly used for the inhalation of medicinal, powdery masses, which are further portioned in cavities of a blister pack. The filled cavities are covered by a laminated aluminum foil.
  • inhalers in particular also known devices in the form of inhalers are known. In these is a blister, which is opened immediately before inhalation, for example, pierced. The inhalation process takes place while flowing through the cavity, wherein the stored medicament is discharged.
  • the emptying of the cavity of the present device is already achieved in the course of an inhalation preparation via the metering pump by first piercing the blister by means of the pump-side needle and thereafter flowing through and emptying it by actuating the pump.
  • the air entraining the preferably powdered medicament expands the bag tied on the plate side, in order to offer an inhalable volume of air displaced with a powder cloud.
  • an air volume of 100 to 400 ml, more preferably 200 ml is available for inhalation in the bag.
  • the stated numerical range also includes all intermediate values, in particular in 1/10 steps, ie about 100.1 ml to 400 ml or 100 ml to 399.9 ml, 100.2 ml to 400 ml or 100 ml to 399, 8 ml or 101.1 ml to 399.9 ml or 100.2 ml to 399.8 ml etc.
  • the air volume offered is particularly associated with the peelable receiving chamber for the blister pack, which further offers an enlarged flow channel cross-section for inhalation is sufficient for a usual inhalation without further effort.
  • the device for inhalation is also suitable for weakened patients, and also for children, especially infants and babies.
  • the plate-side connecting pipe section at the same time a mouthpiece, which may be further equipped optionally after the pumping and prior to the actual inhalation with a mouth and nose covering mask, such as for use in infants.
  • the plate having the bag is removed from the metering pump.
  • the Removed receiving chamber with the pierced blister from the plate-side connecting pipe section and thereafter provided with the inflated bag plate to the patient.
  • the powder cloud in the inflated bag or the volume of air built up in the bag will remain standing for about a minute even with the flow channel otherwise open to the outside for inhalation. There is enough time after preparation for the inhalation process.
  • an overflow channel is provided in the receiving chamber.
  • the air flow directed axially via the connecting pipe section via the metering pump into the receiving chamber for the blister pack is deflected out of the axial alignment via this overflow channel, so more preferably into an axially parallel alignment.
  • the bag wall is in the compressed, ie folded state.
  • this recess may be formed by a peripheral edge of the bottom plate encircling, over the broad side projecting collar, which accordingly offers an inner space for receiving the folded bag.
  • the bag is held in place in this recess, in particular in the delivery state in a protected position.
  • the metering pump is designed as a over a single piston stroke the required amount of air metered dispensing hand pump.
  • Forming the pump as a hand pump is the preparation for inhalation as well as the inhalation process itself, regardless of any supply connections, such as power connections.
  • the chamber volume of the pump corresponds to the volume of air received through the bag, so that the amount of air required to blow out the powdered medicament from the blister pack and to completely fill the bag is sufficient with only a single piston stroke.
  • the pump end position is secured, for example, rest assured.
  • the Pumpansaug ein can also be secured in a corresponding manner.
  • the removable from the plate-side connecting pipe section before the inhalation process receiving chamber for the blister pack has in a further embodiment, a plug-like, insertable in the connecting pipe section cylinder portion. This sits sealing in the connection pipe section.
  • a plug-like, insertable in the connecting pipe section cylinder portion This sits sealing in the connection pipe section.
  • the guide tongue also forms, in cooperation with the connecting tube section which receives the guide tongue. Cross-section of the overflow, this continues with a total of substantially matching cross-sectional configuration of the guide tongue receiving portion of the connecting pipe section.
  • the front concave cavity of the guide tongue forms inserted into the connecting pipe section a wall portion of the vortex chamber into which the overflow opens.
  • the opening cross section of the connecting pipe section receiving the guide tongue is widened at a distance from the sealed swirling chamber.
  • the sealing region of the receiving chamber assigned to the frontal concave cavity reaches, after a displacement of approximately 1 to 2 mm, this cross-sectional widened area which is in communication with the environment, whereby any negative pressure that may be built up via this minimal displacement path is torn off.
  • the mediocre trained in the guide tongue window may support this effect.
  • the bag attachment side is associated with a flow-through in the plate.
  • the latter is seated in the flow direction in the course of the inflating of the bag behind the vortex chamber, via which throughflow opening the particle-laden air flows into the bag.
  • This flow-through opening is enclosed by a circumferential, raised against the plate broad side collar.
  • this circumferential collar has openings radially aligned with the flow opening.
  • Figure 1 is a perspective view of the device, consisting of a pump and an inhaler, regarding the standby position.
  • FIG. 6 shows the longitudinal section along the line VI - VI in Fig. 4.
  • FIG. 8 shows a cross section through the inhaler according to the line VIII - VIII in Fig. 3;
  • FIG. 10 shows a perspective cutout view, showing the region of a pump-side connection section with a needle
  • FIG. 12 shows the enlargement of the area denoted by XII in FIG. 11;
  • FIG. 13 shows a longitudinal sectional illustration according to FIG. 11 after the dosage has been taken;
  • FIG. 12 shows the enlargement of the area denoted by XII in FIG. 11;
  • FIG. 13 shows a longitudinal sectional illustration according to FIG. 11 after the dosage has been taken;
  • FIG. 12 shows the enlargement of the area denoted by XII in FIG. 11;
  • FIG. 13 shows a longitudinal sectional illustration according to FIG. 11 after the dosage has been taken;
  • FIG. 14 is a perspective view according to FIG. 1, but after a metering and subsequent removal of the inhalation part; FIG.
  • Fig. 15 is a longitudinal sectional view of FIG. 6, the ready position of the inhalation for inhalation concerning and
  • FIG. 16 shows a cross-sectional view according to FIG. 8 concerning the ready position according to FIG. 15.
  • a device 1 for the administration of a blisterverpackten drug which consists essentially of a hand-operated pump 2 and a separate inhaler 3.
  • the hand-operated pump 2 initially has an annular in cross section pump cylinder 4. This is closed at one end by a cylinder bottom 5.
  • the cylindrical top 6 opposite the cylinder bottom 5 has a passage opening 7 oriented coaxially to the cylinder axis x-x, which is remote from the limited cylinder space 9 by an annular collar 8 integrally formed with the cylinder cover 6.
  • a piston 10 is guided along the axis x. This is by means of a circumferential lip seal 11 sealingly against the inner wall of the pump cylinder 4.
  • the piston 10 is supported on a tubular piston rod 12 which receives centrally the axis x and the cylinder space 9 in the longitudinal extent Kurs- passing through the passage opening 7 is guided.
  • the piston 10 facing the free end of the piston rod 12 passes through the piston 10 centrally, so that the defined by the piston rod 12 pump flow channel 13 opens freely to the piston rod 12 facing away from the piston surface 14.
  • the piston rod 12 Facing the piston rear side facing away from the piston surface 14, the piston rod 12 carries a radial collar 15 which is supported on the piston rear side.
  • the cylinder section 16 which surrounds the piston rod 12 extends approximately over the entire axial length of the piston rod 12 and, in the end region remote from the radial collar 15, merges into a circular disc-shaped cover 17, which is penetrated centrally by the piston rod 12.
  • the axial length of the cylinder portion 16 is further selected so that in a piston stop position on the cylinder chamber side bottom 5 as shown in Figure 10, the outwardly facing surface of the ceiling 17 in a plane to the free edge of the cylindrical portion 16 comprehensive annular collar 8 extends.
  • the outer diameter of the cylinder section 16 is adapted to the inner diameter of the annular collar 8. Accordingly, the annular collar 8 provides guidance of the piston rod 12 via the cylinder section 16 in the course of the displacement of the piston rod 12 along the cylinder axis x.
  • the projecting beyond the ceiling 17 end portion of the piston rod 12 further carries an actuating handle 18 in the form of an annular disc-shaped Radial extension.
  • This connects directly to the ceiling 17 and has a relation to the pump cylinder side annular collar 8 enlarged diameter, so that the actuating handle 18 circumferentially protrudes radially beyond the annular collar 8.
  • the actuating handle 18 serves at the same time in the pump end position according to FIG. 10 in cooperation with the facing end face of the annular collar 8 as a stop for the piston rod 12.
  • connecting pipe section 19 On the ceiling 17 facing away from the wide area of the actuating handle 18 coaxially aligned with the axis x connecting pipe section 19 is formed. This is formed in a first, emanating from the actuating handle 18 portion hollow cylindrical. The further portion of the connecting pipe section 19, so on about two-thirds of the total length of the connecting pipe section 19 is designed shell-shaped, opening upwards. As a result, a support portion 20 is formed, with an outer diameter corresponding to the outer diameter of the hollow cylindrical coupling portion 21.
  • the valley of the half-shell-shaped support section 20 is provided with an axis-parallel, longitudinal slot-like opening 22.
  • annular step 23 is formed on the inside of the supporting section 20, on which the free end of the connecting pipe section 19 is approximately half the material thickness dimension of the pipe Connecting pipe section 19 reduced diameter connects.
  • the piston rod 12 or the pump flow channel 13 opens within the coupling portion 21 under closure of the mouth cross-section through a molded-on cover 24.
  • the latter has a central opening 25 into which a needle 26 is inserted in the form of a hollow needle. This may be welded to the cover 24.
  • plastic injection-molded parts can at the same time be encapsulated by the covering material in the course of production.
  • the needle 26 is composed essentially of two cross-shaped in cross-section aligned knives, the socket side pass into a cover 24 passing through the hollow body. Facing away from the cover 24, the cutting edges are pointed.
  • the length of the needle 26 is further selected so that its tip slightly, that is further protrudes with a measure of a few mm (1 to 3 mm) over the plane defined by the end edge of the coupling portion 21, perpendicular to the x axis aligned plane.
  • the cylinder section 16 surrounding the piston rod 12 has a longitudinal slot 30 along its length. Whose ends are provided with keyhole-like extensions 31, 32.
  • the annular collar 8 has a radial bore 33 through which a spring-loaded pin 34 radially inward for engagement in the longitudinal slot 30th attacks.
  • the diameter of the pin 34 is adapted to the width dimension of the longitudinal slot 30 which is considered transversely to the axis x.
  • the pin 34 carries an end section 35 which is enlarged in diameter relative to the pin 34.
  • the latter is adapted to the opening cross-section of the extensions 31 and 32.
  • the pin 34 Radially outside the pin 34 is provided with an example thumb-operable handle 36.
  • the pin 34 is loaded radially outward (relative to the axle x) via a spring 37 surrounding the pin 34.
  • the handle 36 is to be pressed down against the force of the spring 37 so that the end section 35 passes radially inward out of the associated extension 31 or 32. Thereafter, the piston rod 12 is displaceable, wherein the longitudinal slot 30 is the pin 34 receivingly guided along the pin 34, this up to the other end position, then spring assisted in the pin-side end portion 35 automatically to achieve the safety catch in the corresponding extension 31 and 32nd the longitudinal slot 30 again invades.
  • the pump 2 is also designed as a tabletop device or the like.
  • the pump cylinder 4 is further provided on the outside wall with two adjustable feet 38. These have different lengths, so that an alignment of the pump 2 sets when stopping on a horizontal surface 39 at an acute angle of about 15 ° between the cylinder axis x and the surface 39, this with increasing piston rod 12 in the direction of the connecting pipe section 19th
  • the inhalation part 3 initially has a circular disk-shaped plate 40 with an upper broad side 41 and a lower broad side 42. Assigned to the upper one Broadside 41 edge-round a segmented axial collar 43 is formed. As a result of this embodiment, a depression 44 is formed in the interior of the axial collar 43, bounded below by the upper broad side 41.
  • the plate 40 is interspersed centrally by a circular flow opening 45. This is associated with the upper broad side 41 surrounded by a circumferential, opposite the plate broad side raised collar 46.
  • the axial height of the collar 46 corresponds approximately to a quarter of the axial height of the circumferential in the edge region of the plate 40 Axialkragens 43.
  • the collar 46 is provided with radially to the flow opening 45 aligned openings 47.
  • the inhalation part 43 On the underside of the plate 40, that is to say associated with the lower broad side 42, the inhalation part 43 is provided at the edge with two diametrically opposite wall sections 48 which are part-circular in plan. By means of this, the inhalation part 3 can be placed on a flat surface.
  • the plate 40 is further a carrier of a bag 49. This is with its opening edge 50 undetachably supported by overlapping the Axialkragens 43 on the plate 40, so in particular by welding, to which further the bag 49 is peripherally circumferentially provided with a reinforcing ring 51.
  • This is in cross-section elongated rectangular shaped with a longitudinal extent transverse to the extension direction of the channel portion 52.
  • the side wall of the channel portion 52 includes the flow opening 45 on the underside semicircular, further the width dimension of the channel portion 52nd measured transversely to the longitudinal extent of the channel portion 52 and the diameter of the semicircular, coaxial to the flow-through opening 45 aligned channel section wall approximately twice the diameter of the flow-through 45 corresponds.
  • the channel section 52 opens into a connection pipe section 53 of the inhalation part 3 which adjoins the plate 40 radially outside, this under conical widening.
  • the connecting pipe section 53 is designed as a hollow cylinder with an annular cross-section.
  • the outer diameter of the connecting pipe section 53 corresponds approximately to the inner diameter of the pump-side connecting pipe section 19 in the region of the supporting section 20.
  • a receiving chamber 54 is received pluggable. This first has a plug-like, in the connecting pipe section 53 insertable cylinder portion 55, to which a flat, projecting into the channel section 52 leading tongue 56 connects. The latter is cross-sectionally adapted to the open cross-section of the channel section 52.
  • the guide tongue 56 forms a concave hollow 57 running transversely to the channel extension. This is assigned in plug connection of the receiving chamber 54 in the connecting pipe section 53 to the flow-through opening 45, in the plan semicircular end portion of the channel section 52, whereby a circular disk-shaped, coaxial with the flow opening 45 aligned and radially limited swirl space 58 is created.
  • the wall of the concave cavity 57 correspondingly forms a partial wall section of the swirling space 58.
  • the accommodated in the connecting pipe section 53 cylinder portion 55 of the receiving chamber 54 has a radially inwardly projecting, circumferential step 59.
  • the powdered drug receiving cavity 64th directed towards the guide tongue 56 projects into a central flow channel 61 of the receiving chamber 54.
  • the blister 60 is bound by an annular collar 62 in the axial direction, for clamping between annular collar 62 and step 59.
  • the annular collar 62 is achieved, for example, by plastic deformation.
  • the cylindrical portion 55 of the receiving chamber 54 faces away from the guide tongue 56 in a radially outwardly flared support collar 63. This lies on the facing frontal edge surface of the connecting pipe section 53 and is compared to the connecting pipe section 53 enlarged diameter, further has a diameter, the corresponds to the pump-side connecting pipe section 19 in the region of the coupling portion 21.
  • the guide tongue 56 is initially designed as a solid component, with a channel section 52 adapted cross-section. In the middle, that is to say viewed in the direction of extension between the cylinder section 55 and the end-side cavity 57, a window 65 passing through the broad sides of the guide tongue 56 is formed.
  • the guide tongue 56 is further provided with a longitudinal extent of the guide tongue 56 aligned laterally projecting rib 66. This occurs in association with the receiving chamber 54 to the channel portion 52 in a correspondingly aligned in the longitudinal direction of the channel portion 52 guide groove 67 a. As a result, a position-oriented allocation of the receiving chamber 54 to the inhalation part 3 is given.
  • the rib 56 extends along the transversely directed to the broad sides of the guide tongue 56 narrow edge surface slit-like in cross-section, the side wall of the guide tongue 56 towards open Matterströmka- In allocation position of the receiving chamber 54 in the channel section 52, the overflow channel 68 is closed by the associated side wall of the channel section 52 in cross section.
  • the overflow channel 68 merges into a branch channel 69 connecting this overflow channel 68 with the central flow channel 61.
  • the channel portion 52 extends cross-sectionally in a subsection, this by extending in the axial direction, bead-shaped recesses 70. These extend starting from the circular cross-section connecting pipe section 53 linearly in the direction of the flow opening 45, this at a distance ending with the receiving chamber 54 formed Whirling space 58, so that in the region of the cavity 57 of the receiving chamber 54 used a sealing chamber cross-section remains.
  • the recesses 70 are still in projection to the receiving chamber side window 65 and open freely in the connecting pipe section 53rd
  • the function of the proposed device 1 is as follows:
  • the inhalation part 3 is present with inserted and equipped with the blister 60 receiving chamber 54, this with compressed, that is folded bag 49th
  • the pump 2 is in the ready position, in which the piston 10 is moved via the piston rod 12 by means of the actuating handle 18 into a pumping space 71 filling the extract position.
  • the sucked into the pump chamber 71 in this case air passes through radial openings 72, the cylinder chamber 9 and enforcing the lip seal 11 of the piston 10 overflowing.
  • This pump preparation position is locked in place via the longitudinal slot-pin arrangement.
  • the inhalation part 3 is closed like a plug. An attempted sucking or blowing on or in the connecting pipe section 53 does not lead to a change in the situation; can not lead accordingly later to a mishalation.
  • the inhalation part 3 is associated with its connection pipe section 53 to the connection pipe section 19 of the pump 2, the free end section of the inhalation-side connection pipe section 53 engaging in the coupling section 21 of the pump 2.
  • the needle 26 dives through the cylinder portion 55 of the receiving chamber 54 for the final piercing of the blister 60, this from the foil-backed back through the cavity 64 in the direction of the flow channel 61st
  • the pierced Kavticianswandung is divided over the cross-knife-like needle 26 into four wall sections, which respectively in the piercing direction of the needle 26 into the flow channel 61 overlap.
  • the piston 10 is displaced via the actuating handle 18 in the direction of the cylinder bottom 5 after the inhalation part 3 has been attached to the pump 2 after the pump-side latching has been discontinued.
  • the air displaced in this case flows via the hollow piston rod 12 and the needle-side through-flow openings 27 and 28 through the opened cavity 64 of the blister 60, for evacuation of the powdery medicament stored in the cavity 64.
  • the wall sections of the cavity 64 that flatten out in the direction of flow optionally lead to a first pre-turbulence of the air flow and of the entrained medicament.
  • the powder-laden air enters tangentially into the swirling space 58 and thereafter via the flow-through opening 45 in the sealed and consequently erecting bag 59th
  • the piston 10 is moved to the stop against the cylinder bottom 5 for almost complete emptying of the pump chamber 71.
  • the asked in the pump chamber 71 available air volume is thereafter fully transferred into the bag 59. This volume of air is sufficient for complete emptying of the blister 60 and for transferring the contained medicament into the bag 49, in which finally an air column with a powder cloud P is established, which is self-holding for a sufficient period of time, for example 1 to 2 minutes.
  • a in the course of pulling the receiving chamber 54 from the connecting pipe section 53 optionally adjusting suction is torn off after a displacement of a few millimeters, preferably 1 to 2 mm, this due to the adjusting this short displacement cross-sectional enlargement of the channel portion 52 through the Recesses 70.
  • the user By removing the receiving chamber 54, the user is offered the full cross section of the channel portion 52 for inhalation.
  • the inhalation part 3 is guided to the mouth, wherein the connecting pipe section 53 also represents the mouthpiece.
  • By usual inhalation standing in the bag 49 powder cloud P is sucked.
  • the resulting negative pressure causes the folding of the bag 49 back into the recess 44 of the inhaler 3, this further optionally under sealing contact the bag wall on the end face of the collar 46.
  • About the radial openings 47 of the collar 46 can also be a radially outwardly of the collar 46 are recessed in the recess 44 still adjusting residual air cushion.
  • the pump 2 In preparation for a next inhalation part 3, the pump 2 is displaced again under suction of air in its piston extraction basic position.
  • the pump 2 is reusable.
  • targeted single dosing of blister-packaged medicaments is also suitable for elderly or weak patients, moreover also for children, in particular infants.
  • the application of the device 1 is simple and self-explanatory. A double dose is not possible since each patient is assigned an inhalation part 3. This also avoids the danger of infection.
  • the handling of the inhalation part 3 prepared for inhalation also proves to be simple and, moreover, hygienic, since, after delivery of the inhalation part 3 after removal from the pump 2, this is detected at a distance from the mouthpiece formed by the connection pipe section 53, in particular in FIG Area of the plate 40. Since the powder cloud P remains in the inflated bag 49 for a sufficient time, there is also the possibility of temporarily stopping the prepared inhalation part 3 on a flat surface, to which the wall sections 48 serve.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Packages (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif (1) permettant l'administration d'un médicament sous blister. Le but de l'invention est d'obtenir un dispositif de construction simple et convenant à l'administration en masse. A cet effet, le dispositif comprend une poche (49) pouvant être gonflée par l'intermédiaire d'une pompe de dosage (2) présentant une section de raccordement tubulaire (53) dans laquelle se trouve un blister, laquelle poche est repliée sur le côté plat (41) d'une plaque (40) et retenue contre le bord de la plaque de base par son bord périphérique. La poche vidée par aspiration est éliminée avec la plaque.
PCT/EP2008/061621 2007-09-04 2008-09-03 Dispositif permettant l'administration d'un médicament sous blister Ceased WO2009030705A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200710041720 DE102007041720A1 (de) 2007-09-04 2007-09-04 Vorrichtung zur Darreichung eines blisterverpackten Medikaments
DE102007041720.0 2007-09-04

Publications (2)

Publication Number Publication Date
WO2009030705A2 true WO2009030705A2 (fr) 2009-03-12
WO2009030705A3 WO2009030705A3 (fr) 2009-06-11

Family

ID=40299122

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/061621 Ceased WO2009030705A2 (fr) 2007-09-04 2008-09-03 Dispositif permettant l'administration d'un médicament sous blister

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Country Link
DE (1) DE102007041720A1 (fr)
WO (1) WO2009030705A2 (fr)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1479283A (en) * 1973-07-23 1977-07-13 Bespak Industries Ltd Inhaler for powdered medicament
WO1981002982A1 (fr) * 1980-04-22 1981-10-29 Key Pharma Dispositif spirometrique d'inhalation pour administrer des medicaments a action pulmonaire
DE19912265A1 (de) * 1999-03-18 2000-09-21 Gsf Forschungszentrum Umwelt Verfahren und Vorrichtung zur Bereitstellung einer konstanten Medikamenten-Dosis für eine inhalatorische Applikation mit niedrigem Inhalationsfluß
GB2375308A (en) * 2001-05-10 2002-11-13 Cambridge Consultants Inhalers
DE10129703A1 (de) * 2001-06-22 2003-01-02 Sofotec Gmbh & Co Kg Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren
US7726310B2 (en) * 2005-08-24 2010-06-01 Andrus Paul G Medical aerosol non-diluting holding chamber
WO2008021451A2 (fr) * 2006-08-14 2008-02-21 Aktiv-Dry Llc Inhalateur à poudre sèche actionné par l'homme et compositions à inhaler sous forme de poudre sèche

Also Published As

Publication number Publication date
DE102007041720A1 (de) 2009-03-05
WO2009030705A3 (fr) 2009-06-11

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