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WO2009028136A1 - 蛍光観察装置 - Google Patents

蛍光観察装置 Download PDF

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Publication number
WO2009028136A1
WO2009028136A1 PCT/JP2008/002091 JP2008002091W WO2009028136A1 WO 2009028136 A1 WO2009028136 A1 WO 2009028136A1 JP 2008002091 W JP2008002091 W JP 2008002091W WO 2009028136 A1 WO2009028136 A1 WO 2009028136A1
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WO
WIPO (PCT)
Prior art keywords
light
fluorescence
component
image
infrared ray
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/002091
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English (en)
French (fr)
Inventor
Jiro Minehisa
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Panasonic Corp
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Panasonic Corp
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Filing date
Publication date
Application filed by Panasonic Corp filed Critical Panasonic Corp
Priority to JP2009529968A priority Critical patent/JPWO2009028136A1/ja
Publication of WO2009028136A1 publication Critical patent/WO2009028136A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4887—Locating particular structures in or on the body
    • A61B5/489—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • Vascular Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

　本発明は、血液中に含まれる光感受性物質からの蛍光の影響を除去して、病変領域の位置や範囲をより正確に特定できる蛍光観察装置に関する。蛍光観察装置は、可視照明光を照射する照明光源と、励起光を照射する励起光源と、赤外光を照射する赤外光源と、観察領域からの反射光を可視光成分および蛍光成分を含む第一の分離光と赤外光成分を含む第二の分離光とに分離する光分離手段と、第一の分離光から励起光成分を除去する励起光除去手段と、励起光成分を除去された第一の分離光を撮像する第一の撮像手段と、第二の分離光を撮像する第二の撮像手段と、第一の撮像手段および第二の撮像手段により撮像された画像を一の画像に合成する画像合成手段とを有する。蛍光観察装置は、赤外光像から血管の位置を特定し、可視光蛍光像から血液中の光感受性物質由来の蛍光成分を除去することで、病変領域の位置や範囲を正確に特定する。
PCT/JP2008/002091 2007-08-29 2008-08-01 蛍光観察装置 Ceased WO2009028136A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009529968A JPWO2009028136A1 (ja) 2007-08-29 2008-08-01 蛍光観察装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-223084 2007-08-29
JP2007223084 2007-08-29

Publications (1)

Publication Number Publication Date
WO2009028136A1 true WO2009028136A1 (ja) 2009-03-05

Family

ID=40386879

Family Applications (1)

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PCT/JP2008/002091 Ceased WO2009028136A1 (ja) 2007-08-29 2008-08-01 蛍光観察装置

Country Status (2)

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JP (1) JPWO2009028136A1 (ja)
WO (1) WO2009028136A1 (ja)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011048886A1 (ja) * 2009-10-20 2011-04-28 オリンパスメディカルシステムズ株式会社 蛍光観察装置
JP2013514156A (ja) * 2009-12-15 2013-04-25 エモリー ユニバーシティ 診断又は治療処置においてリアルタイム解剖学的指針を提供するシステム及び方法
CN103284694A (zh) * 2013-05-22 2013-09-11 西安电子科技大学 一种活体动物血管新生定量分析方法
CN104287689A (zh) * 2014-09-28 2015-01-21 安徽中科医药成像技术科技有限公司 内窥镜及其调节装置
JP2015091351A (ja) * 2014-12-24 2015-05-14 富士フイルム株式会社 内視鏡装置
JP2015129713A (ja) * 2014-01-08 2015-07-16 オリンパス株式会社 画像取得装置および方法
JP2015527909A (ja) * 2012-07-10 2015-09-24 アイマゴ ソシエテ アノニムＡｉｍａｇｏ Ｓ．Ａ． 灌流評価マルチモダリティ光学医用デバイス
US9345389B2 (en) 2010-11-12 2016-05-24 Emory University Additional systems and methods for providing real-time anatomical guidance in a diagnostic or therapeutic procedure
JP2016214507A (ja) * 2015-05-19 2016-12-22 株式会社島津製作所 イメージング装置
CN106943193A (zh) * 2017-04-27 2017-07-14 华中科技大学 共定位手术导航系统和相机头
US9757039B2 (en) 2008-07-10 2017-09-12 Ecole Polytechnique Federale De Lausanne (Epfl) Functional optical coherent imaging
JP2017176811A (ja) * 2016-03-28 2017-10-05 ソニー株式会社 撮像装置、撮像方法及び医療用観察機器
CN107374730A (zh) * 2017-09-06 2017-11-24 东北大学 光学手术导航系统
JP2018201648A (ja) * 2017-05-31 2018-12-27 三菱電機エンジニアリング株式会社 撮像装置
US10169862B2 (en) 2015-05-07 2019-01-01 Novadaq Technologies ULC Methods and systems for laser speckle imaging of tissue using a color image sensor
EP3332689A4 (en) * 2015-08-03 2019-05-08 National Cancer Center WRITTEN-TYPE MEDICAL FLUORESCENCE IMAGING DEVICE AND SYSTEM FOR ORIENTING MULTIPLE FLUORESCENCE IMAGES
WO2019215799A1 (ja) * 2018-05-07 2019-11-14 株式会社島津製作所 医療用イメージング装置
US10575737B2 (en) 2012-04-27 2020-03-03 Novadaq Technologies ULC Optical coherent imaging medical device
CN110868914A (zh) * 2017-07-11 2020-03-06 高露洁-棕榄公司 口腔护理评估系统和方法
JPWO2018216658A1 (ja) * 2017-05-23 2020-03-26 国立研究開発法人産業技術総合研究所 撮像装置、撮像システム、及び撮像方法
JP2020046208A (ja) * 2018-09-14 2020-03-26 株式会社東芝 光学センサ
JPWO2021038734A1 (ja) * 2019-08-27 2021-03-04
JP2021192534A (ja) * 2017-03-23 2021-12-16 株式会社Ｊｖｃケンウッド 撮像装置及び撮像方法
JP2022113067A (ja) * 2021-01-22 2022-08-03 シンクロア株式会社 光源ユニットおよび蛍光性を有する物質の認識支援装置
JP2023062528A (ja) * 2021-10-21 2023-05-08 国立研究開発法人国立がん研究センター 光線力学療法治療支援装置
WO2025223515A1 (zh) * 2024-04-25 2025-10-30 深圳康诺思腾科技有限公司 成像方法和系统及手术机器人系统

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017203448B9 (de) * 2017-03-02 2021-12-23 Carl Zeiss Meditec Ag Mikroskopiesystem und Mikroskopieverfahren zum Quantifizieren einer Fluoreszenz

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07222712A (ja) * 1994-02-10 1995-08-22 Olympus Optical Co Ltd 蛍光内視鏡装置
JPH09294706A (ja) * 1996-04-30 1997-11-18 Fuji Photo Film Co Ltd 蛍光診断装置
JP2003153850A (ja) * 2001-11-22 2003-05-27 Olympus Optical Co Ltd 内視鏡用撮像装置
JP2007143647A (ja) * 2005-11-24 2007-06-14 Olympus Medical Systems Corp 電子内視鏡装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3560671B2 (ja) * 1995-02-23 2004-09-02 オリンパス株式会社 蛍光観察装置
JP3525235B2 (ja) * 1995-12-06 2004-05-10 松下電器産業株式会社 光診断装置
JP2738390B2 (ja) * 1996-06-21 1998-04-08 松下電器産業株式会社 診断・治療装置
JP3962122B2 (ja) * 1996-11-20 2007-08-22 オリンパス株式会社 内視鏡装置
US6826424B1 (en) * 2000-12-19 2004-11-30 Haishan Zeng Methods and apparatus for fluorescence and reflectance imaging and spectroscopy and for contemporaneous measurements of electromagnetic radiation with multiple measuring devices
JP2004024656A (ja) * 2002-06-27 2004-01-29 Fuji Photo Film Co Ltd 蛍光内視鏡装置
JP4258324B2 (ja) * 2003-09-08 2009-04-30 パナソニック株式会社 医療用光源システム
JP2005131129A (ja) * 2003-10-30 2005-05-26 Olympus Corp 撮像装置及び内視鏡装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07222712A (ja) * 1994-02-10 1995-08-22 Olympus Optical Co Ltd 蛍光内視鏡装置
JPH09294706A (ja) * 1996-04-30 1997-11-18 Fuji Photo Film Co Ltd 蛍光診断装置
JP2003153850A (ja) * 2001-11-22 2003-05-27 Olympus Optical Co Ltd 内視鏡用撮像装置
JP2007143647A (ja) * 2005-11-24 2007-06-14 Olympus Medical Systems Corp 電子内視鏡装置

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9757039B2 (en) 2008-07-10 2017-09-12 Ecole Polytechnique Federale De Lausanne (Epfl) Functional optical coherent imaging
US10617303B2 (en) 2008-07-10 2020-04-14 Ecole Polytechnique Federale De Lausanne (Epfl) Functional optical coherent imaging
JPWO2011048886A1 (ja) * 2009-10-20 2013-03-07 オリンパスメディカルシステムズ株式会社 蛍光観察装置
WO2011048886A1 (ja) * 2009-10-20 2011-04-28 オリンパスメディカルシステムズ株式会社 蛍光観察装置
US9451882B2 (en) 2009-12-15 2016-09-27 Emory University Integrated system and methods for real-time anatomical guidance in a diagnostic or therapeutic procedure
JP2013514156A (ja) * 2009-12-15 2013-04-25 エモリー ユニバーシティ 診断又は治療処置においてリアルタイム解剖学的指針を提供するシステム及び方法
US9345389B2 (en) 2010-11-12 2016-05-24 Emory University Additional systems and methods for providing real-time anatomical guidance in a diagnostic or therapeutic procedure
US10575737B2 (en) 2012-04-27 2020-03-03 Novadaq Technologies ULC Optical coherent imaging medical device
JP2015527909A (ja) * 2012-07-10 2015-09-24 アイマゴ ソシエテ アノニムＡｉｍａｇｏ Ｓ．Ａ． 灌流評価マルチモダリティ光学医用デバイス
US10101571B2 (en) 2012-07-10 2018-10-16 Novadaq Technologies ULC Perfusion assessment multi-modality optical medical device
CN103284694A (zh) * 2013-05-22 2013-09-11 西安电子科技大学 一种活体动物血管新生定量分析方法
JP2015129713A (ja) * 2014-01-08 2015-07-16 オリンパス株式会社 画像取得装置および方法
CN104287689A (zh) * 2014-09-28 2015-01-21 安徽中科医药成像技术科技有限公司 内窥镜及其调节装置
JP2015091351A (ja) * 2014-12-24 2015-05-14 富士フイルム株式会社 内視鏡装置
US10169862B2 (en) 2015-05-07 2019-01-01 Novadaq Technologies ULC Methods and systems for laser speckle imaging of tissue using a color image sensor
JP2016214507A (ja) * 2015-05-19 2016-12-22 株式会社島津製作所 イメージング装置
EP3332689A4 (en) * 2015-08-03 2019-05-08 National Cancer Center WRITTEN-TYPE MEDICAL FLUORESCENCE IMAGING DEVICE AND SYSTEM FOR ORIENTING MULTIPLE FLUORESCENCE IMAGES
JP2017176811A (ja) * 2016-03-28 2017-10-05 ソニー株式会社 撮像装置、撮像方法及び医療用観察機器
JP7314976B2 (ja) 2017-03-23 2023-07-26 株式会社Ｊｖｃケンウッド 撮像装置及び撮像方法
JP2021192534A (ja) * 2017-03-23 2021-12-16 株式会社Ｊｖｃケンウッド 撮像装置及び撮像方法
CN106943193A (zh) * 2017-04-27 2017-07-14 华中科技大学 共定位手术导航系统和相机头
JPWO2018216658A1 (ja) * 2017-05-23 2020-03-26 国立研究開発法人産業技術総合研究所 撮像装置、撮像システム、及び撮像方法
JP2018201648A (ja) * 2017-05-31 2018-12-27 三菱電機エンジニアリング株式会社 撮像装置
CN110868914A (zh) * 2017-07-11 2020-03-06 高露洁-棕榄公司 口腔护理评估系统和方法
CN107374730A (zh) * 2017-09-06 2017-11-24 东北大学 光学手术导航系统
JPWO2019215799A1 (ja) * 2018-05-07 2021-03-11 株式会社島津製作所 医療用イメージング装置
WO2019215799A1 (ja) * 2018-05-07 2019-11-14 株式会社島津製作所 医療用イメージング装置
US10837905B2 (en) 2018-09-14 2020-11-17 Kabushiki Kaisha Toshiba Optical sensor
JP2020046208A (ja) * 2018-09-14 2020-03-26 株式会社東芝 光学センサ
JPWO2021038734A1 (ja) * 2019-08-27 2021-03-04
JP2024038065A (ja) * 2019-08-27 2024-03-19 株式会社島津製作所 イメージング方法
JP7700040B2 (ja) 2019-08-27 2025-06-30 株式会社島津製作所 イメージング装置、治療装置およびイメージング方法
JP2022113067A (ja) * 2021-01-22 2022-08-03 シンクロア株式会社 光源ユニットおよび蛍光性を有する物質の認識支援装置
JP2023062528A (ja) * 2021-10-21 2023-05-08 国立研究開発法人国立がん研究センター 光線力学療法治療支援装置
JP7754413B2 (ja) 2021-10-21 2025-10-15 国立研究開発法人国立がん研究センター 光線力学療法治療支援装置
WO2025223515A1 (zh) * 2024-04-25 2025-10-30 深圳康诺思腾科技有限公司 成像方法和系统及手术机器人系统

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