[go: up one dir, main page]

WO2009024678A3 - Device and method for separation of the components of a suspension in particular of blood - Google Patents

Device and method for separation of the components of a suspension in particular of blood Download PDF

Info

Publication number
WO2009024678A3
WO2009024678A3 PCT/FR2008/000961 FR2008000961W WO2009024678A3 WO 2009024678 A3 WO2009024678 A3 WO 2009024678A3 FR 2008000961 W FR2008000961 W FR 2008000961W WO 2009024678 A3 WO2009024678 A3 WO 2009024678A3
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
separation
duct
curved section
suspension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2008/000961
Other languages
French (fr)
Other versions
WO2009024678A2 (en
Inventor
Herve Rostaing
Jean-Luc Achard
Patrick Pouteau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Centre National de la Recherche Scientifique CNRS
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Commissariat a lEnergie Atomique CEA filed Critical Centre National de la Recherche Scientifique CNRS
Publication of WO2009024678A2 publication Critical patent/WO2009024678A2/en
Publication of WO2009024678A3 publication Critical patent/WO2009024678A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/0039—Settling tanks provided with contact surfaces, e.g. baffles, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/0087—Settling tanks provided with means for ensuring a special flow pattern, e.g. even inflow or outflow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/265—Separation of sediment aided by centrifugal force or centripetal force by using a vortex inducer or vortex guide, e.g. coil
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2676—Centrifugal separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/045—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation having annular separation channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0457—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation having three-dimensional spirally wound separation channels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Device for the separation of a liquid suspension (S), comprising a continuous liquid phase (PL) and at least one dispersed phase (GB, GR), said phases having different densities. Said device comprises a first duct (C1) with at least one curved section, at least one second duct (C2), also with a curved section, running parallel to said first duct on the outside of the curve of the latter and at least one chamber (CL), separating said first and second ducts and in turn being curved. A longitudinal slot (F) is arranged in said chamber running along the curved section of the chamber and communicating between said first and second ducts such as to permit the exchange of material between them, said slot (F) being essentially arranged at the mid-point of said chamber (CL). The invention further relates to a method for separation of a liquid suspension using said device.
PCT/FR2008/000961 2007-07-18 2008-07-04 Device and method for separation of the components of a suspension in particular of blood Ceased WO2009024678A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0705180 2007-07-18
FR0705180A FR2918900A1 (en) 2007-07-18 2007-07-18 DEVICE AND METHOD FOR SEPARATING THE COMPONENTS OF A SUSPENSION AND PARTICULARLY BLOOD

Publications (2)

Publication Number Publication Date
WO2009024678A2 WO2009024678A2 (en) 2009-02-26
WO2009024678A3 true WO2009024678A3 (en) 2009-04-23

Family

ID=39047956

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/000961 Ceased WO2009024678A2 (en) 2007-07-18 2008-07-04 Device and method for separation of the components of a suspension in particular of blood

Country Status (2)

Country Link
FR (1) FR2918900A1 (en)
WO (1) WO2009024678A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2897730A4 (en) * 2012-09-21 2016-04-27 Massachusetts Inst Technology MICROFLUIDIC DEVICE AND USES THEREOF
US9804068B2 (en) 2012-09-28 2017-10-31 University Of Maryland Particle separation and concentration using spiral inertial filtration
FR3007665B1 (en) * 2013-06-28 2017-04-07 Commissariat Energie Atomique DEVICE FOR EXTRACTING A LOWER LIQUID PHASE IN PARTICULAR FROM A SUSPENSION
ES2978196T3 (en) * 2015-09-03 2024-09-06 Filterart Ltd A conduit for use in a system for separating suspended particles in a fluid, and a method of designing such a conduit
US9968929B2 (en) * 2015-10-27 2018-05-15 Apex Biotechnology Corp. Reaction cassette and assay device
FR3048778A1 (en) 2016-03-10 2017-09-15 Archimej Tech ANALYSIS DEVICE, PREFERABLY FOR CHEMOMETRY OF A BLOOD SAMPLE.
IL251036A0 (en) 2017-03-08 2017-06-29 Aqua Hd Separation And Filtration Systems Ltd System and method for separating particles suspended in a liquid
US11110374B2 (en) 2017-03-28 2021-09-07 Chromatan Inc. Continuous countercurrent spiral chromatography
CN111801200B (en) * 2018-03-30 2022-08-23 吉列有限责任公司 Shaving razor system including skin interconnect member
AU2020204417B1 (en) * 2020-04-28 2021-10-28 Zhang, Shujun MR Improved apparatus and method for separating particles from a particulate suspension

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2626747A (en) * 1949-03-11 1953-01-27 Emil L Ranseen Centrifugal separator
US3327939A (en) * 1965-11-15 1967-06-27 Wladzia G P Doyle Centrifugal countercurrent exchange device with improved removable strip means
GB2024644A (en) * 1978-07-05 1980-01-16 Hitachi Ltd Centrifugal type counterflow contact apparatus
US4623470A (en) * 1981-11-09 1986-11-18 Helipump, Inc. Process and apparatus for separating or fractionating fluid mixtures
WO2001094024A1 (en) * 2000-06-08 2001-12-13 Westfalia Separator Food Tec Gmbh Centrifuge with a sieve system and method for operating the same
WO2002038502A1 (en) * 2000-11-13 2002-05-16 Bayer Aktiengesellschaft Device for irradiating liquids
US20020196435A1 (en) * 2000-11-22 2002-12-26 Cohen David Samuel Apparatus and methods for separating agglutinants and disperse particles
WO2004113877A1 (en) * 2003-06-13 2004-12-29 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
WO2006020100A2 (en) * 2004-07-16 2006-02-23 Smart Medical Technologies, Llc Continuous blood separator

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2626747A (en) * 1949-03-11 1953-01-27 Emil L Ranseen Centrifugal separator
US3327939A (en) * 1965-11-15 1967-06-27 Wladzia G P Doyle Centrifugal countercurrent exchange device with improved removable strip means
GB2024644A (en) * 1978-07-05 1980-01-16 Hitachi Ltd Centrifugal type counterflow contact apparatus
US4623470A (en) * 1981-11-09 1986-11-18 Helipump, Inc. Process and apparatus for separating or fractionating fluid mixtures
WO2001094024A1 (en) * 2000-06-08 2001-12-13 Westfalia Separator Food Tec Gmbh Centrifuge with a sieve system and method for operating the same
WO2002038502A1 (en) * 2000-11-13 2002-05-16 Bayer Aktiengesellschaft Device for irradiating liquids
US20020196435A1 (en) * 2000-11-22 2002-12-26 Cohen David Samuel Apparatus and methods for separating agglutinants and disperse particles
WO2004113877A1 (en) * 2003-06-13 2004-12-29 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
WO2006020100A2 (en) * 2004-07-16 2006-02-23 Smart Medical Technologies, Llc Continuous blood separator

Also Published As

Publication number Publication date
WO2009024678A2 (en) 2009-02-26
FR2918900A1 (en) 2009-01-23

Similar Documents

Publication Publication Date Title
WO2009024678A3 (en) Device and method for separation of the components of a suspension in particular of blood
WO2008030731A3 (en) Apparatus and method for separating a composite liquid into at least two components
WO2012145414A9 (en) Apparatus and method for separating and concentrating fluids containing multiple components
WO2010132785A3 (en) Surface coalescer
MY169998A (en) Systems and methods for drying drill cuttings
WO2004104553A3 (en) Method and apparatus for separating fluid components
WO2007038363A3 (en) Utilizing ionic liquids for hydrofluorocarbon separation
EP2212198A4 (en) METHOD AND APPARATUS FOR AIRCRAFT TRANSFORMATION WITHOUT PILOT
WO2010056331A3 (en) Small-scale method and appratus for separating mixtures
EP2151230A4 (en) Oil-in-water emulsion composition and method for producing the same
WO2012118735A3 (en) Removal of immunoglobulins and leukocytes from biological fluids
AU2003298048A1 (en) Hydrodynamic static mixing apparatus and method for use thereof in transporting, conditioning and separating oil sands and the like
WO2007092827A3 (en) Improved separation method
CL2008002819A1 (en) METHOD OF EXTRACTION OF ORGANIC MATTER WITH HYDROCARBONS (HC) THAT INCLUDES EXTRACTING THE MATTER BY CONTACTING MATERIAL WITH HC WITH LIQUID WITH TREMENTIN, SEPARATING MIXTURE OF EXTRACTION AND SEPARATING HC PRODUCT FROM LIQUID WITH TREMENTIN; COMPOSITION OF
BRPI0618020A2 (en) CORNER ADAPTATION AND THEIR FORMATION METHOD
WO2013009437A3 (en) Injection flocculation and compression dewatering unit for solids control and management of drilling fluids and methods relating thereto
WO2008139085A3 (en) Method for cooling a cryogenic exchange line
WO2011039399A3 (en) Aircraft ring frame and method for obtaining it
EP2318716A4 (en) Variable capacity type rotary compressor, cooling apparatus having the same, and method for driving the same
Li et al. Exact synchronization by groups for a coupled system of wave equations with Dirichlet boundary controls
NO20053230D0 (en) Sieve and fluid separation apparatus and method using the same.
EP2118003A4 (en) Method, material and apparatus for enhancing dynamic stiffness
WO2007014222A3 (en) Blood processing device and associated systems and methods
ATE528643T1 (en) ELECTROPHORESIS METHOD AND DEVICE FOR SEPARATING OBJECTS
EP3943839A4 (en) Liquid separator, cooling system, and gas-liquid separation method

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08827692

Country of ref document: EP

Kind code of ref document: A2