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WO2009075768A3 - Optical device and method for real-time chemosensitivity testing - Google Patents

Optical device and method for real-time chemosensitivity testing Download PDF

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Publication number
WO2009075768A3
WO2009075768A3 PCT/US2008/013371 US2008013371W WO2009075768A3 WO 2009075768 A3 WO2009075768 A3 WO 2009075768A3 US 2008013371 W US2008013371 W US 2008013371W WO 2009075768 A3 WO2009075768 A3 WO 2009075768A3
Authority
WO
WIPO (PCT)
Prior art keywords
real
time
tumor
optical device
chemosensitivity testing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/013371
Other languages
French (fr)
Other versions
WO2009075768A2 (en
Inventor
Chad Allen Lieber
Mustafa Husen Kabeer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Hospital of Orange County
Original Assignee
Childrens Hospital of Orange County
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hospital of Orange County filed Critical Childrens Hospital of Orange County
Publication of WO2009075768A2 publication Critical patent/WO2009075768A2/en
Publication of WO2009075768A3 publication Critical patent/WO2009075768A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/656—Raman microprobe
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Optical systems and methods for real-time chemosensitivity testing of an in-vivo tumor are described. In one embodiment of the invention, the system comprises a probe (104) that can be inserted near a tumor. Radiation is incident on the tumor and the scattered photons from the tumor are detected by a photonic detector (107). The photonic detector (107) records a Raman spectrum which is compared to one or more Raman spectra in a database.
PCT/US2008/013371 2007-12-07 2008-12-05 Optical device and method for real-time chemosensitivity testing Ceased WO2009075768A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1216307P 2007-12-07 2007-12-07
US61/012,163 2007-12-07

Publications (2)

Publication Number Publication Date
WO2009075768A2 WO2009075768A2 (en) 2009-06-18
WO2009075768A3 true WO2009075768A3 (en) 2009-08-20

Family

ID=40756029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/013371 Ceased WO2009075768A2 (en) 2007-12-07 2008-12-05 Optical device and method for real-time chemosensitivity testing

Country Status (1)

Country Link
WO (1) WO2009075768A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019060427A1 (en) 2017-09-19 2019-03-28 Pendar Technologies, Llc In-vivo monitoring of cellular energetics with raman spectroscopy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020039186A1 (en) * 2000-03-10 2002-04-04 Rosenberg Charles W. Von Optical probes and methods for spectral analysis
US20060294604A1 (en) * 2003-02-17 2006-12-28 Fridman Jordan S Model for studying the role of genes in tumor resistance to chemotherapy
US20070264193A1 (en) * 2006-03-29 2007-11-15 Genentech, Inc. Diagnostics and treatments for tumors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020039186A1 (en) * 2000-03-10 2002-04-04 Rosenberg Charles W. Von Optical probes and methods for spectral analysis
US20060294604A1 (en) * 2003-02-17 2006-12-28 Fridman Jordan S Model for studying the role of genes in tumor resistance to chemotherapy
US20070264193A1 (en) * 2006-03-29 2007-11-15 Genentech, Inc. Diagnostics and treatments for tumors

Also Published As

Publication number Publication date
WO2009075768A2 (en) 2009-06-18

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