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WO2009070045A3 - Imidazole derivatives, process for their preparation, and thier pharmaceutical use - Google Patents

Imidazole derivatives, process for their preparation, and thier pharmaceutical use Download PDF

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Publication number
WO2009070045A3
WO2009070045A3 PCT/PL2008/050016 PL2008050016W WO2009070045A3 WO 2009070045 A3 WO2009070045 A3 WO 2009070045A3 PL 2008050016 W PL2008050016 W PL 2008050016W WO 2009070045 A3 WO2009070045 A3 WO 2009070045A3
Authority
WO
WIPO (PCT)
Prior art keywords
thier
preparation
pharmaceutical use
imidazole derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/PL2008/050016
Other languages
French (fr)
Other versions
WO2009070045A2 (en
Inventor
Stanislaw Sobiak
Marcin Wierzchowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNIWERSYTET MEDYCZNY IM KAROLA MARCINKOWSKIEGO W POZNANIU
Original Assignee
UNIWERSYTET MEDYCZNY IM KAROLA MARCINKOWSKIEGO W POZNANIU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNIWERSYTET MEDYCZNY IM KAROLA MARCINKOWSKIEGO W POZNANIU filed Critical UNIWERSYTET MEDYCZNY IM KAROLA MARCINKOWSKIEGO W POZNANIU
Publication of WO2009070045A2 publication Critical patent/WO2009070045A2/en
Publication of WO2009070045A3 publication Critical patent/WO2009070045A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The subject of the present application are derivatives of imidazole, a method of manufacturing them as well as their use as active substance in medicinal products for use in human and veterinary medicine. The derivatives of imidazole according to the present invention are compounds with the general formula (1) in which R1, R2, R3 and n have the meanings as defined in the description.
PCT/PL2008/050016 2007-11-27 2008-11-27 Imidazole derivatives, process for their preparation, and thier pharmaceutical use Ceased WO2009070045A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL383839A PL213730B1 (en) 2007-11-27 2007-11-27 New derivatives of imidazol, application of new derivatives of imidazol and their production method
PLPL383839 2007-11-27

Publications (2)

Publication Number Publication Date
WO2009070045A2 WO2009070045A2 (en) 2009-06-04
WO2009070045A3 true WO2009070045A3 (en) 2009-09-03

Family

ID=40521836

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2008/050016 Ceased WO2009070045A2 (en) 2007-11-27 2008-11-27 Imidazole derivatives, process for their preparation, and thier pharmaceutical use

Country Status (2)

Country Link
PL (1) PL213730B1 (en)
WO (1) WO2009070045A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1038473C2 (en) * 2010-12-24 2012-06-27 Centre Nat Rech Scient Cancer targeting using carbonic anhydrase isoform ix inhibitors.
AU2015324072B2 (en) * 2014-09-29 2018-12-06 The Penn State Research Foundation A compound for anti-cancer therapy that acts by targeting GOF mutant P53 and stimulates P73
AU2018207776B2 (en) 2017-01-10 2021-06-17 Bayer Aktiengesellschaft Heterocyclene derivatives as pest control agents
AR113206A1 (en) 2017-01-10 2020-02-19 Bayer Cropscience Ag HETEROCYCLIC DERIVATIVES AS PESTICIDES
KR20210057110A (en) 2018-09-13 2021-05-20 바이엘 악티엔게젤샤프트 Heterocyclene derivatives as pest control agents

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 10 August 2006 (2006-08-10), XP002531786, retrieved from STN Database accession no. RN: 900302-18-3 *
E. TYKARSKA ET AL.: "2-(Bromo-2-methyl- 4-nitroimidazol-1-yl)-1-(2-chlorophenyl)- ethanone", ACTA CRYSTALLOGRAPHICA SECTION E, vol. E63, April 2007 (2007-04-01), pages O1669 - O1671, XP002531783 *
SALGADO-ZAMORA H ET AL: "A convenient approach to the synthesis of the imidazo[5,1-b] oxazole ring system", HETEROCYCLES, vol. 50, no. 2, 1 January 1999 (1999-01-01), ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, pages 1081 - 1090, XP008105357, ISSN: 0385-5414 *
SOBIAK S: "Synthesis of some 5-amino-2-methyl-4-nitro-1-phenacylimidazoles", POLISH JOURNAL OF CHEMISTRY, vol. 72, no. 1, 1 January 1998 (1998-01-01), POLISH CHEMICAL SOCIETY, POLAND, pages 78 - 83, XP008105331, ISSN: 0137-5083, Retrieved from the Internet <URL:http://ichf.edu.pl/pjch/pj-1998/pj0198.htm#78> [retrieved on 20090415] *
SOBIAK S: "Tetrabutyl ammonium bromide as a catalyst for reaction of 5(4)-bromo-2-methyl-4(5)-nitroimidazole with phenacyl bromides", ACTA POLONIAE PHARMACEUTICA, vol. 56, no. 2, 1 January 1999 (1999-01-01), POLISH PHARMACEUTICAL SOCIETY, WARZSAW, PL, pages 155 - 158, XP008105335, ISSN: 0001-6837 *
ZAPRUTKO L ET AL: "Azoles. Part 34: nitroimidazole derivatives and their antibacterial and fungicidal activity", PHARMAZIE, vol. 47, no. 4, 1 January 1992 (1992-01-01), GOVI VERLAG, ESCHBORN, DE, pages 258 - 261, XP008105338, ISSN: 0031-7144 *

Also Published As

Publication number Publication date
PL383839A1 (en) 2009-06-08
WO2009070045A2 (en) 2009-06-04
PL213730B1 (en) 2013-04-30

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